{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:02:11Z","timestamp":1785884531889,"version":"3.56.0"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"am","delay-in-days":408,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21673022"],"award-info":[{"award-number":["21673022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21233003"],"award-info":[{"award-number":["21233003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<p>Here, we found that Thioflavin T (ThT) could specifically bind with a G-GGG unit (named as \u201cGuanine Island\u201d) in double stranded DNA (ds-DNA).<\/p>","DOI":"10.1039\/c8an02430h","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T02:05:23Z","timestamp":1550023523000},"page":"2284-2290","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thioflavin T specifically brightening \u201cGuanine Island\u201d in duplex-DNA: a novel fluorescent probe for single-nucleotide mutation"],"prefix":"10.1039","volume":"144","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-7252","authenticated-orcid":false,"given":"Yunchao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louzhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-1206","authenticated-orcid":false,"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Theoretical and Computational Photochemistry"},{"name":"Ministry of Education"},{"name":"College of Chemistry"},{"name":"Beijing Normal University"},{"name":"Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8AN02430H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1039\/c2cs35472a","volume":"42","author":"Ma","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"C8AN02430H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1039\/C6AN01958G","volume":"141","author":"Guo","year":"2016","journal-title":"Analyst"},{"key":"C8AN02430H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/ja037289f","volume":"126","author":"Ho","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12254","DOI":"10.1021\/acs.analchem.5b03369","volume":"87","author":"Huang","year":"2015","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1039\/C5AN01852H","volume":"140","author":"Chen","year":"2015","journal-title":"Analyst"},{"key":"C8AN02430H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1039\/C4CC06824F","volume":"51","author":"Lee","year":"2015","journal-title":"Chem. Commun."},{"key":"C8AN02430H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1021\/ac300348v","volume":"84","author":"Zhang","year":"2012","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/cbic.201200612","volume":"14","author":"Vummidi","year":"2013","journal-title":"ChemBioChem"},{"key":"C8AN02430H-(cit9)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1007\/128_2012_346","volume-title":"Top. Curr. Chem","author":"Largy","year":"2013","unstructured":"E. Largy  ,  A.Granzhan ,  F.Hamon ,  D.Verga  and  M.-P.Teulade-Fichou , in  Top. Curr. Chem , ed.  J. B. Chaires  and  D. Graves ,  Springer ,  Berlin, Heidelberg ,  2013 , pp.  111\u2013177 ,  10.1007\/128_2012_346"},{"key":"C8AN02430H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/acs.analchem.5b04936","volume":"88","author":"Cheng","year":"2016","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1021\/ac802558f","volume":"81","author":"Kong","year":"2009","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1093\/nar\/26.16.3724","volume":"26","author":"Arthanari","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"C8AN02430H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/ac403676x","volume":"86","author":"Jin","year":"2014","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1002\/chem.201505170","volume":"22","author":"Wu","year":"2016","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8AN02430H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1002\/anie.200903685","volume":"48","author":"Alzeer","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8AN02430H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17202","DOI":"10.1038\/srep17202","volume":"5","author":"Hu","year":"2015","journal-title":"Sci. Rep."},{"key":"C8AN02430H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17301","DOI":"10.1021\/jacs.7b10639","volume":"139","author":"Nano","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1039\/c3cs60455a","volume":"43","author":"Granzhan","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"C8AN02430H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1093\/nar\/gkx942","volume":"45","author":"Liu","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"C8AN02430H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1021\/acssensors.8b00141","volume":"3","author":"Zhu","year":"2018","journal-title":"ACS Sens."},{"key":"C8AN02430H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14347","DOI":"10.1021\/acs.analchem.8b03763","volume":"90","author":"Deng","year":"2018","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1039\/c2cc16974f","volume":"48","author":"Mohanty","year":"2012","journal-title":"Chem. Commun."},{"key":"C8AN02430H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1021\/ja309588h","volume":"135","author":"Mohanty","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1021\/acs.jpcb.5b01107","volume":"119","author":"Luo","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"C8AN02430H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1093\/nar\/gkv338","volume":"43","author":"Sugimoto","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"C8AN02430H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.1021\/ac502986g","volume":"86","author":"Tan","year":"2014","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24793","DOI":"10.1038\/srep24793","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"C8AN02430H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.talanta.2014.01.033","volume":"122","author":"Ge","year":"2014","journal-title":"Talanta"},{"key":"C8AN02430H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bios.2013.05.051","volume":"49","author":"Tong","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"C8AN02430H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1093\/nar\/gku833","volume":"42","author":"Zhao","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"C8AN02430H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16458","DOI":"10.1021\/acsami.5b03662","volume":"7","author":"Liu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C8AN02430H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20061","DOI":"10.1039\/C4CP02838D","volume":"16","author":"Biancardi","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"C8AN02430H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.280.5366.1077","volume":"280","author":"Wang","year":"1998","journal-title":"Science"},{"key":"C8AN02430H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/35103535","volume":"2","author":"Syv\u00e4nen","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"C8AN02430H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/ng1547","volume":"37","author":"Gunderson","year":"2005","journal-title":"Nat. Genet."