{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:46Z","timestamp":1790041306476,"version":"4.0.1"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Coenzyme Q10 regulates lipid metabolism to ameliorate the progression of NAFLD by activating the AMPK pathway.<\/p>","DOI":"10.1039\/c8fo01236a","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T22:04:37Z","timestamp":1547762677000},"page":"814-823","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway"],"prefix":"10.1039","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-5811","authenticated-orcid":false,"given":"Ke","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Nutrition"},{"name":"School of Public Health"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8FO01236A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology"},{"key":"C8FO01236A-(cit2)\/*[position()=1]","first-page":"447","volume":"111","author":"Weiss","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"C8FO01236A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"C8FO01236A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.3748\/wjg.v19.i32.5334","volume":"19","author":"Liao","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"C8FO01236A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/jgh.12334","volume":"29","author":"Xiao","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"C8FO01236A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.exger.2013.05.059","volume":"48","author":"Wang","year":"2013","journal-title":"Exp. Gerontol."},{"key":"C8FO01236A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1440-1746.2010.06509.x","volume":"26","author":"Hou","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"C8FO01236A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/j.1440-1746.2005.04058.x","volume":"20","author":"Fan","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"key":"C8FO01236A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"C8FO01236A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radicals Biol. Med."},{"key":"C8FO01236A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"C8FO01236A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.biopha.2017.10.035","volume":"97","author":"Zhou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"C8FO01236A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/07315724.2001.10719063","volume":"20","author":"Crane","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"C8FO01236A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1258\/000456303321610493","volume":"40","author":"Hargreaves","year":"2003","journal-title":"Ann. Clin. Biochem."},{"key":"C8FO01236A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s002530051632","volume":"53","author":"Matthews","year":"2000","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"C8FO01236A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02535072","volume":"24","author":"Kalen","year":"1989","journal-title":"Lipids"},{"key":"C8FO01236A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cca.2015.08.002","volume":"450","author":"Yang","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"C8FO01236A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.juro.2012.03.131","volume":"188","author":"Safarinejad","year":"2012","journal-title":"J. Urol."},{"key":"C8FO01236A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.atherosclerosis.2011.02.050","volume":"217","author":"Toyama","year":"2011","journal-title":"Atherosclerosis"},{"key":"C8FO01236A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/07315724.2015.1021057","volume":"35","author":"Farsi","year":"2016","journal-title":"J. Am. Coll. Nutr."},{"key":"C8FO01236A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.arcmed.2014.11.001","volume":"45","author":"Farhangi","year":"2014","journal-title":"Arch. Med. Res."},{"key":"C8FO01236A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1139\/apnm-2016-0320","volume":"42","author":"Saleh","year":"2017","journal-title":"Appl. Physiol., Nutr., Metab."},{"key":"C8FO01236A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.RES.80.4.482","volume":"80","author":"Makinde","year":"1997","journal-title":"Circ. Res."},{"key":"C8FO01236A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1073\/pnas.252625599","volume":"99","author":"Zong","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01236A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1096\/fasebj.9.7.7737463","volume":"9","author":"Henin","year":"1995","journal-title":"FASEB J."},{"key":"C8FO01236A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/ars.2010.3350","volume":"14","author":"Bour","year":"2011","journal-title":"Antioxid. Redox Signaling"},{"key":"C8FO01236A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1089\/ars.2013.5406","volume":"20","author":"Tian","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"key":"C8FO01236A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"key":"C8FO01236A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-132-2-200001180-00004","volume":"132","author":"Bellentani","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"C8FO01236A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"Cai","year":"2005","journal-title":"Nat. Med."},{"key":"C8FO01236A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/er.2008-0009","volume":"29","author":"Stefan","year":"2008","journal-title":"Endocr. Rev."},{"key":"C8FO01236A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"C8FO01236A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2009.12.006","volume":"48","author":"Kim","year":"2010","journal-title":"Free Radicals Biol. Med."},{"key":"C8FO01236A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"C8FO01236A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00019.2009","volume":"90","author":"Tappy","year":"2010","journal-title":"Physiol. Rev."},{"key":"C8FO01236A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00018-003-3216-3","volume":"61","author":"Mandard","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"C8FO01236A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1038\/s41598-017-08899-7","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"C8FO01236A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.bcp.2009.07.008","volume":"78","author":"Sohet","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"C8FO01236A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40200-014-0081-6","volume":"13","author":"Zahedi","year":"2014","journal-title":"J. Diabetes Metab. Disord."},{"key":"C8FO01236A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/jmf.2010.1202","volume":"14","author":"Lee","year":"2011","journal-title":"J. Med. Food"},{"key":"C8FO01236A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jnutbio.2014.06.001","volume":"25","author":"Yang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"C8FO01236A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5483\/BMBRep.2013.46.4.153","volume":"46","author":"Quan","year":"2013","journal-title":"BMB Rep."},{"issue":"Suppl 4","key":"C8FO01236A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/ijo.2008.116","volume":"32","author":"Hardie","year":"2008","journal-title":"Int. J. Obes."},{"key":"C8FO01236A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metab."},{"key":"C8FO01236A-(cit45)\/*[position()=1]","first-page":"G364","volume":"298","author":"Shen","year":"2010","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/FO\/C8FO01236A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:53:34Z","timestamp":1782885214000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/10\/2\/814-823\/605353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,20]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo01236a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8FO01236A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Ke Chen (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1709-5811","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 14 July 2018; Accepted 5 January 2019;  Accepted Manuscript published 18 January 2019;  Advance Article published 24 January 2019;  Version of Record published 20 February 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}