{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:31:59Z","timestamp":1784763119864,"version":"3.55.0"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","funder":[{"DOI":"10.13039\/501100005362","name":"Universita degli Studi di Bari Aldo Moro","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005362","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>The regioselective functionalization of four- and six-membered cyclic sulfones was investigated using a lithiation\/functionalization strategy.<\/p>","DOI":"10.1039\/c7ob00846e","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T08:56:35Z","timestamp":1495097795000},"page":"5000-5015","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles"],"prefix":"10.1039","volume":"15","author":[{"given":"Giovanna","family":"Parisi","sequence":"first","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"},{"name":"Department of Pharmaceutical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-9419","authenticated-orcid":false,"given":"Leonardo","family":"Degennaro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Carlucci","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modesto","family":"de Candia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-458X","authenticated-orcid":false,"given":"Piero","family":"Mastrorilli","sequence":"additional","affiliation":[{"name":"DICATECh"},{"name":"Politecnico di Bari"},{"name":"70125 Bari"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Roller","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry"},{"name":"University of Vienna"},{"name":"1090 \u2013 Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Holzer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"University of Vienna"},{"name":"1090 \u2013 Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo Damiano","family":"Altomare","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-5930","authenticated-orcid":false,"given":"Vittorio","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"University of Vienna"},{"name":"1090 \u2013 Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-7908","authenticated-orcid":false,"given":"Renzo","family":"Luisi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Drug Sciences"},{"name":"University of Bari \u201cA. Moro\u201d"},{"name":"FLAME-Lab \u2013 Flow Chemistry and Microreactor Technology Laboratory"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7OB00846E-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1021\/jm501998m","volume":"58","author":"Burch","year":"2015","journal-title":"J. Med. Chem."},{"key":"C7OB00846E-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1039\/C5OB00549C","volume":"13","author":"Morgan","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C7OB00846E-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.1021\/cr500127b","volume":"114","author":"Carreira","year":"2014","journal-title":"Chem. Rev."},{"key":"C7OB00846E-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1021\/acs.joc.6b01827","volume":"82","author":"Bosset","year":"2017","journal-title":"J. Org. Chem."},{"key":"C7OB00846E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/00397918808064015","volume":"18","author":"Frazier","year":"1988","journal-title":"Synth. Commun."},{"key":"C7OB00846E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1016\/0040-4020(73)80249-2","volume":"29","author":"Kattenberg","year":"1973","journal-title":"Tetrahedron"},{"key":"C7OB00846E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0031-9422(95)00005-R","volume":"39","author":"Lin","year":"1995","journal-title":"Phytochemistry"},{"key":"C7OB00846E-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1021\/jo026636l","volume":"68","author":"Katritzky","year":"2003","journal-title":"J. Org. Chem."},{"key":"C7OB00846E-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9191","DOI":"10.1021\/jo051157i","volume":"70","author":"Katritzky","year":"2005","journal-title":"J. Org. Chem."},{"key":"C7OB00846E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1021\/ol053132b","volume":"8","author":"Vel\u00e0zquez","year":"2006","journal-title":"Org. Lett."},{"key":"C7OB00846E-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"861a","DOI":"10.1039\/C3973000861A","author":"Marino","year":"1973","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"C7OB00846E-(cit11b)\/*[position()=1]","volume-title":"Asymmetric Synthesis","author":"Gais","year":"2008","unstructured":"H.-J.\n              Gais\n            , Asymmetric Reactions of \u03b1-Sulfonyl Carbanions in Organosulfur Chemistry, in Asymmetric Synthesis, ed. T. Toru and C. Bolm, Wiley-VCH, Weinheim, 2008, ch. 11, pp. 375\u2013398"},{"key":"C7OB00846E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1021\/jm9016027","volume":"53","author":"Vel\u00e0zquez","year":"2010","journal-title":"J. Med. Chem."},{"key":"C7OB00846E-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12190","DOI":"10.1002\/chem.201403141","volume":"20","author":"Zenzola","year":"2014","journal-title":"Chem. \u2013 Eur. J."},{"key":"C7OB00846E-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1039\/c3cc48555b","volume":"50","author":"Degennaro","year":"2014","journal-title":"Chem. Commun."},{"key":"C7OB00846E-(cit13c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15588","DOI":"10.1039\/C5CC06323J","volume":"51","author":"Parisi","year":"2015","journal-title":"Chem. Commun."},{"key":"C7OB00846E-(cit13d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1039\/C6OB01665K","volume":"15","author":"Antermite","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"C7OB00846E-(cit13e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1515\/pac-2016-0602","volume":"88","author":"Parisi","year":"2016","journal-title":"Pure Appl. Chem."},{"key":"C7OB00846E-(cit13f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1002\/ejoc.201600372","author":"Pisano","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"C7OB00846E-(cit13g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1039\/C4OB02329C","volume":"13","author":"Castagnolo","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C7OB00846E-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1039\/C4OB00173G","volume":"12","author":"Carroccia","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"C7OB00846E-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s10593-017-2060-6","volume":"53","author":"Tota","year":"2017","journal-title":"Chem. Heterocycl. Compd."},{"key":"C7OB00846E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1021\/acs.joc.5b02126","volume":"80","author":"Degennaro","year":"2015","journal-title":"J. Org. Chem."