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Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid contents of phosphatidylethanolamine and phosphatidylserine plasmalogens, sphingolipids, phosphatidylinositols, phosphatidylcholine, and phosphatidylethanolamine, which have been shown to be related to species, life-cycle of the parasite, and macrophage infection. L. infantum displayed a higher content of phosphatidylethanolamine plasmalogens than L. amazonensis, which may help to differentiate their unique clinical manifestations. Phosphatidylserines plasmalogens are also found to be an important lipid class for the intracellular form of the parasite. Our findings also reveal lipid classes that may be involved in visceralization pathways and parasite differentiation.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c7mb00381a","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T08:35:14Z","timestamp":1505896514000},"page":"2401-2406","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lipidomic alterations of\n                    <i>in vitro<\/i>\n                    macrophage infection by\n                    <i>L. infantum<\/i>\n                    and\n                    <i>L. amazonensis<\/i>"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-6511","authenticated-orcid":false,"given":"Fernanda","family":"Negr\u00e3o","sequence":"first","affiliation":[{"name":"Laboratory of Leishmaniasis, Department of Animal Biology, Institute of Biology, University of Campinas b , UNICAMP 13083-970 Campinas \u2013 SP, Brazil"},{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Ab\u00e1nades","sequence":"additional","affiliation":[{"name":"Laboratory of Leishmaniasis, Department of Animal Biology, Institute of Biology, University of Campinas b , UNICAMP 13083-970 Campinas \u2013 SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline F","family":"Jaeeger","sequence":"additional","affiliation":[{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-2819","authenticated-orcid":false,"given":"Daniele F O","family":"Rocha","sequence":"additional","affiliation":[{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia R A","family":"Belaz","sequence":"additional","affiliation":[{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Giorgio","sequence":"additional","affiliation":[{"name":"Laboratory of Leishmaniasis, Department of Animal Biology, Institute of Biology, University of Campinas b , UNICAMP 13083-970 Campinas \u2013 SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos N","family":"Eberlin","sequence":"additional","affiliation":[{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-3471","authenticated-orcid":false,"given":"C\u00e9lio F F","family":"Angolini","sequence":"additional","affiliation":[{"name":"ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas a , UNICAMP 13083-970 Campinas \u2013 SP, Brazil \u00a0 celio.fernando@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"2026041420322663700_cit1"},{"key":"2026041420322663700_cit2","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"2026041420322663700_cit3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev-micro-090110-102913","volume":"65","author":"McConville","year":"2011","journal-title":"Annu. 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