{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:45Z","timestamp":1791330945497,"version":"4.3.1"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"am","delay-in-days":341,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2017R1C1B2011672"],"award-info":[{"award-number":["2017R1C1B2011672"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"crossref","award":["116135-3"],"award-info":[{"award-number":["116135-3"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>EGF and EGFR gene-releasing PEI\/chitosan patch (EErP-CPs) was developed to increase the regeneration of tympanic membrane perforations.<\/p>","DOI":"10.1039\/c7bm01061c","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T02:33:52Z","timestamp":1512700432000},"page":"364-371","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Chitosan\/PEI patch releasing EGF and the EGFR gene for the regeneration of the tympanic membrane after perforation"],"prefix":"10.1039","volume":"6","author":[{"given":"Myung Chul","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Seonwoo","sequence":"additional","affiliation":[{"name":"Department of Industrial Machinery Engineering"},{"name":"Sunchon National university"},{"name":"315 Maegok-dong Sunchon"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Garg","sequence":"additional","affiliation":[{"name":"Research Institute for Agriculture and Life Sciences"},{"name":"Seoul National University"},{"name":"Seoul"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Je","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shambhavi","family":"Pandey","sequence":"additional","affiliation":[{"name":"Research Institute for Agriculture and Life Sciences"},{"name":"Seoul National University"},{"name":"Seoul"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Bae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewoon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hoon","family":"Choung","sequence":"additional","affiliation":[{"name":"Department of Otalaryngology"},{"name":"Ajou University School of Medicine"},{"name":"Suwon 443-749"},{"name":"Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-5655","authenticated-orcid":false,"given":"Jong Hoon","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biosystems & Biomaterials Science and Engineering"},{"name":"Seoul National University"},{"name":"Seoul 151-742"},{"name":"Republic of Korea"},{"name":"Research Institute for Agriculture and Life Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7BM01061C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1001\/archotol.1987.01860120031002","volume":"113","author":"Lindeman","year":"1987","journal-title":"Arch. Otolaryngol."},{"key":"C7BM01061C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2273.1992.tb01004.x","volume":"17","author":"Browning","year":"1992","journal-title":"Clin. Otolaryngol."},{"key":"C7BM01061C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1089\/ten.teb.2012.0389","volume":"19","author":"Teh","year":"2013","journal-title":"Tissue Eng., Part B"},{"key":"C7BM01061C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.ijporl.2014.10.007","volume":"78","author":"Wang","year":"2014","journal-title":"Int. J. Pediatr. Otorhi."},{"key":"C7BM01061C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/MLG.0b013e318038168a","volume":"117","author":"Caye-Thomasen","year":"2007","journal-title":"Laryngoscope"},{"key":"C7BM01061C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/00005537-200104000-00025","volume":"111","author":"Laidlaw","year":"2001","journal-title":"Laryngoscope"},{"key":"C7BM01061C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/019459988509300217","volume":"93","author":"Camnitz","year":"1985","journal-title":"Otolaryngol.\u2013Head Neck Surg."},{"key":"C7BM01061C-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0194-5998(03)00124-4","volume":"128","author":"Golz","year":"2003","journal-title":"Otolaryngol.\u2013Head Neck Surg."},{"key":"C7BM01061C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1749-4486.2011.02319.x","volume":"36","author":"Lou","year":"2011","journal-title":"Clin. Otolaryngol."},{"key":"C7BM01061C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1524-475X.2009.00565.x","volume":"18","author":"Kim","year":"2010","journal-title":"Wound Repair Regen."},{"key":"C7BM01061C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/0885328209104289","volume":"24","author":"Ghassemifar","year":"2010","journal-title":"J. Biomater. Appl."},{"key":"C7BM01061C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/ten.tea.2009.0476","volume":"16","author":"Kim","year":"2010","journal-title":"Tissue Eng., Part A"},{"key":"C7BM01061C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jbm.a.32119","volume":"90A","author":"Kim","year":"2009","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"C7BM01061C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1089\/ten.tea.2010.0533","volume":"17","author":"Kim","year":"2011","journal-title":"Tissue Eng., Part A"},{"key":"C7BM01061C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0142-9612(95)94151-A","volume":"16","author":"Bonzon","year":"1995","journal-title":"Biomaterials"},{"key":"C7BM01061C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/01.mlg.0000208549.44462.fa","volume":"116","author":"Weber","year":"2006","journal-title":"Laryngoscope"},{"key":"C7BM01061C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/MAO.0b013e318064e912","volume":"28","author":"Johnson","year":"2007","journal-title":"Otol. Neurotol."