{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:49:55Z","timestamp":1785887395232,"version":"3.56.0"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"am","delay-in-days":415,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81761148028"],"award-info":[{"award-number":["81761148028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21773026"],"award-info":[{"award-number":["21773026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["17540712000"],"award-info":[{"award-number":["17540712000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>\n                    Multifunctional folic acid-modified G5 PAMAM dendrimers can be radiolabeled with\n                    <sup>64<\/sup>\n                    Cu for PET imaging of folate receptor-expressing tumors.\n                  <\/p>","DOI":"10.1039\/c7nr09269e","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T12:25:37Z","timestamp":1519129537000},"page":"6113-6124","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["<sup>64<\/sup>\n                    Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging"],"prefix":"10.1039","volume":"10","author":[{"given":"Wenhui","family":"Ma","sequence":"first","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Chemistry"},{"name":"Chemical Engineering and Biotechnology"},{"name":"Donghua University"},{"name":"Shanghai 201620"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials"},{"name":"College of Materials Science and Engineering"},{"name":"Donghua University"},{"name":"Shanghai 201620"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Zhu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine"},{"name":"Xijing Hospital"},{"name":"The Fourth Military Medical University"},{"name":"Xi'an"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Conti","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-6645","authenticated-orcid":false,"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Chemistry"},{"name":"Chemical Engineering and Biotechnology"},{"name":"Donghua University"},{"name":"Shanghai 201620"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-1182","authenticated-orcid":false,"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center"},{"name":"Department of Radiology"},{"name":"Keck School of Medicine"},{"name":"University of Southern California"},{"name":"Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7NR09269E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1101\/gad.1047403","volume":"17","author":"Massoud","year":"2003","journal-title":"Genes Dev."},{"key":"C7NR09269E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.seminoncol.2010.11.005","volume":"38","author":"Chen","year":"2011","journal-title":"Semin. Oncol."},{"key":"C7NR09269E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1148\/radiology.219.2.r01ma19316","volume":"219","author":"Weissleder","year":"2001","journal-title":"Radiology"},{"key":"C7NR09269E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1021\/cr0782426","volume":"108","author":"Ametamey","year":"2008","journal-title":"Chem. Rev."},{"key":"C7NR09269E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.addr.2010.09.004","volume":"62","author":"Chen","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"C7NR09269E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1039\/c0dt01595d","volume":"40","author":"Zeglis","year":"2011","journal-title":"Dalton Trans."},{"key":"C7NR09269E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1021\/cr900325h","volume":"110","author":"Wadas","year":"2010","journal-title":"Chem. Rev."},{"key":"C7NR09269E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1021\/mp500354x","volume":"11","author":"Li","year":"2014","journal-title":"Mol. Pharmaceutics"},{"key":"C7NR09269E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/mp3005676","volume":"10","author":"Chen","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"C7NR09269E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/ml300236m","volume":"3","author":"Chen","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"C7NR09269E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1021\/ar800255q","volume":"42","author":"Shokeen","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"C7NR09269E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2174\/156802611794785172","volume":"11","author":"Ma","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"C7NR09269E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1874471011104020109","volume":"4","author":"Hao","year":"2011","journal-title":"Curr. Radiopharm."},{"key":"C7NR09269E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2174\/156802610791384225","volume":"10","author":"Chen","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"C7NR09269E-(cit15)\/*[position()=1]","first-page":"10","volume":"2","author":"Xing","year":"2014","journal-title":"Austin J. Nanomed. Nanotechnol."},{"key":"C7NR09269E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"290","DOI":"10.7150\/thno.7341","volume":"4","author":"Xing","year":"2014","journal-title":"Theranostics"},{"key":"C7NR09269E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.2967\/jnumed.114.146019","volume":"55","author":"Chen","year":"2014","journal-title":"J. Nucl. Med."},{"key":"C7NR09269E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7150\/thno.3463","volume":"2","author":"Yu","year":"2012","journal-title":"Theranostics"},{"key":"C7NR09269E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1016\/j.biomaterials.2013.03.009","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16416","DOI":"10.1021\/am504849x","volume":"6","author":"Fu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C7NR09269E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1016\/j.biomaterials.2014.05.046","volume":"35","author":"Zhu","year":"2014","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2174\/156802608785849021","volume":"8","author":"Longmire","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"C7NR09269E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10717544.2017.1399299","volume":"24","author":"Zhao","year":"2017","journal-title":"Drug Delivery"},{"key":"C7NR09269E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1016\/j.biomaterials.2013.07.070","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit25)\/*[position()=1]","first-page":"195","volume":"90","author":"Sadler","year":"2002","journal-title":"J. Biotechnol."