{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:58:12Z","timestamp":1790535492420,"version":"4.1.0"},"reference-count":166,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty liver disease involves the accumulation of hepatocellular fat in hepatocytes that can progress to hepatitis. Steatohepatitis is categorized into alcoholic (ASH) or non-alcoholic (NASH) steatohepatitis based on the etiology of the insult. Both pathologies involve an initial steatosis followed by a progressive inflammation of the liver and eventual hepatic fibrosis (steatohepatitis) and cirrhosis. The involvement of pharmaceuticals and other chemicals in the initiation and progression of fatty liver disease has received increased study. This review will examine not only how xenobiotics initiate hepatic steatosis and steatohepatitis but also how the presence of fatty liver may modify the metabolism and pathologic effects of xenobiotics. The feeding of a high fat diet results in changes in the expression of nuclear receptors that are involved in adaptive and adverse liver effects following xenobiotic exposure. High fat diets also modulate cellular and molecular pathways involved in inflammation, metabolism, oxidative phosphorylation and cell growth. Understanding the role of hepatic steatosis and steatohepatitis on the sequelae of toxic and pathologic changes seen following xenobiotic exposure has importance in defining proper and meaningful human risk characterization of the drugs and other chemical agents.<\/jats:p>","DOI":"10.1039\/c7tx00326a","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T13:34:14Z","timestamp":1526650454000},"page":"664-680","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Role of xenobiotics in the induction and progression of fatty liver disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-2223","authenticated-orcid":false,"given":"James E.","family":"Klaunig","sequence":"first","affiliation":[{"name":"Indiana University, School of Public Health, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Li","sequence":"additional","affiliation":[{"name":"Indiana University, School of Public Health, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Wang","sequence":"additional","affiliation":[{"name":"Indiana University, School of Public Health, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"2021031806402959700_cit1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jcmgh.2015.05.006","article-title":"Alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences","volume":"1","author":"Joshi-Barve","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"2021031806402959700_cit2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrgastro.2016.3","article-title":"Management of NAFLD: a stage-based approach","volume":"13","author":"Rinella","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2021031806402959700_cit3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0192623312468517","article-title":"Toxicant-associated Steatohepatitis","volume":"41","author":"Wahlang","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"2021031806402959700_cit4","doi-asserted-by":"crossref","first-page":"168905","DOI":"10.1155\/2015\/168905","article-title":"Drug induced steatohepatitis: an uncommon culprit of a common disease","volume":"2015","author":"Rabinowich","year":"2015","journal-title":"BioMed Res. Int."},{"key":"2021031806402959700_cit5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"2021031806402959700_cit6","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms141020704","article-title":"Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)","volume":"14","author":"Takaki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"2021031806402959700_cit7","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"2021031806402959700_cit8","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s10620-016-4049-x","article-title":"Innate immunity and inflammation in NAFLD\/NASH","volume":"61","author":"Arrese","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"2021031806402959700_cit9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2021031806402959700_cit10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.molmet.2016.06.003","article-title":"Non-alcoholic fatty liver and the gut microbiota","volume":"5","author":"Bashiardes","year":"2016","journal-title":"Mol. Metab."},{"key":"2021031806402959700_cit11","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms141020704","article-title":"Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)","volume":"14","author":"Takaki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"2021031806402959700_cit12","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jhep.2011.10.027","article-title":"Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace","volume":"56","author":"Baffy","year":"2012","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"2021031806402959700_cit14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/toxsci\/kfl173","article-title":"Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis","volume":"96","author":"Roberts","year":"2006","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jhep.2004.08.020","article-title":"Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease","volume":"41","author":"Angulo","year":"2004","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.20965","article-title":"Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells","volume":"42","author":"Aleffi","year":"2005","journal-title":"Hepatology"},{"key":"2021031806402959700_cit17","first-page":"G998","article-title":"Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding","volume":"290","author":"Thakur","year":"2006","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2021031806402959700_cit18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/gut.2003.037010","article-title":"Adiponectin and its receptors in non-alcoholic steatohepatitis","volume":"54","author":"Kaser","year":"2005","journal-title":"Gut"},{"key":"2021031806402959700_cit19","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology"},{"key":"2021031806402959700_cit20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver Fibrosis, but no Other Histologic Features, Associates with Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"2021031806402959700_cit21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hep4.1054","article-title":"Nonalcoholic steatofibrosis independently predicts mortality in nonalcoholic fatty liver disease","volume":"1","author":"Younossi","year":"2017","journal-title":"Hepatol. Commun."