{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:11:05Z","timestamp":1792797065855,"version":"4.5.0"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"am","delay-in-days":554,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    Quercetin can ameliorate alcohol-induced acute liver injury\n                    <italic>via<\/italic>\n                    inducing heme oxygenase-1 and inhibiting NLRP3 inflammasome activation.\n                  <\/p>","DOI":"10.1039\/c8fo00650d","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T09:06:34Z","timestamp":1531127194000},"page":"4184-4193","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury\n                    <i>via<\/i>\n                    inhibiting NLRP3 inflammasome activation"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-4879","authenticated-orcid":false,"given":"Shu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Geriatrics"},{"name":"The First Affiliated Hospital of China Medical University"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"},{"name":"The First Affiliated Hospital of Jinzhou Medical University"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangrui","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology"},{"name":"Shengjing Hospital of China Medical University"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics"},{"name":"The First Affiliated Hospital of China Medical University"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics"},{"name":"The First Affiliated Hospital of China Medical University"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"issue":"2","key":"C8FO00650D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0192393","DOI":"10.1371\/journal.pone.0192393","volume":"13","author":"Hughes","year":"2018","journal-title":"PLoS One"},{"issue":"5","key":"C8FO00650D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acsnano.7b01522","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"issue":"8","key":"C8FO00650D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1039\/C4NP00130C","volume":"32","author":"AlQathama","year":"2015","journal-title":"Nat. Prod. Rep."},{"issue":"5","key":"C8FO00650D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1159\/000484075","volume":"43","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"C8FO00650D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fct.2018.02.019","volume":"114","author":"Zhu","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"C8FO00650D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1039\/C7FO01383C","volume":"8","author":"Zhao","year":"2017","journal-title":"Food Funct."},{"issue":"1","key":"C8FO00650D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"C8FO00650D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31777","DOI":"10.1038\/srep31777","volume":"6","author":"Rojas","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"C8FO00650D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jhep.2007.02.008","volume":"47","author":"Yao","year":"2007","journal-title":"J. Hepatol."},{"issue":"13","key":"C8FO00650D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.2174\/0929867324666170616110748","volume":"25","author":"Pittala","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"C8FO00650D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"C8FO00650D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","volume":"62","author":"Affo","year":"2013","journal-title":"Gut"},{"issue":"3","key":"C8FO00650D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3892\/ijmm.2013.1229","volume":"31","author":"Chang","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"9","key":"C8FO00650D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00210-017-1389-9","volume":"390","author":"Atef","year":"2017","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"issue":"6","key":"C8FO00650D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2841","DOI":"10.1038\/cddis.2017.236","volume":"8","author":"Ge","year":"2017","journal-title":"Cell Death Dis."},{"issue":"3","key":"C8FO00650D-(cit16)\/*[position()=1]","first-page":"1139","volume":"9","author":"Zong","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"C8FO00650D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"751374","DOI":"10.1155\/2013\/751374","volume":"2013","author":"DeSantis","year":"2013","journal-title":"Mediators Inflammation"},{"issue":"4","key":"C8FO00650D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"C8FO00650D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/nu8010027","volume":"8","author":"Yu","year":"2016","journal-title":"Nutrients"},{"key":"C8FO00650D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.fct.2014.02.022","volume":"67","author":"Tang","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"C8FO00650D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/mnfr.201400913","volume":"59","author":"Pisonero-Vaquero","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"C8FO00650D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/10520295.2015.1085093","volume":"91","author":"Taslidere","year":"2016","journal-title":"Biotech. Histochem."},{"issue":"48","key":"C8FO00650D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/0973-1296.192203","volume":"12","author":"Zhu","year":"2016","journal-title":"Pharmacogn. Mag."},{"issue":"1","key":"C8FO00650D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1293\/tox.2015-0035","volume":"29","author":"Palipoch","year":"2016","journal-title":"J. Toxicol. Pathol."},{"key":"C8FO00650D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.03.014","volume":"269","author":"Kemelo","year":"2017","journal-title":"Chem.-Biol. Interact."},{"key":"C8FO00650D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2017.02.016","volume":"102","author":"Wang","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"C8FO00650D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1600858","DOI":"10.1002\/mnfr.201600858","volume":"61","author":"Wu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO00650D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejphar.2014.06.006","volume":"738","author":"Xin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"C8FO00650D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.3892\/mmr.2014.2026","volume":"9","author":"Wang","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"C8FO00650D-(cit30)\/*[position()=1]","first-page":"H861","volume":"283","author":"Takamiya","year":"2002","journal-title":"Am. J. Physiol."},{"issue":"6","key":"C8FO00650D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"1","key":"C8FO00650D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e84953","DOI":"10.1371\/journal.pone.0084953","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"C8FO00650D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.24341","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatology"},{"issue":"10","key":"C8FO00650D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","volume":"122","author":"Petrasek","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"2","key":"C8FO00650D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1189\/jlb.3AB1214-590R","volume":"98","author":"Petrasek","year":"2015","journal-title":"J. Leukocyte Biol."},{"key":"C8FO00650D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.intimp.2017.09.007","volume":"52","author":"Hu","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"C8FO00650D-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2014.02.017","volume":"20","author":"Luo","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"C8FO00650D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/ijms19020562","volume":"19","author":"Hennig","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"C8FO00650D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jnutbio.2017.10.010","volume":"53","author":"Borghi","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"6","key":"C8FO00650D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1139\/cjpp-2015-0038","volume":"93","author":"Wang","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"9\u201310","key":"C8FO00650D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.imbio.2010.05.020","volume":"215","author":"Sierra-Filardi","year":"2010","journal-title":"Immunobiology"},{"issue":"1","key":"C8FO00650D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12876-017-0651-4","volume":"17","author":"Zhang","year":"2017","journal-title":"BMC Gastroenterol."},{"issue":"1","key":"C8FO00650D-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yexcr.2017.10.029","volume":"362","author":"Yu","year":"2018","journal-title":"Exp. Cell Res."},{"key":"C8FO00650D-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3389\/fimmu.2017.00883","volume":"8","author":"Carasi","year":"2017","journal-title":"Front. Immunol."},{"issue":"4","key":"C8FO00650D-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1053\/j.gastro.2012.12.025","volume":"144","author":"Cnyiah","year":"2013","journal-title":"Gastroenterology"},{"issue":"4","key":"C8FO00650D-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23427","volume":"51","author":"Mandal","year":"2010","journal-title":"Hepatology"},{"key":"C8FO00650D-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1423-0127-17-12","volume":"17","author":"Bai","year":"2010","journal-title":"J. Biomed. Sci."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C8FO00650D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:35:40Z","timestamp":1782876940000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/9\/8\/4184-4193\/605227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo00650d","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8FO00650D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Shu Liu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2409-4879","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 10 April 2018; Accepted 14 June 2018;  Accepted Manuscript published 9 July 2018;  Advance Article published 11 July 2018;  Version of Record published 15 August 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}