{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:00:19Z","timestamp":1782889219630,"version":"3.54.5"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"am","delay-in-days":395,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31671933"],"award-info":[{"award-number":["31671933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<p>\n                    A label-free biosensor was proposed for\n                    <italic>HIV-1<\/italic>\n                    gene detection based on cascade toehold-mediated strand displacement reactions.\n                  <\/p>","DOI":"10.1039\/c8an02340a","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T22:04:22Z","timestamp":1548885862000},"page":"2173-2178","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A cascade toehold-mediated strand displacement strategy for label-free and sensitive non-enzymatic recycling amplification detection of the\n                    <i>HIV-1<\/i>\n                    gene"],"prefix":"10.1039","volume":"144","author":[{"given":"Qiong","family":"Li","sequence":"first","affiliation":[{"name":"College of Bioscience and Biotechnology"},{"name":"Hunan Agricultural University"},{"name":"Changsha 410128"},{"name":"China"},{"name":"Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology"},{"name":"Hunan Agricultural University"},{"name":"Changsha 410128"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management"},{"name":"Guangdong Institute of Eco-Environmental and Science &Technology"},{"name":"Guangzhou 510650"},{"name":"China"},{"name":"College of Natural Resources and Environment"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management"},{"name":"Guangdong Institute of Eco-Environmental and Science &Technology"},{"name":"Guangzhou 510650"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuai","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Geochemistry"},{"name":"Institute of Geochemistry"},{"name":"Chinese Academy of Sciences"},{"name":"Guiyang 550081"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9450-7272","authenticated-orcid":false,"given":"Junhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management"},{"name":"Guangdong Institute of Eco-Environmental and Science &Technology"},{"name":"Guangzhou 510650"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8AN02340A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.3390\/molecules17055988","volume":"17","author":"Zheng","year":"2017","journal-title":"Molecules"},{"key":"C8AN02340A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bios.2013.09.016","volume":"52","author":"Li","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"C8AN02340A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1007\/s00604-017-2368-z","volume":"184","author":"Yin","year":"2017","journal-title":"Microchim. Acta"},{"key":"C8AN02340A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.21390","volume":"81","author":"V\u00e9ronique","year":"2009","journal-title":"J. Med. Virol."},{"key":"C8AN02340A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e85999","DOI":"10.1371\/journal.pone.0085999","volume":"9","author":"Kiselinova","year":"2014","journal-title":"PLoS One"},{"key":"C8AN02340A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1537-2995.2009.02477.x","volume":"50","author":"Edelmann","year":"2010","journal-title":"Transfusion"},{"key":"C8AN02340A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nnano.2012.186","volume":"7","author":"De","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"C8AN02340A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bios.2017.08.042","volume":"100","author":"Diao","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"C8AN02340A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24438","DOI":"10.1021\/acsami.5b08154","volume":"7","author":"Zhou","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C8AN02340A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/C6BM00527F","volume":"5","author":"Ali","year":"2017","journal-title":"Biomater. Sci."},{"key":"C8AN02340A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1021\/acs.analchem.7b01149","volume":"89","author":"Le","year":"2017","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1021\/acs.analchem.8b02042","volume":"12","author":"Channon","year":"2018","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23949","DOI":"10.1038\/srep23949","volume":"6","author":"Long","year":"2016","journal-title":"Sci. Rep."},{"key":"C8AN02340A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.aca.2015.06.059","volume":"890","author":"Wang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"C8AN02340A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bios.2016.10.033","volume":"89","author":"Qaddare","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"C8AN02340A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11084","DOI":"10.1039\/C5CC03723A","volume":"51","author":"Li","year":"2015","journal-title":"Chem. Commun."},{"key":"C8AN02340A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/smll.201303558","volume":"10","author":"Wu","year":"2014","journal-title":"Small"},{"key":"C8AN02340A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1021\/acs.analchem.8b01966","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1073\/pnas.0909380107","volume":"107","author":"Soloveichik","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8AN02340A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1126\/science.1132493","volume":"314","author":"Seelig","year":"2006","journal-title":"Science"},{"key":"C8AN02340A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118102","DOI":"10.1103\/PhysRevLett.90.118102","volume":"90","author":"Turberfield","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"C8AN02340A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.1148532","volume":"318","author":"Zhang","year":"2007","journal-title":"Science"},{"key":"C8AN02340A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14473","DOI":"10.1038\/ncomms14473","volume":"8","author":"Engelen","year":"2017","journal-title":"Nat. Commun."},{"key":"C8AN02340A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/nar\/gkw1146","volume":"45","author":"Peng","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"C8AN02340A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17637","DOI":"10.1021\/acsami.7b04553","volume":"9","author":"Feng","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C8AN02340A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1021\/acs.analchem.5b02654","volume":"87","author":"Lv","year":"2015","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1021\/acs.analchem.5b02418","volume":"87","author":"Shi","year":"2015","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/chem.201001331","volume":"17","author":"Hu","year":"2011","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8AN02340A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1021\/ja9051763","volume":"131","author":"Peng","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02340A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1039\/b918241a","volume":"47","author":"Pu","year":"2009","journal-title":"Chem. Commun."},{"key":"C8AN02340A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1021\/acs.analchem.5b02790","volume":"87","author":"Hou","year":"2015","journal-title":"Anal. Chem."},{"key":"C8AN02340A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1021\/acsami.7b18676","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C8AN02340A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1021\/bi992070s","volume":"38","author":"Ren","year":"1999","journal-title":"Biochemistry"},{"key":"C8AN02340A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1093\/nar\/26.16.3724","volume":"26","author":"Arthanari","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"C8AN02340A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1039\/c3an36657j","volume":"138","author":"Zhao","year":"2013","journal-title":"Analyst"},{"key":"C8AN02340A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bios.2015.09.042","volume":"77","author":"Chen","year":"2016","journal-title":"Biosens. Bioelectron."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/AN\/C8AN02340A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:24:13Z","timestamp":1782883453000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/144\/6\/2173-2178\/591690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3,11]]}},"URL":"https:\/\/doi.org\/10.1039\/c8an02340a","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8AN02340A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Junhua Chen (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9450-7272","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 3 December 2018; Accepted 30 January 2019;  Accepted Manuscript published 31 January 2019;  Advance Article published 15 February 2019;  Version of Record published 11 March 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}