{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:20:32Z","timestamp":1791390032746,"version":"4.3.3"},"reference-count":123,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":804,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/12719-0"],"award-info":[{"award-number":["2017\/12719-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2017\/12719-0"],"award-info":[{"award-number":["2017\/12719-0"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Zinc finger proteins are one of the most abundant families of proteins and present a wide range of structures and functions. The structural zinc ion provides the correct conformation to specifically recognize DNA, RNA and protein sequences. Zinc fingers have essential functions in transcription, protein degradation, DNA repair, cell migration, and others. Recently, reports on the extensive participation of zinc fingers in disease have been published. On the other hand, much information remains to be unravelled as many genomes and proteomes are being reported. A variety of zinc fingers have been identified; however, their functions are still under investigation. Because zinc fingers have identified functions in several diseases, they are being increasingly recognized as drug targets. The replacement of Zn(ii) by another metal ion in zinc fingers is one of the most prominent methods of inhibition. From one side, zinc fingers play roles in the toxicity mechanisms of Ni(ii), Hg(ii), Cd(ii) and others. From the other side, gold, platinum, cobalt, and selenium complexes are amongst the compounds being developed as zinc finger inhibitors for therapy. The main challenge in the design of therapeutic zinc finger inhibitors is to achieve selectivity. Recently, the design of novel compounds and elucidation of the mechanisms of zinc substitution have renewed the possibilities of selective zinc finger inhibition by metal complexes. This review aims to update the status of novel strategies to selectively target zinc finger domains by metal complexes.<\/jats:p>","DOI":"10.1039\/c8mt00262b","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T08:34:51Z","timestamp":1537864491000},"page":"15-28","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Zinc finger domains as therapeutic targets for metal-based compounds \u2013 an update"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-2252","authenticated-orcid":false,"given":"C","family":"Abbehausen","sequence":"first","affiliation":[{"name":"Institute of Chemistry, University of Campinas \u2013 UNICAMP, P.O. Box 6154, CEP 13083-970, Campinas, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"2026041420234858400_cit1","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/cddiscovery.2017.71","article-title":"Zinc-finger proteins in health and disease","volume":"3","author":"Cassandri","year":"2017","journal-title":"Cell Death Dis."},{"key":"2026041420234858400_cit2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc3748","article-title":"New PARP targets for cancer therapy","volume":"14","author":"Vyas","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"2026041420234858400_cit3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13045-017-0500-5","article-title":"MDM2\/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer","volume":"10","author":"Tisato","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"2026041420234858400_cit4","doi-asserted-by":"crossref","first-page":"99482","DOI":"10.18632\/oncotarget.20107","article-title":"Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells","volume":"8","author":"Sakata","year":"2017","journal-title":"Oncotarget"},{"key":"2026041420234858400_cit5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.drudis.2018.01.022","article-title":"NCp7: targeting a multitask protein for next-generation anti-HIV drug development part 2. Noncovalent inhibitors and nucleic acid binders","volume":"23","author":"Iraci","year":"2018","journal-title":"Drug Discovery Today"},{"key":"2026041420234858400_cit6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.drudis.2017.10.017","article-title":"NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors","volume":"23","author":"Sancineto","year":"2018","journal-title":"Drug Discovery Today"},{"key":"2026041420234858400_cit7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.virol.2016.07.019","article-title":"Inhibition of influenza A virus matrix and nonstructural gene expression using RNA interference","volume":"497","author":"McMillen","year":"2016","journal-title":"Virology"},{"key":"2026041420234858400_cit8","doi-asserted-by":"crossref","first-page":"32340","DOI":"10.1038\/srep32340","article-title":"Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1","volume":"6","author":"Mosier","year":"2016","journal-title":"Sci. Rep."},{"key":"2026041420234858400_cit9","doi-asserted-by":"crossref","first-page":"e1006168","DOI":"10.1371\/journal.ppat.1006168","article-title":"Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay","volume":"13","author":"Toots","year":"2017","journal-title":"PLoS Pathog."