{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:12:30Z","timestamp":1783455150985,"version":"3.55.0"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"68","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"am","delay-in-days":582,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP23102014"],"award-info":[{"award-number":["JP23102014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP18H04606"],"award-info":[{"award-number":["JP18H04606"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP26242073"],"award-info":[{"award-number":["JP26242073"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP18K14343"],"award-info":[{"award-number":["JP18K14343"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>An aplyronine A\u2013swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities.<\/p>","DOI":"10.1039\/c8cc04613a","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:04:10Z","timestamp":1533513850000},"page":"9537-9540","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a novel inducer of protein\u2013protein interactions based on aplyronine A"],"prefix":"10.1039","volume":"54","author":[{"given":"Takayuki","family":"Ohyoshi","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Namiki","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Ebihara","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-9078","authenticated-orcid":false,"given":"Ichiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Applied Chemistry"},{"name":"Graduate School of Natural Science and Technology"},{"name":"Okayama University"},{"name":"Okayama 700-8530"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-5129","authenticated-orcid":false,"given":"Hideo","family":"Kigoshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Tsukuba 305-8571"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8CC04613A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"C8CC04613A-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/358070a0","volume":"358","author":"Kuo","year":"1992","journal-title":"Nature"},{"key":"C8CC04613A-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","volume":"369","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"C8CC04613A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1039\/C4NP00129J","volume":"32","author":"Kita","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"C8CC04613A-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1021\/ja00076a082","volume":"115","author":"Yamada","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8501","DOI":"10.1016\/S0040-4039(00)61369-2","volume":"34","author":"Ojika","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit4c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1016\/S0040-4039(00)61370-9","volume":"34","author":"Ojika","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit4d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1021\/ja00095a071","volume":"116","author":"Ojika","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1021\/ja00095a072","volume":"116","author":"Kigoshi","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1021\/jo9606113","volume":"61","author":"Kigoshi","year":"1996","journal-title":"J. Org. Chem."},{"key":"C8CC04613A-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1039\/C6OB02241C","volume":"15","author":"Hayakawa","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"C8CC04613A-(cit5d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1039\/C7OB03204H","volume":"16","author":"Anzicek","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"C8CC04613A-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/B800263K","volume":"26","author":"Yamada","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"C8CC04613A-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3987\/REV-14-809","volume":"91","author":"Hayakawa","year":"2015","journal-title":"Heterocycles"},{"key":"C8CC04613A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18089","DOI":"10.1021\/ja406580w","volume":"135","author":"Kita","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C8CC04613A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1016\/j.tet.2007.02.011","volume":"63","author":"Ojika","year":"2007","journal-title":"Tetrahedron"},{"key":"C8CC04613A-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0960-894X(96)00620-8","volume":"7","author":"Suenaga","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C8CC04613A-(cit10b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0040-4020(01)01206-6","volume":"58","author":"Kigoshi","year":"2002","journal-title":"Tetrahedron"},{"key":"C8CC04613A-(cit10c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1016\/j.tetlet.2004.05.078","volume":"45","author":"Suenaga","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit10d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1016\/j.tet.2006.06.046","volume":"62","author":"Suenaga","year":"2006","journal-title":"Tetrahedron"},{"key":"C8CC04613A-(cit10e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.bmcl.2012.12.052","volume":"23","author":"Ohno","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C8CC04613A-(cit10f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/bc050324i","volume":"17","author":"Kuroda","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"C8CC04613A-(cit10g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/cmdc.201402150","volume":"9","author":"Pereira","year":"2014","journal-title":"ChemMedChem"},{"key":"C8CC04613A-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/S0040-4039(00)99131-7","volume":"30","author":"Fusetani","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit11b)\/*[position()=1]","first-page":"29710","volume":"269","author":"Saito","year":"1994","journal-title":"J. Mol. Biol."},{"key":"C8CC04613A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.jbchem.a021449","volume":"120","author":"Saito","year":"1996","journal-title":"J. Biochem."},{"key":"C8CC04613A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/ol300182r","volume":"14","author":"Kobayashi","year":"2012","journal-title":"Org. Lett."},{"key":"C8CC04613A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jmb.2005.12.031","volume":"356","author":"Hirata","year":"2006","journal-title":"J. Mol. Biol."},{"key":"C8CC04613A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nsb1006","volume":"10","author":"Klenchin","year":"2003","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C8CC04613A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1248\/cpb.42.19","volume":"42","author":"Kobayashi","year":"1994","journal-title":"Chem. Pharm. Bull."},{"key":"C8CC04613A-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0040-4039(00)61925-1","volume":"26","author":"Carmely","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1016\/S0040-4039(00)99170-6","volume":"30","author":"Kobayashi","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"C8CC04613A-(cit17c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1021\/ja00165a094","volume":"112","author":"Kitagawa","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1074\/jbc.270.8.3463","volume":"270","author":"Bubb","year":"1995","journal-title":"J. Biol. Chem."},{"key":"C8CC04613A-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.jbchem.a021975","volume":"123","author":"Saito","year":"1998","journal-title":"J. Biochem."},{"key":"C8CC04613A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chembiol.2005.02.011","volume":"12","author":"Klenchin","year":"2005","journal-title":"Chem. Biol."},{"key":"C8CC04613A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1021\/ol1029657","volume":"13","author":"Kobayashi","year":"2011","journal-title":"Org. Lett."},{"key":"C8CC04613A-(cit21a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1021\/ja00278a057","volume":"108","author":"Jin","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit21b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1021\/ja00279a068","volume":"108","author":"Takai","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC04613A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1021\/ol050864v","volume":"7","author":"Nakamura","year":"2005","journal-title":"Org. Lett."},{"key":"C8CC04613A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1021\/ja00283a046","volume":"108","author":"Takai","year":"1986","journal-title":"J. Am. Chem. Soc."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/CC\/C8CC04613A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:55:28Z","timestamp":1783450528000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/54\/68\/9537-9540\/594292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":42,"journal-issue":{"issue":"68","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8cc04613a","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8CC04613A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Ichiro Hayakawa (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2749-9078","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Ichiro Hayakawa (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/D-4345-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Hideo Kigoshi (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1554-5129","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Authors can choose between single-blind and double-blind peer review","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 June 2018; Accepted 4 August 2018;  Accepted Manuscript published 6 August 2018;  Advance Article published 10 August 2018;  Version of Record published 21 August 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}