{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:05:09Z","timestamp":1771643109145,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"am","delay-in-days":375,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Toxicol. Res."],"abstract":"<p><italic>Scope<\/italic>: Particle-induced lung injury is a kind of comprehensive pulmonary disease with not only inflammation but also fibrosis.<\/p>","DOI":"10.1039\/c7tx00304h","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T03:03:58Z","timestamp":1515639838000},"page":"258-270","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner"],"prefix":"10.1093","volume":"7","author":[{"given":"Lian","family":"Xue","sequence":"first","affiliation":[{"name":"School of Public Health"},{"name":"Medical College of Soochow University"},{"name":"Suzhou 215123"},{"name":"China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Medical College of Soochow University"},{"name":"Suzhou 215123"},{"name":"China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Medical College of Soochow University"},{"name":"Suzhou 215123"},{"name":"China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyan","family":"Li","sequence":"additional","affiliation":[{"name":"Experimental Center of Medical College"},{"name":"Soochow University"},{"name":"Suzhou 215123"},{"name":"China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Medical College of Soochow University"},{"name":"Suzhou 215123"},{"name":"China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-3829","authenticated-orcid":false,"given":"Shasha","family":"Tao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease"},{"name":"School of Public Health"},{"name":"Soochow University"},{"name":"Suzhou"},{"name":"PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C7TX00304H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3322\/caac.21214","volume":"64","author":"Steenland","year":"2014","journal-title":"CA-Cancer J. Clin."},{"key":"C7TX00304H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.disamonth.2007.09.020","volume":"53","author":"Greenberg","year":"2007","journal-title":"DM, Dis.-Mon."},{"key":"C7TX00304H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/oem.2009.047126","volume":"67","author":"Laney","year":"2010","journal-title":"Occup. Environ. Med."},{"key":"C7TX00304H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(12)60235-9","volume":"379","author":"Leung","year":"2012","journal-title":"Lancet"},{"key":"C7TX00304H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.taap.2016.04.003","volume":"301","author":"Perkins","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl 4","key":"C7TX00304H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.00108s4675","volume":"108","author":"Castranova","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"C7TX00304H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s10495-011-0647-4","volume":"16","author":"Yao","year":"2011","journal-title":"Apoptosis"},{"key":"C7TX00304H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1189\/jlb.0104019","volume":"76","author":"Misson","year":"2004","journal-title":"J. Leukocyte Biol."},{"key":"C7TX00304H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.3892\/mmr.2017.6402","volume":"15","author":"Peng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"C7TX00304H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1023\/A:1003485312164","volume":"30","author":"Orfila","year":"1998","journal-title":"Histochem. J."},{"key":"C7TX00304H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1165\/ajrcmb\/5.4.395","volume":"5","author":"Mohr","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"C7TX00304H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.225680.113","volume":"27","author":"Jaramillo","year":"2013","journal-title":"Genes Dev."},{"key":"C7TX00304H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"C7TX00304H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/labinvest.2016.101","volume":"96","author":"Yang","year":"2016","journal-title":"Lab. Invest."},{"key":"C7TX00304H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.redox.2013.10.004","volume":"1","author":"Tao","year":"2013","journal-title":"Redox Biol."},{"key":"C7TX00304H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1158\/1940-6207.CAPR-14-0359","volume":"8","author":"Long","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"C7TX00304H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.08.028","volume":"265","author":"Zheng","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"C7TX00304H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1089\/ars.2012.5117","volume":"19","author":"Tao","year":"2013","journal-title":"Antioxid. Redox Signaling"},{"key":"C7TX00304H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ki.2013.343","volume":"85","author":"Jiang","year":"2014","journal-title":"Kidney Int."},{"key":"C7TX00304H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1096\/fj.03-1127fje","volume":"18","author":"Cho","year":"2004","journal-title":"FASEB J."},{"key":"C7TX00304H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"C7TX00304H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1128\/MCB.24.24.10941-10953.2004","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"C7TX00304H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"C7TX00304H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1073\/pnas.172398899","volume":"99","author":"Dinkova-Kostova","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C7TX00304H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18760","DOI":"10.1038\/srep18760","volume":"6","author":"Tao","year":"2016","journal-title":"Sci. Rep."},{"key":"C7TX00304H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.biopha.2017.02.052","volume":"89","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"C7TX00304H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.freeradbiomed.2015.08.028","volume":"89","author":"Tao","year":"2015","journal-title":"Free Radical Biol. Med."