},{"key":"C7NR09269E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/b11014","volume":"228","author":"Yamaguchi","year":"2003","journal-title":"Top. Curr. Chem."},{"key":"C7NR09269E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.drup.2014.10.002","volume":"17","author":"Assaraf","year":"2014","journal-title":"Drug Resist. Updates"},{"key":"C7NR09269E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/annonc\/mdv250","volume":"26","author":"Ledermann","year":"2015","journal-title":"Ann. Oncol."},{"key":"C7NR09269E-(cit29)\/*[position()=1]","first-page":"5329","volume":"51","author":"Campbell","year":"1991","journal-title":"Cancer Res."},{"key":"C7NR09269E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/1097-0142(19940501)73:9<2432::AID-CNCR2820730929>3.0.CO;2-S","volume":"73","author":"Ross","year":"1994","journal-title":"Cancer"},{"key":"C7NR09269E-(cit31)\/*[position()=1]","first-page":"3396","volume":"52","author":"Weitman","year":"1992","journal-title":"Cancer Res."},{"key":"C7NR09269E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.biomaterials.2012.09.054","volume":"34","author":"Wang","year":"2013","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13346-012-0119-6","volume":"3","author":"Sadekar","year":"2013","journal-title":"Drug Delivery Transl. Res."},{"key":"C7NR09269E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12832","DOI":"10.1039\/C4CC03454F","volume":"50","author":"Wang","year":"2014","journal-title":"Chem. Commun."},{"key":"C7NR09269E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jrras.2014.12.001","volume":"8","author":"Rahmania","year":"2015","journal-title":"J. Radiat. Res. Appl. Sci."},{"key":"C7NR09269E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1039\/c1py00179e","volume":"2","author":"Wang","year":"2011","journal-title":"Polym. Chem."},{"key":"C7NR09269E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.biomaterials.2010.12.060","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11307-011-0479-1","volume":"14","author":"Chen","year":"2012","journal-title":"Mol. Imaging Biol."},{"key":"C7NR09269E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chembiol.2006.11.015","volume":"14","author":"Hong","year":"2007","journal-title":"Chem. Biol."},{"key":"C7NR09269E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1016\/j.biomaterials.2013.03.009","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.biomaterials.2012.11.010","volume":"34","author":"Wen","year":"2013","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1039\/B612972B","volume":"3","author":"Shi","year":"2007","journal-title":"Soft Matter"},{"key":"C7NR09269E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2014.08.002","volume":"44","author":"Qiao","year":"2015","journal-title":"Prog. Polym. Sci."},{"key":"C7NR09269E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1021\/bm101013s","volume":"11","author":"Wang","year":"2010","journal-title":"Biomacromolecules"},{"key":"C7NR09269E-(cit45)\/*[position()=1]","first-page":"6547","volume":"34","author":"Aljammaz","year":"2014","journal-title":"Anticancer Res."},{"key":"C7NR09269E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/acs.molpharmaceut.5b00989","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Pharmaceutics"},{"key":"C7NR09269E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1016\/j.biomaterials.2010.01.010","volume":"31","author":"Xie","year":"2010","journal-title":"Biomaterials"},{"key":"C7NR09269E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/jm030383m","volume":"47","author":"Boswell","year":"2004","journal-title":"J. Med. Chem."},{"key":"C7NR09269E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/jm0103817","volume":"45","author":"Sun","year":"2002","journal-title":"J. Med. Chem."},{"key":"C7NR09269E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1021\/bc900537f","volume":"21","author":"Cai","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"C7NR09269E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nucmedbio.2009.09.001","volume":"37","author":"Cai","year":"2010","journal-title":"Nucl. Med. Biol."},{"key":"C7NR09269E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1021\/es048961r","volume":"39","author":"Diallo","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"C7NR09269E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2174\/138955706775475975","volume":"6","author":"Chen","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"C7NR09269E-(cit54)\/*[position()=1]","first-page":"1781","volume":"61","author":"Haubner","year":"2001","journal-title":"Cancer Res."},{"key":"C7NR09269E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/bc800455p","volume":"20","author":"Shi","year":"2009","journal-title":"Bioconjugate Chem."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/NR\/C7NR09269E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:04:34Z","timestamp":1782885874000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/10\/13\/6113-6124\/573975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":55,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7nr09269e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7NR09269E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Xiangyang Shi (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6785-6645","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Xiangyang Shi (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/A-1289-2007","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Kai Chen (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8647-1182","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Kai Chen (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-7881-2016","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 December 2017; Accepted 18 February 2018;  Accepted Manuscript published 20 February 2018;  Advance Article published 16 March 2018;  Version of Record published 29 March 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}