},{"key":"2021031806402959700_cit22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","volume":"90","author":"Yanguas","year":"2016","journal-title":"Arch. Toxicol."},{"key":"2021031806402959700_cit23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/01.jom.0000137722.66767.38","article-title":"Liver fibrosis in asymptomatic polyvinyl chloride workers","volume":"46","author":"Hsiao","year":"2004","journal-title":"J. Occup. Environ. Med."},{"key":"2021031806402959700_cit24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2007.06.089","article-title":"Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers","volume":"239","author":"Hsieh","year":"2007","journal-title":"Toxicology"},{"key":"2021031806402959700_cit25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"2021031806402959700_cit26","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2021031806402959700_cit27","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/jsfa.4723","article-title":"Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis","volume":"92","author":"Chen","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"2021031806402959700_cit28","first-page":"879","article-title":"Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum","volume":"17","author":"Qin","year":"2014","journal-title":"Iran. J. Basic Med. Sci."},{"key":"2021031806402959700_cit29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/0192623315617033","article-title":"Drug-induced Liver Fibrosis: Testing Nevirapine in a Viral-like Liver Setting Using Histopathology, MALDI IMS, and Gene Expression","volume":"44","author":"Brown","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"2021031806402959700_cit30","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"2021031806402959700_cit31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cmet.2012.04.008","article-title":"Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase","volume":"15","author":"Kumari","year":"2012","journal-title":"Cell Metab."},{"key":"2021031806402959700_cit32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/hep.27943","article-title":"Potential mechanism underlying the PNPLA3(I) (148) (M) -Hepatic steatosis connection","volume":"63","author":"Wu","year":"2016","journal-title":"Hepatology"},{"key":"2021031806402959700_cit33","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1172\/JCI65179","article-title":"Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis","volume":"122","author":"Li","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2021031806402959700_cit34","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/hep.29041","article-title":"The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells","volume":"65","author":"Bruschi","year":"2017","journal-title":"Hepatology"},{"key":"2021031806402959700_cit35","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","author":"Kozlitina","year":"2014","journal-title":"Nat. Genet."},{"key":"2021031806402959700_cit36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/00365520701559003","article-title":"Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet","volume":"43","author":"Machado","year":"2008","journal-title":"Scand. J. Gastroenterol."},{"key":"2021031806402959700_cit37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2152\/jmi.56.88","article-title":"Saturated fatty acids and insulin resistance","volume":"56","author":"Funaki","year":"2009","journal-title":"J. Med. Invest."},{"key":"2021031806402959700_cit38","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2008.02.011","article-title":"Fructose consumption as a risk factor for non-alcoholic fatty liver disease","volume":"48","author":"Ouyang","year":"2008","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/nu9030230","article-title":"Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism","volume":"9","author":"Jegatheesan","year":"2017","journal-title":"Nutrients"},{"key":"2021031806402959700_cit40","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/hep.23535","article-title":"Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease","volume":"51","author":"Abdelmalek","year":"2010","journal-title":"Hepatology"},{"key":"2021031806402959700_cit41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biochi.2004.11.008","article-title":"Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver","volume":"87","author":"Dentin","year":"2005","journal-title":"Biochimie"},{"key":"2021031806402959700_cit42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0959-9673.2006.00465.x","article-title":"Mouse models in non-alcoholic fatty liver disease and steatohepatitis research","volume":"87","author":"Anstee","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"2021031806402959700_cit43","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/hep.1840400405","article-title":"PPAR\u03b1 in the pathogenesis of fatty liver disease","volume":"40","author":"Sambasiva Rao","year":"2004","journal-title":"Hepatology"},{"key":"2021031806402959700_cit44","first-page":"145","article-title":"Prevention\/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats","volume":"16","author":"Rao","year":"2001","journal-title":"In Vivo"},{"key":"2021031806402959700_cit45","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1194\/jlr.M800240-JLR200","article-title":"ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob\/ob mice","volume":"49","author":"Chen","year":"2008","journal-title":"J. Lipid Res."},{"key":"2021031806402959700_cit46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.nutr.20.1.663","article-title":"The role of the microsomal triglygeride transfer protein in abetalipoproteinemia","volume":"20","author":"Berriot-Varoqueaux","year":"2000","journal-title":"Annu. Rev. Nutr."},{"key":"2021031806402959700_cit47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/S0004-28032011000100015","article-title":"Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis","volume":"48","author":"Marcolin","year":"2011","journal-title":"Arq. Gastroenterol."