{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:03:03Z","timestamp":1787004183781,"version":"build-2736575974"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"am","delay-in-days":590,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>As a major component of green tea, (\u2212)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists owing to its potential to combat a variety of human diseases including abnormal glucose metabolism in obesity and diabetes.<\/p>","DOI":"10.1039\/c8fo01293h","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:36:42Z","timestamp":1534243002000},"page":"4651-4663","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["(\u2212)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR\/CAR-mediated phase II metabolism in diabetic mice"],"prefix":"10.1039","volume":"9","author":[{"given":"Xiaopeng","family":"Li","sequence":"first","affiliation":[{"name":"College of Food Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering"},{"name":"Wuhan Polytechnic University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Informatics"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijun","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-4367","authenticated-orcid":false,"given":"Zhida","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8FO01293H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2007.12.009","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab."},{"key":"C8FO01293H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0914798107","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01293H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2016.08.001","volume":"21","author":"Almazroo","year":"2017","journal-title":"Clin. Liver Dis."},{"key":"C8FO01293H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18831","DOI":"10.1073\/pnas.0909731106","volume":"106","author":"Dong","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01293H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","volume":"33","author":"Sugatani","year":"2001","journal-title":"Hepatol."},{"key":"C8FO01293H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/mp700103m","volume":"5","author":"Moreau","year":"2008","journal-title":"Mol. Pharm."},{"key":"C8FO01293H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1124\/dmd.110.035568","volume":"38","author":"Gao","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"C8FO01293H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2009.03.003","volume":"20","author":"Wada","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"C8FO01293H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1021\/jf903711q","volume":"58","author":"Yao","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01293H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","volume":"28","author":"Xu","year":"2005","journal-title":"Arch. Pharmacal Res."},{"key":"C8FO01293H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"614","DOI":"10.2174\/138920008785821666","volume":"9","author":"Kakizaki","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"C8FO01293H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/1389200054633899","volume":"6","author":"Qatanani","year":"2005","journal-title":"Curr. Drug Metab."},{"key":"C8FO01293H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tips.2012.07.003","volume":"33","author":"Gao","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"C8FO01293H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45139","DOI":"10.1074\/jbc.M405423200","volume":"279","author":"Bhalla","year":"2004","journal-title":"J. Biol. Chem."},{"key":"C8FO01293H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1074\/jbc.M510713200","volume":"281","author":"Miao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"C8FO01293H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1128\/MCB.24.18.7931-7940.2004","volume":"24","author":"Kodama","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"C8FO01293H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1124\/mol.107.041012","volume":"73","author":"Roth","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"C8FO01293H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/mnfr.200700437","volume":"52","author":"Lin","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO01293H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1093\/jn\/136.10.2512","volume":"136","author":"Wolfram","year":"2006","journal-title":"J. Nutr."},{"key":"C8FO01293H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/ajcn\/87.3.778","volume":"87","author":"Venables","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"C8FO01293H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34933","DOI":"10.1074\/jbc.M204672200","volume":"277","author":"Waltner-Law","year":"2002","journal-title":"J. Biol. Chem."},{"key":"C8FO01293H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.freeradbiomed.2006.09.028","volume":"42","author":"Kluth","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"C8FO01293H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0278-6915(02)00022-4","volume":"40","author":"Embola","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"C8FO01293H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/jf970963q","volume":"46","author":"Lin","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01293H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0278-6915(98)00019-2","volume":"36","author":"Bu-Abbas","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"C8FO01293H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1039\/C7FO00749C","volume":"8","author":"Li","year":"2017","journal-title":"Food Funct."},{"key":"C8FO01293H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.freeradbiomed.2006.09.028","volume":"42","author":"Kluth","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"C8FO01293H-(cit28)\/*[position()=1]","first-page":"1045","volume":"25","author":"Chen","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"C8FO01293H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2174\/138920006778520552","volume":"7","author":"Feng","year":"2006","journal-title":"Curr. Drug Metab."