{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:02:04Z","timestamp":1787666524175,"version":"build-2736575974"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"am","delay-in-days":395,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003200","name":"Kementerian Sains, Teknologi dan Inovasi","doi-asserted-by":"crossref","award":["10-05-ABI-FB 037"],"award-info":[{"award-number":["10-05-ABI-FB 037"]}],"id":[{"id":"10.13039\/501100003200","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Winged bean seed hydrolysate is found to reduce blood pressure in spontaneously hypertensive rats. Peptide of non-Current Good Manufacturing Practice grade demonstrates toxicity and is not suitable for testing in animals.<\/p>","DOI":"10.1039\/c7fo01769c","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:33:45Z","timestamp":1517358825000},"page":"1657-1671","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Blood-pressure lowering efficacy of winged bean seed hydrolysate in spontaneously hypertensive rats, peptide characterization and a toxicity study in Sprague-Dawley rats"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-4764","authenticated-orcid":false,"given":"Shyan Yea","family":"Chay","sequence":"first","affiliation":[{"name":"Department of Food Science"},{"name":"Faculty of Food Science and Technology"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4142-0418","authenticated-orcid":false,"given":"Annas","family":"Salleh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Laboratory Diagnostics"},{"name":"Faculty of Veterinary Medicine"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-4623","authenticated-orcid":false,"given":"Nor Fazila","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Agro-Biotechnology Institute (ABI)"},{"name":"HQ MARDI"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-4834","authenticated-orcid":false,"given":"Najib","family":"Zainal Abidin","sequence":"additional","affiliation":[{"name":"Department of Food Science"},{"name":"Faculty of Food Science and Technology"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-6369","authenticated-orcid":false,"given":"Mohamad Ariff","family":"Hanafi","sequence":"additional","affiliation":[{"name":"Department of Food Science"},{"name":"Faculty of Food Science and Technology"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1573-347X","authenticated-orcid":false,"given":"Mohammad","family":"Zarei","sequence":"additional","affiliation":[{"name":"Department of Food Science"},{"name":"Faculty of Food Science and Technology"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-9415","authenticated-orcid":false,"given":"Nazamid","family":"Saari","sequence":"additional","affiliation":[{"name":"Department of Food Science"},{"name":"Faculty of Food Science and Technology"},{"name":"Universiti Putra Malaysia"},{"name":"43400 Serdang"},{"name":"Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7FO01769C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"C7FO01769C-(cit2)\/*[position()=1]","volume-title":"A global brief on hypertension: Silent killer, global public health crisis: World Health Day 2013","author":"World Health Organisation","year":"2013","unstructured":"World Health Organisation  ,  A global brief on hypertension: Silent killer, global public health crisis: World Health Day 2013 ,  World Health Organization ,  Geneva ,  2013"},{"key":"C7FO01769C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1383\/medc.30.7.174.28209","volume":"30","author":"Elliott","year":"2002","journal-title":"Medicine"},{"key":"C7FO01769C-(cit4)\/*[position()=1]","volume-title":"Enzymic hydrolysis of food proteins","author":"Adler-Nissen","year":"1986","unstructured":"J. Adler-Nissen  ,  Enzymic hydrolysis of food proteins ,  Elsevier Applied Science Publishers ,  New York ,  1986"},{"key":"C7FO01769C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1039\/c3fo60667h","volume":"5","author":"Chay","year":"2014","journal-title":"Food Funct."},{"key":"C7FO01769C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem. Pharmacol."},{"key":"C7FO01769C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1021\/ac901775h","volume":"81","author":"Jimsheena","year":"2009","journal-title":"Anal. Chem."},{"key":"C7FO01769C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.foodchem.2013.07.108","volume":"145","author":"Doyen","year":"2014","journal-title":"Food Chem."},{"key":"C7FO01769C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.3390\/nu7095358","volume":"7","author":"Malomo","year":"2015","journal-title":"Nutrients"},{"key":"C7FO01769C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature01370","volume":"421","author":"Natesh","year":"2003","journal-title":"Nature"},{"key":"C7FO01769C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cis.2010.11.001","volume":"165","author":"Hern\u00e1ndez Ledesma","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"key":"C7FO01769C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.idairyj.2004.04.007","volume":"14","author":"Gomez-Ruiz","year":"2004","journal-title":"Int. Dairy J."},{"key":"C7FO01769C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0162-3109(99)00118-6","volume":"44","author":"Fujita","year":"1999","journal-title":"Immunopharmacology"},{"key":"C7FO01769C-(cit15)\/*[position()=1]","volume-title":"Biochemistry","author":"Das","year":"2005","unstructured":"D. Das  , in  Biochemistry , ed.  