},{"key":"2026041420234858400_cit10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijid.2016.02.776","article-title":"Genome wide collation of zinc finger family in P. falciparum","volume":"45","author":"Kaushik","year":"2016","journal-title":"Int. J. Infect. Dis."},{"key":"2026041420234858400_cit11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/cmi.12268","article-title":"The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei","volume":"16","author":"Kolev","year":"2014","journal-title":"Cell. Microbiol."},{"key":"2026041420234858400_cit12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4331\/wjbc.v7.i1.146","article-title":"Regulation of RNA binding proteins in trypanosomatid protozoan parasites","volume":"7","author":"Romaniuk","year":"2016","journal-title":"World J. Biol. Chem."},{"key":"2026041420234858400_cit13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2018.01.006","article-title":"Knockout of the CCCH zinc finger protein TcZC3H31 blocks Trypanosoma cruzi differentiation into the infective metacyclic form","volume":"221","author":"Alcantara","year":"2018","journal-title":"Mol. Biochem. Parasitol."},{"key":"2026041420234858400_cit14","first-page":"1","article-title":"Tristetraprolin: a novel mediator of the anticancer properties of resveratrol","volume":"15","author":"Li","year":"2016","journal-title":"GMR, Genet. Mol. Res."},{"key":"2026041420234858400_cit15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/annrheumdis-2016-209424","article-title":"via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression","volume":"76","author":"Ross","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"2026041420234858400_cit16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.schres.2015.01.036","article-title":"Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis","volume":"162","author":"Sun","year":"2015","journal-title":"Schizophr. Res."},{"key":"2026041420234858400_cit17","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1021\/ar500039w","article-title":"Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies","volume":"47","author":"Gersbach","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"2026041420234858400_cit18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.14348\/molcells.2017.0139","article-title":"Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research","volume":"40","author":"Kim","year":"2017","journal-title":"Mol. Cells"},{"key":"2026041420234858400_cit19","first-page":"7","article-title":"First in vivo gene-editing drugs enter the clinic","volume":"17","author":"Mullard","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026041420234858400_cit20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ddtec.2018.01.001","article-title":"The multiplexed CRISPR targeting platforms","volume":"28","author":"Cao","year":"2018","journal-title":"Drug Discovery Today: Technol."},{"key":"2026041420234858400_cit21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12033-018-0072-9","article-title":"Genome Editing in Stem Cells for Disease Therapeutics","volume":"60","author":"Song","year":"2018","journal-title":"Mol. Biotechnol."},{"key":"2026041420234858400_cit22","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/978-3-319-73344-9_24","volume-title":"Mitochondrial Biology and Experimental Therapeutics","author":"Bacman","year":"2018"},{"key":"2026041420234858400_cit23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.bbmt.2018.03.021","article-title":"Applications of Gene Editing Technologies to Cellular Therapies","volume":"24","author":"Rein","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2026041420234858400_cit24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s12272-018-1037-z","article-title":"Generation of genetically-engineered animals using engineered endonucleases","volume":"41","author":"Lee","year":"2018","journal-title":"Arch. Pharmacal Res."},{"key":"2026041420234858400_cit25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1039\/c0mt00070a","article-title":"Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences","volume":"3","author":"Quintal","year":"2011","journal-title":"Metallomics"},{"key":"2026041420234858400_cit26","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1021\/ja00192a050","article-title":"On the metal ion specificity of zinc finger proteins","volume":"111","author":"Berg","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"2026041420234858400_cit27","first-page":"195","article-title":"Metal replacement in \u201czinc finger\u201d and its effect on DNA binding","volume":"102","author":"Predki","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"2026041420234858400_cit28","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1016\/S0021-9258(18)42630-0","article-title":"Effect of replacement of \u201czinc finger\u201d zinc on estrogen receptor DNA interactions","volume":"267","author":"Predki","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2026041420234858400_cit29","first-page":"646","article-title":"Metal replacement in DNA-binding zinc finger proteins and its relevance to mutagenicity and carcinogenicity through free radical generation","volume":"11","author":"Sarkar","year":"1995","journal-title":"Nutrition"},{"key":"2026041420234858400_cit30","first-page":"219","article-title":"Comparative effects of gold on the interactions of transcription factors with DNA","volume":"44","author":"Handel","year":"1993","journal-title":"Agents Actions Suppl."