{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:18:25Z","timestamp":1782929905008,"version":"3.54.5"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"am","delay-in-days":639,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>Scaffolds have been identified which provide promising platforms for future development of chemotherapeutic agents against resistant glioblastoma subtypes.<\/p>","DOI":"10.1039\/c8md00436f","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T04:04:27Z","timestamp":1538453067000},"page":"1850-1861","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Towards identifying potent new hits for glioblastoma"],"prefix":"10.1039","volume":"9","author":[{"given":"Chris","family":"Sherer","sequence":"first","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences"},{"name":"University of Central Lancashire"},{"name":"Preston"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Prabhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"University of East Anglia"},{"name":"Norwich NR4 7TJ"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences"},{"name":"University of Central Lancashire"},{"name":"Preston"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hayes","sequence":"additional","affiliation":[{"name":"School of Physical Sciences and Computing"},{"name":"University of Central Lancashire"},{"name":"Preston"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Rowther","sequence":"additional","affiliation":[{"name":"Brain Tumour Research Centre"},{"name":"University of Wolverhampton"},{"name":"Wolverhampton"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-8299","authenticated-orcid":false,"given":"Ibrahim","family":"Tolaymat","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science"},{"name":"Anglia Ruskin University"},{"name":"Chelmsford"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Warr","sequence":"additional","affiliation":[{"name":"Brain Tumour Research Centre"},{"name":"University of Wolverhampton"},{"name":"Wolverhampton"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-4491","authenticated-orcid":false,"given":"Timothy J.","family":"Snape","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences"},{"name":"University of Central Lancashire"},{"name":"Preston"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8MD00436F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ejca.2014.12.014","volume":"51","author":"Brodbelt","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"C8MD00436F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"C8MD00436F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.bmc.2013.01.032","volume":"21","author":"Prabhu","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"C8MD00436F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1021\/ja002455u","volume":"123","author":"Wright","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"C8MD00436F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/jp037247d","volume":"108","author":"Leopoldini","year":"2004","journal-title":"J. Phys. Chem. A"},{"key":"C8MD00436F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s11224-014-0546-8","volume":"26","author":"Farmanzadeh","year":"2015","journal-title":"Struct. Chem."},{"key":"C8MD00436F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","volume":"455","author":"Chin","year":"2008","journal-title":"Nature"},{"key":"C8MD00436F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"C8MD00436F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"key":"C8MD00436F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-010-0283-9","volume":"102","author":"Blough","year":"2011","journal-title":"J. Neuro-Oncol."},{"key":"C8MD00436F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"46348","DOI":"10.18632\/oncotarget.18013","volume":"8","author":"Murnyak","year":"2017","journal-title":"Oncotarget"},{"key":"C8MD00436F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1158\/0008-5472.CAN-10-1250","volume":"70","author":"Gaspar","year":"2010","journal-title":"Cancer Res."},{"key":"C8MD00436F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/neuonc\/noq086","volume":"12","author":"Potter","year":"2010","journal-title":"J. Neuro-Oncol."},{"key":"C8MD00436F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.drudis.2011.10.024","volume":"17","author":"Sun","year":"2012","journal-title":"Drug Discovery Today"},{"key":"C8MD00436F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11130-004-0049-7","volume":"59","author":"Yao","year":"2004","journal-title":"Plant Foods Hum. Nutr."},{"key":"C8MD00436F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.3390\/molecules15107313","volume":"15","author":"Dai","year":"2010","journal-title":"Molecules"},{"key":"C8MD00436F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1021\/acs.accounts.5b00365","volume":"48","author":"Parkinson","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"C8MD00436F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0959-8049(00)00103-9","volume":"36","author":"Owen","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"C8MD00436F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1021\/jm030956v","volume":"46","author":"Gomes","year":"2003","journal-title":"J. Med. Chem."},{"key":"C8MD00436F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nchembio.85","volume":"4","author":"Winterbourn","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"C8MD00436F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0304-4165(02)00509-3","volume":"1620","author":"Kagan","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"C8MD00436F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.foodchem.2014.05.073","volume":"165","author":"Javan","year":"2014","journal-title":"Food Chem."},{"key":"C8MD00436F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.foodchem.2005.05.042","volume":"97","author":"Trouillas","year":"2006","journal-title":"Food Chem."},{"key":"C8MD00436F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/chem.200390052","volume":"9","author":"Zhang","year":"2003","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8MD00436F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1063\/1.556020","volume":"27","author":"dos Santos","year":"1998","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"C8MD00436F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19550","DOI":"10.1039\/C4CP02640C","volume":"16","author":"Rybina","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"C8MD00436F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14076","DOI":"10.1021\/acs.est.5b03189","volume":"49","author":"Jiang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"C8MD00436F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1359-6446(02)02411-X","volume":"7","author":"Sheridan","year":"2002","journal-title":"Drug Discovery Today"},{"key":"C8MD00436F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"C8MD00436F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/ci800315d","volume":"49","author":"Vainio","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"C8MD00436F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/jcc.21460","volume":"31","author":"Puranen","year":"2010","journal-title":"J. Comput. Chem."},{"key":"C8MD00436F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/14756360500381210","volume":"21","author":"Suzen","year":"2006","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C8MD00436F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.pharmtox.38.1.257","volume":"38","author":"Satoh","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"C8MD00436F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2174\/138955709788452649","volume":"9","author":"Alves","year":"2009","journal-title":"Mini-Rev. Med. Chem."},{"key":"C8MD00436F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"C8MD00436F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.1103\/PhysRevB.33.8822","volume":"33","author":"Perdew","year":"1986","journal-title":"Phys. Rev. B: Condens. Matter Mater. Phys."},{"key":"C8MD00436F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/qua.22555","volume":"111","author":"Kosinova","year":"2011","journal-title":"Int. J. Quantum Chem."},{"key":"C8MD00436F-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jcc.540040303","volume":"4","author":"Clark","year":"1983","journal-title":"J. Comput. Chem."},{"key":"C8MD00436F-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1063\/1.447079","volume":"80","author":"Frisch","year":"1984","journal-title":"J. Chem. Phys."},{"key":"C8MD00436F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1063\/1.438955","volume":"72","author":"Krishnan","year":"1980","journal-title":"J. Chem. Phys."},{"key":"C8MD00436F-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1063\/1.438980","volume":"72","author":"McLean","year":"1980","journal-title":"J. Chem. Phys."},{"key":"C8MD00436F-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1055\/s-0028-1083523","author":"Snape","year":"2008","journal-title":"Synlett"},{"key":"C8MD00436F-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0959-8049(00)00245-8","volume":"36","author":"Lewandowicz","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"C8MD00436F-(cit45)\/*[position()=1]","volume-title":"Methods in Molecular Medicine","volume":"vol. 110","author":"Voigt","year":"2005","unstructured":"W. Voigt , in Methods in Molecular Medicine , 2005 , vol. 110 , pp. 39\u201348"}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/MD\/C8MD00436F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:36:34Z","timestamp":1782927394000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/9\/11\/1850-1861\/607385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,14]]}},"URL":"https:\/\/doi.org\/10.1039\/c8md00436f","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8MD00436F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Joseph Hayes (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-1166-2010","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Ibrahim Tolaymat (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8903-8299","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Timothy J. Snape (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2766-4491","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 31 August 2018; Accepted 1 October 2018; Accepted Manuscript published 2 October 2018; Advance Article published 9 October 2018; Version of Record published 14 November 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}