{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:01:41Z","timestamp":1787004101175,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"am","delay-in-days":436,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"crossref","award":["2012-0891"],"award-info":[{"award-number":["2012-0891"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Integr. Biol."],"abstract":"<p>Our 3D-scar-on-a-chip model resembles fibroblast proliferation and activation, extracellular matrix deposition and stiffening upon application of only cyclic mechanical stretching.<\/p>","DOI":"10.1039\/c7ib00199a","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T06:03:51Z","timestamp":1520921031000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A three-dimensional\n                    <i>in vitro<\/i>\n                    dynamic micro-tissue model of cardiac scar formation"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-2019","authenticated-orcid":false,"given":"Paola","family":"Occhetta","sequence":"first","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-607X","authenticated-orcid":false,"given":"Giuseppe","family":"Isu","sequence":"additional","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lemme","sequence":"additional","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Conficconi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-4980","authenticated-orcid":false,"given":"Philipp","family":"Oertle","sequence":"additional","affiliation":[{"name":"Biozentrum and the Swiss Nanoscience Institute"},{"name":"University of Basel"},{"name":"4056 Basel"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"R\u00e4z","sequence":"additional","affiliation":[{"name":"Biozentrum and the Swiss Nanoscience Institute"},{"name":"University of Basel"},{"name":"4056 Basel"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Visone","sequence":"additional","affiliation":[{"name":"Department of Electronics"},{"name":"Information and Bioengineering"},{"name":"Politecnico di Milano"},{"name":"20133 Milano"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Cerino","sequence":"additional","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-8179","authenticated-orcid":false,"given":"Marija","family":"Plodinec","sequence":"additional","affiliation":[{"name":"Biozentrum and the Swiss Nanoscience Institute"},{"name":"University of Basel"},{"name":"4056 Basel"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rasponi","sequence":"additional","affiliation":[{"name":"Department of Electronics"},{"name":"Information and Bioengineering"},{"name":"Politecnico di Milano"},{"name":"20133 Milano"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-0823","authenticated-orcid":false,"given":"Anna","family":"Marsano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine"},{"name":"University of Basel"},{"name":"CH-4031 Basel"},{"name":"Switzerland"},{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7IB00199A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/dev.120576","volume":"143","author":"Furtado","year":"2016","journal-title":"Development"},{"key":"C7IB00199A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1755-1536-6-5","volume":"6","author":"Turner","year":"2013","journal-title":"Fibrog. Tissue Repair"},{"key":"C7IB00199A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/1074248413485434","volume":"18","author":"Sonin","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"C7IB00199A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e22847","DOI":"10.7554\/eLife.22847","volume":"6","author":"Ugolini","year":"2017","journal-title":"eLife"},{"key":"C7IB00199A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1091\/mbc.E17-01-0014","volume":"28","author":"Herum","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"C7IB00199A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e39969","DOI":"10.1371\/journal.pone.0039969","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"C7IB00199A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/bit.25847","volume":"113","author":"Ugolini","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"C7IB00199A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","volume":"142","author":"Hinz","year":"2016","journal-title":"Exp. Eye Res."},{"key":"C7IB00199A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1601434","DOI":"10.1002\/adhm.201601434","volume":"6","author":"Sadeghi","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"C7IB00199A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2015.11.025","volume":"93","author":"van Putten","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C7IB00199A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/emboj.2011.418","volume":"31","author":"Duan","year":"2012","journal-title":"EMBO J."},{"key":"C7IB00199A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"key":"C7IB00199A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/08977194.2011.595714","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"key":"C7IB00199A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/jid.2014.90","volume":"134","author":"Achterberg","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"C7IB00199A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nbt1055","volume":"23","author":"Lutolf","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"C7IB00199A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1039\/C5BM00140D","volume":"3","author":"Sapudom","year":"2015","journal-title":"Biomater. Sci."},{"key":"C7IB00199A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1039\/C5LC01356A","volume":"16","author":"Marsano","year":"2016","journal-title":"Lab Chip"},{"key":"C7IB00199A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nprot.2008.40","volume":"3","author":"Radisic","year":"2008","journal-title":"Nat. Protoc."},{"key":"C7IB00199A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-4827(02)00015-0","volume":"282","author":"Evans","year":"2003","journal-title":"Exp. Cell Res."},{"key":"C7IB00199A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"C7IB00199A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1063\/1.1150021","volume":"70","author":"Sader","year":"1999","journal-title":"Rev. Sci. Instrum."},{"key":"C7IB00199A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.bpj.2010.02.013","volume":"98","author":"Loparic","year":"2010","journal-title":"Biophys. J."},{"key":"C7IB00199A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nnano.2012.167","volume":"7","author":"Plodinec","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"C7IB00199A-(cit24)\/*[position()=1]","first-page":"1564","volume-title":"Journal of Materials Research","author":"Oliver","year":"1992","unstructured":"W. C. Oliver   and  G. M.Pharr ,  Journal of Materials Research ,  Cambridge University Press ,  1992 , vol. 7,  1564"},{"key":"C7IB00199A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1590\/S0100-879X2008001200009","volume":"41","author":"Soufen","year":"2008","journal-title":"Braz. J. Med. Biol. Res."},{"key":"C7IB00199A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1089\/ars.2006.8.1907","volume":"8","author":"Frangogiannis","year":"2006","journal-title":"Antioxid. Redox Signaling"},{"key":"C7IB00199A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2014.02.017","volume":"70","author":"Deb","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C7IB00199A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.healun.2008.11.910","volume":"28","author":"Felkin","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"C7IB00199A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1074\/jbc.M115.712380","volume":"291","author":"Southern","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C7IB00199A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.RES.69.1.116","volume":"69","author":"Carver","year":"1991","journal-title":"Circ. Res."},{"key":"C7IB00199A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1600571","DOI":"10.1002\/adhm.201600571","volume":"6","author":"Deddens","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"C7IB00199A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.cub.2011.11.037","volume":"21","author":"Buscemi","year":"2011","journal-title":"Curr. Biol."},{"key":"C7IB00199A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1167\/iovs.16-20638","volume":"57","author":"Utsunomiya","year":"2016","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"C7IB00199A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2014.00123","volume":"5","author":"Kendall","year":"2014","journal-title":"Front. Pharmacol."},{"key":"C7IB00199A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbadis.2009.06.004","volume":"1792","author":"Pohlers","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"C7IB00199A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.03.005","volume":"94","author":"Pellman","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C7IB00199A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.actbio.2017.04.027","volume":"55","author":"Li","year":"2017","journal-title":"Acta Biomater."}],"container-title":["Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/IB\/C7IB00199A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T15:33:24Z","timestamp":1547825604000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ib\/article\/10\/3\/174-183\/5115766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7ib00199a","relation":{},"ISSN":["1757-9694","1757-9708"],"issn-type":[{"value":"1757-9694","type":"print"},{"value":"1757-9708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Paola Occhetta (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5758-2019","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Giuseppe Isu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8440-607X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Philipp Oertle (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4193-4980","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Marija Plodinec (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5260-8179","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Marco Rasponi (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-5010-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Anna Marsano (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3084-0823","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 November 2017; Accepted 28 February 2018;  Advance Article published 13 March 2018;  Version of Record published 19 March 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}