{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:01:21Z","timestamp":1782936081020,"version":"3.54.5"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>Drug-delivery of aminoglycosides was studied using the biophysical platform of a quartz crystal microbalance. Guanidino modification enhanced the biomolecule-membrane interaction.<\/p>","DOI":"10.1039\/c7md00054e","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T04:55:18Z","timestamp":1491454518000},"page":"1112-1120","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance"],"prefix":"10.1039","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-5964","authenticated-orcid":false,"given":"Torsten","family":"John","sequence":"first","affiliation":[{"name":"School of Chemistry"},{"name":"Monash University"},{"name":"Clayton"},{"name":"Australia"},{"name":"Leibniz Institute of Surface Modification, and Wilhelm-Ostwald-Institute for Physical and Theoretical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Xiang","family":"Voo","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"Monash University"},{"name":"Clayton"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Kubeil","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"Monash University"},{"name":"Clayton"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Abel","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Surface Modification, and Wilhelm-Ostwald-Institute for Physical and Theoretical Chemistry"},{"name":"Leipzig University"},{"name":"04318 Leipzig"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bim","family":"Graham","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry"},{"name":"Monash Institute of Pharmaceutical Sciences"},{"name":"Monash University"},{"name":"Parkville"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leone","family":"Spiccia","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"Monash University"},{"name":"Clayton"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-5813","authenticated-orcid":false,"given":"Lisandra L.","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"Monash University"},{"name":"Clayton"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7MD00054E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.2174\/138161207782110408","volume":"13","author":"Lange","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"C7MD00054E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"C7MD00054E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/QCO.0b013e328358afe5","volume":"25","author":"Bergen","year":"2012","journal-title":"Curr. Opin. Infect. Dis."},{"key":"C7MD00054E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/cid\/cir153","volume":"52","author":"Spellberg","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"C7MD00054E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/C5MD00344J","volume":"7","author":"Garneau-Tsodikova","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"C7MD00054E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ja.2013.49","volume":"67","author":"Walsh","year":"2014","journal-title":"J. Antibiot."},{"key":"C7MD00054E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/ar000118k","volume":"34","author":"Gallego","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"C7MD00054E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrmicro3155","volume":"12","author":"Wilson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"C7MD00054E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1039\/C4MD00163J","volume":"5","author":"Fosso","year":"2014","journal-title":"MedChemComm"},{"key":"C7MD00054E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/jmbi.1997.1552","volume":"277","author":"Fourmy","year":"1998","journal-title":"J. Mol. Biol."},{"key":"C7MD00054E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1074-5521(98)90073-4","volume":"5","author":"Wong","year":"1998","journal-title":"Chem. Biol."},{"key":"C7MD00054E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/jmbi.1996.0526","volume":"262","author":"Recht","year":"1996","journal-title":"J. Mol. Biol."},{"key":"C7MD00054E-(cit13)\/*[position()=1]","first-page":"21","volume":"2009","author":"Chittapragada","year":"2009","journal-title":"Perspect. Medicin. Chem."},{"key":"C7MD00054E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1039\/C5MD00503E","volume":"7","author":"Mingeot-Leclercq","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"C7MD00054E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/cb3005116","volume":"8","author":"Becker","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"C7MD00054E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(93)90720-B","volume":"74","author":"Zapp","year":"1993","journal-title":"Cell"},{"key":"C7MD00054E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/cbic.200300680","volume":"4","author":"Tor","year":"2003","journal-title":"ChemBioChem"},{"key":"C7MD00054E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1039\/B813252F","volume":"7","author":"Belousoff","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"C7MD00054E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/cr0301088","volume":"105","author":"Magnet","year":"2005","journal-title":"Chem. Rev."},{"key":"C7MD00054E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1039\/C5MD00453E","volume":"7","author":"Chandrika","year":"2016","journal-title":"MedChemComm"},{"key":"C7MD00054E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0006-2952(80)90382-2","volume":"29","author":"Lodhi","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"C7MD00054E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/08860229209106642","volume":"14","author":"Kaloyanides","year":"1992","journal-title":"Renal Failure"},{"key":"C7MD00054E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408440701524519","volume":"38","author":"Zepik","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"C7MD00054E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/cmdc.201200150","volume":"7","author":"Fair","year":"2012","journal-title":"ChemMedChem"},{"key":"C7MD00054E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1016\/S0021-9258(18)45638-4","volume":"262","author":"Zimmerman","year":"1987","journal-title":"J. Biol. Chem."},{"key":"C7MD00054E-(cit26)\/*[position()=1]","first-page":"5282","volume":"92","author":"Tan","year":"1995","journal-title":"Biochemistry"},{"key":"C7MD00054E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/emboj\/19.1.1","volume":"19","author":"Schroeder","year":"2000","journal-title":"EMBO J."},{"key":"C7MD00054E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbamem.2014.10.019","volume":"1848","author":"Joshi","year":"2015","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C7MD00054E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10945","DOI":"10.1021\/jacs.6b04831","volume":"138","author":"Brezden","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"C7MD00054E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/emboj\/21.10.2323","volume":"21","author":"Fong","year":"2002","journal-title":"EMBO J."},{"key":"C7MD00054E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/ardp.19943271002","volume":"327","author":"Seydel","year":"1994","journal-title":"Arch. Pharm."