{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:17:00Z","timestamp":1792178220525,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000736","name":"University of East Anglia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000736","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1039\/c7pp00225d","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T14:41:11Z","timestamp":1513867271000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle-photosensitiser conjugates"],"prefix":"10.1007","volume":"17","author":[{"given":"Paula","family":"Garc\u00eda Calavia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Chambrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"17030281_CR1","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1021\/cr900300p","volume":"110","author":"J P Celli","year":"2010","unstructured":"J. P. Celli, B. Q. Spring, I. Rizvi, C. L. Evans, K. S. Samkoe, S. Verma, B. W. Pogue and T. Hasan, Imaging and photo- dynamic therapy: Mechanisms, monitoring and optimiz- ation, Chem. Rev., 2010, 110, 2795\u20132838.","journal-title":"Chem. Rev."},{"key":"17030281_CR2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"D E J G J Dolmans","year":"2003","unstructured":"D. E. J. G. J. Dolmans, D. Fukumura and R. K. Jain, Photodynamic therapy for cancer, Nat. Rev. Cancer, 2003, 3, 380\u2013387.","journal-title":"Nat. Rev. Cancer"},{"key":"17030281_CR3","doi-asserted-by":"publisher","first-page":"6158","DOI":"10.1002\/anie.201201468","volume":"51","author":"G Obaid","year":"2012","unstructured":"G. Obaid, I. Chambrier, M. J. Cook and D. A. Russell, Targeting the oncofetal Thomsen-Friedenreich disacchar- ide using jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy, Angew. Chem., Int. Ed., 2012, 51, 6158\u20136162.","journal-title":"Angew. Chem., Int. Ed."},{"key":"17030281_CR4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1039\/C4PP00312H","volume":"14","author":"G Obaid","year":"2015","unstructured":"G. Obaid, I. Chambrier, M. J. Cook and D. A. Russell, Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles, Photochem. Photobiol. Sci., 2015, 14, 737\u2013747.","journal-title":"Photochem. Photobiol. Sci."},{"key":"17030281_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1039\/b311429e","volume":"14","author":"S Wang","year":"2004","unstructured":"S. Wang, R. Gao, F. Zhou and M. Selke, Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy, J. Mater. Chem., 2004, 14, 487\u2013493.","journal-title":"J. Mater. Chem."},{"key":"17030281_CR6","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.addr.2008.08.003","volume":"60","author":"D K Chatterjee","year":"2008","unstructured":"D. K. Chatterjee, L. S. Fong and Y. Zhang, Nanoparticles in photodynamic therapy: An emerging paradigm, Adv. Drug Delivery Rev., 2008, 60, 1627\u20131637.","journal-title":"Adv. Drug Delivery Rev."},{"key":"17030281_CR7","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1021\/la0256230","volume":"18","author":"D C Hone","year":"2002","unstructured":"D. C. Hone, P. I. Walker, R. Evans-Gowing, S. FitzGerald, A. Beeby, I. Chambrier, M. J. Cook and D. A. Russell, Generation of cytotoxic singlet oxygen via phthalocyanine- stabilized gold nanoparticles: A potential delivery vehicle for photodynamic therapy, Langmuir, 2002, 18, 2985\u20132987.","journal-title":"Langmuir"},{"key":"17030281_CR8","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1039\/c1pp05014a","volume":"10","author":"T Stuchinskaya","year":"2011","unstructured":"T. Stuchinskaya, M. Moreno, M. J. Cook, D. R. Edwards and D. A. Russell, Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nano- particle conjugates, Photochem. Photobiol. Sci., 2011, 10, 822\u2013831.","journal-title":"Photochem. Photobiol. Sci."},{"key":"17030281_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1023\/A:1016875709579","volume":"12","author":"C D Geddes","year":"2002","unstructured":"C. D. Geddes and J. R. Lakowicz, Metal-enhanced fluo- rescence, J. Fluoresc., 2002, 12, 121\u2013129.","journal-title":"J. Fluoresc."},{"key":"17030281_CR10","doi-asserted-by":"publisher","first-page":"15695","DOI":"10.1039\/c3cp50206f","volume":"15","author":"W Deng","year":"2013","unstructured":"W. Deng, F. Xie, H. T. M. C. M. Baltar and E. M. Goldys, Metal-enhanced fluorescence in the life sciences: here, now and beyond, Phys. Chem. Chem. Phys., 2013, 15, 15695\u201315708.","journal-title":"Phys. Chem. Chem. Phys."},{"key":"17030281_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ab.2004.11.026","volume":"337","author":"J R Lakowicz","year":"2005","unstructured":"J. R. Lakowicz, Radiative decay engineering 5: metal- enhanced fluorescence and plasmon emission, Anal. Biochem., 2005, 337, 171\u2013194.","journal-title":"Anal. Biochem."