{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:41:22Z","timestamp":1782934882834,"version":"3.54.5"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"am","delay-in-days":444,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"crossref","award":["17-08512Y"],"award-info":[{"award-number":["17-08512Y"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"crossref","award":["LO1305"],"award-info":[{"award-number":["LO1305"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"crossref","award":["CZ.1.05\/2.1.00\/19.0377"],"award-info":[{"award-number":["CZ.1.05\/2.1.00\/19.0377"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<p>\n                    [Os(\u03b7\n                    <sup>6<\/sup>\n                    -\n                    <italic>p<\/italic>\n                    cym)(dpa)(VP)]PF\n                    <sub>6<\/sub>\n                    (\n                    <bold>1-VP<\/bold>\n                    ), containing the histone deacetylase inhibitor valproate, shows\n                    <italic>ca.<\/italic>\n                    3-fold higher\n                    <italic>in vitro<\/italic>\n                    cytotoxicity against the A2780 human ovarian carcinoma cells than its chlorido analogue [Os(\u03b7\n                    <sup>6<\/sup>\n                    -\n                    <italic>p<\/italic>\n                    cym)(dpa)Cl]PF\n                    <sub>6<\/sub>\n                    (\n                    <bold>1-Cl<\/bold>\n                    ).\n                  <\/p>","DOI":"10.1039\/c8dt00193f","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T07:04:16Z","timestamp":1521615856000},"page":"5714-5724","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A potential method to improve the\n                    <i>in vitro<\/i>\n                    cytotoxicity of half-sandwich Os(\n                    <scp>ii<\/scp>\n                    ) complexes against A2780 cells"],"prefix":"10.1039","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-045X","authenticated-orcid":false,"given":"Pavel","family":"\u0160tarha","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials"},{"name":"Faculty of Science"},{"name":"Palack\u00fd University in Olomouc"},{"name":"771 46 Olomouc"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-7874","authenticated-orcid":false,"given":"Zden\u011bk","family":"Tr\u00e1vn\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials"},{"name":"Faculty of Science"},{"name":"Palack\u00fd University in Olomouc"},{"name":"771 46 Olomouc"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-4666","authenticated-orcid":false,"given":"Radovan","family":"Herchel","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials"},{"name":"Faculty of Science"},{"name":"Palack\u00fd University in Olomouc"},{"name":"771 46 Olomouc"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Jewula","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials"},{"name":"Faculty of Science"},{"name":"Palack\u00fd University in Olomouc"},{"name":"771 46 Olomouc"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-3585","authenticated-orcid":false,"given":"Zden\u011bk","family":"Dvo\u0159\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics & Regional Centre of Advanced Technologies and Materials"},{"name":"Faculty of Science"},{"name":"Palack\u00fd University in Olomouc"},{"name":"783 71 Olomouc"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8DT00193F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"C8DT00193F-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1039\/c3cc41143e","volume":"49","author":"Barry","year":"2013","journal-title":"Chem. Commun."},{"key":"C8DT00193F-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.drudis.2014.06.016","volume":"19","author":"Hanif","year":"2014","journal-title":"Drug Discovery Today"},{"key":"C8DT00193F-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1021\/jm100560f","volume":"53","author":"Fu","year":"2010","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e3852","DOI":"10.1002\/aoc.3852","volume":"31","author":"Matsheku","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"C8DT00193F-(cit3c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acs.inorgchem.6b02430","volume":"56","author":"Riedl","year":"2017","journal-title":"Inorg. Chem."},{"key":"C8DT00193F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1021\/jm701538w","volume":"51","author":"Kostrhunova","year":"2008","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1021\/acs.jmedchem.5b00655","volume":"58","author":"Romero-Canel\u00f3n","year":"2015","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E3800","DOI":"10.1073\/pnas.1500925112","volume":"112","author":"Hearn","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8DT00193F-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/jm3017442","volume":"56","author":"Romero-Canel\u00f3n","year":"2013","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1039\/C5SC04205D","volume":"7","author":"Raveendran","year":"2016","journal-title":"Chem. Sci."},{"key":"C8DT00193F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/acs.organomet.6b00197","volume":"35","author":"Agonigi","year":"2016","journal-title":"Organometallics"},{"key":"C8DT00193F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/bjc.1992.145","volume":"65","author":"Rhodes","year":"1992","journal-title":"Br. J. Cancer"},{"key":"C8DT00193F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/pr.111.005512","volume":"65","author":"Chiu","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"C8DT00193F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1517\/13543784.2013.853037","volume":"22","author":"\u010cin\u010d\u00e1rov\u00e1","year":"2013","journal-title":"Expert Opin. Invest. Drugs"},{"key":"C8DT00193F-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1517\/13543784.2010.510514","volume":"19","author":"Marks","year":"2010","journal-title":"Expert Opin. Invest. Drugs"},{"key":"C8DT00193F-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"C8DT00193F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/ejic.201601249","volume":"2017","author":"Gichumbi","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"C8DT00193F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3390\/molecules21121725","volume":"21","author":"\u0160tarha","year":"2016","journal-title":"Molecules"},{"key":"C8DT00193F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jinorgbio.2011.03.001","volume":"105","author":"Griffith","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"C8DT00193F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0928-0987(02)00146-X","volume":"17","author":"Gulyaeva","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"C8DT00193F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1107\/S0108768102003890","volume":"58","author":"Allen","year":"2002","journal-title":"Acta Crystallogr., Sect. B: Struct. Sci."