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Currently, no effective vaccine is available for humans and animals except for dogs. In the present study, an extensive bioinformatics pipeline was established to predict new candidates that can be used for vaccine development including building the protein\u2013protein interaction network based on orthologues of experimentally verified protein\u2013protein interaction networks, elucidation of the proteins involved in the immune response, selection of the topologically-interesting proteins and their prioritization based on their antigenicity. Proteomic network analysis yielded an interactome network with 120 nodes with 97 interactions. Proteins were selected to obtain a subnet containing only the borrelial membrane proteins and immune-related host proteins. This strategy resulted in the selection of 15 borrelial targets, which were subjected to extensive bioinformatics analysis to predict their antigenic properties. Based on the strategy applied in this study the proteins encoded by erpX (ErpX proteins, UniProt ID: H7C7L6), erpL (ErpL protein, UniProt ID: H7C7M3) and erpY (ErpY protein, UniProt ID: Q9S0D9) are suggested as a novel set of vaccine targets to control Lyme disease. Moreover, five different tools were used to validate their antigenicity regarding B-cells. The combination of all these proteins in a vaccine should allow improved protection against Borrelia infection.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c8mo00130h","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T16:34:10Z","timestamp":1533314050000},"page":"330-340","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Omics and bioinformatics applied to vaccine development against\n                    <i>Borrelia<\/i>"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-1812","authenticated-orcid":false,"given":"Elena","family":"Bencurova","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Biocenter, Am Hubland a , D-97074 Wuerzburg, Germany \u00a0 bencurova.elena@gmail.com \u00a0 dandekar@biozentrum.uni-wuerzburg.de \u00a0 +49-931-3184552 \u00a0 +49-931-3184551"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-1597","authenticated-orcid":false,"given":"Shishir K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Biocenter, Am Hubland a , D-97074 Wuerzburg, Germany \u00a0 bencurova.elena@gmail.com \u00a0 dandekar@biozentrum.uni-wuerzburg.de \u00a0 +49-931-3184552 \u00a0 +49-931-3184551"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Oskoueian","sequence":"additional","affiliation":[{"name":"Mashhad Branch, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education, and Extension Organization (AREEO) b , Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangesh","family":"Bhide","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences d , Dubravska cesta 9, Bratislava Slovakia"},{"name":"University of Veterinary Medicine and Pharmacy, Laboratory of Biomedical Microbiology and Immunology c , Komenskeho 73, 04181 Kosice Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-7625","authenticated-orcid":false,"given":"Thomas","family":"Dandekar","sequence":"additional","affiliation":[{"name":"EMBL Heidelberg, BioComputing Unit e , Meyerhofstr. 1, 69117 Heidelberg Germany"},{"name":"Department of Bioinformatics, Biocenter, Am Hubland a , D-97074 Wuerzburg, Germany \u00a0 bencurova.elena@gmail.com \u00a0 dandekar@biozentrum.uni-wuerzburg.de \u00a0 +49-931-3184552 \u00a0 +49-931-3184551"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"issue":"9","key":"2026010815041464000_cit1","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1128\/iai.55.9.2311-2313.1987","article-title":"Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi","volume":"55","author":"Takayama","year":"1987","journal-title":"Infect. 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Gupta (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2335-1597","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Thomas Dandekar (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1886-7625","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 6 June 2018; Accepted 3 August 2018; Accepted Manuscript published 3 August 2018; Advance Article published 16 August 2018; Version of Record published 8 October 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}