{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:51:54Z","timestamp":1792785114316,"version":"4.5.0"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31600745"],"award-info":[{"award-number":["31600745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31670938"],"award-info":[{"award-number":["31670938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CSTC","award":["2014jcyjA10107"],"award-info":[{"award-number":["2014jcyjA10107"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Intranasal administration with 2C-Staph\/NE yielded strong mucosal response than that induced by the intramuscular vaccination route.<\/p>","DOI":"10.1039\/c7ra13630g","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T05:03:46Z","timestamp":1520831026000},"page":"9996-10008","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective effects of a nanoemulsion adjuvant vaccine (2C-Staph\/NE) administered intranasally against invasive\n                    <i>Staphylococcus aureus<\/i>\n                    pneumonia"],"prefix":"10.1039","volume":"8","author":[{"given":"Liu-yang","family":"Yang","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Tong","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-sheng","family":"Peng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-hang","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-bo","family":"Diao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-8424","authenticated-orcid":false,"given":"Hong-wu","family":"Sun","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-ming","family":"Zou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Immunological Products"},{"name":"Department of Microbiology and Biochemical Pharmacy"},{"name":"College of Pharmacy"},{"name":"Third Military Medical University"},{"name":"Chongqing 400038"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7RA13630G-(cit1)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/nejm199808203390806","volume":"339","author":"Lowy","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"C7RA13630G-(cit2)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1172\/jci23825","volume":"114","author":"Foster","year":"2004","journal-title":"J. Clin. Invest."},{"key":"C7RA13630G-(cit3)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"C7RA13630G-(cit4)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrmicro1098","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"C7RA13630G-(cit5)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1039\/c3cs60218d","volume":"43","author":"Rizzello","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"C7RA13630G-(cit6)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1039\/c5cs00041f","volume":"44","author":"Miller","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"C7RA13630G-(cit7)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ccr.2017.11.019","volume":"357","author":"Zheng","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"C7RA13630G-(cit8)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"7934","DOI":"10.1021\/acsnano.6b03862","volume":"10","author":"Zheng","year":"2016","journal-title":"ACS Nano"},{"key":"C7RA13630G-(cit9)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1021\/acsnano.7b02035","volume":"11","author":"Zheng","year":"2017","journal-title":"ACS Nano"},{"key":"C7RA13630G-(cit10)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1016\/j.vaccine.2013.04.002","volume":"31","author":"Jansen","year":"2013","journal-title":"Vaccine"},{"key":"C7RA13630G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1073\/pnas.1424924112","volume":"112","author":"Bagnoli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7RA13630G-(cit12)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1093\/cid\/cis033","volume":"54","author":"Proctor","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"C7RA13630G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev-pathol-012615-044351","volume":"11","author":"Thomer","year":"2016","journal-title":"Annu. Rev. Phytopathol."},{"key":"C7RA13630G-(cit14)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrmicro3161","volume":"12","author":"Foster","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"C7RA13630G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/toxins8030072","volume":"8","author":"Kong","year":"2016","journal-title":"Toxins"},{"key":"C7RA13630G-(cit16)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev.micro.112408.134309","volume":"64","author":"Otto","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"C7RA13630G-(cit17)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"e90445","DOI":"10.1371\/journal.pone.0090445","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"},{"key":"C7RA13630G-(cit18)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00281-011-0294-4","volume":"34","author":"Cassat","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"C7RA13630G-(cit19)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"12371","DOI":"10.1038\/srep12371","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."},{"key":"C7RA13630G-(cit20)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"e0149638","DOI":"10.1371\/journal.pone.0149638","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"C7RA13630G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1001\/jama.2013.3010","volume":"309","author":"Fowler","year":"2013","journal-title":"Jama"},{"key":"C7RA13630G-(cit22)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3389\/fimmu.2015.00439","volume":"6","author":"Monaci","year":"2015","journal-title":"Front. Immunol."