{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:52:41Z","timestamp":1791615161821,"version":"4.3.4"},"reference-count":60,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"am","delay-in-days":625,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21467017"],"award-info":[{"award-number":["21467017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81660538"],"award-info":[{"award-number":["81660538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Vitamin C, an excellent reducing agent, aids in increasing absorbable ferrous iron in iron deficiency anemia.<\/p>","DOI":"10.1039\/c7fo02057k","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T10:04:36Z","timestamp":1537265076000},"page":"5390-5401","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload"],"prefix":"10.1039","volume":"9","author":[{"given":"Huan","family":"He","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Institute of Hypertension"},{"name":"the First Affiliated Hospital of Nanchang University"},{"name":"Nanchang 330006"},{"name":"China"},{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"},{"name":"Nanchang University School of Pharmaceutical Science"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"},{"name":"Nanchang University School of Pharmaceutical Science"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelong","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"},{"name":"Nanchang University School of Pharmaceutical Science"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"},{"name":"Nanchang University School of Pharmaceutical Science"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangping","family":"Liao","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Basic Pharmacology"},{"name":"Nanchang University School of Pharmaceutical Science"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Molecular Medicine"},{"name":"the Second Affiliated Hospital of Nanchang University"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-3583","authenticated-orcid":false,"given":"Ming","family":"He","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Hypertension"},{"name":"the First Affiliated Hospital of Nanchang University"},{"name":"Nanchang 330006"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7FO02057K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.3390\/nu6093747","volume":"6","author":"Beck","year":"2014","journal-title":"Nutrients"},{"key":"C7FO02057K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"C7FO02057K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.3390\/nu9030192","volume":"9","author":"Li","year":"2017","journal-title":"Nutrients"},{"key":"C7FO02057K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(13)70174-8","volume":"2","author":"Fern\u00e1ndez-Real","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"C7FO02057K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.bbadis.2015.03.011","volume":"1852","author":"Silva","year":"2015","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"C7FO02057K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1586\/17474124.2016.1119043","volume":"10","author":"Brissot","year":"2016","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"C7FO02057K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2015.08.017","volume":"765","author":"Wongjaikam","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"C7FO02057K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1182\/asheducation-2014.1.210","volume":"2014","author":"Wood","year":"2014","journal-title":"Hematology"},{"key":"C7FO02057K-(cit9)\/*[position()=1]","first-page":"164","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"C7FO02057K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/liv.13020","volume":"36","author":"Pietrangelo","year":"2016","journal-title":"Liver Int."},{"key":"C7FO02057K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000343856","volume":"3","author":"Kew","year":"2014","journal-title":"Liver Cancer"},{"key":"C7FO02057K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1499-3872(16)60135-2","volume":"15","author":"Sikorska","year":"2016","journal-title":"Hepatobiliary Pancreatic Dis. Int."},{"key":"C7FO02057K-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/mnfr.201400036","volume":"58","author":"Gudjoncik","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"C7FO02057K-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00204-014-1329-0","volume":"88","author":"Finazzi","year":"2014","journal-title":"Arch. Toxicol."},{"key":"C7FO02057K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"230182","DOI":"10.1155\/2015\/230182","volume":"2015","author":"Gammella","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"C7FO02057K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3892\/mmr.2013.1316","volume":"7","author":"Liu","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"C7FO02057K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.3892\/mmr.2014.2544","volume":"10","author":"Zhang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"C7FO02057K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1161\/01.CIR.0000124229.40424.80","volume":"109","author":"Oudit","year":"2004","journal-title":"Circulation"},{"key":"C7FO02057K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/978-3-319-15126-7_47","volume":"803","author":"Shimada","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"C7FO02057K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1089\/ars.2013.5205","volume":"19","author":"May","year":"2013","journal-title":"Antioxid. Redox Signaling"},{"key":"C7FO02057K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.3390\/nu9040339","volume":"9","author":"Hemil\u00e4","year":"2017","journal-title":"Nutrients"},{"key":"C7FO02057K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1139\/o90-173","volume":"68","author":"Padh","year":"1990","journal-title":"Biochem. Cell Biol."