},{"key":"C7BM01061C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.amjoto.2011.07.006","volume":"33","author":"Lou","year":"2012","journal-title":"Am. J. Otolaryng."},{"key":"C7BM01061C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.ijporl.2011.07.012","volume":"75","author":"Lou","year":"2011","journal-title":"Int. J. Pediatr. Otorhi."},{"key":"C7BM01061C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1288\/00005537-199512000-00007","volume":"105","author":"Dvorak","year":"1995","journal-title":"Laryngoscope"},{"key":"C7BM01061C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00129492-200305000-00004","volume":"24","author":"Guneri","year":"2003","journal-title":"Otol. Neurotol."},{"key":"C7BM01061C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1089\/ten.tea.2012.0617","volume":"19","author":"Seonwoo","year":"2013","journal-title":"Tissue Eng., Part A"},{"key":"C7BM01061C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0194-5998(99)70122-1","volume":"121","author":"Chauvin","year":"1999","journal-title":"Otolaryngol.\u2013Head Neck Surg."},{"key":"C7BM01061C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1017\/S0022215111002817","volume":"126","author":"Onal","year":"2012","journal-title":"J. Laryngol. Otol."},{"key":"C7BM01061C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1472-6750-4-23","volume":"4","author":"Vancha","year":"2004","journal-title":"BMC Biotechnol."},{"key":"C7BM01061C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/00007890-200204150-00004","volume":"73","author":"Svensjo","year":"2002","journal-title":"Transplantation"},{"key":"C7BM01061C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1358\/dot.2003.39.10.799472","volume":"39","author":"Grazul-Bilska","year":"2003","journal-title":"Drugs Today"},{"key":"C7BM01061C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20428","DOI":"10.1074\/jbc.M007601200","volume":"276","author":"Pienimaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"C7BM01061C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.progpolymsci.2007.04.002","volume":"32","author":"Goddard","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"C7BM01061C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/(SICI)1097-4636(19980905)41:3<422::AID-JBM12>3.0.CO;2-K","volume":"41","author":"Webb","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"C7BM01061C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(92)90167-B","volume":"70","author":"Lowenstein","year":"1992","journal-title":"Cell"},{"key":"C7BM01061C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1128\/MCB.14.8.5192","volume":"14","author":"Batzer","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"C7BM01061C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1016\/S0021-9258(17)41718-2","volume":"269","author":"Hallberg","year":"1994","journal-title":"J. Biol. Chem."},{"key":"C7BM01061C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"C7BM01061C-(cit35)\/*[position()=1]","first-page":"473843","volume":"2012","author":"Cappione 3rd","year":"2012","journal-title":"Int. J. Proteomics"},{"key":"C7BM01061C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cell.2006.05.013","volume":"125","author":"Zhang","year":"2006","journal-title":"Cell"},{"key":"C7BM01061C-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ydbio.2011.03.023","volume":"354","author":"Fraguas","year":"2011","journal-title":"Dev. Biol."},{"key":"C7BM01061C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.stem.2010.06.021","volume":"7","author":"Ferron","year":"2010","journal-title":"Cell Stem Cell"},{"key":"C7BM01061C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e04437","DOI":"10.7554\/eLife.04437","volume":"3","author":"Castanieto","year":"2014","journal-title":"eLife"},{"key":"C7BM01061C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1005634","DOI":"10.1371\/journal.pgen.1005634","volume":"11","author":"Jin","year":"2015","journal-title":"PLoS Genet."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/BM\/C7BM01061C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:48:47Z","timestamp":1782884927000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/6\/2\/364-371\/554392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7bm01061c","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7BM01061C","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Jong Hoon Chung (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0711-5655","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 16 November 2017; Accepted 8 December 2017; Accepted Manuscript published 8 December 2017; Advance Article published 2 January 2018; Version of Record published 30 January 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}