{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:24:57Z","timestamp":1782854697490,"version":"3.54.5"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"40","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM087596"],"award-info":[{"award-number":["GM087596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>Pseudouridine modifications in helix 69 of bacterial ribosomes impact aminoglycoside interactions by altering the RNA conformational states and accessibility to chemical probes.<\/p>","DOI":"10.1039\/c7ob02147j","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T06:33:37Z","timestamp":1506321217000},"page":"8535-8543","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes"],"prefix":"10.1039","volume":"15","author":[{"given":"Yogo","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Wayne State University"},{"name":"Detroit"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-4553","authenticated-orcid":false,"given":"Christine S.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Wayne State University"},{"name":"Detroit"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7OB02147J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0026-895X(25)14722-6","volume":"1","author":"Davies","year":"1965","journal-title":"Mol. Pharmacol."},{"key":"C7OB02147J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(77)90147-7","volume":"10","author":"Edelmann","year":"1977","journal-title":"Cell"},{"key":"C7OB02147J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nsmb1271","volume":"14","author":"Borovinskaya","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1021\/jo001142e","volume":"65","author":"Baker","year":"2000","journal-title":"J. Org. Chem."},{"key":"C7OB02147J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/embo-reports\/kve062","volume":"2","author":"B\u00f6ttger","year":"2001","journal-title":"EMBO Rep."},{"key":"C7OB02147J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.sbi.2005.05.001","volume":"15","author":"Hermann","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"C7OB02147J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12374","DOI":"10.1021\/ja0360135","volume":"125","author":"Luedtke","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB02147J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1021\/jacs.5b02248","volume":"137","author":"Matsushita","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB02147J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1021\/ja9020149","volume":"131","author":"Pushechnikov","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB02147J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1016\/j.bmcl.2005.08.027","volume":"15","author":"Wang","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C7OB02147J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1074-5521(98)90073-4","volume":"5","author":"Wong","year":"1998","journal-title":"Chem. Biol."},{"key":"C7OB02147J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35030019","volume":"407","author":"Carter","year":"2000","journal-title":"Nature"},{"key":"C7OB02147J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/327389a0","volume":"327","author":"Moazed","year":"1987","journal-title":"Nature"},{"key":"C7OB02147J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1060612","volume":"292","author":"Ogle","year":"2001","journal-title":"Science"},{"key":"C7OB02147J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0092-8674(02)01086-3","volume":"111","author":"Ogle","year":"2002","journal-title":"Cell"},{"key":"C7OB02147J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1126\/science.1060089","volume":"292","author":"Yusupov","year":"2001","journal-title":"Science"},{"key":"C7OB02147J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1126\/science.274.5291.1367","volume":"274","author":"Fourmy","year":"1996","journal-title":"Science"},{"key":"C7OB02147J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0969-2126(01)00629-3","volume":"9","author":"Vicens","year":"2001","journal-title":"Structure"},{"key":"C7OB02147J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nsmb.2360","volume":"19","author":"Wang","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nsmb.1755","volume":"17","author":"Stanley","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.molcel.2006.08.011","volume":"23","author":"Ali","year":"2006","journal-title":"Mol. Cell"},{"key":"C7OB02147J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1261\/rna.5220504","volume":"10","author":"Maiv\u00e4li","year":"2004","journal-title":"RNA"},{"key":"C7OB02147J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jmb.2008.10.065","volume":"385","author":"Kipper","year":"2009","journal-title":"J. Mol. Biol."},{"key":"C7OB02147J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2199-6-18","volume":"6","author":"Liiv","year":"2005","journal-title":"BMC Mol. Biol."},{"key":"C7OB02147J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1006\/jmbi.1995.0659","volume":"254","author":"O'Connor","year":"1995","journal-title":"J. Mol. Biol."},{"key":"C7OB02147J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1097-2765(03)00009-1","volume":"11","author":"Bashan","year":"2003","journal-title":"Mol. Cell"},{"key":"C7OB02147J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1038\/emboj.2010.139","volume":"29","author":"Korostelev","year":"2010","journal-title":"EMBO J."},{"key":"C7OB02147J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature07115","volume":"454","author":"Laurberg","year":"2008","journal-title":"Nature"},{"key":"C7OB02147J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1126\/science.1164840","volume":"322","author":"Weixlbaumer","year":"2008","journal-title":"Science"},{"key":"C7OB02147J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1073\/pnas.0401904101","volume":"101","author":"Agrawal","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7OB02147J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.emboj.7600525","volume":"24","author":"Wilson","year":"2005","journal-title":"EMBO J."