},{"key":"2021031806402959700_cit48","first-page":"2683","article-title":"Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL\/6 mice","volume":"6","author":"Itagaki","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"2021031806402959700_cit49","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ccell.2014.09.003","article-title":"Metabolic activation of intrahepatic CD8+T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes","volume":"26","author":"Wolf","year":"2014","journal-title":"Cancer Cell"},{"key":"2021031806402959700_cit50","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.3748\/wjg.v18.i19.2300","article-title":"Animal models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"18","author":"Takahashi","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"2021031806402959700_cit51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pone.0056100","article-title":"Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis","volume":"8","author":"Dixon","year":"2013","journal-title":"PLoS One"},{"key":"2021031806402959700_cit52","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2353\/ajpath.2009.080703","article-title":"High Fat Diet Induced Hepatic Steatosis Establishes a Permissive Microenvironment for Colorectal Metastases and Promotes Primary Dysplasia in a Murine Model","volume":"175","author":"VanSaun","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2021031806402959700_cit53","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.taap.2014.06.019","article-title":"Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease","volume":"279","author":"Wahlang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021031806402959700_cit54","first-page":"G987","article-title":"Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent","volume":"295","author":"Tetri","year":"2008","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2021031806402959700_cit55","first-page":"G159","article-title":"Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition (vol 301, pg G825, 2011)","volume":"308","author":"Charlton","year":"2015","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2021031806402959700_cit56","first-page":"G483","article-title":"Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment","volume":"305","author":"Clapper","year":"2013","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2021031806402959700_cit57","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1074\/jbc.M807616200","article-title":"Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease role of stearoyl-CoA desaturase","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021031806402959700_cit58","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit59","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0192623314549960","article-title":"Identification of environmental chemicals associated with the development of toxicant-associated fatty liver disease in rodents","volume":"43","author":"Al-Eryani","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"2021031806402959700_cit60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"2021031806402959700_cit61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/1756283X11430859","article-title":"Secondary causes of nonalcoholic fatty liver disease","volume":"5","author":"Kneeman","year":"2012","journal-title":"Ther. Adv. Gastroenterol."},{"key":"2021031806402959700_cit62","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.4254\/wjh.v7.i9.1251","article-title":"Valproic acid and nonalcoholic fatty liver disease: A possible association?","volume":"7","author":"Farinelli","year":"2015","journal-title":"World J. Hepatol."},{"key":"2021031806402959700_cit63","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/aps.2013.135","article-title":"Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats","volume":"35","author":"Zhang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"2021031806402959700_cit64","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/hep.24290","article-title":"Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells","volume":"53","author":"Antherieu","year":"2011","journal-title":"Hepatology"},{"key":"2021031806402959700_cit65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fphar.2017.00003","article-title":"New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease","volume":"8","author":"L\u00f3pez-Riera","year":"2017","journal-title":"Front. Pharmacol."},{"key":"2021031806402959700_cit66","doi-asserted-by":"crossref","first-page":"823763","DOI":"10.1155\/2014\/823763","article-title":"Methotrexate-associated nonalcoholic fatty liver disease with transaminitis in rheumatoid arthritis","volume":"2014","author":"Sakthiswary","year":"2014","journal-title":"Sci. World J."},{"key":"2021031806402959700_cit67","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jfma.2015.05.006","article-title":"Association between tamoxifen treatment and the development of different stages of nonalcoholic fatty liver disease among breast cancer patients","volume":"115","author":"Pan","year":"2016","journal-title":"J. Formosan Med. Assoc."},{"key":"2021031806402959700_cit68","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.23321","article-title":"Toxicant-associated steatohepatitis in vinyl chloride workers","volume":"51","author":"Cave","year":"2010","journal-title":"Hepatology"},{"key":"2021031806402959700_cit69","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.taap.2016.10.001","article-title":"Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome","volume":"313","author":"Guardiola","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021031806402959700_cit70","doi-asserted-by":"crossref","first-page":"D921","DOI":"10.1093\/nar\/gku955","article-title":"Open TG-GATEs: a large-scale toxicogenomics database","volume":"43","author":"Igarashi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2021031806402959700_cit71","doi-asserted-by":"crossref","first-page":"e114085","DOI":"10.1371\/journal.pone.0114085","article-title":"Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome","volume":"9","author":"Sahini","year":"2014","journal-title":"PLoS One"},{"key":"2021031806402959700_cit72","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1091581812466418","article-title":"Putative Mechanisms of Environmental Chemical\u2013Induced Steatosis","volume":"31","author":"Kaiser","year":"2012","journal-title":"Int. J. Toxicol."