},{"key":"2026041420234858400_cit31","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1073\/pnas.92.10.4497","article-title":"Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos","volume":"92","author":"Handel","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026041420234858400_cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/revic-2012-0006","article-title":"Chemistry of antimony-based drugs in biological systems and studies of their mechanism of action","volume":"33","author":"Fr\u00e9zard","year":"2013","journal-title":"Rev. Inorg. Chem."},{"key":"2026041420234858400_cit33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1039\/c2mt00176d","article-title":"Greater binding affinity of trivalent antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins","volume":"4","author":"Frezard","year":"2012","journal-title":"Metallomics"},{"key":"2026041420234858400_cit34","first-page":"135","article-title":"Inhibition of immunopurified DNA polymerase-alpha from PA-3 prostate tumor cells by platinum(ii) antitumor drugs","volume":"13","author":"Kelley","year":"1993","journal-title":"Cancer Biochem. Biophys."},{"key":"2026041420234858400_cit35","first-page":"1778","article-title":"Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motifs","author":"Yuan","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"2026041420234858400_cit36","doi-asserted-by":"crossref","first-page":"19836","DOI":"10.3390\/ijms160819836","article-title":"Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy","volume":"16","author":"Kohno","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2026041420234858400_cit37","doi-asserted-by":"crossref","first-page":"e26325","DOI":"10.1371\/journal.pone.0026325","article-title":"Minimal Functional Sites Allow a Classification of Zinc Sites in Proteins","volume":"6","author":"Andreini","year":"2011","journal-title":"PLoS One"},{"key":"2026041420234858400_cit38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tibs.2006.12.007","article-title":"Sticky fingers: zinc-fingers as protein-recognition motifs","volume":"32","author":"Gamsjaeger","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"2026041420234858400_cit39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0959-440X(00)00167-6","article-title":"Zinc finger proteins: new insights into structural and functional diversity","volume":"11","author":"Laity","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2026041420234858400_cit40","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0969-2126(00)00527-X","article-title":"Solution Structures of Two CCHC Zinc Fingers from the FOG Family Protein U-Shaped that Mediate Protein\u2013Protein Interactions","volume":"8","author":"Liew","year":"2000","journal-title":"Structure"},{"key":"2026041420234858400_cit41","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.celrep.2017.02.080","article-title":"The human CCHC-type Zinc Finger Nucleic Acid Binding Protein binds G-rich elements in target mRNA coding sequences and promotes translation","volume":"18","author":"Benhalevy","year":"2017","journal-title":"Cell Rep."},{"key":"2026041420234858400_cit42","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1110\/ps.9.9.1743","article-title":"Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription","volume":"9","author":"Chen","year":"2000","journal-title":"Protein Sci."},{"key":"2026041420234858400_cit43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/34675","article-title":"The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control","volume":"391","author":"Garkavtsev","year":"1998","journal-title":"Nature"},{"key":"2026041420234858400_cit44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10549-010-1182-7","article-title":"The RING heterodimer BRCA1\u2013BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs","volume":"126","author":"Atipairin","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"2026041420234858400_cit45","doi-asserted-by":"crossref","first-page":"26524","DOI":"10.1074\/jbc.M204121200","article-title":"m-Bop, a Repressor Protein Essential for Cardiogenesis, Interacts with skNAC, a Heart- and Muscle-specific Transcription Factor","volume":"277","author":"Sims","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2026041420234858400_cit46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/CritRevEukaryotGeneExpr.2015013022","article-title":"Emerging roles of CCCH-type zinc finger proteins in destabilizing mRNA encoding inflammatory factors and regulating immune responses","volume":"25","author":"Yang","year":"2015","journal-title":"Crit. Rev. Eukaryotic Gene Expression"},{"key":"2026041420234858400_cit47","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1021\/ar500182d","article-title":"Structural Metal