{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:17:18Z","timestamp":1790245038437,"version":"4.1.0"},"reference-count":31,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"crossref","award":["Frontiers of Nanoscience program"],"award-info":[{"award-number":["Frontiers of Nanoscience program"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["Advanced grants SynDiv (no. 669598)"],"award-info":[{"award-number":["Advanced grants SynDiv (no. 669598)"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["Consolidator Grant Designer- Pores (no. 647144)"],"award-info":[{"award-number":["Consolidator Grant Designer- Pores (no. 647144)"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000727","name":"Trinity College, University of Cambridge","doi-asserted-by":"crossref","award":["Trinity-Henry Barlow Scholarship"],"award-info":[{"award-number":["Trinity-Henry Barlow Scholarship"]}],"id":[{"id":"10.13039\/501100000727","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007443","name":"Friedrich Naumann Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007443","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011693","name":"Department for Business, Energy and Industrial Strategy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011693","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<p>We quantify the membranolytic activity of antimicrobial peptides on biomimetic lipid vesicles in a multilayer microfluidic total analysis system.<\/p>","DOI":"10.1039\/c8lc00932e","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T07:16:01Z","timestamp":1548832561000},"page":"837-844","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["A microfluidic platform for the characterisation of membrane active antimicrobials"],"prefix":"10.1039","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-5894","authenticated-orcid":false,"given":"K.","family":"Al Nahas","sequence":"first","affiliation":[{"name":"Cavendish Laboratory"},{"name":"Univ. of Cambridge"},{"name":"Cambridge CB3 0HE"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-1941","authenticated-orcid":false,"given":"J.","family":"Cama","sequence":"additional","affiliation":[{"name":"Cavendish Laboratory"},{"name":"Univ. of Cambridge"},{"name":"Cambridge CB3 0HE"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-9598","authenticated-orcid":false,"given":"M.","family":"Schaich","sequence":"additional","affiliation":[{"name":"Cavendish Laboratory"},{"name":"Univ. of Cambridge"},{"name":"Cambridge CB3 0HE"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hammond","sequence":"additional","affiliation":[{"name":"National Physical Laboratory"},{"name":"Middlesex TW11 0LW"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-8962","authenticated-orcid":false,"given":"S.","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Kavli Institute of Nanoscience"},{"name":"Delft Univ. of Technology"},{"name":"Delft 2629 HZ"},{"name":"Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-071X","authenticated-orcid":false,"given":"C.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Kavli Institute of Nanoscience"},{"name":"Delft Univ. of Technology"},{"name":"Delft 2629 HZ"},{"name":"Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-1154","authenticated-orcid":false,"given":"M. G.","family":"Ryadnov","sequence":"additional","affiliation":[{"name":"National Physical Laboratory"},{"name":"Middlesex TW11 0LW"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-5414","authenticated-orcid":false,"given":"U. F.","family":"Keyser","sequence":"additional","affiliation":[{"name":"Cavendish Laboratory"},{"name":"Univ. of Cambridge"},{"name":"Cambridge CB3 0HE"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8LC00932E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1016\/j.bmc.2016.06.044","volume":"24","author":"Silver","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"C8LC00932E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/00222615-46-1-1","volume":"46","author":"Hancock","year":"1997","journal-title":"J. Med. Microbiol."},{"key":"C8LC00932E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0167-7799(97)01156-6","volume":"16","author":"Hancock","year":"1998","journal-title":"Trends Biotechnol."},{"key":"C8LC00932E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","volume":"11","author":"Fjell","year":"2012","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C8LC00932E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-319-32189-9_4","volume":"915","author":"Jepson","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"C8LC00932E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1039\/C6SC02925F","volume":"8","author":"Pyne","year":"2017","journal-title":"Chem. Sci."},{"key":"C8LC00932E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bpj.2011.06.044","volume":"101","author":"Li","year":"2011","journal-title":"Biophys. J."},{"key":"C8LC00932E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1039\/C4LC00217B","volume":"14","author":"Cama","year":"2014","journal-title":"Lab Chip"},{"key":"C8LC00932E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32824","DOI":"10.1038\/srep32824","volume":"6","author":"Cama","year":"2016","journal-title":"Sci. Rep."