{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:30:28Z","timestamp":1790753428689,"version":"4.1.0"},"reference-count":60,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"am","delay-in-days":433,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","award":["PDR T.0090.15 to D. A."],"award-info":[{"award-number":["PDR T.0090.15 to D. A."]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","award":["WELBIO-CR-2015A-05"],"award-info":[{"award-number":["WELBIO-CR-2015A-05"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e9 Catholique de Louvain"},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["693630"],"award-info":[{"award-number":["693630"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale Horiz."],"abstract":"<p>Red blood cells present a complex cell plasma membrane architecture with submicrometric organization leading to nanomechanical heterogeneities.<\/p>","DOI":"10.1039\/c7nh00187h","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T07:03:48Z","timestamp":1520665428000},"page":"293-304","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Nanoscale membrane architecture of healthy and pathological red blood cells"],"prefix":"10.1039","volume":"3","author":[{"given":"Andra C.","family":"Dumitru","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"Institute of Life Sciences"},{"name":"B-1348 Louvain-la-Neuve"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9gane A.","family":"Poncin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"Institute of Life Sciences"},{"name":"B-1348 Louvain-la-Neuve"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Conrard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"de Duve Institute"},{"name":"B-1200 Woluwe-Saint-Lambert"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves F.","family":"Dufr\u00eane","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"Institute of Life Sciences"},{"name":"B-1348 Louvain-la-Neuve"},{"name":"Belgium"},{"name":"Walloon Excellence in Life sciences and Biotechnology (WELBIO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatienne","family":"Tyteca","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"de Duve Institute"},{"name":"B-1200 Woluwe-Saint-Lambert"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-113X","authenticated-orcid":false,"given":"David","family":"Alsteens","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain"},{"name":"Institute of Life Sciences"},{"name":"B-1348 Louvain-la-Neuve"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7NH00187H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1182\/blood-2008-07-161166","volume":"112","author":"Mohandas","year":"2008","journal-title":"Blood"},{"key":"C7NH00187H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1126\/science.7973655","volume":"266","author":"Discher","year":"1994","journal-title":"Science"},{"key":"C7NH00187H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev.bb.23.060194.004035","volume":"23","author":"Mohandas","year":"1994","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"C7NH00187H-(cit4)\/*[position()=1]","volume-title":"Current Topics in Membranes","author":"Fowler","year":"2013","unstructured":"V. M. Fowler , in Current Topics in Membranes , ed. V. Bennett , Academic Press , 2013 , vol. 72, pp. 39\u201388"},{"key":"C7NH00187H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2015.12.004","volume":"62","author":"Carquin","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"C7NH00187H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41598-017-04388-z","volume":"7","author":"Leonard","year":"2017","journal-title":"Sci. Rep."},{"key":"C7NH00187H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI106670","volume":"50","author":"Jacob","year":"1971","journal-title":"J. Clin. Invest."},{"key":"C7NH00187H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI105392","volume":"45","author":"Reed","year":"1966","journal-title":"J. Clin. Invest."},{"key":"C7NH00187H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0002-9343(66)90034-9","volume":"41","author":"Jacob","year":"1966","journal-title":"Am. J. Med."},{"key":"C7NH00187H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmat1001","volume":"2","author":"Bao","year":"2003","journal-title":"Nat. Mater."},{"key":"C7NH00187H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2017-05-787051","volume":"130","author":"Nowak","year":"2017","journal-title":"Blood"},{"key":"C7NH00187H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1021\/nn303824j","volume":"7","author":"Picas","year":"2013","journal-title":"ACS Nano"},{"key":"C7NH00187H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.micron.2012.03.019","volume":"43","author":"Girasole","year":"2012","journal-title":"Micron"},{"key":"C7NH00187H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3991(00)00081-4","volume":"86","author":"O\u2019Reilly","year":"2001","journal-title":"Ultramicroscopy"},{"key":"C7NH00187H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/sia.1174","volume":"33","author":"Nowakowski","year":"2002","journal-title":"Surf. Interface Anal."},{"key":"C7NH00187H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1039\/C5NR03145A","volume":"7","author":"Ciasca","year":"2015","journal-title":"Nanoscale"},{"key":"C7NH00187H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbbm.2005.11.003","volume":"66","author":"Duli\u0144ska","year":"2006","journal-title":"J. Biochem. Biophys. Methods"},{"key":"C7NH00187H-(cit18)\/*[position()=1]","first-page":"307","volume":"42","author":"Lekka","year":"2005","journal-title":"Biorheology"},{"key":"C7NH00187H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12013-016-0755-4","volume":"74","author":"Li","year":"2016","journal-title":"Cell Biochem. Biophys."},{"key":"C7NH00187H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jbiomech.2010.11.008","volume":"44","author":"Maciaszek","year":"2011","journal-title":"J. Biomech."},{"key":"C7NH00187H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bioelechem.2006.03.019","volume":"70","author":"Betz","year":"2007","journal-title":"Bioelectrochemistry"},{"key":"C7NH00187H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nmeth.2602","volume":"10","author":"Dufrene","year":"2013","journal-title":"Nat. Methods"},{"key":"C7NH00187H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nnano.2017.45","volume":"12","author":"Dufr\u00eane","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"C7NH00187H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nmeth.3479","volume":"12","author":"Alsteens","year":"2015","journal-title":"Nat. Methods"},{"key":"C7NH00187H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nnano.2016.228","volume":"12","author":"Alsteens","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"C7NH00187H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/acsnano.5b07162","volume":"10","author":"Calzado-Mart\u00edn","year":"2016","journal-title":"ACS Nano"},{"key":"C7NH00187H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1021\/nn5015837","volume":"8","author":"Xia","year":"2014","journal-title":"ACS Nano"},{"key":"C7NH00187H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16738","DOI":"10.1021\/la303891j","volume":"28","author":"Alsteens","year":"2012","journal-title":"Langmuir"},{"key":"C7NH00187H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.bpj.2015.01.016","volume":"108","author":"Eghiaian","year":"2015","journal-title":"Biophys. J."