{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:16:28Z","timestamp":1782972988035,"version":"3.54.5"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"48","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"am","delay-in-days":681,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"name":"Boehringer Ingelheim","award":["PID-39-010"],"award-info":[{"award-number":["PID-39-010"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<p>Making use of a quartz crystal microbalance, concentrated solutions of therapeutic antibodies were studied with respect to their behavior under shear excitation with frequencies in the MHz range.<\/p>","DOI":"10.1039\/c7cp05711c","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T10:33:55Z","timestamp":1510569235000},"page":"32698-32707","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterizing protein\u2013protein-interaction in high-concentration monoclonal antibody systems with the quartz crystal microbalance"],"prefix":"10.1039","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-1043","authenticated-orcid":false,"given":"Josef","family":"Hartl","sequence":"first","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH and Co. KG"},{"name":"Protein Science"},{"name":"88397 Biberach\/Riss"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Peschel","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry"},{"name":"Clausthal University of Technology"},{"name":"38678 Clausthal-Zellerfeld"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethelm","family":"Johannsmann","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry"},{"name":"Clausthal University of Technology"},{"name":"38678 Clausthal-Zellerfeld"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Garidel","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH and Co. KG"},{"name":"Protein Science"},{"name":"88397 Biberach\/Riss"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7CP05711C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.tibs.2016.08.013","volume":"41","author":"Rivas","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"C7CP05711C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1529\/biophysj.104.051078","volume":"89","author":"Banks","year":"2005","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9310","DOI":"10.1021\/jp302748k","volume":"116","author":"Minton","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"C7CP05711C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1073\/pnas.2035072100","volume":"100","author":"Thirumalai","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7CP05711C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.addr.2011.09.008","volume":"63","author":"Jezek","year":"2011","journal-title":"Adv. Drug Delivery Rev."},{"key":"C7CP05711C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejpb.2017.06.029","volume":"119","author":"Garidel","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C7CP05711C-(cit7)\/*[position()=1]","first-page":"94","volume":"17","author":"Richard","year":"2012","journal-title":"European Journal of Parenteral Sciences and Pharmaceutical Sciences"},{"key":"C7CP05711C-(cit8)\/*[position()=1]","first-page":"2549","volume":"5","author":"Nikam","year":"2013","journal-title":"Int. J. Pharm. Technol."},{"key":"C7CP05711C-(cit9)\/*[position()=1]","first-page":"1579","volume":"34","author":"Leveque","year":"2014","journal-title":"Anticancer Res."},{"key":"C7CP05711C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2165\/00063030-200721020-00005","volume":"21","author":"Gardulf","year":"2007","journal-title":"BioDrugs"},{"key":"C7CP05711C-(cit11)\/*[position()=1]","volume-title":"Protein Pharmaceuticals-Formulation, Analytics and Delivery","author":"Garidel","year":"2010","unstructured":"P. Garidel  ,  W.Kliche ,  S.Pisch-Heberle  and  M.Thierolf , in  Protein Pharmaceuticals-Formulation, Analytics and Delivery , ed.  H. C. Mahler ,  G. Borchard  and  H. Luessen ,  2010 ,  pp. 44\u201389"},{"key":"C7CP05711C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/10837450.2013.871032","volume":"20","author":"Garidel","year":"2015","journal-title":"Pharm. Dev. Technol."},{"key":"C7CP05711C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2004.11.014","volume":"289","author":"Wang","year":"2005","journal-title":"Int. J. Pharm."},{"key":"C7CP05711C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.addr.2011.07.006","volume":"63","author":"Kamerzell","year":"2011","journal-title":"Adv. Drug Delivery Rev."},{"key":"C7CP05711C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.xphs.2016.11.014","volume":"106","author":"Zbacnik","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1073\/pnas.122225399","volume":"99","author":"Timasheff","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7CP05711C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1007\/s11095-009-9963-6","volume":"26","author":"Esue","year":"2009","journal-title":"Pharm. Res."},{"key":"C7CP05711C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bpc.2016.08.003","volume":"220","author":"Reiche","year":"2017","journal-title":"Biophys. Chem."},{"key":"C7CP05711C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.colsurfa.2012.09.024","volume":"415","author":"Wagner","year":"2012","journal-title":"Colloids Surf., A"},{"key":"C7CP05711C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10424","DOI":"10.1063\/1.469891","volume":"103","author":"Muschol","year":"1995","journal-title":"J. Chem. Phys."},{"key":"C7CP05711C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1021\/jp507886r","volume":"118","author":"Roberts","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"C7CP05711C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nmat3847","volume":"13","author":"Ido","year":"2014","journal-title":"Nat. Mater."},{"key":"C7CP05711C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12665\/J84.Sugui","volume":"8","author":"Garidel","year":"2010","journal-title":"BioProcess Int."