},{"key":"C7OB02147J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1117230","volume":"310","author":"Schuwirth","year":"2005","journal-title":"Science"},{"key":"C7OB02147J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1175275","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"C7OB02147J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1021\/ja2005658","volume":"133","author":"Sakakibara","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C7OB02147J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/cb200497q","volume":"7","author":"Sakakibara","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"C7OB02147J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1073\/pnas.76.4.1760","volume":"76","author":"Peattie","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7OB02147J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/nar\/gkp1253","volume":"38","author":"Scheunemann","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"C7OB02147J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1074-5521(02)00125-4","volume":"9","author":"Llano-Sotelo","year":"2002","journal-title":"Chem. Biol."},{"key":"C7OB02147J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1021\/bi962095g","volume":"36","author":"Wang","year":"1997","journal-title":"Biochemistry"},{"key":"C7OB02147J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12095","DOI":"10.1002\/anie.201206000","volume":"51","author":"Sakakibara","year":"2012","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"C7OB02147J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1093\/nar\/gkt1329","volume":"42","author":"Jiang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"C7OB02147J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.289.5481.920","volume":"289","author":"Nissen","year":"2000","journal-title":"Science"},{"key":"C7OB02147J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bpc.2015.03.001","volume":"200\u2013201","author":"Jiang","year":"2015","journal-title":"Biophys. Chem."},{"key":"C7OB02147J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1073\/pnas.77.8.4679","volume":"77","author":"Peattie","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7OB02147J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/acs.accounts.6b00014","volume":"49","author":"Jiang","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"C7OB02147J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1261\/rna.779908","volume":"14","author":"Abeysirigunawardena","year":"2008","journal-title":"RNA"},{"key":"C7OB02147J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1039\/b812731j","volume":"6","author":"Desaulniers","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"C7OB02147J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/bip.21706","volume":"97","author":"Sumita","year":"2012","journal-title":"Biopolymers"},{"key":"C7OB02147J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nsmb.2994","volume":"22","author":"Noeske","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.1175800","volume":"325","author":"Blaha","year":"2009","journal-title":"Science"},{"key":"C7OB02147J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1126\/science.1179700","volume":"326","author":"Schmeing","year":"2009","journal-title":"Science"},{"key":"C7OB02147J-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nsmb.1790","volume":"17","author":"Jenner","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1236086","DOI":"10.1126\/science.1236086","volume":"340","author":"Zhou","year":"2013","journal-title":"Science"},{"key":"C7OB02147J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.1179709","volume":"326","author":"Gao","year":"2009","journal-title":"Science"},{"key":"C7OB02147J-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nsmb1282","volume":"14","author":"Weixlbaumer","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C7OB02147J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/ijch.201300012","volume":"53","author":"Jiang","year":"2013","journal-title":"Isr. J. Chem."},{"key":"C7OB02147J-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1365-2958.2012.08168.x","volume":"85","author":"Monshupanee","year":"2012","journal-title":"Mol. Microbiol."},{"key":"C7OB02147J-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.molcel.2006.11.025","volume":"24","author":"Shoji","year":"2006","journal-title":"Mol. Cell"},{"key":"C7OB02147J-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nchembio.274","volume":"6","author":"Feldman","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"C7OB02147J-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0076-6879(00)17021-1","volume":"317","author":"Blaha","year":"2000","journal-title":"Methods Enzymol."},{"key":"C7OB02147J-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0092-8674(86)90813-5","volume":"47","author":"Moazed","year":"1986","journal-title":"Cell"}],"container-title":["Org. Biomol. Chem."],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/OB\/C7OB02147J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:26:56Z","timestamp":1782851216000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/15\/40\/8535-8543\/575116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":61,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7ob02147j","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7OB02147J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Christine S. Chow (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5538-4553","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 28 August 2017; Accepted 25 September 2017; Accepted Manuscript published 25 September 2017; Advance Article published 29 September 2017; Version of Record published 18 October 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}