{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:09:41Z","timestamp":1789988981577,"version":"4.0.1"},"reference-count":32,"publisher":"Royal Society of Chemistry (RSC)","issue":"50","funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["Starting Grant"],"award-info":[{"award-number":["Starting Grant"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"crossref","award":["VIDI grant"],"award-info":[{"award-number":["VIDI grant"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>In metal-based photoactivated chemotherapy (PACT), two photoproducts are generated by light-triggered photosubstitution of a metal-bound ligand: the free ligand itself and an aquated metal complex.<\/p>","DOI":"10.1039\/c7cc03469e","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T03:53:25Z","timestamp":1496634805000},"page":"6768-6771","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["To cage or to be caged? The cytotoxic species in ruthenium-based photoactivated chemotherapy is not always the metal"],"prefix":"10.1039","volume":"53","author":[{"given":"Jordi-Amat","family":"Cuello-Garibo","sequence":"first","affiliation":[{"name":"Leiden Institute of Chemistry"},{"name":"University of Leiden"},{"name":"Leiden"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry"},{"name":"University of Leiden"},{"name":"Leiden"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-3657","authenticated-orcid":false,"given":"Sylvestre","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry"},{"name":"University of Leiden"},{"name":"Leiden"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7CC03469E-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ccr.2005.11.013","volume":"250","author":"Balzani","year":"2006","journal-title":"Coord. Chem. Rev."},{"key":"C7CC03469E-(cit1b)\/*[position()=1]","volume-title":"Photochemistry and Photophysics of Coordination Compounds: Ruthenium","author":"Campagna","year":"2007","unstructured":"S.\n              Campagna\n            , F.Puntoriero, F.Nastasi, G.Bergamini and V.Balzani, Photochemistry and Photophysics of Coordination Compounds: Ruthenium, Topics in Current Chemistry, Springer-Verlag Berlin, Heidelberg, 2007, vol. 280, pp. 117\u2013214"},{"key":"C7CC03469E-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/ic011014o","volume":"41","author":"Baranoff","year":"2002","journal-title":"Inorg. Chem."},{"key":"C7CC03469E-(cit1d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1039\/b004982o","author":"Baranoff","year":"2000","journal-title":"Chem. Commun."},{"key":"C7CC03469E-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1039\/B917757D","volume":"46","author":"Fernandez-Moreira","year":"2010","journal-title":"Chem. Commun."},{"key":"C7CC03469E-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15300","DOI":"10.1021\/ja508043q","volume":"136","author":"Martin","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit2c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nchem.406","volume":"1","author":"Gill","year":"2009","journal-title":"Nat. Chem."},{"key":"C7CC03469E-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1039\/C4SC03759F","volume":"6","author":"Mari","year":"2015","journal-title":"Chem. Sci."},{"key":"C7CC03469E-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1021\/ja405058y","volume":"135","author":"Frasconi","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1021\/ic201615u","volume":"50","author":"Garner","year":"2011","journal-title":"Inorg. Chem."},{"key":"C7CC03469E-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1021\/ja508272h","volume":"136","author":"Albani","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/(SICI)1099-0682(199903)1999:3<383::AID-EJIC383>3.0.CO;2-9","author":"Laemmel","year":"1999","journal-title":"Eur. J. Inorg. Chem."},{"key":"C7CC03469E-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1021\/ja8025906","volume":"130","author":"Salassa","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jinorgbio.2016.01.009","volume":"158","author":"Sainuddin","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"C7CC03469E-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jinorgbio.2013.10.008","volume":"130","author":"Hufziger","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"C7CC03469E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8324","DOI":"10.1021\/ja3009677","volume":"134","author":"Howerton","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jinorgbio.2010.08.003","volume":"104","author":"Filevich","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"C7CC03469E-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20120330","DOI":"10.1098\/rsta.2012.0330","volume":"371","author":"Zayat","year":"2013","journal-title":"Philos. Trans. R. Soc., A"},{"key":"C7CC03469E-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14038","DOI":"10.1039\/C5CC05172J","volume":"51","author":"Karaoun","year":"2015","journal-title":"Chem. Commun."},{"key":"C7CC03469E-(cit8d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/cmdc.201400081","volume":"9","author":"Respondek","year":"2014","journal-title":"ChemMedChem"},{"key":"C7CC03469E-(cit8e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1039\/C6SC03028A","volume":"8","author":"Smith","year":"2017","journal-title":"Chem. Sci."},{"key":"C7CC03469E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12369","DOI":"10.1021\/bi00038a034","volume":"34","author":"Novakova","year":"1995","journal-title":"Biochemistry"},{"key":"C7CC03469E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1021\/ic102482c","volume":"50","author":"Garner","year":"2011","journal-title":"Inorg. Chem."},{"key":"C7CC03469E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/ic00178a028","volume":"23","author":"Pinnick","year":"1984","journal-title":"Inorg. Chem."},{"key":"C7CC03469E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1039\/C5PP00424A","volume":"15","author":"Hopkins","year":"2016","journal-title":"Photochem. Photobiol. Sci."},{"key":"C7CC03469E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17734","DOI":"10.1021\/ja053387k","volume":"127","author":"Wang","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"C7CC03469E-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1039\/C6SC00167J","volume":"7","author":"van Rixel","year":"2016","journal-title":"Chem. Sci."},{"key":"C7CC03469E-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1039\/C6DT01242F","volume":"45","author":"Fu","year":"2016","journal-title":"Dalton Trans."},{"key":"C7CC03469E-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14421","DOI":"10.1002\/chem.201402796","volume":"20","author":"Mari","year":"2014","journal-title":"Chem. \u2013 Eur. J."},{"key":"C7CC03469E-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1021\/jm500566f","volume":"57","author":"Frei","year":"2014","journal-title":"J. Med. Chem."},{"key":"C7CC03469E-(cit15c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccr.2014.04.012","volume":"282\u2013283","author":"Shi","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"C7CC03469E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/hlca.19960790428","volume":"79","author":"Garc\u00eca-Fresnadillo","year":"1996","journal-title":"Helv. Chim. Acta"}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/CC\/C7CC03469E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:40:40Z","timestamp":1782852040000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/53\/50\/6768-6771\/555549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":32,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7cc03469e","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7CC03469E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Sylvestre Bonnet (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5810-3657","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Sylvestre Bonnet (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-9944-2010","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 4 May 2017; Accepted 31 May 2017;  Accepted Manuscript published 5 June 2017;  Advance Article published 9 June 2017;  Version of Record published 20 June 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}