{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:02:13Z","timestamp":1787356933782,"version":"build-2736575974"},"reference-count":144,"publisher":"Oxford University Press (OUP)","issue":"10","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["15H04501"],"award-info":[{"award-number":["15H04501"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008666","name":"Sapporo Bioscience Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008666","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Metallomics"],"abstract":"<p>Transient neonatal zinc deficiency (TNZD) results from loss of function mutations in the<italic>SLC30A2\/ZnT2<\/italic>gene. Nursing mothers harboring this defective zinc transporter produce zinc-deficient milk. Consequently, their exclusively breastfed infants develop severe zinc deficiency. The present review summarizes our current knowledge on<italic>SLC30A2\/ZnT2<\/italic>gene mutations and highlights the molecular mechanisms underlying this zinc deficiency. We further propose novel approaches for the early diagnosis and prevention of TNZD.<\/p>","DOI":"10.1039\/c7mt00162b","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T13:55:02Z","timestamp":1497362102000},"page":"1352-1366","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The role of the zinc transporter SLC30A2\/ZnT2 in transient neonatal zinc deficiency"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-3638","authenticated-orcid":false,"given":"Yarden","family":"Golan","sequence":"first","affiliation":[{"name":"The Fred Wyszkowski Cancer Research Laboratory"},{"name":"Department of Biology"},{"name":"Technion-Israel Institute of Technology"},{"name":"Haifa"},{"name":"Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-063X","authenticated-orcid":false,"given":"Taiho","family":"Kambe","sequence":"additional","affiliation":[{"name":"Division of Integrated Life Science"},{"name":"Graduate School of Biostudies"},{"name":"Kyoto University"},{"name":"Sakyo-ku"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-8221","authenticated-orcid":false,"given":"Yehuda G.","family":"Assaraf","sequence":"additional","affiliation":[{"name":"The Fred Wyszkowski Cancer Research Laboratory"},{"name":"Department of Biology"},{"name":"Technion-Israel Institute of Technology"},{"name":"Haifa"},{"name":"Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7MT00162B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/pr050361j","volume":"5","author":"Andreini","year":"2006","journal-title":"J. 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Clin. Pathol."},{"key":"C7MT00162B-(cit18)\/*[position()=1]","first-page":"1","author":"Jackson","year":"1989","journal-title":"Zinc Hum. Biol."},{"key":"C7MT00162B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1007\/s00018-014-1617-0","volume":"71","author":"Kambe","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"C7MT00162B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ajcn\/53.3.755","volume":"53","author":"Taylor","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"C7MT00162B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.nutr.21.1.429","volume":"21","author":"Hambidge","year":"2001","journal-title":"Annu. Rev. Nutr."},{"issue":"suppl 1","key":"C7MT00162B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000348261","volume":"62","author":"Krebs","year":"2013","journal-title":"Ann. Nutr. 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Genet."},{"key":"C7MT00162B-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cmet.2015.05.002","volume":"22","author":"Jenkitkasemwong","year":"2015","journal-title":"Cell Metab."},{"key":"C7MT00162B-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ajhg.2015.11.003","volume":"97","author":"Park","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"C7MT00162B-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1038\/ncomms11601","volume":"7","author":"Tuschl","year":"2016","journal-title":"Nat. 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Biol."},{"key":"C7MT00162B-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1126\/science.1143748","volume":"317","author":"Lu","year":"2007","journal-title":"Science"},{"key":"C7MT00162B-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e92141","DOI":"10.1371\/journal.pone.0092141","volume":"9","author":"Zeytuni","year":"2014","journal-title":"PLoS One"},{"key":"C7MT00162B-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e77445","DOI":"10.1371\/journal.pone.0077445","volume":"8","author":"Fujimoto","year":"2013","journal-title":"PLoS One"},{"key":"C7MT00162B-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1042\/BCJ20160324","volume":"473","author":"Fujimoto","year":"2016","journal-title":"Biochem. J."},{"key":"C7MT00162B-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17677","DOI":"10.1074\/jbc.M109.007203","volume":"284","author":"Ohana","year":"2009","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1039\/C4MT00108G","volume":"6","author":"Shusterman","year":"2014","journal-title":"Metallomics"},{"key":"C7MT00162B-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13546","DOI":"10.1074\/jbc.M116.732693","volume":"291","author":"Golan","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14773","DOI":"10.1074\/jbc.M116.728014","volume":"291","author":"Nishito","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1073\/pnas.1200362109","volume":"109","author":"Hoch","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7MT00162B-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1074\/jbc.M707646200","volume":"283","author":"Kawachi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30956","DOI":"10.1074\/jbc.M506902200","volume":"280","author":"Suzuki","year":"2005","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fob.2013.04.004","volume":"3","author":"Tanaka","year":"2013","journal-title":"FEBS Open Bio."},{"key":"C7MT00162B-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e5896","DOI":"10.1371\/journal.pone.0005896","volume":"4","author":"Salazar","year":"2009","journal-title":"PLoS One"},{"key":"C7MT00162B-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1074\/jbc.M113.533786","volume":"289","author":"Lasry","year":"2014","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29348","DOI":"10.1074\/jbc.M112.368159","volume":"287","author":"Lasry","year":"2012","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28811","DOI":"10.1074\/jbc.M505500200","volume":"280","author":"Ellis","year":"2005","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1091\/mbc.E07-08-0805","volume":"19","author":"Fang","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"C7MT00162B-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1111\/febs.13252","volume":"282","author":"Fujiwara","year":"2015","journal-title":"FEBS J."},{"key":"C7MT00162B-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30798","DOI":"10.1074\/jbc.M109.026435","volume":"284","author":"Fukunaka","year":"2009","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1074\/jbc.M114.617332","volume":"290","author":"Golan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"C7MT00162B-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/tra.12371","volume":"17","author":"Zhao","year":"2016","journal-title":"Traffic"},{"key":"C7MT00162B-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jama.1953.03690060025009","volume":"152","author":"Dillaha","year":"1953","journal-title":"J. Am. Med. Assoc."},{"key":"C7MT00162B-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/jid.1955.29","volume":"24","author":"Bloom","year":"1955","journal-title":"J. Invest. Dermatol."},{"key":"C7MT00162B-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-17819-6","volume-title":"Acrodermatitis Enteropathica","author":"Beigi","year":"2015","unstructured":"P. K. M. Beigi and E.Maverakis, Acrodermatitis Enteropathica, Springer International Publishing, Cham, 2015, pp. 3\u20135"},{"key":"C7MT00162B-(cit78)\/*[position()=1]","first-page":"327","volume":"66","author":"Barnes","year":"1973","journal-title":"Proc. R. Soc. Med."},{"key":"C7MT00162B-(cit79)\/*[position()=1]","first-page":"3547","volume":"74","author":"Hurley","year":"1977","journal-title":"Med. Sci."},{"key":"C7MT00162B-(cit80)\/*[position()=1]","first-page":"E556","volume":"235","author":"Duncan","year":"1978","journal-title":"Am. J. Physiol.: Endocrinol. Metab."},{"key":"C7MT00162B-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ajcn\/32.2.275","volume":"32","author":"Piletz","year":"1979","journal-title":"Am. J. Clin. 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