},{"key":"C7NH00187H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nnano.2012.163","volume":"7","author":"Gavara","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"C7NH00187H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1525-1594.2002.06702.x","volume":"26","author":"Ohta","year":"2002","journal-title":"Artif. Organs"},{"key":"C7NH00187H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.nano.2010.06.004","volume":"6","author":"Girasole","year":"2010","journal-title":"Nanomedicine"},{"key":"C7NH00187H-(cit33)\/*[position()=1]","volume-title":"Methods in Cell Biology","author":"Radmacher","year":"2007","unstructured":"M. Radmacher , Methods in Cell Biology , Academic Press , 2007 , vol. 83, pp. 347\u2013372"},{"key":"C7NH00187H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"055102","DOI":"10.1088\/0957-4484\/24\/5\/055102","volume":"24","author":"Rebelo","year":"2013","journal-title":"Nanotechnology"},{"key":"C7NH00187H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"148102","DOI":"10.1103\/PhysRevLett.87.148102","volume":"87","author":"Fabry","year":"2001","journal-title":"Phys. Rev. Lett."},{"key":"C7NH00187H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bpj.2013.12.037","volume":"106","author":"Cartagena","year":"2014","journal-title":"Biophys. J."},{"key":"C7NH00187H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1021\/acsnano.5b00430","volume":"9","author":"Rigato","year":"2015","journal-title":"ACS Nano"},{"key":"C7NH00187H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nphys4104","volume":"13","author":"Rigato","year":"2017","journal-title":"Nat. Phys."},{"key":"C7NH00187H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1038\/srep11692","volume":"5","author":"Cartagena-Rivera","year":"2015","journal-title":"Sci. Rep."},{"key":"C7NH00187H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/nnano.2011.186","volume":"6","author":"Raman","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"C7NH00187H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bpj.2009.05.010","volume":"97","author":"Roduit","year":"2009","journal-title":"Biophys. J."},{"key":"C7NH00187H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19686","DOI":"10.1038\/srep19686","volume":"6","author":"Staunton","year":"2016","journal-title":"Sci. Rep."},{"key":"C7NH00187H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/acsnano.5b03959","volume":"10","author":"Wang","year":"2016","journal-title":"ACS Nano"},{"key":"C7NH00187H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.bpj.2011.09.050","volume":"101","author":"Nans","year":"2011","journal-title":"Biophys. J."},{"key":"C7NH00187H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1088\/1367-2630\/9\/11\/429","volume":"9","author":"Gov","year":"2007","journal-title":"New J. Phys."},{"key":"C7NH00187H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/j.bpj.2015.10.036","volume":"109","author":"Lai","year":"2015","journal-title":"Biophys. J."},{"key":"C7NH00187H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.0909533107","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7NH00187H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1083\/jcb.100.1.47","volume":"100","author":"Fowler","year":"1985","journal-title":"J. Cell Biol."},{"key":"C7NH00187H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1182\/blood.V79.5.1351.1351","volume":"79","author":"Waugh","year":"1992","journal-title":"Blood"},{"key":"C7NH00187H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1091\/mbc.e14-12-1583","volume":"26","author":"Gokhin","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"C7NH00187H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1194\/jlr.M034314","volume":"54","author":"D'Auria","year":"2013","journal-title":"J. Lipid Res."},{"key":"C7NH00187H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1073\/pnas.0903825106","volume":"106","author":"Ursell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7NH00187H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"C7NH00187H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1073\/pnas.1606751113","volume":"113","author":"Pivkin","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7NH00187H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1172\/JCI113284","volume":"81","author":"Waugh","year":"1988","journal-title":"J. Clin. Invest."},{"key":"C7NH00187H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"012715","DOI":"10.1103\/PhysRevE.92.012715","volume":"92","author":"Li","year":"2015","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C7NH00187H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1182\/blood-2011-06-361907","volume":"119","author":"Ubukawa","year":"2012","journal-title":"Blood"},{"key":"C7NH00187H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1063\/1.1143970","volume":"64","author":"Hutter","year":"1993","journal-title":"Rev. Sci. Instrum."},{"key":"C7NH00187H-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1038\/s41598-017-05383-0","volume":"7","author":"Schillers","year":"2017","journal-title":"Sci. Rep."},{"key":"C7NH00187H-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1515\/crll.1882.92.156","volume":"92","author":"Hertz","year":"1882","journal-title":"J. Reine Angew. Math."}],"container-title":["Nanoscale Horizons"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/NH\/C7NH00187H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:12:48Z","timestamp":1782929568000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nh\/article\/3\/3\/293-304\/569577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7nh00187h","relation":{},"ISSN":["2055-6756","2055-6764"],"issn-type":[{"value":"2055-6756","type":"print"},{"value":"2055-6764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7NH00187H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"David Alsteens (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9229-113X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 November 2017; Accepted 9 March 2018; Accepted Manuscript published 10 March 2018; Advance Article published 19 March 2018; Version of Record published 3 May 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}