},{"key":"C8DT00193F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1021\/om100127f","volume":"29","author":"Romain","year":"2010","journal-title":"Organometallics"},{"key":"C8DT00193F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jorganchem.2014.08.034","volume":"772\u2013773","author":"Makhubela","year":"2014","journal-title":"J. Organomet. Chem."},{"key":"C8DT00193F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jinorgbio.2015.12.003","volume":"156","author":"Zajac","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"C8DT00193F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/jm901556u","volume":"53","author":"van Rijt","year":"2010","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1039\/C4RA15649H","volume":"5","author":"Patalenszki","year":"2015","journal-title":"RSC Adv."},{"key":"C8DT00193F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jinorgbio.2017.07.027","volume":"175","author":"P\u0103unescu","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"C8DT00193F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1039\/c3cc40432c","volume":"49","author":"Kandioller","year":"2013","journal-title":"Chem. Commun."},{"key":"C8DT00193F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1039\/c0mt00101e","volume":"3","author":"Groessl","year":"2011","journal-title":"Metallomics"},{"key":"C8DT00193F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s002800000166","volume":"46","author":"McKeage","year":"2000","journal-title":"Cancer Chemother. Pharmacol."},{"key":"C8DT00193F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1003","DOI":"10.1038\/cddis.2013.540","volume":"5","author":"Bachran","year":"2014","journal-title":"Cell Death Dis."},{"key":"C8DT00193F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radicals Biol. Med."},{"key":"C8DT00193F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1073\/pnas.0800076105","volume":"105","author":"Dougan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8DT00193F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphar.2014.00151","volume":"5","author":"Ribas","year":"2014","journal-title":"Front. Pharmacol."},{"key":"C8DT00193F-(cit30)\/*[position()=1]","first-page":"836","volume":"8","author":"Alas","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"C8DT00193F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/cplu.201600413","volume":"81","author":"Cross","year":"2016","journal-title":"ChemPlusChem"},{"key":"C8DT00193F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/jm00002a007","volume":"38","author":"Frejaville","year":"1995","journal-title":"J. Med. Chem."},{"key":"C8DT00193F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jmr.2005.08.013","volume":"178","author":"Stoll","year":"2006","journal-title":"J. Magn. Reson."},{"key":"C8DT00193F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.freeradbiomed.2005.12.029","volume":"40","author":"Culcasi","year":"2006","journal-title":"Free Radicals Biol. Med."},{"key":"C8DT00193F-(cit35)\/*[position()=1]","first-page":"73","volume":"2","author":"Neese","year":"2012","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"key":"C8DT00193F-(cit36a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B: Condens. Matter Mater. Phys."},{"key":"C8DT00193F-(cit36b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1063\/1.464304","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"C8DT00193F-(cit36c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"C8DT00193F-(cit36d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11623","DOI":"10.1021\/j100096a001","volume":"98","author":"Stephens","year":"1994","journal-title":"J. Phys. Chem."},{"key":"C8DT00193F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1039\/b508541a","volume":"7","author":"Weigend","year":"2005","journal-title":"Phys. Chem. Chem. Phys."},{"key":"C8DT00193F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1021\/jp9716997","volume":"102","author":"Barone","year":"1998","journal-title":"J. Phys. Chem. A"},{"key":"C8DT00193F-(cit39a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"154104","DOI":"10.1063\/1.3382344","volume":"132","author":"Grimme","year":"2010","journal-title":"J. Chem. Phys."},{"key":"C8DT00193F-(cit39b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/jcc.21759","volume":"32","author":"Grimme","year":"2011","journal-title":"J. Comput. Chem."},{"key":"C8DT00193F-(cit40a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1142\/9789812830586_0008","volume-title":"Recent Advances in Density Functional Methods, Part 1","author":"Barone","year":"1995","unstructured":"V. Barone  , in  Recent Advances in Density Functional Methods, Part 1 , ed.  D. P. Chong ,  World Scientific ,  Singapore ,  1995 , p.  287"},{"key":"C8DT00193F-(cit40b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1063\/1.472906","volume":"105","author":"Rega","year":"1996","journal-title":"J. Chem. Phys."},{"key":"C8DT00193F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1002\/chem.201500534","volume":"21","author":"Coverdale","year":"2015","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8DT00193F-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1021\/jo971176v","volume":"62","author":"Gottlieb","year":"1997","journal-title":"J. Org. Chem."},{"key":"C8DT00193F-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr., Sect. C: Struct. Chem."},{"key":"C8DT00193F-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1107\/S0021889807067908","volume":"41","author":"Macrae","year":"2008","journal-title":"J. Appl. Crystallogr."}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/DT\/C8DT00193F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:51:48Z","timestamp":1782928308000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/47\/16\/5714-5724\/601713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":55,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8dt00193f","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8DT00193F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=C8DT00193F","name":"related_data"},{"value":"Pavel \u0160tarha (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0422-045X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zden\u011bk Tr\u00e1vn\u00ed\u010dek (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5890-7874","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Radovan Herchel (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8262-4666","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Radovan Herchel (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/B-4339-2008","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zden\u011bk Dvo\u0159\u00e1k (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3938-3585","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 16 January 2018; Accepted 20 March 2018;  Accepted Manuscript published 21 March 2018;  Advance Article published 10 April 2018;  Version of Record published 24 April 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}