},{"key":"C7RA13630G-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0168-3659(00)00199-1","volume":"67","author":"Chen","year":"2000","journal-title":"J. Controlled Release"},{"key":"C7RA13630G-(cit24)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/21645515.2014.1004026","volume":"11","author":"He","year":"2015","journal-title":"Hum. Vaccines Immunother."},{"key":"C7RA13630G-(cit25)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1586\/erv.11.23","volume":"10","author":"O'Hagan","year":"2011","journal-title":"Expert Rev. Vaccines"},{"key":"C7RA13630G-(cit26)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/sj.clpt.6100402","volume":"82","author":"O'Hagan","year":"2007","journal-title":"Clin. Pharmacol. Ther. Ser."},{"key":"C7RA13630G-(cit27)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ijpharm.2008.04.036","volume":"364","author":"Perrie","year":"2008","journal-title":"Int. J. Pharm."},{"key":"C7RA13630G-(cit28)\/*[position()=1]","first-page":"491","volume":"409","author":"Pozzi","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"C7RA13630G-(cit29)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1080\/14760584.2016.1179583","volume":"15","author":"Dayan","year":"2016","journal-title":"Expert Rev. Vaccines"},{"key":"C7RA13630G-(cit30)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1016\/j.vaccine.2011.11.006","volume":"30","author":"Proctor","year":"2012","journal-title":"Vaccine"},{"key":"C7RA13630G-(cit31)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1128\/iai.69.4.2031-2036.2001","volume":"69","author":"Stiles","year":"2001","journal-title":"Infect. Immun."},{"key":"C7RA13630G-(cit32)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"e0151581","DOI":"10.1371\/journal.pone.0151581","volume":"11","author":"Xu","year":"2016","journal-title":"PLoS One"},{"key":"C7RA13630G-(cit33)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.2147\/ijn.s36071","volume":"7","author":"Sun","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"C7RA13630G-(cit34)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.2147\/ijn.s91529","volume":"10","author":"Sun","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"C7RA13630G-(cit35)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ijpharm.2012.07.008","volume":"436","author":"Cai","year":"2012","journal-title":"Int. J. Pharm."},{"key":"C7RA13630G-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1016\/S0264-410X(03)00381-5","volume":"21","author":"Myc","year":"2003","journal-title":"Vaccine"},{"key":"C7RA13630G-(cit37)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"20929","DOI":"10.1038\/srep20929","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"C7RA13630G-(cit38)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1128\/aac.00944-13","volume":"57","author":"Harris","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"C7RA13630G-(cit39)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"336","DOI":"10.4161\/hv.18946","volume":"8","author":"Joshi","year":"2012","journal-title":"Hum. Vaccines Immunother."},{"key":"C7RA13630G-(cit40)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00281-011-0291-7","volume":"34","author":"Parker","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"C7RA13630G-(cit41)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.vaccine.2016.11.010","volume":"35","author":"Frenck Jr","year":"2017","journal-title":"Vaccine"},{"key":"C7RA13630G-(cit42)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1128\/cvi.00399-16","volume":"23","author":"Chen","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"key":"C7RA13630G-(cit43)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/nm.3409","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"key":"C7RA13630G-(cit44)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/S0140-6736(09)61114-4","volume":"374","author":"van der Poll","year":"2009","journal-title":"Lancet"},{"key":"C7RA13630G-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0952-7915(02)00384-9","volume":"14","author":"Eriksson","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"C7RA13630G-(cit46)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.addr.2009.11.012","volume":"62","author":"Chadwick","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"C7RA13630G-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/infdis\/jit823","volume":"209","author":"Spaulding","year":"2014","journal-title":"J. Infect. Dis."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/RA\/C7RA13630G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:28:30Z","timestamp":1783276110000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/8\/18\/9996-10008\/583569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":47,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7ra13630g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7RA13630G","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Hong-wu Sun (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4318-8424","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 25 December 2017; Accepted 13 February 2018; Version of Record published 12 March 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}