{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:55:49Z","timestamp":1782975349815,"version":"3.54.5"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"am","delay-in-days":673,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    This study provides insight into the system-level hypoglycemic mechanisms of\n                    <italic>Ganoderma lucidum<\/italic>\n                    polysaccharides F31 by the integrative analysis of transcriptomics and proteomics data.\n                  <\/p>","DOI":"10.1039\/c8fo01656a","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T01:04:14Z","timestamp":1541379854000},"page":"6495-6507","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hypoglycemic mechanisms of\n                    <i>Ganoderma lucidum<\/i>\n                    polysaccharides F31 in db\/db mice\n                    <i>via<\/i>\n                    RNA-seq and iTRAQ"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-657X","authenticated-orcid":false,"given":"Chun","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China"},{"name":"Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application"},{"name":"Guangdong Open Laboratory of Applied Microbiology"},{"name":"Guangdong Institute of Microbiology"},{"name":"Guangzhou 510070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China"},{"name":"Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application"},{"name":"Guangdong Open Laboratory of Applied Microbiology"},{"name":"Guangdong Institute of Microbiology"},{"name":"Guangzhou 510070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China"},{"name":"Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application"},{"name":"Guangdong Open Laboratory of Applied Microbiology"},{"name":"Guangdong Institute of Microbiology"},{"name":"Guangzhou 510070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Toxicology"},{"name":"Center for Disease Control and Prevention of Guangdong Province"},{"name":"Guangzhou 510020"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YinRun","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China"},{"name":"Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application"},{"name":"Guangdong Open Laboratory of Applied Microbiology"},{"name":"Guangdong Institute of Microbiology"},{"name":"Guangzhou 510070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China"},{"name":"Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application"},{"name":"Guangdong Open Laboratory of Applied Microbiology"},{"name":"Guangdong Institute of Microbiology"},{"name":"Guangzhou 510070"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8FO01656A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1055\/s-0035-1546131","volume":"81","author":"Ros","year":"2015","journal-title":"Planta Med."},{"key":"C8FO01656A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"C8FO01656A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MED.0b013e328350583a","volume":"19","author":"Lam","year":"2012","journal-title":"Curr. Opin. Endocrinol., Diabetes Obes."},{"key":"C8FO01656A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-012-0187-4","volume":"56","author":"De Silva","year":"2012","journal-title":"Fungal Divers."},{"key":"C8FO01656A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1615\/IntJMedMushr.v13.i5.10","volume":"13","author":"Lo","year":"2011","journal-title":"Int. J. Med. Mushrooms"},{"key":"C8FO01656A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.phytochem.2015.02.017","volume":"114","author":"Ma","year":"2015","journal-title":"Phytochemistry"},{"key":"C8FO01656A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2007-969507","author":"Hikino","year":"1985","journal-title":"Planta Med."},{"key":"C8FO01656A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/S0031-9422(00)83748-6","volume":"25","author":"Tomoda","year":"1986","journal-title":"Phytochemistry"},{"key":"C8FO01656A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/s-2006-962057","author":"Hikino","year":"1989","journal-title":"Planta Med."},{"key":"C8FO01656A-(cit10)\/*[position()=1]","first-page":"191","volume":"25","author":"Zhang","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"C8FO01656A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1021\/jf200527y","volume":"59","author":"Teng","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01656A-(cit12)\/*[position()=1]","first-page":"166","volume":"16","author":"Teng","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"C8FO01656A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1017\/S0007114512000153","volume":"108","author":"Wang","year":"2012","journal-title":"Br. J. Nutr."},{"key":"C8FO01656A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e68332","DOI":"10.1371\/journal.pone.0068332","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"key":"C8FO01656A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.phymed.2011.03.011","volume":"18","author":"Fatmawati","year":"2011","journal-title":"Phytomedicine"},{"key":"C8FO01656A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1016\/j.bmcl.2013.08.084","volume":"23","author":"Fatmawati","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C8FO01656A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.phymed.2008.10.004","volume":"16","author":"Seto","year":"2009","journal-title":"Phytomedicine"},{"key":"C8FO01656A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s12272-012-1012-z","volume":"35","author":"Xiao","year":"2012","journal-title":"Arch. Pharmacal Res."},{"key":"C8FO01656A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jep.2016.11.044","volume":"196","author":"Xiao","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"C8FO01656A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1074\/mcp.M700500-MCP200","volume":"7","author":"Ralhan","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"C8FO01656A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/1471-2164-13-412","volume":"13","author":"Tonner","year":"2012","journal-title":"BMC Genomics"},{"key":"C8FO01656A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/nmeth.1436","volume":"7","author":"Gehlenborg","year":"2010","journal-title":"Nat. Methods"},{"key":"C8FO01656A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0009-8981(71)90332-9","volume":"32","author":"Stevens","year":"1971","journal-title":"Clin. Chim. Acta"},{"key":"C8FO01656A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"C8FO01656A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"C8FO01656A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"C8FO01656A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1093\/nar\/gkq224","volume":"38","author":"Hansen","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"C8FO01656A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1101\/gr.124321.111","volume":"21","author":"Tarazona","year":"2011","journal-title":"Genome Res."},{"key":"C8FO01656A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1021\/pr900251d","volume":"8","author":"Xu","year":"2009","journal-title":"J. Proteome Res."