Sites in Nonclassical Zinc Finger Proteins Involved in Transcriptional and Translational Regulation","volume":"47","author":"Lee","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"2026041420234858400_cit48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/acs.inorgchem.7b02406","article-title":"X-ray Absorption Spectroscopy Combined with Time-Dependent Density Functional Theory Elucidates Differential Substitution Pathways of Au(i) and Au(iii) with Zinc Fingers","volume":"57","author":"Abbehausen","year":"2018","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit49","doi-asserted-by":"crossref","first-page":"11280","DOI":"10.1021\/ic401535s","article-title":"Gold(i)-phosphine-N-heterocycles: Biological activity and specific (ligand) interactions on the C-terminal HIVNCp7 zinc finger","volume":"52","author":"Abbehausen","year":"2013","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit50","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/1541-7786.MCR-13-0672","article-title":"Transcriptional Roles of PARP1 in Cancer","volume":"12","author":"Schiewer","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"2026041420234858400_cit51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1615\/CritRevEukaryotGeneExpr.2013006875","article-title":"Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases","volume":"24","author":"Morales","year":"2014","journal-title":"Crit. Rev. Eukaryotic Gene Expression"},{"key":"2026041420234858400_cit52","first-page":"215","article-title":"PARP inhibitors: review of mechanisms of action and BRCA1\/2 mutation targeting","volume":"15","author":"Dziadkowiec","year":"2016","journal-title":"Przegl. Menopauzalny"},{"key":"2026041420234858400_cit53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2015.01.015","article-title":"PARP inhibitors: A new era of targeted therapy","volume":"81","author":"Tangutoori","year":"2015","journal-title":"Maturitas"},{"key":"2026041420234858400_cit54","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/ajco.12636","article-title":"Practical guidance on the use of olaparib capsules as maintenance therapy for women with BRCA mutations and platinum-sensitive recurrent ovarian cancer","volume":"12","author":"Friedlander","year":"2016","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"2026041420234858400_cit55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pharmthera.2015.05.008","article-title":"Sp1 transcription factor: A long-standing target in cancer chemotherapy","volume":"152","author":"Vizca\u00edno","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"2026041420234858400_cit56","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/febs.13148","article-title":"Sp1 and the \u2018hallmarks of cancer\u2019","volume":"282","author":"Beishline","year":"2014","journal-title":"FEBS J."},{"key":"2026041420234858400_cit57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF03214639","article-title":"Gold compounds for rheumatoid arthritis","volume":"19","author":"Sutton","year":"1986","journal-title":"Gold Bull."},{"key":"2026041420234858400_cit58","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/art.1780390412","article-title":"Reduction in long-term disability in patients with rheumatoid arthritis by disease-modifying antirheumatic drug-based treatment strategies","volume":"39","author":"Fries","year":"1996","journal-title":"Arthritis Rheum."},{"key":"2026041420234858400_cit59","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0026-895X(25)15375-3","article-title":"Inhibition of DNA binding and transcriptional activity of a nuclear receptor transcription factor by aurothiomalate and other metal ions","volume":"40","author":"Handel","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"2026041420234858400_cit60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-5793(95)00157-5","article-title":"Inhibition of the DNA-binding activity of NF-\u03baB by gold compounds in vitro","volume":"361","author":"Yang","year":"1995","journal-title":"FEBS Lett."},{"key":"2026041420234858400_cit61","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1039\/b917748p","article-title":"Reactions of palladium and gold complexes with zinc-thiolate chelates using electrospray mass spectrometry and X-ray diffraction: molecular identification of [Pd(bme-dach)], [Au(bme-dach)]+ and [ZnCl(bme-dach)]2Pd","author":"de Paula","year":"2009","journal-title":"Dalton Trans."},{"key":"2026041420234858400_cit62","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jinorgbio.2009.07.002","article-title":"Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M = Pt, Pd, Au)","volume":"103","author":"de Paula","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit63","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1021\/jm2000135","article-title":"Metal-Based Inhibition of Poly(ADP-ribose) Polymerase\u201a The Guardian Angel of DNA","volume":"54","author":"Mendes","year":"2011","journal-title":"J. Med. Chem."