},{"key":"C7FO02057K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s13054-014-0460-x","volume":"18","author":"Oudemans-van Straaten","year":"2014","journal-title":"Crit. Care"},{"key":"C7FO02057K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1219","DOI":"10.3390\/molecules21091219","volume":"21","author":"Qiao","year":"2016","journal-title":"Molecules"},{"key":"C7FO02057K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12011-013-9695-7","volume":"153","author":"Khoshfetrat","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"C7FO02057K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0300-483X(92)90015-7","volume":"76","author":"Galleano","year":"1992","journal-title":"Toxicology"},{"key":"C7FO02057K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0076-6879(67)10078-5","volume":"10","author":"Brumby","year":"1967","journal-title":"Methods Enzymol."},{"key":"C7FO02057K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"C7FO02057K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"C7FO02057K-(cit30)\/*[position()=1]","first-page":"158","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"C7FO02057K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/01.CIR.96.7.2414","volume":"96","author":"Hill","year":"1997","journal-title":"Circulation"},{"key":"C7FO02057K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"C7FO02057K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymol."},{"key":"C7FO02057K-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2016.06.010","volume":"786","author":"Lu","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"C7FO02057K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13424","DOI":"10.1016\/S0021-9258(17)38738-0","volume":"26","author":"Beavis","year":"1985","journal-title":"J. Biol. Chem."},{"key":"C7FO02057K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biochi.2015.06.006","volume":"115","author":"Salama","year":"2015","journal-title":"Biochimie"},{"key":"C7FO02057K-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.peptides.2014.11.008","volume":"64","author":"Aydin","year":"2015","journal-title":"Peptides"},{"key":"C7FO02057K-(cit38)\/*[position()=1]","first-page":"G117","volume":"310","author":"Handa","year":"2016","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"C7FO02057K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2741\/4253","volume":"19","author":"Kontoghiorghe","year":"2014","journal-title":"Front. Biosci., Landmark Ed."},{"key":"C7FO02057K-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.3390\/jcm6050050","volume":"6","author":"Enns","year":"2017","journal-title":"J. Clin. Med."},{"key":"C7FO02057K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.gde.2016.02.004","volume":"38","author":"Rouault","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"C7FO02057K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/mnfr.201400730","volume":"59","author":"Liao","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"C7FO02057K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1309\/LMF28S2GIMXNWHMM","volume":"45","author":"Winter","year":"2014","journal-title":"Lab. Med."},{"key":"C7FO02057K-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3945\/ajcn.114.103366","volume":"102","author":"Peyrin-Biroulet","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"C7FO02057K-(cit45)\/*[position()=1]","first-page":"165","volume":"96","author":"Chiamchanya","year":"2013","journal-title":"J. Med. Assoc. Thailand"},{"key":"C7FO02057K-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3109\/09637486.2014.918589","volume":"65","author":"Chaturvedi","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"key":"C7FO02057K-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1578235","DOI":"10.1155\/2016\/1578235","volume":"2016","author":"Murillo-Ortiz","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"C7FO02057K-(cit48)\/*[position()=1]","first-page":"239","volume":"10","author":"Mobarra","year":"2016","journal-title":"Int. J. Hematol. Oncol. Stem Cell Res."},{"key":"C7FO02057K-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"121762","DOI":"10.1155\/2013\/121762","volume":"2013","author":"Makis","year":"2013","journal-title":"Anemia"},{"key":"C7FO02057K-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000109879","volume":"118","author":"Otto-Duessel","year":"2007","journal-title":"Acta Haematol."},{"key":"C7FO02057K-(cit51)\/*[position()=1]","first-page":"740573","volume":"2013","author":"Cheng","year":"2013","journal-title":"BioMed Res. Int."},{"key":"C7FO02057K-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2014.07.007","volume":"75","author":"Lane","year":"2014","journal-title":"Free Radicals Biol. Med."},{"key":"C7FO02057K-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11908-016-0530-0","volume":"18","author":"Li","year":"2016","journal-title":"Curr. Infect. Dis. Rep."},{"key":"C7FO02057K-(cit54)\/*[position()=1]","first-page":"4024672","volume":"2017","author":"Gao","year":"2017","journal-title":"Mediators Inflammation"},{"key":"C7FO02057K-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1139\/cjpp-2014-0509","volume":"93","author":"Chen","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"C7FO02057K-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"C7FO02057K-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med."},{"key":"C7FO02057K-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1089\/ars.2006.8.1651","volume":"8","author":"Brady","year":"2006","journal-title":"Antioxid. Redox Signaling"},{"key":"C7FO02057K-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1529\/biophysj.103.035097","volume":"87","author":"Brady","year":"2004","journal-title":"Biophys. J."},{"key":"C7FO02057K-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1038\/onc.2012.348","volume":"32","author":"Kilbride","year":"2013","journal-title":"Oncogene"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C7FO02057K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:24:45Z","timestamp":1782879885000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/9\/10\/5390-5401\/567051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10,17]]}},"URL":"https:\/\/doi.org\/10.1039\/c7fo02057k","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Ming He (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1007-3583","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 26 December 2017; Accepted 17 September 2018; Accepted Manuscript published 18 September 2018; Advance Article published 1 October 2018; Version of Record published 17 October 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}