},{"key":"C7MD00054E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbrc.2007.08.162","volume":"363","author":"Dennison","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C7MD00054E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00249-010-0652-5","volume":"40","author":"McCubbin","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"C7MD00054E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.bbamem.2011.03.002","volume":"1808","author":"Piantavigna","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C7MD00054E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1021\/ac0709504","volume":"79","author":"Cho","year":"2007","journal-title":"Anal. Chem."},{"key":"C7MD00054E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1002\/1521-3773(20001117)39:22<4004::AID-ANIE4004>3.0.CO;2-2","volume":"39","author":"Janshoff","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"C7MD00054E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15228","DOI":"10.1021\/jp209658y","volume":"115","author":"Wang","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"C7MD00054E-(cit38)\/*[position()=1]","first-page":"995","volume":"81","author":"Kubeil","year":"2016","journal-title":"Chem. Commun."},{"key":"C7MD00054E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1021\/bm020116i","volume":"4","author":"Marx","year":"2003","journal-title":"Biomacromolecules"},{"key":"C7MD00054E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S0006-3495(98)74057-3","volume":"75","author":"Keller","year":"1998","journal-title":"Biophys. J."},{"key":"C7MD00054E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1529\/biophysj.107.116525","volume":"93","author":"Mechler","year":"2007","journal-title":"Biophys. J."},{"key":"C7MD00054E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF01337937","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Z. Physik."},{"key":"C7MD00054E-(cit43)\/*[position()=1]","first-page":"151","volume":"19","author":"Dixon","year":"2008","journal-title":"J. Biomol. Tech."},{"key":"C7MD00054E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1021\/ac00285a062","volume":"57","author":"Kanazawa","year":"1985","journal-title":"Anal. Chem."},{"key":"C7MD00054E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1238\/Physica.Regular.059a00391","volume":"59","author":"Voinova","year":"1999","journal-title":"Phys. Scr."},{"key":"C7MD00054E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1021\/la100798c","volume":"26","author":"Ellis","year":"2010","journal-title":"Langmuir"},{"key":"C7MD00054E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ab.2004.10.028","volume":"337","author":"Kamimori","year":"2005","journal-title":"Anal. Biochem."},{"key":"C7MD00054E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0005-2736(84)90221-9","volume":"776","author":"Dufourc","year":"1984","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C7MD00054E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1021\/ja002421m","volume":"122","author":"Luedtke","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"C7MD00054E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.biomaterials.2008.10.016","volume":"30","author":"Mechler","year":"2009","journal-title":"Biomaterials"},{"key":"C7MD00054E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1039\/c2ra20462b","volume":"2","author":"Joshi","year":"2012","journal-title":"RSC Adv."},{"key":"C7MD00054E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jelechem.2008.04.010","volume":"621","author":"Tkac","year":"2008","journal-title":"J. Electroanal. Chem."},{"key":"C7MD00054E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/elan.200403224","volume":"17","author":"Carvalhal","year":"2005","journal-title":"Electroanalysis"},{"key":"C7MD00054E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1021\/ja00183a049","volume":"111","author":"Bain","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"C7MD00054E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1367-5931(01)00269-1","volume":"5","author":"Sinner","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"key":"C7MD00054E-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1039\/c0sc00158a","volume":"1","author":"Sheikh","year":"2010","journal-title":"Chem. Sci."},{"key":"C7MD00054E-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1021\/ma030297w","volume":"37","author":"Munro","year":"2004","journal-title":"Macromolecules"},{"key":"C7MD00054E-(cit58)\/*[position()=1]","volume-title":"Schr\u00f6dinger","author":"Maestro","year":"2012","unstructured":"S. Maestro , Schr\u00f6dinger, LLC, New York, NY, 2012"},{"key":"C7MD00054E-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"C7MD00054E-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-3495(85)83882-0","volume":"47","author":"Tamm","year":"1985","journal-title":"Biophys. J."},{"key":"C7MD00054E-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0005-2736(92)90414-H","volume":"1107","author":"Perkins","year":"1992","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C7MD00054E-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11086","DOI":"10.1021\/acs.langmuir.5b01644","volume":"31","author":"Nelson","year":"2015","journal-title":"Langmuir"},{"key":"C7MD00054E-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1021\/la0610396","volume":"23","author":"Dorvel","year":"2007","journal-title":"Langmuir"},{"key":"C7MD00054E-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14632","DOI":"10.1021\/jp5074939","volume":"118","author":"Frenkel","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"C7MD00054E-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1039\/B611597G","author":"Freire","year":"2007","journal-title":"Chem. Commun."},{"key":"C7MD00054E-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bioorg.2010.04.003","volume":"38","author":"Fuentes-Mart\u00ednez","year":"2010","journal-title":"Bioorg. Chem."},{"key":"C7MD00054E-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","volume":"276","author":"Futaki","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/MD\/C7MD00054E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:17:14Z","timestamp":1782929834000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/8\/5\/1112-1120\/568838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7md00054e","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7MD00054E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Torsten John (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6059-5964","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Torsten John (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/H-6087-2016","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Clemens Kubeil (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/I-5609-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Lisandra L. Martin (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0486-5813","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Lisandra L. Martin (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/E-4482-2010","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 31 January 2017; Accepted 24 March 2017; Advance Article published 6 April 2017; Version of Record published 24 May 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}