},{"key":"17030281_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/abio.2001.5377","volume":"298","author":"J R Lakowicz","year":"2001","unstructured":"J. R. Lakowicz, Radiative decay engineering: biophysical and biomedical applications, Anal. Biochem., 2001, 298, 1\u201324.","journal-title":"Anal. Biochem."},{"key":"17030281_CR13","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.1039\/b817373g","volume":"11","author":"S K Ghosh","year":"2009","unstructured":"S. K. Ghosh and T. Pal, Photophysical aspects of molecular probes near nanostructured gold surfaces, Phys. Chem. Chem. Phys., 2009, 11, 3831\u20133844.","journal-title":"Phys. Chem. Chem. Phys."},{"key":"17030281_CR14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1021\/jp9087173","volume":"114","author":"A Kotiaho","year":"2010","unstructured":"A. Kotiaho, R. Lahtinen, A. Efimov, H. K. Metsberg, E. Sariola, H. Lehtivuori, N. V. Tkachenko and H. Lemmetyinen, Photoinduced charge and energy transfer in phthalocyanine-functionalized gold nanoparticles, J. Phys. Chem. C, 2010, 114, 162\u2013168.","journal-title":"J. Phys. Chem. C"},{"key":"17030281_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.saa.2011.09.046","volume":"85","author":"Y Zhang","year":"2012","unstructured":"Y. Zhang, B. L. Mali and C. D. Geddes, Metal-enhanced fluorescence exciplex emission, Spectrochim. Acta, Part A, 2012, 85, 134\u2013138.","journal-title":"Spectrochim. Acta, Part A"},{"key":"17030281_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s10895-007-0196-y","volume":"17","author":"Y Zhang","year":"2007","unstructured":"Y. Zhang, K. Aslan, M. J. R. Previte and C. D. Geddes, Metal-enhanced singlet oxygen generation: a consequence of plasmon enhanced triplet yields, J. Fluoresc., 2007, 17, 345\u2013349.","journal-title":"J. Fluoresc."},{"key":"17030281_CR17","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1073\/pnas.0709501105","volume":"105","author":"Y Zhang","year":"2008","unstructured":"Y. Zhang, K. Aslan, M. J. R. Previte and C. D. Geddes, Plasmonic engineering of singlet oxygen generation, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 1798\u20131802.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"17030281_CR18","doi-asserted-by":"publisher","first-page":"25108","DOI":"10.1021\/jp065261v","volume":"110","author":"Y Zhang","year":"2006","unstructured":"Y. Zhang, K. Aslan, M. J. R. Previte, S. N. Malyn and C. D. Geddes, Metal-enhanced phosphorescence: interpret- ation in terms of triplet-coupled radiating plasmons, J. Phys. Chem. B, 2006, 110, 25108\u201325114.","journal-title":"J. Phys. Chem. B"},{"key":"17030281_CR19","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1021\/jacs.5b12704","volume":"138","author":"O Planas","year":"2016","unstructured":"O. Planas, N. Macia, M. Agut, S. Nonell and B. Heyne, Distance-dependent plasmon-enhanced singlet oxygen pro- duction and emission for bacterial inactivation, J. Am. Chem. Soc., 2016, 138, 2762\u20132768.","journal-title":"J. Am. Chem. Soc."},{"key":"17030281_CR20","doi-asserted-by":"publisher","first-page":"15740","DOI":"10.1039\/c3cp50950h","volume":"15","author":"J Karolin","year":"2013","unstructured":"J. Karolin and C. D. Geddes, Metal-enhanced fluorescence based excitation volumetric effect of plasmon-enhanced singlet oxygen and super oxide generation, Phys. Chem. Chem. Phys., 2013, 15, 15740\u201315745.","journal-title":"Phys. Chem. Chem. Phys."},{"key":"17030281_CR21","doi-asserted-by":"publisher","first-page":"15727","DOI":"10.1039\/c3cp44227f","volume":"15","author":"X Huang","year":"2013","unstructured":"X. Huang, X.-J. Tian, W.-L. Yang, B. Ehrenberg and J.-Y. Chen, The conjugates of gold nanorods and chlorin e6 for enhancing the fluorescence detection and photo- dynamic therapy of cancers, Phys. Chem. Chem. Phys., 2013, 15, 15727\u201315733.","journal-title":"Phys. Chem. Chem. Phys."},{"key":"17030281_CR22","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1039\/C6SC01463A","volume":"7","author":"X L Hu","year":"2016","unstructured":"X. L. Hu, Y. Zang, J. Li, G. R. Chen, T. D. James, X. P. He and H. Tian, Targeted multimodal theranostics via bio- recognition controlled aggregation of metallic nanoparticle composites, Chem. Sci., 2016, 7, 4004\u20134008.","journal-title":"Chem. Sci."},{"key":"17030281_CR23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jcis.2017.10.030","volume":"512","author":"P Garc\u00eda Calavia","year":"2018","unstructured":"P. Garc\u00eda Calavia, I. Chambrier, M. J. Cook, A. H. Haines, R. A. Field and D. A. Russell, Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles, J. Colloid Interface Sci., 2018, 512, 249\u2013259.","journal-title":"J. Colloid Interface Sci."},{"key":"17030281_CR24","first-page":"1283","volume-title":"Synthesis","author":"I Chambrier","year":"1995","unstructured":"I. Chambrier, M. J. Cook and D. A. Russell, Synthesis and characterisation of functionalised phthalocyanine com- pounds for fabrication of self-assembled monolayers, Synthesis, 1995, 1283\u20131286."