},{"key":"2021031806402959700_cit73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0192623314549960","article-title":"Identification of environmental chemicals associated with the development of toxicant associated fatty liver disease in rodents","volume":"43","author":"Al-Eryani","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"2021031806402959700_cit74","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/en.2017-00887","article-title":"Endocrine Disruptors and Developmental Origins of Nonalcoholic Fatty Liver Disease","volume":"159","author":"Trevi\u00f1o","year":"2017","journal-title":"Endocrinology"},{"key":"2021031806402959700_cit75","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbagrm.2016.03.002","article-title":"Nuclear receptors and nonalcoholic fatty liver disease","volume":"1859","author":"Cave","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2021031806402959700_cit76","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/pr.55.4.2","article-title":"Induction of drug metabolism: the role of nuclear receptors","volume":"55","author":"Handschin","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"2021031806402959700_cit77","doi-asserted-by":"crossref","first-page":"101178","DOI":"10.11131\/2015\/101178","article-title":"Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions","volume":"2","author":"Prakash","year":"2015","journal-title":"Nucl. Recept. Res."},{"key":"2021031806402959700_cit78","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/j.gastro.2010.03.033","article-title":"A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"2021031806402959700_cit79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2013.835784","article-title":"Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARalpha) as a case study","volume":"44","author":"Corton","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"2021031806402959700_cit80","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"Suppl 1","key":"2021031806402959700_cit81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2014.905767","article-title":"A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans","volume":"44","author":"Chang","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"2021031806402959700_cit82","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/713608372","article-title":"PPAR\u03b1 agonist-induced rodent tumors: modes of action and human relevance","volume":"33","author":"Klaunig","year":"2003","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"2021031806402959700_cit83","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta\/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit84","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0005-2760(92)90258-W","article-title":"The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid","volume":"1128","author":"Haughom","year":"1992","journal-title":"Biochim. Biophys. Acta, Lipids Lipid Metab."},{"key":"2021031806402959700_cit85","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/taap.1997.8186","article-title":"Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice","volume":"145","author":"Kudo","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021031806402959700_cit86","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/toxsci\/kfm065","article-title":"Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity","volume":"97","author":"Martin","year":"2007","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit87","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tox.2016.12.007","article-title":"Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis","volume":"378","author":"Das","year":"2017","journal-title":"Toxicology"},{"key":"2021031806402959700_cit88","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbagen.2012.03.010","article-title":"PFOS-induced hepatic steatosis, the mechanistic actions on \u03b2-oxidation and lipid transport","volume":"1820","author":"Wan","year":"2012","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"2021031806402959700_cit89","doi-asserted-by":"crossref","first-page":"e61409","DOI":"10.1371\/journal.pone.0061409","article-title":"High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways","volume":"8","author":"Tan","year":"2013","journal-title":"PLoS One"},{"key":"2021031806402959700_cit90","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","article-title":"Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes","volume":"288","author":"Bjork","year":"2011","journal-title":"Toxicology"},{"key":"2021031806402959700_cit91","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00204-010-0572-2","article-title":"Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARalpha and CAR\/PXR","volume":"84","author":"Elcombe","year":"2010","journal-title":"Arch. Toxicol."},{"key":"2021031806402959700_cit92","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/hep.20170","article-title":"Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice","volume":"39","author":"Ip","year":"2004","journal-title":"Hepatology"},{"key":"2021031806402959700_cit93","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1161\/ATVBAHA.110.220525","article-title":"Peroxisome Proliferator\u2013Activated Receptor-\u03b1 Gene Level Differently Affects Lipid Metabolism and Inflammation in Apolipoprotein E2 Knock-In Mice","volume":"31","author":"Lalloyer","year":"2011","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2021031806402959700_cit94","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cccn.2005.05.003","article-title":"Monitoring phthalate exposure in humans","volume":"361","author":"Latini","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"2021031806402959700_cit95","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10408440600779065","article-title":"Effects of DEHP in the Liver: Modes of Action and Species-Specific Differences","volume":"36","author":"Rusyn","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"2021031806402959700_cit96","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/14756360802205059","article-title":"Molecular modelling of phthalates\u2013PPARs