{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:50:04Z","timestamp":1768449004423,"version":"3.49.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could play important roles in various biological processes and be associated with the pathogenesis of different kinds of diseases including RA. Although a large number of lncRNAs have been found, our knowledge of their function and physiological\/pathological significance is still in its infancy. In order to reveal functional lncRNAs and identify the key lncRNAs in RA, we reconstructed a global triple network based on the competitive endogenous RNA (ceRNA) theory using the data from National Center for Biotechnology Information Gene Expression Omnibus and our previous paper. Meanwhile, Gene Ontology (GO) and pathway analysis were performed using Cytoscape plug-in BinGO and Database for Annotation, Visualization, and Integration Discovery (DAVID), respectively. We found that the lncRNA\u2013miRNA\u2013mRNA network was composed of 7 lncRNA nodes, 90 mRNA nodes, 24 miRNA nodes, and 301 edges. The functional assay showed that 147 GO terms and 23 pathways were enriched. In addition, three lncRNAs (S5645.1, XR_006437.1, J01878) were highly related to RA, and therefore, were selected as key lncRNAs. This study suggests that specific lncRNAs are associated with the development of RA, and three lncRNAs (S5645.1, XR_006437.1, J01878) could be used as potential diagnostic biomarkers and therapeutic targets.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c7mb00094d","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T09:24:03Z","timestamp":1493112243000},"page":"1182-1192","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Reconstruction and analysis of the lncRNA\u2013miRNA\u2013mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-9430","authenticated-orcid":false,"given":"Hui","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Disease, University of North Texas Health Sciences Center c , 3500 Camp Bowie Boulevard, Fort Worth, 76107, USA"},{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine b , 117 Meishan Road, Hefei, 230031, China"},{"name":"College of Basic Medicine, Anhui Medical University a , 81 Meishan Road, Hefei, 230032, China \u00a0 jhanbing@163.com \u00a0 +86-551-62838553"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Disease, University of North Texas Health Sciences Center c , 3500 Camp Bowie Boulevard, Fort Worth, 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubiao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University d , 1 Minde Road, Nanchang, 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine b , 117 Meishan Road, Hefei, 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Anhui Medical University a , 81 Meishan Road, Hefei, 230032, China \u00a0 jhanbing@163.com \u00a0 +86-551-62838553"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Anhui Medical University a , 81 Meishan Road, Hefei, 230032, China \u00a0 jhanbing@163.com \u00a0 +86-551-62838553"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"2026010816062763100_cit1","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.19082\/2700","volume":"8","author":"Sarabi","year":"2016","journal-title":"Electron. 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