},{"key":"C8LC00932E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"044105","DOI":"10.1063\/1.4816712","volume":"7","author":"Robinson","year":"2013","journal-title":"Biomicrofluidics"},{"key":"C8LC00932E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1038\/s41467-018-04821-5","volume":"9","author":"Ohmann","year":"2018","journal-title":"Nat. Commun."},{"key":"C8LC00932E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1021\/cb800012x","volume":"3","author":"Veatch","year":"2008","journal-title":"ACS Chem. Biol."},{"key":"C8LC00932E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1039\/C7TB01322A","volume":"5","author":"Kamiya","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"C8LC00932E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1039\/c2lc41121k","volume":"13","author":"Van Swaay","year":"2013","journal-title":"Lab Chip"},{"key":"C8LC00932E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nprot.2017.160","volume":"13","author":"Deshpande","year":"2018","journal-title":"Nat. Protoc."},{"key":"C8LC00932E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1039\/C8LC00582F","volume":"18","author":"Haller","year":"2018","journal-title":"Lab Chip"},{"key":"C8LC00932E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1432-1033.1982.tb06857.x","volume":"127","author":"Hultmark","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"C8LC00932E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"034106","DOI":"10.1063\/1.4983174","volume":"11","author":"Deshpande","year":"2017","journal-title":"Biomicrofluidics"},{"key":"C8LC00932E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10447","DOI":"10.1038\/ncomms10447","volume":"7","author":"Deshpande","year":"2016","journal-title":"Nat. Commun."},{"key":"C8LC00932E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1021\/acs.analchem.5b03772","volume":"88","author":"Kazayama","year":"2016","journal-title":"Anal. Chem."},{"key":"C8LC00932E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nprot.2009.234","volume":"5","author":"Qin","year":"2010","journal-title":"Nat. Protoc."},{"key":"C8LC00932E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0250-6874(86)80008-7","volume":"9","author":"Offenbacher","year":"1986","journal-title":"Sens. Actuators"},{"key":"C8LC00932E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1017\/S1551929500055541","volume":"15","author":"Stuurman","year":"2007","journal-title":"Microsc. Today"},{"key":"C8LC00932E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"C8LC00932E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4165(97)00024-X","volume":"1336","author":"Chen","year":"1997","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"C8LC00932E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/la501549v","volume":"30","author":"Efimova","year":"2014","journal-title":"Langmuir"},{"key":"C8LC00932E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1073\/pnas.1222824110","volume":"110","author":"Rakowska","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8LC00932E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s10059-013-2132-0","volume":"35","author":"Hu","year":"2013","journal-title":"Mol. Cells"},{"key":"C8LC00932E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1038\/s41598-018-33289-y","volume":"8","author":"Pfeil","year":"2018","journal-title":"Sci. Rep."},{"key":"C8LC00932E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/acsnano.7b08411","volume":"12","author":"Deshpande","year":"2018","journal-title":"ACS Nano"},{"key":"C8LC00932E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20162","DOI":"10.1074\/jbc.M113.459560","volume":"288","author":"Ryan","year":"2013","journal-title":"J. Biol. Chem."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/LC\/C8LC00932E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:37:49Z","timestamp":1783532269000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/19\/5\/837-844\/607011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,2,26]]}},"URL":"https:\/\/doi.org\/10.1039\/c8lc00932e","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8LC00932E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"K. Al Nahas (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4568-5894","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"J. Cama (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5982-1941","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. Schaich (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5432-9598","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"S. Deshpande (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7137-8962","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"C. Dekker (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6273-071X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. G. Ryadnov (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4847-1154","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"U. F. Keyser (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3188-5414","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 3 September 2018; Accepted 5 December 2018;  Advance Article published 30 January 2019;  Version of Record published 26 February 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}