interactions","volume":"23","author":"Kambia","year":"2008","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"2021031806402959700_cit97","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.etap.2015.12.016","article-title":"Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms","volume":"42","author":"Chen","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"2021031806402959700_cit98","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1289\/ehp.02110853","article-title":"Linking dioxins to diabetes: epidemiology and biologic plausibility","volume":"110","author":"Remillard","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"2021031806402959700_cit99","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfs277","article-title":"TCDD-Elicited Effects on Liver, Serum, and Adipose Lipid Composition in C57BL\/6 Mice","volume":"131","author":"Angrish","year":"2013","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit100","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/j.gastro.2010.03.033","article-title":"A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"2021031806402959700_cit101","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/toxsci\/kfr226","article-title":"Aryl Hydrocarbon Receptor\u2013Mediated Induction of Stearoyl-CoA Desaturase 1 Alters Hepatic Fatty Acid Composition in TCDD-Elicited Steatosis","volume":"124","author":"Angrish","year":"2011","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit102","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1292\/jvms.66.1377","article-title":"Down regulation of hepatic PPARalpha function by AhR ligand","volume":"66","author":"Shaban","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"2021031806402959700_cit103","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1289\/ehp.0901347","article-title":"Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA","volume":"118","author":"Schecter","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"2021031806402959700_cit104","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.2337\/dc06-0543","article-title":"A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes","volume":"29","author":"Lee","year":"2006","journal-title":"Diabetes Care"},{"key":"2021031806402959700_cit105","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00125-007-0755-4","article-title":"Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999\u20132002","volume":"50","author":"Lee","year":"2007","journal-title":"Diabetologia"},{"key":"2021031806402959700_cit106","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40200-015-0218-2","article-title":"The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease","volume":"14","author":"Boucher","year":"2015","journal-title":"J. Diabetes Metab. Disord."},{"key":"2021031806402959700_cit107","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/toxsci\/kfv215","article-title":"PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats","volume":"149","author":"Gadupudi","year":"2016","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit108","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jnutbio.2013.01.009","article-title":"Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6\/J mice","volume":"24","author":"Wahlang","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"2021031806402959700_cit109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0041-008X(79)80005-8","article-title":"Acute, subchronic, and chronic toxicity of chlordecone","volume":"48","author":"Larson","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021031806402959700_cit110","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0273-2300(89)90051-2","article-title":"Chlordane: 24-month tumorigenicity and chronic toxicity test in mice","volume":"10","author":"Khasawinah","year":"1989","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"2021031806402959700_cit111","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/toxsci\/kfq118","article-title":"Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo","volume":"116","author":"Ross","year":"2010","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit112","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.taap.2008.08.011","article-title":"Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL\/6 mice","volume":"233","author":"Lee","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021031806402959700_cit113","first-page":"428","article-title":"Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis","volume":"156","author":"Ray","year":"2017","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit114","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2004.06.014","article-title":"Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver","volume":"203","author":"Laughter","year":"2004","journal-title":"Toxicology"},{"key":"2021031806402959700_cit115","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1289\/ehp.1001928","article-title":"Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPAR\u03b1-Humanized Mice","volume":"118","author":"Ramdhan","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"2021031806402959700_cit116","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1289\/ehp.1307359","article-title":"Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues","volume":"122","author":"Guyton","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"2021031806402959700_cit117","doi-asserted-by":"crossref","first-page":"057006","DOI":"10.1289\/EHP788","article-title":"Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population","volume":"125","author":"Cichocki","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"2021031806402959700_cit118","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/toxsci\/kfx120","article-title":"Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice","volume":"159","author":"Cichocki","year":"2017","journal-title":"Toxicol. Sci."},{"key":"2021031806402959700_cit119","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/03602532.2011.577781","article-title":"Drug metabolism alterations in nonalcoholic fatty liver disease","volume":"43","author":"Merrell","year":"2011","journal-title":"Drug Metab. Rev."