{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:57:16Z","timestamp":1782975436203,"version":"3.54.5"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"am","delay-in-days":339,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<p>A tuneable sensitive microgel assay based on fluorescence recovery for hcmv-miR-US4-5p detection.<\/p>","DOI":"10.1039\/c8an02166j","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:57:58Z","timestamp":1544104678000},"page":"1369-1378","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["One-step scalable fluorescent microgel bioassay for the ultrasensitive detection of endogenous viral miR-US4-5p"],"prefix":"10.1039","volume":"144","author":[{"given":"Tania Mariastella","family":"Caputo","sequence":"first","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Cummaro","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Lettera","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Mazzarotta","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-9176","authenticated-orcid":false,"given":"Edmondo","family":"Battista","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"},{"name":"Interdisciplinary Research Centre on Biomaterials (CRIB)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Antonio","family":"Netti","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"},{"name":"Interdisciplinary Research Centre on Biomaterials (CRIB)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-3857","authenticated-orcid":false,"given":"Filippo","family":"Causa","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomaterials for Healthcare@CRIB"},{"name":"Istituto Italiano di Tecnologia (IIT)"},{"name":"80125 Naples"},{"name":"Italy"},{"name":"Interdisciplinary Research Centre on Biomaterials (CRIB)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8AN02166J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4437","volume":"235","author":"Griffiths","year":"2015","journal-title":"J. Pathol."},{"key":"C8AN02166J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.2014-1173","volume":"134","author":"Goderis","year":"2014","journal-title":"Pediatrics"},{"key":"C8AN02166J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000322141","volume":"37","author":"Schottstedt","year":"2010","journal-title":"Transfus. Med. Hemother."},{"key":"C8AN02166J-(cit4)\/*[position()=1]","first-page":"466","volume":"11","author":"Ross","year":"2011","journal-title":"Infect. Disord.: Drug Targets"},{"key":"C8AN02166J-(cit5)\/*[position()=1]","volume-title":"Manual of Clinical Microbiology","author":"Hodinka","year":"2015","unstructured":"R. Hodinka  , in  Manual of Clinical Microbiology ,  American Society of Microbiology ,  2015 , pp.  1718\u20131737"},{"key":"C8AN02166J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13613-016-0207-8","volume":"6","author":"Al-Omari","year":"2016","journal-title":"Ann. Intensive Care"},{"key":"C8AN02166J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Delivery Rev."},{"key":"C8AN02166J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.it.2008.04.004","volume":"29","author":"Lindsay","year":"2008","journal-title":"Trends Immunol."},{"key":"C8AN02166J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbadis.2011.02.002","volume":"1812","author":"Bueno","year":"2011","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"C8AN02166J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.clinbiochem.2013.03.015","volume":"46","author":"De Guire","year":"2013","journal-title":"Clin. Biochem."},{"key":"C8AN02166J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","volume":"328","author":"Najafi-Shoushtari","year":"2010","journal-title":"Science"},{"key":"C8AN02166J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/sj.onc.1209912","volume":"25","author":"Jovanovic","year":"2006","journal-title":"Oncogene"},{"key":"C8AN02166J-(cit13)\/*[position()=1]","first-page":"1","author":"Kawahara","year":"2012","journal-title":"Front. Neurosci."},{"key":"C8AN02166J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/MCB.01395-06","volume":"27","author":"Kulshreshtha","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"C8AN02166J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0609.2009.01348.x","volume":"84","author":"Vasilatou","year":"2010","journal-title":"Eur. J. Haematol."},{"key":"C8AN02166J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jcp.25056","volume":"231","author":"Wang","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"C8AN02166J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tins.2008.12.003","volume":"32","author":"H\u00e9bert","year":"2009","journal-title":"Trends Neurosci."},{"key":"C8AN02166J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jacc.2014.01.050","volume":"63","author":"Condorelli","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"C8AN02166J-(cit19)\/*[position()=1]","first-page":"1","volume":"2012","author":"Nielsen","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"C8AN02166J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2015.00040","volume":"6","author":"Femminella","year":"2015","journal-title":"Front. Physiol."},{"key":"C8AN02166J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"C8AN02166J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrm3313","volume":"13","author":"Rottiers","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C8AN02166J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2013.00408","volume":"4","author":"Hitachi","year":"2014","journal-title":"Front. Physiol."},{"key":"C8AN02166J-(cit24)\/*[position()=1]","first-page":"25","volume":"10","author":"Louten","year":"2016","journal-title":"Biomarker Insights"},{"key":"C8AN02166J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1874357901206010038","volume":"6","author":"Meshesha","year":"2012","journal-title":"Open Virol. J."},{"key":"C8AN02166J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nmeth746","volume":"2","author":"Pfeffer","year":"2005","journal-title":"Nat. Methods"},{"key":"C8AN02166J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12095","DOI":"10.1128\/JVI.79.18.12095-12099.2005","volume":"79","author":"Grey","year":"2005","journal-title":"J. Virol."},{"key":"C8AN02166J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature07757","volume":"457","author":"Cullen","year":"2009","journal-title":"Nature"},{"key":"C8AN02166J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.gene.2015.08.040","volume":"575","author":"Meshesha","year":"2016","journal-title":"Gene"},{"key":"C8AN02166J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1080\/15476286.2017.1367888","volume":"14","author":"Keller","year":"2017","journal-title":"RNA Biol."},{"key":"C8AN02166J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Yoon","year":"2017","journal-title":"Sci. Rep."