{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:25:09Z","timestamp":1790259909056,"version":"4.1.0"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21575121"],"award-info":[{"award-number":["21575121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21628502"],"award-info":[{"award-number":["21628502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"crossref","award":["FRG2\/15- 16\/002"],"award-info":[{"award-number":["FRG2\/15- 16\/002"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"crossref","award":["HMRF\/14130522"],"award-info":[{"award-number":["HMRF\/14130522"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Grants Council","award":["HKBU\/12301115"],"award-info":[{"award-number":["HKBU\/12301115"]}]},{"name":"Research Grants Council","award":["HKBU\/204612"],"award-info":[{"award-number":["HKBU\/204612"]}]},{"name":"Research Grants Council","award":["HKBU\/201913"],"award-info":[{"award-number":["HKBU\/201913"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2015A030313816"],"award-info":[{"award-number":["2015A030313816"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Development Fund","award":["098\/2014\/A2"],"award-info":[{"award-number":["098\/2014\/A2"]}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"crossref","award":["MYRG2015-00137-ICMS-QRCM"],"award-info":[{"award-number":["MYRG2015-00137-ICMS-QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"crossref","award":["MYRG2016- 00151-ICMS-QRCM"],"award-info":[{"award-number":["MYRG2016- 00151-ICMS-QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"crossref","award":["MRG044\/LCH\/2015\/ICMS"],"award-info":[{"award-number":["MRG044\/LCH\/2015\/ICMS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science and Technology","award":["MOST 105-2622-E-005-006-CC2"],"award-info":[{"award-number":["MOST 105-2622-E-005-006-CC2"]}]},{"name":"Ministry of Science and Technology","award":["MOST 104-2221-E-005-096-MY2"],"award-info":[{"award-number":["MOST 104-2221-E-005-096-MY2"]}]},{"name":"Ministry of Science and Technology","award":["MOST 104-2628-E-005-004-MY3"],"award-info":[{"award-number":["MOST 104-2628-E-005-004-MY3"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<p>\n                    This study reports the first use of an iridium(\n                    <sc>iii<\/sc>\n                    ) compound and its enantiomer to inhibit the H-Ras\/Raf-I PPI\n                    <italic>in vitro<\/italic>\n                    and repress renal cancer xenografts\n                    <italic>in vivo<\/italic>\n                    .\n                  <\/p>","DOI":"10.1039\/c7sc00311k","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T12:29:22Z","timestamp":1494937762000},"page":"4756-4763","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Inhibition of the Ras\/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(\n                    <scp>iii<\/scp>\n                    ) metal-based compound"],"prefix":"10.1039","volume":"8","author":[{"given":"Li-Juan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine"},{"name":"Institute of Chinese Medical Sciences"},{"name":"University of Macau"},{"name":"Macao"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Oceanology and Food Science"},{"name":"Quanzhou Normal University"},{"name":"Quanzhou 362000"},{"name":"China"},{"name":"Key Laboratory for the Development of Bioactive Material from Marine Algae"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Hong","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Environmental and Biological Analysis"},{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine"},{"name":"Institute of Chinese Medical Sciences"},{"name":"University of Macau"},{"name":"Macao"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Tian","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Environmental and Biological Analysis"},{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Environmental and Biological Analysis"},{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-9568","authenticated-orcid":false,"given":"Hui-Min David","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering"},{"name":"National Chung Hsing University"},{"name":"Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik-Lung","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Hong Kong Baptist University"},{"name":"Kowloon Tong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-3786","authenticated-orcid":false,"given":"Chung-Hang","family":"Leung","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine"},{"name":"Institute of Chinese Medical Sciences"},{"name":"University of Macau"},{"name":"Macao"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7SC00311K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd.2016.29","volume":"15","author":"Scott","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C7SC00311K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.4155\/fmc.15.138","volume":"7","author":"Skwarczynska","year":"2015","journal-title":"Future Med. Chem."},{"key":"C7SC00311K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature11503","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"C7SC00311K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/468851a","volume":"468","author":"Bonetta","year":"2010","journal-title":"Nature"},{"key":"C7SC00311K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.tips.2016.05.008","volume":"37","author":"Modell","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"C7SC00311K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tips.2013.04.007","volume":"34","author":"Ivanov","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"C7SC00311K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-pharmtox-011613-140028","volume":"54","author":"Jin","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"C7SC00311K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12487","DOI":"10.1002\/chem.201601542","volume":"22","author":"Gothe","year":"2016","journal-title":"Chem.\u2013Eur. J."},{"key":"C7SC00311K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1039\/C4CC10014J","volume":"51","author":"Gothe","year":"2015","journal-title":"Chem. Commun."},{"key":"C7SC00311K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.1039\/C6DT90135B","volume":"45","author":"Metzler-Nolte","year":"2016","journal-title":"Dalton Trans."