},{"key":"2021031806402959700_cit120","article-title":"Xenobiotic Nuclear Receptors Expression in High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease: A Time-Course Study","volume-title":"The Toxicologist","author":"Klaunig","year":"2018"},{"key":"2021031806402959700_cit121","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear receptors, RXR, and the big bang","volume":"157","author":"Evans","year":"2014","journal-title":"Cell"},{"key":"2021031806402959700_cit122","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mce.2010.05.019","article-title":"Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements","volume":"325","author":"Song","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021031806402959700_cit123","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/612089","article-title":"Peroxisome proliferator-activated receptor alpha target genes","volume":"2010","author":"Rakhshandehroo","year":"2010","journal-title":"PPAR Res."},{"key":"2021031806402959700_cit124","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jhep.2015.02.019","article-title":"PPAR\u03b1 gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis","volume":"63","author":"Francque","year":"2015","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit125","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/en.2005-1132","article-title":"Peroxisome proliferator-activated receptor \u03b1 mediates the effects of high-fat diet on hepatic gene expression","volume":"147","author":"Patsouris","year":"2006","journal-title":"Endocrinology"},{"key":"2021031806402959700_cit126","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-008-9982-3","article-title":"Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice","volume":"323","author":"Zou","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"2021031806402959700_cit127","doi-asserted-by":"crossref","first-page":"50743","DOI":"10.1074\/jbc.M408014200","article-title":"Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes","volume":"279","author":"de Fourmestraux","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021031806402959700_cit128","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"2021031806402959700_cit129","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation()","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"2021031806402959700_cit130","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2009.05.036","article-title":"Identification of a physiologically relevant endogenous ligand for PPARalpha in liver","volume":"138","author":"Chakravarthy","year":"2009","journal-title":"Cell"},{"key":"2021031806402959700_cit131","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2164-13-84","article-title":"C57Bl\/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia","volume":"13","author":"Desmarchelier","year":"2012","journal-title":"BMC Genomics"},{"key":"2021031806402959700_cit132","doi-asserted-by":"crossref","first-page":"34268","DOI":"10.1074\/jbc.M300043200","article-title":"Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass","volume":"278","author":"Gavrilova","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021031806402959700_cit133","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2005.08.070","article-title":"Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice","volume":"336","author":"Inoue","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021031806402959700_cit134","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.4254\/wjh.v7.i8.1012","article-title":"Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease","volume":"7","author":"Souza-Mello","year":"2015","journal-title":"World J. Hepatol."},{"key":"2021031806402959700_cit135","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1073\/pnas.0511253103","article-title":"PPARdelta regulates glucose metabolism and insulin sensitivity","volume":"103","author":"Lee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2021031806402959700_cit136","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/hep.26461","article-title":"Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha\/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"58","author":"Staels","year":"2013","journal-title":"Hepatology"},{"key":"2021031806402959700_cit137","doi-asserted-by":"crossref","first-page":"E1369","DOI":"10.1073\/pnas.1202464109","article-title":"Protection from liver fibrosis by a peroxisome proliferator-activated receptor \u03b4 agonist","volume":"109","author":"Iwaisako","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2021031806402959700_cit138","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2006.02.028","article-title":"Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet","volume":"536","author":"Nagasawa","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"2021031806402959700_cit139","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2009.03.003","article-title":"PXR and CAR in energy metabolism","volume":"20","author":"Wada","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"2021031806402959700_cit140","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1124\/mol.107.041012","article-title":"Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression","volume":"73","author":"Roth","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"2021031806402959700_cit141","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cgh.2006.12.021","article-title":"and hepatic cytochrome P-450 3A activity","volume":"5","author":"Kolwankar","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"2021031806402959700_cit142","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1124\/dmd.109.027466","article-title":"Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease","volume":"37","author":"Fisher","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"2021031806402959700_cit143","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1124\/dmd.115.065979","article-title":"CYP3A activity and expression in nonalcoholic fatty liver disease","volume":"43","author":"Woolsey","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"2021031806402959700_cit144","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.legalmed.2007.12.006","article-title":"Gene expression on liver toxicity induced by administration of haloperidol in rats with severe fatty liver","volume":"10","author":"Hanagama","year":"2008","journal-title":"Legal Med."