},{"key":"C7OB00846E-(cit16a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/cssc.201100780","volume":"5","author":"Pace","year":"2012","journal-title":"ChemSusChem"},{"key":"C7OB00846E-(cit16b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1071\/CH11490","volume":"65","author":"Pace","year":"2012","journal-title":"Aust. J. Chem."},{"key":"C7OB00846E-(cit16c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00706-016-1879-3","volume":"148","author":"Monticelli","year":"2017","journal-title":"Monatsh. Chem."},{"key":"C7OB00846E-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/op060155c","volume":"11","author":"Aycock","year":"2007","journal-title":"Org. Process Res. Dev."},{"key":"C7OB00846E-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1039\/c2gc35305a","volume":"14","author":"Pace","year":"2012","journal-title":"Green Chem."},{"key":"C7OB00846E-(cit17c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.tet.2011.01.067","volume":"67","author":"Pace","year":"2011","journal-title":"Tetrahedron"},{"key":"C7OB00846E-(cit17d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1039\/c1gc15574a","volume":"13","author":"Pace","year":"2011","journal-title":"Green Chem."},{"key":"C7OB00846E-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7848","DOI":"10.1039\/C6OB00766J","volume":"14","author":"Pace","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"C7OB00846E-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1021\/acs.orglett.6b01226","volume":"18","author":"Pace","year":"2016","journal-title":"Org. Lett."},{"key":"C7OB00846E-(cit18c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18966","DOI":"10.1002\/chem.201504247","volume":"21","author":"Pace","year":"2015","journal-title":"Chem. \u2013 Eur. J."},{"key":"C7OB00846E-(cit18d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1002\/adsc.201400630","volume":"356","author":"Pace","year":"2014","journal-title":"Adv. Synth. Catal."},{"key":"C7OB00846E-(cit18e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1055\/s-0034-1379209","author":"Pace","year":"2014","journal-title":"Synthesis"},{"key":"C7OB00846E-(cit18f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.1039\/c3cc44255a","volume":"49","author":"Pace","year":"2013","journal-title":"Chem. Commun."},{"key":"C7OB00846E-(cit20a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/S0040-4039(01)89885-3","volume":"34","author":"Kaiser","year":"1967","journal-title":"Tetrahedron Lett."},{"key":"C7OB00846E-(cit20b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1021\/ja00746a025","volume":"93","author":"Kaiser","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB00846E-(cit20b)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/anie.198506961","volume":"24","author":"Vollhardt","year":"1985","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"C7OB00846E-(cit21)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/ja00267a006","volume":"108","author":"Bors","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB00846E-(cit24)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1021\/jo00831a026","volume":"35","author":"Truce","year":"1970","journal-title":"J. Org. Chem."},{"key":"C7OB00846E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2174\/1568026013395100","volume":"1","author":"Avdeef","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"C7OB00846E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/PL00012496","volume":"59","author":"Avdeef","year":"2002","journal-title":"Cell Mol. Life Sci."},{"key":"C7OB00846E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ddtec.2004.10.006","volume":"1","author":"Hartmann","year":"2004","journal-title":"Drug Discovery Today Technol."},{"key":"C7OB00846E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1021\/ac061649a","volume":"79","author":"Chen","year":"2007","journal-title":"Anal. Chem."},{"key":"C7OB00846E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/jm0000822","volume":"43","author":"Lombardo","year":"2000","journal-title":"J. Med. Chem."},{"key":"C7OB00846E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1023\/A:1011968630713","volume":"15","author":"Kraemer","year":"1998","journal-title":"Pharm. Res."},{"key":"C7OB00846E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejps.2005.05.001","volume":"26","author":"de Candia","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"C7OB00846E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.bcp.2007.12.010","volume":"75","author":"Soto-Otero","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"C7OB00846E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/ardp.201200007","volume":"345","author":"Soto-Otero","year":"2012","journal-title":"Arch. Pharm."},{"key":"C7OB00846E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1021\/ac00076a006","volume":"66","author":"Tan","year":"1994","journal-title":"Anal. Chem."},{"key":"C7OB00846E-(cit36)\/*[position()=1]","volume-title":"Practical Aspects of Organolithium\nChemistry in Lithium Compounds in Organic Synthesis: From Fundamentals to Applications","author":"Degennaro","year":"2014","unstructured":"L.\n            Degennaro\n          , L.Carroccia, A.Giovine and R.Luisi, Practical Aspects of Organolithium\nChemistry in Lithium Compounds in Organic Synthesis: From Fundamentals to Applications, ed. R. Luisi and V. Capriati, Wiley VHC, 2014, ch. 18, pp. 513\u2013538"}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/OB\/C7OB00846E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:59:22Z","timestamp":1783533562000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/15\/23\/5000-5015\/574629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":52,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7ob00846e","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7OB00846E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=C7OB00846E","name":"related_data"},{"value":"Leonardo Degennaro (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2187-9419","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Piero Mastrorilli (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8841-458X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Vittorio Pace (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3037-5930","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Renzo Luisi (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9882-7908","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 April 2017; Accepted 16 May 2017;  Accepted Manuscript published 18 May 2017;  Advance Article published 1 June 2017;  Version of Record published 14 June 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}