{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:55:00Z","timestamp":1790949300032,"version":"4.1.0"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"am","delay-in-days":444,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81701928"],"award-info":[{"award-number":["81701928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y20160040"],"award-info":[{"award-number":["Y20160040"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Osteoarthritis (OA), an age-related degenerative disease, is characterized by progressive degradation of the articular cartilage.<\/p>","DOI":"10.1039\/c8fo01786g","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T12:12:51Z","timestamp":1553083971000},"page":"2161-2175","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Inhibiting the PI3K\/AKT\/NF-\u03baB signal pathway with nobiletin for attenuating the development of osteoarthritis:\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    studies"],"prefix":"10.1039","volume":"10","author":[{"given":"Linzhen","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanguang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-0742","authenticated-orcid":false,"given":"Leyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou 325000"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8FO01786G-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/art.10976","volume":"48","author":"Squires","year":"2003","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"62900","DOI":"10.18632\/oncotarget.17036","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"key":"C8FO01786G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/bmj.332.7542.639","volume":"332","author":"Hunter","year":"2006","journal-title":"Br. Med. J."},{"key":"C8FO01786G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1756-185X.2010.01529.x","volume":"13","author":"Haq","year":"2010","journal-title":"Int. J. Rheum. Dis."},{"key":"C8FO01786G-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/art.24737","volume":"61","author":"Dahaghin","year":"2009","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/art.20776","volume":"52","author":"Kobayashi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11926-001-0069-3","volume":"3","author":"Abramson","year":"2001","journal-title":"Curr. Rheumatol. Rep."},{"key":"C8FO01786G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0891-5849(02)01004-3","volume":"33","author":"Ahmed","year":"2002","journal-title":"Free Radicals Biol. Med."},{"key":"C8FO01786G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jor.22577","volume":"32","author":"Chen","year":"2014","journal-title":"J. Orthop. Res."},{"key":"C8FO01786G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2165\/11599350-000000000-00000","volume":"29","author":"Jotanovic","year":"2012","journal-title":"Drugs Aging"},{"key":"C8FO01786G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.joca.2010.12.003","volume":"19","author":"Kerkhof","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1002\/jcb.23257","volume":"112","author":"Lam","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"C8FO01786G-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1248\/bpb.33.1814","volume":"33","author":"Cui","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"C8FO01786G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4161\/cbt.7.6.5967","volume":"7","author":"Luo","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"C8FO01786G-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db10-0589","volume":"60","author":"Mulvihill","year":"2011","journal-title":"Diabetes"},{"key":"C8FO01786G-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jff.2015.09.035","volume":"19","author":"Wu","year":"2015","journal-title":"J. Funct. Foods"},{"key":"C8FO01786G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1254\/jphs.10193SC","volume":"115","author":"Harada","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"C8FO01786G-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1039\/C7FO01311F","volume":"8","author":"Yang","year":"2017","journal-title":"Food Funct."},{"key":"C8FO01786G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s10753-017-0558-9","volume":"40","author":"Zheng","year":"2017","journal-title":"Inflammation"},{"key":"C8FO01786G-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1039\/C7FO01199G","volume":"9","author":"Zheng","year":"2018","journal-title":"Food Funct."},{"key":"C8FO01786G-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"C8FO01786G-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/annrheumdis-2014-205743","volume":"74","author":"Vasheghani","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"C8FO01786G-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s10753-018-0753-3","volume":"41","author":"Li","year":"2018","journal-title":"Inflammation"},{"key":"C8FO01786G-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2011.04.011","volume":"19","author":"Lewis","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"key":"C8FO01786G-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2013.01.057","volume":"708","author":"Ding","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"C8FO01786G-(cit30)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1661-x","author":"Hagenlocher","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"C8FO01786G-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2013.08.029","volume":"439","author":"Yoshigai","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C8FO01786G-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00002281-199805000-00018","volume":"10","author":"Amin","year":"1998","journal-title":"Curr. Opin. Rheumatol."},{"key":"C8FO01786G-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1172\/JCI113823","volume":"82","author":"Goldring","year":"1988","journal-title":"J. Clin. Invest."},{"key":"C8FO01786G-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/375408a0","volume":"375","author":"Wei","year":"1995","journal-title":"Nature"},{"key":"C8FO01786G-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/oxfordjournals.jbchem.a021955","volume":"123","author":"Sasaki","year":"1998","journal-title":"J. Biochem."},{"issue":"Suppl 1","key":"C8FO01786G-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1097\/00002371-200203001-00009","volume":"25","author":"Futani","year":"2002","journal-title":"J. Immunother."},{"key":"C8FO01786G-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1073\/pnas.0911377107","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01786G-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"C8FO01786G-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"key":"C8FO01786G-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","volume":"97","author":"Mitchell","year":"1996","journal-title":"J. Clin. Invest."},{"key":"C8FO01786G-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1016\/j.bmc.2005.07.076","volume":"13","author":"Hu","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"C8FO01786G-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/art.22334","volume":"56","author":"Song","year":"2007","journal-title":"Arthritis Rheum."},{"key":"C8FO01786G-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbrc.2008.05.171","volume":"373","author":"Imada","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C8FO01786G-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2016.11.009","volume":"42","author":"Zheng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"C8FO01786G-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10753-017-0530-8","volume":"40","author":"Zheng","year":"2017","journal-title":"Inflammation"},{"key":"C8FO01786G-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"C8FO01786G-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13859","DOI":"10.1073\/pnas.95.23.13859","volume":"95","author":"Miagkov","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8FO01786G-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"C8FO01786G-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joca.2005.10.009","volume":"14","author":"Lianxu","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcb.24362","volume":"114","author":"Chen","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"C8FO01786G-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.3892\/etm.2016.3642","volume":"12","author":"Fu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"C8FO01786G-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biopha.2017.01.130","volume":"89","author":"Xue","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"C8FO01786G-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bcp.2007.01.005","volume":"73","author":"Shakibaei","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"C8FO01786G-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"C8FO01786G-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03008207.2016.1177036","volume":"57","author":"Wei","year":"2016","journal-title":"Connect. Tissue Res."},{"issue":"9","key":"C8FO01786G-(cit57)\/*[position()=1]","first-page":"1461","volume":"56","author":"Hugle","year":"2017","journal-title":"Rheumatology"},{"key":"C8FO01786G-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1016\/j.fct.2012.06.030","volume":"50","author":"Surichan","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"C8FO01786G-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/jf505545x","volume":"63","author":"Zheng","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"C8FO01786G-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.freeradbiomed.2011.10.002","volume":"52","author":"Su","year":"2012","journal-title":"Free Radicals Biol. Med."},{"key":"C8FO01786G-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1021\/acs.jafc.5b05156","volume":"63","author":"Wu","year":"2015","journal-title":"J. Agric. Food Chem."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/FO\/C8FO01786G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:17:32Z","timestamp":1782929852000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/10\/4\/2161-2175\/605482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4,17]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo01786g","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Leyi Cai (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5475-0742","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 11 September 2018; Accepted 19 March 2019; Accepted Manuscript published 20 March 2019; Advance Article published 2 April 2019; Version of Record published 17 April 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}