},{"key":"C7CP05711C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1021\/jp512027j","volume":"119","author":"Li","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"C7CP05711C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1002\/jps.21322","volume":"97","author":"Kanai","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/jps.23002","volume":"101","author":"Galush","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.bpj.2013.01.007","volume":"104","author":"Pathak","year":"2013","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/jps.21898","volume":"99","author":"Yadav","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1002\/jps.22190","volume":"99","author":"Yadav","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejpb.2010.01.009","volume":"75","author":"Le Brun","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C7CP05711C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/j.bpj.2010.08.020","volume":"99","author":"Saluja","year":"2010","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1088\/0305-4470\/11\/5\/022","volume":"11","author":"Felderhof","year":"1978","journal-title":"J. Phys. A: Math. Gen."},{"key":"C7CP05711C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0021-9797(92)90424-K","volume":"149","author":"Petsev","year":"1992","journal-title":"J. Colloid Interface Sci."},{"key":"C7CP05711C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.bpj.2014.02.036","volume":"106","author":"Yearley","year":"2014","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1021\/acs.jpcb.5b07260","volume":"120","author":"Godfrin","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"C7CP05711C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1021\/jp1028646","volume":"114","author":"Scherer","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"C7CP05711C-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bpj.2012.04.047","volume":"103","author":"Connolly","year":"2012","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/jps.20342","volume":"94","author":"Saluja","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/jps.20663","volume":"95","author":"Saluja","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1002\/jps.21610","volume":"98","author":"Patel","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"C7CP05711C-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/bit.25834","volume":"113","author":"Schermeyer","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"C7CP05711C-(cit42)\/*[position()=1]","volume-title":"Label-Free Detection of Protein-Ligand Interactions by the Quartz Crystal Microbalance","author":"Janshoff","year":"2005","unstructured":"A. Janshoff   and  C.Steinem , in  Label-Free Detection of Protein-Ligand Interactions by the Quartz Crystal Microbalance , ed.  G. Ulrich Nienhaus ,  Humana Press ,  Totowa, NJ ,  2005 ,  pp. 47\u201363"},{"key":"C7CP05711C-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1063\/1.1145396","volume":"66","author":"Rodahl","year":"1995","journal-title":"Rev. Sci. Instrum."},{"key":"C7CP05711C-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF01337937","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Z. Phys."},{"key":"C7CP05711C-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/ac801523w","volume":"81","author":"Edvardsson","year":"2008","journal-title":"Anal. Chem."},{"key":"C7CP05711C-(cit46)\/*[position()=1]","volume-title":"The Quartz Crystal Microbalance in Soft Matter Research: Fundamentals and Modeling","author":"Johannsmann","year":"2014","unstructured":"D. Johannsmann  ,  The Quartz Crystal Microbalance in Soft Matter Research: Fundamentals and Modeling ,  Springer International Publishing ,  2014"},{"key":"C7CP05711C-(cit47)\/*[position()=1]","volume-title":"Handbook\nof Therapeutic Antibodies","author":"Bergemann","year":"2007","unstructured":"K. Bergemann  ,  C.Eckermann ,  P.Garidel ,  S.Grammatikos ,  A.Jacobi ,  H.Kaufmann ,  R.Kempken  and  S.Pisch Heberle ,  Handbook\nof Therapeutic Antibodies ,  2007 ,  pp. 199\u2013237"},{"key":"C7CP05711C-(cit48)\/*[position()=1]","volume-title":"Handbook of Therapeutic Antibodies","author":"Jacobi","year":"2014","unstructured":"A. Jacobi  ,  B.Enenkel ,  P.Garidel ,  C.Eckermann ,  M.Knappenberger ,  I.Presser  and  H.Kaufmann ,  Handbook of Therapeutic Antibodies ,  2014 ,  pp. 601\u2013664"},{"key":"C7CP05711C-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/btpr.1682","volume":"29","author":"Karow","year":"2013","journal-title":"Biotechnol. Prog."},{"key":"C7CP05711C-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/S0006-3495(02)75513-6","volume":"82","author":"Tessier","year":"2002","journal-title":"Biophys. J."},{"key":"C7CP05711C-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/bbpc.198800327","volume":"92","author":"Beck","year":"1988","journal-title":"Ber. Bunsenges. Phys. Chem."},{"key":"C7CP05711C-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1021\/bm301125g","volume":"13","author":"Ogaki","year":"2012","journal-title":"Biomacromolecules"},{"key":"C7CP05711C-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/jcis.2001.8144","volume":"248","author":"Giesbers","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"C7CP05711C-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/jps.22506","volume":"100","author":"Lehermayr","year":"2011","journal-title":"J. Pharm. Sci."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/CP\/C7CP05711C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:54:23Z","timestamp":1782968063000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cp\/article\/19\/48\/32698-32707\/560829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":54,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7cp05711c","relation":{},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Josef Hartl (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0338-1043","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 August 2017; Accepted 13 November 2017;  Accepted Manuscript published 13 November 2017;  Advance Article published 4 December 2017;  Version of Record published 13 December 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}