},{"key":"C8AN02430H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1039\/C4SC03375B","volume":"6","author":"Wu","year":"2015","journal-title":"Chem. Sci."},{"key":"C8AN02430H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1039\/C4CC09984B","volume":"51","author":"Wu","year":"2015","journal-title":"Chem. Commun."},{"key":"C8AN02430H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11293","DOI":"10.1021\/jacs.8b05309","volume":"140","author":"Zhang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1021\/ac4040373","volume":"86","author":"Wu","year":"2014","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/acs.accounts.7b00040","volume":"50","author":"Deng","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"C8AN02430H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1039\/C6AN00912C","volume":"141","author":"Kamoto","year":"2016","journal-title":"Analyst"},{"key":"C8AN02430H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13465","DOI":"10.1021\/jacs.6b05628","volume":"138","author":"Stancescu","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nchem.2859","volume":"9","author":"Xu","year":"2017","journal-title":"Nat. Chem."},{"key":"C8AN02430H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1021\/acs.analchem.7b02077","volume":"89","author":"Lin","year":"2017","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1021\/acs.orglett.6b01378","volume":"18","author":"Kumar Verma","year":"2016","journal-title":"Org. Lett."},{"key":"C8AN02430H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14099","DOI":"10.1021\/ja304663t","volume":"134","author":"Johnson","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/jp0348068","volume":"107","author":"Heinlein","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"C8AN02430H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1010-6030(03)00320-4","volume":"162","author":"Ilanchelian","year":"2004","journal-title":"J. Photochem. Photobiol., A"},{"key":"C8AN02430H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/chir.22064","volume":"24","author":"Vorl\u00ed\u010dkov\u00e1","year":"2012","journal-title":"Chirality"},{"key":"C8AN02430H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1021\/acs.jpcb.6b05002","volume":"120","author":"Zhang","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"C8AN02430H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13156","DOI":"10.1021\/ja105849m","volume":"132","author":"Li","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gku111","volume":"42","author":"Renaud de la Faverie","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"C8AN02430H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1021\/bi4006072","volume":"52","author":"Gabelica","year":"2013","journal-title":"Biochemistry"},{"key":"C8AN02430H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1021\/acs.jpcb.6b05002","volume":"120","author":"Zhang","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"C8AN02430H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1021\/ac1019446","volume":"82","author":"Li","year":"2010","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1021\/ac503730j","volume":"87","author":"Zhang","year":"2015","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/355564a0","volume":"355","author":"Bock","year":"1992","journal-title":"Nature"},{"key":"C8AN02430H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/ja108962j","volume":"133","author":"Lucas","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12648","DOI":"10.1039\/C4CP00099D","volume":"16","author":"Nishio","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"C8AN02430H-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9198","DOI":"10.1021\/jacs.5b02674","volume":"137","author":"Doan","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"C8AN02430H-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1021\/jp037273b","volume":"108","author":"Nguyen","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"C8AN02430H-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9820","DOI":"10.1021\/jp506797j","volume":"118","author":"Sjoqvist","year":"2014","journal-title":"J. Phys. Chem. A"},{"key":"C8AN02430H-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1021\/ac403326m","volume":"86","author":"Liu","year":"2014","journal-title":"Anal. Chem."},{"key":"C8AN02430H-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1039\/c3mb70201d","volume":"9","author":"Liu","year":"2013","journal-title":"Mol. BioSyst."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/AN\/C8AN02430H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:36:36Z","timestamp":1783532196000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/144\/7\/2284-2290\/591714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,3,25]]}},"URL":"https:\/\/doi.org\/10.1039\/c8an02430h","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8AN02430H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Yunchao Li (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5554-7252","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Yunchao Li (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/F-8846-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Xiaohong Li (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2043-1206","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 December 2018; Accepted 12 February 2019;  Accepted Manuscript published 13 February 2019;  Advance Article published 28 February 2019;  Version of Record published 25 March 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}