},{"key":"2021031806402959700_cit145","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1124\/dmd.107.017731","article-title":"Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet","volume":"36","author":"Osabe","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"2021031806402959700_cit146","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1124\/dmd.117.075655","article-title":"High-Fat Diet Feeding Alters Expression of Hepatic Drug-metabolizing Enzymes in Mice","volume":"45","author":"Ning","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"2021031806402959700_cit147","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jnutbio.2009.11.009","article-title":"Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease","volume":"22","author":"Kirpich","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"2021031806402959700_cit148","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1073\/pnas.0409481102","article-title":"Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites","volume":"102","author":"Sonoda","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2021031806402959700_cit149","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1124\/dmd.106.010645","article-title":"Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4alpha expression","volume":"34","author":"Sugatani","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"2021031806402959700_cit150","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/acs.jafc.6b01663","article-title":"Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine\/Choline-Deficient Diet","volume":"64","author":"Cho","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"2021031806402959700_cit151","doi-asserted-by":"crossref","first-page":"e38734","DOI":"10.1371\/journal.pone.0038734","article-title":"Activation of pregnane X receptor by pregnenolone 16 \u03b1-carbonitrile prevents high-fat diet-induced obesity in AKR\/J mice","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"2021031806402959700_cit152","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/187569209788654005","article-title":"Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation","volume":"7","author":"Hernandez","year":"2009","journal-title":"Curr. Pharmacogenomics Pers. Med."},{"key":"2021031806402959700_cit153","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2174\/138920008785821710","article-title":"CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme","volume":"9","author":"Wang","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"2021031806402959700_cit154","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"2021031806402959700_cit155","volume-title":"Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms","author":"Gunes","year":"2008"},{"key":"2021031806402959700_cit156","first-page":"120","article-title":"Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease","volume":"21","author":"George","year":"1995","journal-title":"Hepatology"},{"key":"2021031806402959700_cit157","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nutres.2017.06.002","article-title":"Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice","volume":"44","author":"Moyer","year":"2017","journal-title":"Nutr. Res."},{"key":"2021031806402959700_cit158","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1073\/pnas.92.6.2096","article-title":"OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor","volume":"92","author":"Teboul","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2021031806402959700_cit159","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bcp.2013.03.016","article-title":"The liver X receptor: a master regulator of the gut-liver axis and a target for non alcoholic fatty liver disease","volume":"86","author":"Ducheix","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2021031806402959700_cit160","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s10620-014-3289-x","article-title":"Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease","volume":"59","author":"Ahn","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"2021031806402959700_cit161","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1017\/S0007114514003717","article-title":"Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition","volume":"113","author":"Ghoneim","year":"2015","journal-title":"Br. J. Nutr."},{"key":"2021031806402959700_cit162","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1758-5996-4-32","article-title":"Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice","volume":"4","author":"Yang","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"2021031806402959700_cit163","first-page":"E462","article-title":"Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis","volume":"297","author":"Basciano","year":"2009","journal-title":"Am. J. Physiol.: Endocrinol. Metab."},{"key":"2021031806402959700_cit164","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/cr.2008.289","article-title":"FXR: a metabolic regulator and cell protector","volume":"18","author":"Wang","year":"2008","journal-title":"Cell Res."},{"key":"2021031806402959700_cit165","first-page":"5","article-title":"Recent advances in the development of farnesoid X receptor agonists","volume":"3","author":"Ali","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"2021031806402959700_cit166","first-page":"1082","article-title":"Role of microRNAs in Nonalcoholic Fatty Liver Disease. The Toxicologists: 150 (1)","author":"Li","year":"2017","journal-title":"Soc. Toxicol."}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxres\/article-pdf\/7\/4\/664\/36632209\/toxres_7_4_664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/toxres\/article-pdf\/7\/4\/664\/36632209\/toxres_7_4_664.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T06:43:59Z","timestamp":1616049839000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/7\/4\/664\/5555795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":166,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,6,6]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1039\/c7tx00326a","relation":{},"ISSN":["2045-4538"],"issn-type":[{"value":"2045-4538","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,6,6]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"James E. Klaunig (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4736-2223","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 8 December 2017; Accepted 9 May 2018; Accepted Manuscript published 18 May 2018; Advance Article published 6 June 2018; Version of Record published 2 July 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}