},{"key":"C8FO01656A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.3390\/ijms161025121","volume":"16","author":"Fang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"C8FO01656A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22011","DOI":"10.3390\/ijms151222011","volume":"15","author":"Tang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"C8FO01656A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","volume":"20","author":"Saldanha","year":"2004","journal-title":"Bioinformatics"},{"key":"C8FO01656A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"C8FO01656A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1039\/C5FO00497G","volume":"6","author":"Xiao","year":"2015","journal-title":"Food Funct."},{"key":"C8FO01656A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1074\/mcp.M900020-MCP200","volume":"9","author":"Deng","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"C8FO01656A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jep.2016.11.044","volume":"196","author":"Xiao","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"C8FO01656A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e72367","DOI":"10.1371\/journal.pone.0072367","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"C8FO01656A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1074\/mcp.M112.023986","volume":"12","author":"Wang","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"C8FO01656A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1016\/j.febslet.2009.10.036","volume":"583","author":"Maier","year":"2009","journal-title":"FEBS Lett."},{"key":"C8FO01656A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrg3037","volume":"12","author":"Muers","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"C8FO01656A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.beem.2007.09.001","volume":"21","author":"Agius","year":"2007","journal-title":"Best Pract. Res., Clin. Endocrinol. Metab."},{"key":"C8FO01656A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.molmet.2014.12.007","volume":"4","author":"Haeusler","year":"2015","journal-title":"Mol. Metab."},{"key":"C8FO01656A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1248\/bpb.29.1634","volume":"29","author":"Yoshinari","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"C8FO01656A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/bbrc.1999.0202","volume":"255","author":"Enriquez","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C8FO01656A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1016\/j.bmcl.2007.10.041","volume":"17","author":"Matthews","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C8FO01656A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0005-2760(91)90034-F","volume":"1083","author":"Borghini","year":"1991","journal-title":"Biochim. Biophys. Acta, Lipids Lipid Metab."},{"key":"C8FO01656A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14788","DOI":"10.1073\/pnas.93.25.14788","volume":"93","author":"Weng","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01656A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2337\/diabetes.53.3.672","volume":"53","author":"Sauvaget","year":"2004","journal-title":"Diabetes"},{"key":"C8FO01656A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2337\/diabetes.50.3.643","volume":"50","author":"Castellani","year":"2001","journal-title":"Diabetes"},{"key":"C8FO01656A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00125-014-3451-1","volume":"58","author":"Thorens","year":"2015","journal-title":"Diabetologia"},{"key":"C8FO01656A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbi.2016.07.009","volume":"256","author":"Rathinam","year":"2016","journal-title":"Chem.-Biol. Interact."},{"issue":"Pt 1","key":"C8FO01656A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3370001","volume":"337","author":"Yamada","year":"1999","journal-title":"Biochem. J."},{"key":"C8FO01656A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2500625","volume":"250","author":"Taylor","year":"1988","journal-title":"Biochem. J."},{"key":"C8FO01656A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.biopha.2017.01.146","volume":"88","author":"Dhananjayan","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"C8FO01656A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1242\/jcs.114.8.1439","volume":"114","author":"Cantrell","year":"2001","journal-title":"J. Cell Sci."},{"key":"C8FO01656A-(cit56)\/*[position()=1]","first-page":"110","volume":"2","author":"Acosta-Martinez","year":"2011","journal-title":"Front. Endocrinol."},{"key":"C8FO01656A-(cit57)\/*[position()=1]","first-page":"252","author":"Wu","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"C8FO01656A-(cit58)\/*[position()=1]","first-page":"F1138","volume":"284","author":"Sharma","year":"2003","journal-title":"Am. J. Physiol.: Renal, Fluid Electrolyte Physiol."},{"key":"C8FO01656A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/oby.2009.228","volume":"18","author":"Oswal","year":"2010","journal-title":"Obesity"},{"key":"C8FO01656A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ijo.2015.188","volume":"40","author":"de Moura","year":"2016","journal-title":"Int. J. Obes."},{"key":"C8FO01656A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature14549","volume":"524","author":"Bai","year":"2015","journal-title":"Nature"},{"key":"C8FO01656A-(cit62)\/*[position()=1]","first-page":"783","volume":"44","author":"Zhou","year":"2015","journal-title":"Chin. J. Pathol."},{"key":"C8FO01656A-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/S0024-3205(03)00594-0","volume":"73","author":"Zhang","year":"2003","journal-title":"Life Sci."},{"key":"C8FO01656A-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1111\/febs.13709","volume":"283","author":"Gurzov","year":"2016","journal-title":"FEBS J."},{"key":"C8FO01656A-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4103\/1673-5374.179032","volume":"11","author":"Maiese","year":"2016","journal-title":"Neural Regener. Res."},{"key":"C8FO01656A-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ygcen.2014.09.006","volume":"210","author":"Liu","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"C8FO01656A-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13105-015-0384-1","volume":"71","author":"Zhang","year":"2015","journal-title":"J. Physiol. Biochem."},{"issue":"Suppl 1","key":"C8FO01656A-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/dom.12343","volume":"16","author":"Shibasaki","year":"2014","journal-title":"Diabetes, Obes. Metab."},{"key":"C8FO01656A-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2337\/db14-1036","volume":"64","author":"Tian","year":"2015","journal-title":"Diabetes"},{"key":"C8FO01656A-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ejmech.2016.10.044","volume":"127","author":"Plisson","year":"2016","journal-title":"Eur. J. Med. Chem."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C8FO01656A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:22:50Z","timestamp":1782969770000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/9\/12\/6495-6507\/605456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12,13]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo01656a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8FO01656A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Chun Xiao (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4606-657X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 August 2018; Accepted 5 November 2018; Accepted Manuscript published 5 November 2018; Advance Article published 23 November 2018; Version of Record published 13 December 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}