},{"key":"C8AN02166J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1373\/clinchem.2010.157198","volume":"57","author":"McDonald","year":"2011","journal-title":"Clin. Chem."},{"key":"C8AN02166J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/ajt.13222","volume":"15","author":"Lisboa","year":"2015","journal-title":"Am. J. Transplant."},{"key":"C8AN02166J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/JVI.05903-11","volume":"86","author":"Stark","year":"2012","journal-title":"J. Virol."},{"key":"C8AN02166J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ni.2097","volume":"12","author":"Kim","year":"2011","journal-title":"Nat. Immunol."},{"key":"C8AN02166J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23007","DOI":"10.1038\/srep23007","volume":"6","author":"Pan","year":"2016","journal-title":"Sci. Rep."},{"key":"C8AN02166J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00604-014-1243-4","volume":"181","author":"R\u00f6diger","year":"2014","journal-title":"Microchim. Acta"},{"key":"C8AN02166J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/acsnano.6b01254","volume":"10","author":"Kim","year":"2016","journal-title":"ACS Nano"},{"key":"C8AN02166J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.eurpolymj.2015.02.022","volume":"72","author":"Le Goff","year":"2015","journal-title":"Eur. Polym. J."},{"key":"C8AN02166J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/gels3020020","volume":"3","author":"Battista","year":"2017","journal-title":"Gels"},{"key":"C8AN02166J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.colsurfb.2016.04.036","volume":"145","author":"Celetti","year":"2016","journal-title":"Colloids Surf., B"},{"key":"C8AN02166J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","volume":"6","author":"Ahmed","year":"2015","journal-title":"J. Adv. Res."},{"key":"C8AN02166J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9370","DOI":"10.1021\/ac302128u","volume":"84","author":"Choi","year":"2012","journal-title":"Anal. Chem."},{"key":"C8AN02166J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1002\/anie.201006523","volume":"50","author":"Chapin","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8AN02166J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.1134929","volume":"315","author":"Pregibon","year":"2007","journal-title":"Science"},{"key":"C8AN02166J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1021\/acs.langmuir.6b01518","volume":"32","author":"Ma","year":"2016","journal-title":"Langmuir"},{"key":"C8AN02166J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1021\/cr400113m","volume":"114","author":"Nakano","year":"2014","journal-title":"Chem. Rev."},{"key":"C8AN02166J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17303","DOI":"10.1021\/ja906987s","volume":"131","author":"Zhang","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02166J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1021\/ja511644b","volume":"137","author":"Causa","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02166J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1039\/C5AN02001H","volume":"141","author":"Aliberti","year":"2016","journal-title":"Analyst"},{"key":"C8AN02166J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/nprot.2011.400","volume":"6","author":"Appleyard","year":"2011","journal-title":"Nat. Protoc."},{"key":"C8AN02166J-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"C8AN02166J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"W43","DOI":"10.1093\/nar\/gkm234","volume":"35","author":"Kibbe","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"C8AN02166J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"C8AN02166J-(cit55)\/*[position()=1]","volume-title":"Methods in Molecular Biology","volume":"453","author":"Markham","year":"2008","unstructured":"N. R. Markham   and  M.Zuker , in  Methods in Molecular Biology ,  Humana Press ,  2008 , vol.  453 , pp.  3\u201331"},{"key":"C8AN02166J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1021\/ja1073239","volume":"133","author":"Genot","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02166J-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nchem.957","volume":"3","author":"Zhang","year":"2011","journal-title":"Nat. Chem."},{"key":"C8AN02166J-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.chom.2015.05.014","volume":"17","author":"Kim","year":"2015","journal-title":"Cell Host Microbe"},{"key":"C8AN02166J-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/pi.5076","volume":"65","author":"Battista","year":"2016","journal-title":"Polym. Int."},{"key":"C8AN02166J-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/anie.200503888","volume":"45","author":"Berndt","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8AN02166J-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.colsurfb.2012.09.020","volume":"102","author":"Baker","year":"2013","journal-title":"Colloids Surf., B"},{"key":"C8AN02166J-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1021\/acsnano.7b08673","volume":"12","author":"Li","year":"2018","journal-title":"ACS Nano"},{"key":"C8AN02166J-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/leu.2012.106","volume":"26","author":"Grasedieck","year":"2012","journal-title":"Leukemia"},{"key":"C8AN02166J-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1021\/ac2012575","volume":"83","author":"Riahi","year":"2011","journal-title":"Anal. Chem."},{"key":"C8AN02166J-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"064114","DOI":"10.1063\/1.4967489","volume":"10","author":"Dannhauser","year":"2016","journal-title":"Biomicrofluidics"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/AN\/C8AN02166J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:24:16Z","timestamp":1782969856000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/144\/4\/1369-1378\/630798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2,11]]}},"URL":"https:\/\/doi.org\/10.1039\/c8an02166j","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8AN02166J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Edmondo Battista (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0915-9176","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Edmondo Battista (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/B-3104-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Filippo Causa (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5436-3857","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 November 2018; Accepted 5 December 2018;  Accepted Manuscript published 6 December 2018;  Advance Article published 19 December 2018;  Version of Record published 11 February 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}