},{"key":"C7TX00304H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/0717-6287-47-49","volume":"47","author":"Moreira","year":"2014","journal-title":"Biol. Res."},{"key":"C7TX00304H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/ptr.5088","volume":"28","author":"Stohs","year":"2014","journal-title":"Phytother. Res."},{"key":"C7TX00304H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1016\/j.fct.2011.07.009","volume":"49","author":"Auttachoat","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"C7TX00304H-(cit31)\/*[position()=1]","first-page":"290","volume":"41","author":"Zhang","year":"2007","journal-title":"Zhonghua Yufang Yixue Zazhi"},{"key":"C7TX00304H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.2042-7158.1998.tb06872.x","volume":"50","author":"He","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"C7TX00304H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1158\/0008-5472.CAN-14-1439","volume":"74","author":"Tao","year":"2014","journal-title":"Cancer Res."},{"key":"C7TX00304H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1165\/rcmb.2012-0519OC","volume":"51","author":"Moreno-Vinasco","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"C7TX00304H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2147\/IJN.S76114","volume":"10","author":"Guo","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"C7TX00304H-(cit36)\/*[position()=1]","first-page":"10","volume":"27","author":"Liu","year":"1993","journal-title":"Zhonghua Yufang Yixue Zazhi"},{"key":"C7TX00304H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.taap.2008.03.003","volume":"230","author":"Wang","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"C7TX00304H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.freeradbiomed.2017.04.002","volume":"108","author":"Zhang","year":"2017","journal-title":"Free Radical Biol. Med."},{"key":"C7TX00304H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21133","DOI":"10.1038\/srep21133","volume":"6","author":"Lin","year":"2016","journal-title":"Sci. Rep."},{"key":"C7TX00304H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"Oberdorster","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"C7TX00304H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1743-8977-3-13","volume":"3","author":"Peters","year":"2006","journal-title":"Part. Fibre Toxicol."},{"key":"C7TX00304H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"C7TX00304H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/157340208786241336","volume":"4","author":"Chen","year":"2008","journal-title":"Curr. Hypertens. Rev."},{"key":"C7TX00304H-(cit44)\/*[position()=1]","first-page":"432","volume":"23","author":"Sato","year":"1996","journal-title":"J. Rheumatol."},{"key":"C7TX00304H-(cit45)\/*[position()=1]","first-page":"L533","volume":"275","author":"Rahman","year":"1998","journal-title":"Am. J. Physiol."},{"key":"C7TX00304H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/MCB.24.1.36-45.2004","volume":"24","author":"Itoh","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"C7TX00304H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbrc.2010.05.019","volume":"396","author":"Manea","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C7TX00304H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-4835(02)00274-9","volume":"76","author":"Koga","year":"2003","journal-title":"Exp. Eye Res."},{"key":"C7TX00304H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15244","DOI":"10.1074\/jbc.M113.540633","volume":"289","author":"Cuadrado","year":"2014","journal-title":"J. Biol. Chem."},{"key":"C7TX00304H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"C7TX00304H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"key":"C7TX00304H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"C7TX00304H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2657","DOI":"10.1038\/cddis.2017.78","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"C7TX00304H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/19390211.2012.653530","volume":"9","author":"Ulbricht","year":"2012","journal-title":"J. Diet. Suppl."},{"key":"C7TX00304H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1039\/a701304c","volume":"122","author":"Levy","year":"1997","journal-title":"Analyst"},{"key":"C7TX00304H-(cit56)\/*[position()=1]","first-page":"94","volume":"4","author":"Junior","year":"2005","journal-title":"GMR, Genet. Mol. Res."},{"key":"C7TX00304H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11010-015-2354-x","volume":"403","author":"Somacal","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"C7TX00304H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839095","DOI":"10.1155\/2014\/839095","volume":"2014","author":"Roehrs","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"C7TX00304H-(cit59)\/*[position()=1]","volume-title":"Evaluation of certain food additives and contaminants. Eightieth report of the Joint FAO\/WHO Expert Committee on Food Additives","author":"O. World Health","year":"2016","unstructured":"O. World Health , Evaluation of certain food additives and contaminants. Eightieth report of the Joint FAO\/WHO Expert Committee on Food Additives , World Health Organization technical report series , 2016 , pp. 1\u2013114 , back cover"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/TX\/C7TX00304H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T05:07:30Z","timestamp":1660280850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/7\/2\/258-270\/5559289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c7tx00304h","relation":{},"ISSN":["2045-452X","2045-4538"],"issn-type":[{"value":"2045-452X","type":"print"},{"value":"2045-4538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C7TX00304H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Shasha Tao (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6765-3829","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 November 2017; Accepted 10 January 2018; Accepted Manuscript published 11 January 2018; Advance Article published 2 February 2018; Version of Record published 5 March 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}