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Therefore, it is very necessary to develop some new methods. Although the existing methods are very helpful in this regard, they all present some shortcomings; thus, some new methods need to be developed to overcome these shortcomings. In this study, a method based on dual network sparse graph regularized matrix factorization (DNSGRMF) was proposed, which increased the sparsity by adding the L2,1-norm. Moreover, Gaussian interaction profile kernels were introduced. The experiments showed that our method was feasible and had a high AUC value. Additionally, the five-fold cross-validation method was used to evaluate this method. A simulation experiment was used to predict some new associations on the datasets, and the obtained experimental results were satisfactory, which proved that our method was indeed feasible.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c8mo00244d","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T20:36:01Z","timestamp":1548102961000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Dual-network sparse graph regularized matrix factorization for predicting miRNA\u2013disease associations"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-2600","authenticated-orcid":false,"given":"Ming-Ming","family":"Gao","sequence":"first","affiliation":[{"name":"School of Information Science and Engineering, Qufu Normal University a , Rizhao, China \u00a0 gaommzjr@126.com \u00a0 sdcavell@126.com \u00a0 cuizhensdws@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-6750","authenticated-orcid":false,"given":"Zhen","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Information Science and Engineering, Qufu Normal University a , Rizhao, China \u00a0 gaommzjr@126.com \u00a0 sdcavell@126.com \u00a0 cuizhensdws@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Lian","family":"Gao","sequence":"additional","affiliation":[{"name":"Library of Qufu Normal University, Qufu Normal University b , Rizhao, China \u00a0 yinliangao@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-2149","authenticated-orcid":false,"given":"Jin-Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Co-Innovation Center for Information Supply & Assurance Technology, Anhui University c , Hefei, China \u00a0 zhengch99@126.com"},{"name":"School of Information Science and Engineering, Qufu Normal University a , Rizhao, China \u00a0 gaommzjr@126.com \u00a0 sdcavell@126.com \u00a0 cuizhensdws@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hou","family":"Zheng","sequence":"additional","affiliation":[{"name":"Co-Innovation Center for Information Supply & Assurance Technology, Anhui University c , Hefei, China \u00a0 zhengch99@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"issue":"7","key":"2026010815043814800_cit1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(01)00616-X","article-title":"microRNAs: Tiny Regulators with Great Potential","volume":"107","author":"Ambros","year":"2001","journal-title":"Cell"},{"issue":"5","key":"2026010815043814800_cit2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"6772","key":"2026010815043814800_cit3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"issue":"4","key":"2026010815043814800_cit4","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/nar\/gki200","article-title":"Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis","volume":"33","author":"Cheng","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"2026010815043814800_cit5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gde.2005.08.005","article-title":"How microRNAs control cell division, differentiation and death","volume":"15","author":"Miska","year":"2005","journal-title":"Curr. 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