D. Das ,  Academic Publishers ,  Kolkata ,  2005 , pp.  107\u2013147"},{"key":"C7FO01769C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"C7FO01769C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e91051","DOI":"10.1371\/journal.pone.0091051","volume":"9","author":"He","year":"2014","journal-title":"PLoS One"},{"key":"C7FO01769C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/jf5002606","volume":"62","author":"Girgih","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"C7FO01769C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.peptides.2010.02.022","volume":"31","author":"Jimsheena","year":"2010","journal-title":"Peptides"},{"key":"C7FO01769C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1007\/s00018-004-4239-0","volume":"61","author":"Sturrock","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"C7FO01769C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jff.2016.05.016","volume":"25","author":"M\u00e4kinen","year":"2016","journal-title":"J. Funct. Foods"},{"key":"C7FO01769C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.peptides.2007.11.011","volume":"29","author":"Zhao","year":"2008","journal-title":"Peptides"},{"key":"C7FO01769C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"859","DOI":"10.5251\/abjna.2010.1.5.859.865","volume":"1","author":"Ogbonnia","year":"2010","journal-title":"Agric. Biol. J. North Am."},{"key":"C7FO01769C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.etp.2005.10.002","volume":"57","author":"Petterino","year":"2006","journal-title":"Exp. Toxicol. Pathol."},{"key":"C7FO01769C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5625\/lar.2010.26.2.153","volume":"26","author":"Han","year":"2010","journal-title":"Lab. Anim. Res."},{"key":"C7FO01769C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-60761-147-9","volume-title":"Heart failure: Contemporary cardiology","author":"Mar\u00edn-Garc\u00eda","year":"2010","unstructured":"J. Mar\u00edn-Garc\u00eda  , in  Heart failure: Contemporary cardiology , ed.  C. P. Cannon ,  Humana Press ,  New Jersey ,  2010 , pp.  15\u201322"},{"key":"C7FO01769C-(cit27)\/*[position()=1]","volume-title":"The nature of disease: Pathology for the health professions","author":"McConnell","year":"2007","unstructured":"T. H. McConnell  ,  The nature of disease: Pathology for the health professions ,  Lippincott Williams & Wilkins ,  Pennsylvania ,  2007"},{"key":"C7FO01769C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/01926230490465874","volume":"32","author":"Bailey","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"C7FO01769C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-8741(03)00078-3","volume":"86","author":"Odigie","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"C7FO01769C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/toxsci\/57.1.61","volume":"57","author":"Siglin","year":"2000","journal-title":"Toxicol. Sci."},{"key":"C7FO01769C-(cit31)\/*[position()=1]","volume-title":"Oxford desk reference: Toxicology","author":"Bateman","year":"2014","unstructured":"D. N. Bateman  , in  Oxford desk reference: Toxicology , ed.  N. Bateman ,  R. Jefferson ,  S. Thomas ,  J. Thompson  and  A. Vale ,  Oxford University Press ,  Oxford ,  2014 , pp.  1\u201330"},{"key":"C7FO01769C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1039\/c3mt20196a","volume":"5","author":"Bresson","year":"2013","journal-title":"Metallomics"},{"key":"C7FO01769C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/01926230701595300","volume":"35","author":"Sellers","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"C7FO01769C-(cit34)\/*[position()=1]","volume-title":"Fundamentals of toxicologic pathology","author":"Haschek","year":"2010","unstructured":"W. M. Haschek  ,  C. G.Rousseaux  and  M. A.Wallig ,  Fundamentals of toxicologic pathology ,  Academic Press ,  London ,  2010"},{"key":"C7FO01769C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1289\/ehp.8773125","volume":"73","author":"Maronpot","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"C7FO01769C-(cit36)\/*[position()=1]","volume-title":"Lead molecules from natural products- Discovery and new trends","author":"Matsui","year":"2006","unstructured":"T. Matsui   and  K.Matsumoto , in  Lead molecules from natural products- Discovery and new trends , ed.  M. T. H. Khan  and  A. Ather ,  Elsevier Science ,  London ,  2006 , pp.  255\u2013272"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C7FO01769C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:22:43Z","timestamp":1782886963000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/9\/3\/1657-1671\/566978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7fo01769c","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Shyan Yea Chay (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8624-4764","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Annas Salleh (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4142-0418","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Nor Fazila Sulaiman (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2742-4623","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Najib Zainal Abidin (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2742-4834","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mohamad Ariff Hanafi (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9132-6369","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mohammad Zarei (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1573-347X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mohammad Zarei (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/B-8556-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Nazamid Saari (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4185-9415","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 10 November 2017; Accepted 26 January 2018;  Accepted Manuscript published 31 January 2018;  Advance Article published 22 February 2018;  Version of Record published 21 March 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}