},{"key":"C8FO01293H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.foodchem.2016.06.100","volume":"214","author":"Tan","year":"2017","journal-title":"Food Chem."},{"key":"C8FO01293H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.foodchem.2010.11.016","volume":"126","author":"Zhang","year":"2011","journal-title":"Food Chem."},{"key":"C8FO01293H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jff.2016.08.022","volume":"26","author":"Kadouh","year":"2016","journal-title":"J. Funct. Foods"},{"key":"C8FO01293H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1021\/acs.jafc.5b01082","volume":"63","author":"Wu","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01293H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jff.2016.08.010","volume":"27","author":"Li","year":"2016","journal-title":"J. Funct. Foods"},{"key":"C8FO01293H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.addr.2010.08.006","volume":"62","author":"Tolson","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"C8FO01293H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/ijms11041365","volume":"11","author":"Hanhineva","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"C8FO01293H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/mnfr.201200511","volume":"57","author":"Williamson","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO01293H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/mnfr.201200206","volume":"56","author":"Forester","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO01293H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/10408398.2010.548108","volume":"53","author":"Xiao","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"C8FO01293H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1021\/jf301147n","volume":"60","author":"Yilmazer-Musa","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01293H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.febslet.2004.12.099","volume":"579","author":"Johnston","year":"2005","journal-title":"FEBS Lett."},{"key":"C8FO01293H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1469-7793.2001.0585h.x","volume":"531","author":"Kellett","year":"2001","journal-title":"J. Physiol."},{"key":"C8FO01293H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.clnu.2008.03.007","volume":"27","author":"Hsu","year":"2008","journal-title":"Clin. Nutr."},{"key":"C8FO01293H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1017\/S0007114508047727","volume":"101","author":"Brown","year":"2009","journal-title":"Br. J. Nutr."},{"key":"C8FO01293H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1039\/c0fo00132e","volume":"1","author":"Monagas","year":"2010","journal-title":"Food Funct."},{"key":"C8FO01293H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1124\/jpet.108.147371","volume":"329","author":"Wang","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"C8FO01293H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pneurobio.2012.09.003","volume":"100","author":"Zhang","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"C8FO01293H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1039\/C7FO00749C","volume":"8","author":"Li","year":"2017","journal-title":"Food Funct."},{"key":"C8FO01293H-(cit49)\/*[position()=1]","first-page":"1","author":"Pan","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"C8FO01293H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.2337\/db11-1716","volume":"61","author":"Xu","year":"2012","journal-title":"Diabetes"},{"key":"C8FO01293H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11154-014-9305-9","volume":"16","author":"Zhang","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"C8FO01293H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2006.11.012","volume":"5","author":"Chen","year":"2007","journal-title":"Cell Metab."},{"key":"C8FO01293H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biopha.2015.12.013","volume":"78","author":"Chowdhury","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"C8FO01293H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/mnfr.201500428","volume":"60","author":"Yang","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO01293H-(cit55)\/*[position()=1]","first-page":"1","volume":"62","author":"Huang","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"C8FO01293H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.2337\/dc10-0460","volume":"33","author":"Sun","year":"2010","journal-title":"Diabetes Care"},{"key":"C8FO01293H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BJ20070481","volume":"407","author":"Kodama","year":"2007","journal-title":"Biochem. J."},{"key":"C8FO01293H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30143","DOI":"10.1074\/jbc.M702390200","volume":"282","author":"Collins","year":"2007","journal-title":"J. Biol. Chem."},{"key":"C8FO01293H-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","volume":"46","author":"Na","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"C8FO01293H-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1039\/C7FO01554B","volume":"9","author":"Mi","year":"2018","journal-title":"Food Funct."},{"key":"C8FO01293H-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/me.2015-1145","volume":"29","author":"Gao","year":"2015","journal-title":"Mol. Endocrinol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C8FO01293H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:38:45Z","timestamp":1782851925000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/9\/9\/4651-4663\/605361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo01293h","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8FO01293H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Zhida Sun (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2822-4367","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 June 2018; Accepted 10 August 2018;  Accepted Manuscript published 14 August 2018;  Advance Article published 5 September 2018;  Version of Record published 19 September 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}