},{"key":"17030281_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1039\/a903940f","volume":"10","author":"D J Revell","year":"2000","unstructured":"D. J. Revell, I. Chambrier, M. J. Cook and D. A. Russell, Formation and spectroscopic characterisation of self- assembled phthalocyanine monolayers, J. Mater. Chem., 2000, 10, 31\u201337.","journal-title":"J. Mater. Chem."},{"key":"17030281_CR26","doi-asserted-by":"publisher","first-page":"13534","DOI":"10.1039\/C5CC05352H","volume":"51","author":"M C Staniford","year":"2015","unstructured":"M. C. Staniford, M. M. Lezhnina, M. Gruener, L. Stegemann, R. Kuczius, V. Bleicher, C. A. Strassert and U. H. Kynast, Photophysical efficiency boost of aqueous aluminium phthalocyanine by hybrid formation with nano- clays, Chem. Commun., 2015, 51, 13534\u201313537.","journal-title":"Chem. Commun."},{"key":"17030281_CR27","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1038\/sj.onc.1204436","volume":"20","author":"C A Belmokhtar","year":"2001","unstructured":"C. A. Belmokhtar, J. Hillion and E. Segal-Bendirdjian, Staurosporine induces apoptosis through both caspase- dependent and caspase-independent mechanisms, Oncogene, 2001, 20, 3354\u20133362.","journal-title":"Oncogene"},{"key":"17030281_CR28","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1039\/C5PP00126A","volume":"14","author":"L Rodriguez","year":"2015","unstructured":"L. Rodriguez, P. Vallercosa, S. Battah, G. Di Venosa, G. Calvo, L. Mamone, D. Saenz, M. C. Gonzalez, A. Batlle, A. J. MacRobert and A. Casas, Aminolevulinic acid dendri- mers in photodynamic treatment of cancer and atheroma- tous disease, Photochem. Photobiol. Sci., 2015, 14, 1617\u20131627.","journal-title":"Photochem. Photobiol. Sci."},{"key":"17030281_CR29","doi-asserted-by":"publisher","first-page":"1130021","DOI":"10.1103\/PhysRevLett.96.113002","volume":"96","author":"P Anger","year":"2006","unstructured":"P. Anger, P. Bharadwajand L. Novotny, Enhancement and quenching of single-molecule fluorescence, Phys. Rev. Lett., 2006, 96, 1130021\u20131130024.","journal-title":"Phys. Rev. Lett."},{"key":"17030281_CR30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1477-3155-9-16","volume":"9","author":"K A Kang","year":"2011","unstructured":"K. A. Kang, J. Wang, J. B. Jasinski and S. Achilefu, Fluorescence manipulation by gold nanoparticles: from complete quenching to extensive enhancement, J. Nanobiotechnol., 2011, 9, 16\u201329.","journal-title":"J. Nanobiotechnol."},{"key":"17030281_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1021\/nn700241w","volume":"2","author":"G Battistini","year":"2008","unstructured":"G. Battistini, P. G. Cozzi, J. P. Jalkanen, M. Montalti, L. Prodi, N. Zaccheroni and F. Zerbetto, The erratic emis- sion of pyrene on gold nanoparticles, ACS Nano, 2008, 2, 77\u201384.","journal-title":"ACS Nano"},{"key":"17030281_CR32","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.1021\/jm3000664","volume":"55","author":"M Wang","year":"2012","unstructured":"M. Wang, L. Huang, S. K. Sharma, S. Jeon, S. Thota, F. F. Sperandio, S. Nayka, J. Chang, M. R. Hamblin and L. Y. Chiang, Synthesis and photodynamic effect of new highly photostable decacationically armed [60]- and [70] Fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells, J. Med. Chem., 2012, 55, 4274\u20134285.","journal-title":"J. Med. Chem."},{"key":"17030281_CR33","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.fob.2014.02.006","volume":"4","author":"A Banerjee","year":"2014","unstructured":"A. Banerjee, P. Majumder, S. Sanyal, J. Singh, K. Jana, C. Das and D. Dasgupta, The DNA intercalators ethidium bromide and propidium iodide also bind to core histones, FEBS Open Bio, 2014, 4, 251\u2013259.","journal-title":"FEBS Open Bio"},{"key":"17030281_CR34","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1021\/bm060300u","volume":"7","author":"N P Gabrielson","year":"2006","unstructured":"N. P. Gabrielson and D. W. Pack, Acetylation of polyethyl- enimine enhances gene delivery via weakened polymer\/ DNA interactions, Biomacromolecules, 2006, 7, 2427\u20132435.","journal-title":"Biomacromolecules"}],"container-title":["Photochemical & Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c7pp00225d.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1039\/c7pp00225d\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/PP\/C7PP00225D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c7pp00225d.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T15:23:15Z","timestamp":1667402595000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1039\/c7pp00225d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["17030281"],"URL":"https:\/\/doi.org\/10.1039\/c7pp00225d","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"16 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}