{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:47:47Z","timestamp":1790218067047,"version":"4.1.0"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21572161"],"award-info":[{"award-number":["21572161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21603163"],"award-info":[{"award-number":["21603163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21871210"],"award-info":[{"award-number":["21871210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31500684"],"award-info":[{"award-number":["31500684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81603064"],"award-info":[{"award-number":["81603064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>We report a mitochondria-targeted and superoxide-responsive nitric oxide donor with good protection against ischemia\/reperfusion injury in H9c2 cells and isolated rat hearts.<\/p>","DOI":"10.1039\/c8cc07304j","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T07:05:00Z","timestamp":1542697500000},"page":"1205-1208","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia\/reperfusion injury"],"prefix":"10.1039","volume":"55","author":[{"given":"Jingli","family":"Hou","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saipeng","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering"},{"name":"Northwest University"},{"name":"Xi\u2019an"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qian","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Tan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Han","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Song","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhelong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pathophysiology"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-3602","authenticated-orcid":false,"given":"Yangping","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics"},{"name":"School of Pharmacy"},{"name":"Tianjin Medical University"},{"name":"Tianjin 300070"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8CC07304J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41557-018-0055-2","volume":"10","author":"Zheng","year":"2018","journal-title":"Nat. Chem."},{"key":"C8CC07304J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15846","DOI":"10.1002\/anie.201608732","volume":"55","author":"Ji","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8CC07304J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1021\/jacs.6b01373","volume":"138","author":"Kang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"C8CC07304J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3389\/fphar.2017.00664","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"C8CC07304J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/ol5010643","volume":"16","author":"Dharmaraja","year":"2014","journal-title":"Org. Lett."},{"key":"C8CC07304J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13352","DOI":"10.1039\/C7CC08526E","volume":"53","author":"Ravikumar","year":"2017","journal-title":"Chem. Commun."},{"key":"C8CC07304J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1039\/C4CC00968A","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun."},{"key":"C8CC07304J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"C8CC07304J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/med.21433","volume":"38","author":"Zheng","year":"2018","journal-title":"Med. Res. Rev."},{"key":"C8CC07304J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/cvr\/cvv171","volume":"107","author":"Alburquerqueb\u00e9jar","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"C8CC07304J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","volume":"15","author":"Farah","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"C8CC07304J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.0000018745.11739.9B","volume":"105","author":"Hallstr\u00f6m","year":"2002","journal-title":"Circulation"},{"key":"C8CC07304J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1161\/01.CIR.101.23.2742","volume":"101","author":"Kanno","year":"2000","journal-title":"Circulation"},{"key":"C8CC07304J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.yjmcc.2009.01.012","volume":"46","author":"Nadtochiy","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C8CC07304J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yjmcc.2005.09.011","volume":"40","author":"Jones","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C8CC07304J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/oxfordjournals.eurheartj.a060456","volume":"15","author":"Pernow","year":"1994","journal-title":"Eur. Heart J."},{"key":"C8CC07304J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pharmthera.2005.04.005","volume":"108","author":"Schulz","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"C8CC07304J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1471-4159.2004.02500.x","volume":"90","author":"Zhu","year":"2004","journal-title":"J. Neurochem."},{"key":"C8CC07304J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(03)00697-9","volume":"349","author":"Lee","year":"2003","journal-title":"Neurosci. Lett."},{"key":"C8CC07304J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0076-6879(96)68030-6","volume":"268","author":"Keefer","year":"1996","journal-title":"Methods Enzymol."},{"key":"C8CC07304J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1701043","DOI":"10.1002\/advs.201701043","volume":"5","author":"Yang","year":"2018","journal-title":"Adv. Sci."},{"key":"C8CC07304J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/cb200274r","volume":"6","author":"Keefer","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"C8CC07304J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/cr000028t","volume":"102","author":"Hrabie","year":"2002","journal-title":"Chem. Rev."},{"key":"C8CC07304J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"H1410","DOI":"10.1152\/ajpheart.00731.2011","volume":"302","author":"Lee","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"C8CC07304J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/ars.2007.1845","volume":"10","author":"Burwell","year":"2008","journal-title":"Antioxid. Redox Signaling"},{"key":"C8CC07304J-(cit26)\/*[position()=1]","first-page":"935","volume":"38","author":"Hausenloy","year":"2016","journal-title":"Eur. Heart J."},{"key":"C8CC07304J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1073\/pnas.0903250106","volume":"106","author":"Prime","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8CC07304J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/CIRCULATIONAHA.117.029859","volume":"136","author":"Hausenloy","year":"2017","journal-title":"Circulation"},{"key":"C8CC07304J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jvs.2003.10.060","volume":"39","author":"Nanobashvili","year":"2004","journal-title":"J. Vasc. Surg."},{"key":"C8CC07304J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1038\/s41598-017-08441-9","volume":"7","author":"Le","year":"2017","journal-title":"Sci. Rep."},{"key":"C8CC07304J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.117.027575","volume":"136","author":"Pasupathy","year":"2017","journal-title":"Circulation"},{"key":"C8CC07304J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/cbic.200600392","volume":"8","author":"Xu","year":"2007","journal-title":"ChemBioChem"},{"key":"C8CC07304J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1039\/C5CC09976E","volume":"52","author":"Zhang","year":"2016","journal-title":"Chem. Commun."},{"key":"C8CC07304J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1021\/acs.analchem.5b00917","volume":"87","author":"Anifowose","year":"2015","journal-title":"Anal. Chem."},{"key":"C8CC07304J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"C8CC07304J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12607","DOI":"10.1021\/jp8070579","volume":"112","author":"Villamena","year":"2008","journal-title":"J. Phys. Chem. A"},{"key":"C8CC07304J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e99143","DOI":"10.1371\/journal.pone.0099143","volume":"9","author":"Lopez-Sanchez","year":"2014","journal-title":"PLoS One"},{"key":"C8CC07304J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biopha.2017.03.043","volume":"90","author":"Tullio","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/CC\/C8CC07304J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:25:07Z","timestamp":1782879907000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/55\/9\/1205-1208\/595060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,1,24]]}},"URL":"https:\/\/doi.org\/10.1039\/c8cc07304j","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8CC07304J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Yangping Liu (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5455-3602","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Authors can choose between single-blind and double-blind peer review","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 8 September 2018; Accepted 20 November 2018;  Accepted Manuscript published 20 November 2018;  Advance Article published 27 November 2018;  Version of Record published 24 January 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}