},{"key":"C7SC00311K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4155\/fmc.15.22","volume":"7","author":"Hess","year":"2015","journal-title":"Future Med. Chem."},{"key":"C7SC00311K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9178","DOI":"10.1002\/anie.201404686","volume":"53","author":"Ma","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"C7SC00311K-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1039\/C5SC02321A","volume":"6","author":"Zhong","year":"2015","journal-title":"Chem. Sci."},{"key":"C7SC00311K-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16144","DOI":"10.1039\/C6DT03328H","volume":"45","author":"Qiu","year":"2016","journal-title":"Dalton Trans."},{"key":"C7SC00311K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1158\/0008-5472.CAN-08-4408","volume":"69","author":"Meng","year":"2009","journal-title":"Cancer Res."},{"key":"C7SC00311K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.1039\/c2dt30654a","volume":"41","author":"Bratsos","year":"2012","journal-title":"Dalton Trans."},{"key":"C7SC00311K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"C7SC00311K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1021\/ar500310z","volume":"47","author":"Ma","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"C7SC00311K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"key":"C7SC00311K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/carcin\/bgp337","volume":"31","author":"Niault","year":"2010","journal-title":"Carcinogenesis"},{"key":"C7SC00311K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2174\/092986712799320510","volume":"19","author":"Rusconi","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"C7SC00311K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.febslet.2014.06.025","volume":"588","author":"Cseh","year":"2014","journal-title":"FEBS Lett."},{"key":"C7SC00311K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/anie.200353089","volume":"43","author":"Waldmann","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"C7SC00311K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","volume":"26","author":"Roberts","year":"2007","journal-title":"Oncogene"},{"key":"C7SC00311K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.bbamcr.2007.05.001","volume":"1773","author":"Leicht","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"C7SC00311K-(cit26)\/*[position()=1]","first-page":"4182","volume":"55","author":"Oka","year":"1995","journal-title":"Cancer Res."},{"key":"C7SC00311K-(cit27)\/*[position()=1]","first-page":"5251","volume":"48","author":"Fujita","year":"1988","journal-title":"Cancer Res."},{"key":"C7SC00311K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa060655","volume":"356","author":"Escudier","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"C7SC00311K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(15)60054-X","volume":"385","author":"Boudou-Rouquette","year":"2015","journal-title":"Lancet"},{"key":"C7SC00311K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"Llovet","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"C7SC00311K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cell.2016.03.045","volume":"165","author":"Athuluri-Divakar","year":"2016","journal-title":"Cell"},{"key":"C7SC00311K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42860","DOI":"10.1038\/srep42860","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"C7SC00311K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"36044","DOI":"10.1038\/srep36044","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"C7SC00311K-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12278","DOI":"10.1039\/C6CC06155A","volume":"52","author":"Liu","year":"2016","journal-title":"Chem. Commun."},{"key":"C7SC00311K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13965","DOI":"10.18632\/oncotarget.7369","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"C7SC00311K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/cplu.201400014","volume":"79","author":"Zhong","year":"2014","journal-title":"ChemPlusChem"},{"key":"C7SC00311K-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/protein\/14.1.39","volume":"14","author":"Zeng","year":"2001","journal-title":"Protein Eng."},{"key":"C7SC00311K-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1074\/jbc.271.1.233","volume":"271","author":"Drugan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"C7SC00311K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nchembio.1211","volume":"9","author":"Simon","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"C7SC00311K-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bios.2015.02.030","volume":"69","author":"Lee","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"C7SC00311K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.leu.2402945","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"C7SC00311K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nchem.1375","volume":"4","author":"Song","year":"2012","journal-title":"Nat. Chem."},{"key":"C7SC00311K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8111","DOI":"10.1021\/acs.inorgchem.5b01349","volume":"54","author":"Rajaratnam","year":"2015","journal-title":"Inorg. Chem."},{"key":"C7SC00311K-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/acs.jmedchem.6b00112","volume":"59","author":"Kang","year":"2016","journal-title":"J. Med. Chem."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/SC\/C7SC00311K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:13:45Z","timestamp":1783275225000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/8\/7\/4756-4763\/583876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c7sc00311k","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7SC00311K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Hui-Min David Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3407-9568","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Chung-Hang Leung (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2988-3786","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 January 2017; Accepted 8 May 2017;  Accepted Manuscript published 16 May 2017;  Advance Article published 15 June 2017;  Version of Record published 27 June 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}