},{"key":"2026041420234858400_cit64","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1021\/ic800157t","article-title":"Spectroscopic evidence for the formation of goldfingers","volume":"47","author":"Franzman","year":"2008","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit65","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jinorgbio.2018.04.005","article-title":"Linear gold(i) complex with tris-(2-carboxyethyl)phosphine (TCEP): Selective antitumor activity and inertness toward sulfur proteins","volume":"186","author":"Gomes","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit66","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jinorgbio.2016.05.011","article-title":"Effects of coordination mode of 2-mercaptothiazoline on reactivity of Au(i) compounds with thiols and sulfur-containing proteins","volume":"165","author":"Abbehausen","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit67","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1021\/acs.inorgchem.7b01762","article-title":"the HIV-1 NCp7 Nucleocapsid Protein with Site-Specific Gold(i)\u2013Phosphine Complexes","volume":"56","author":"de Paiva","year":"2017","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit68","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1021\/acs.inorgchem.5b00360","article-title":"Reactivity of Cys4 zinc finger domains with gold(iii) complexes: Insights into the formation of \u201cgold fingers\u201d","volume":"54","author":"Jacques","year":"2015","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1021\/ic501784n","article-title":"[Au(dien)(N-heterocycle)]3+: Reactivity with biomolecules and zinc finger peptides","volume":"54","author":"Spell","year":"2015","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit70","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1039\/C4CC07490D","article-title":"Gold finger formation studied by high-resolution mass spectrometry and in silico methods","volume":"51","author":"Laskay","year":"2015","journal-title":"Chem. Commun."},{"key":"2026041420234858400_cit71","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1039\/C7CC08406D","article-title":"Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics","volume":"54","author":"Wenzel","year":"2018","journal-title":"Chem. Commun."},{"key":"2026041420234858400_cit72","doi-asserted-by":"crossref","first-page":"9305","DOI":"10.1002\/anie.201803082","article-title":"Gold-Catalyzed C\u2013S Aryl-Group Transfer in Zinc Finger Proteins","volume":"57","author":"de Paiva","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026041420234858400_cit73","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1039\/c2sc20627g","article-title":"Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?","volume":"3","author":"Casini","year":"2012","journal-title":"Chem. Sci."},{"key":"2026041420234858400_cit74","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/psc.2490","article-title":"Interaction of cisplatin with a CCHC zinc finger motif","volume":"19","author":"Castiglione Morelli Maria","year":"2013","journal-title":"J. Pept. Sci."},{"key":"2026041420234858400_cit75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2014.12.003","article-title":"The reaction of dichlorodiammineplatinum(ii), [PtCl2(NH3)2], isomers with zinc fingers","volume":"143","author":"Tsotsoros","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit76","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1039\/c2cc38517a","article-title":"Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein","volume":"49","author":"Chen","year":"2013","journal-title":"Chem. Commun."},{"key":"2026041420234858400_cit77","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jinorgbio.2016.04.030","article-title":"Effects of Cu(ii) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport","volume":"161","author":"Yan","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit78","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1039\/C6SC03445D","article-title":"Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]2+ for HIVNCp7 targeting","volume":"8","author":"Tsotsoros","year":"2017","journal-title":"Chem. Sci."},{"key":"2026041420234858400_cit79","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jinorgbio.2013.09.020","article-title":"Modulation of the stacking interaction of MN4 (M = Pt, Pd, Au) complexes with tryptophan through N-heterocyclic ligands","volume":"132","author":"Tsotsoros","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit80","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1021\/acs.inorgchem.6b01925","article-title":"Interaction of the HIV NCp7 Protein with Platinum(ii) and Gold(iii) Complexes Containing Tridentate Ligands","volume":"55","author":"Bernardes","year":"2016","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit81","doi-asserted-by":"crossref","first-page":"12258","DOI":"10.1002\/anie.201206596","article-title":"Trans-Platinum\/Thiazole Complex Interferes with Sp1 Zinc-Finger Protein","volume":"51","author":"Chen","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026041420234858400_cit82","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1039\/C6DT01128D","article-title":"Tuning the reactivity of Sp1 zinc fingers with platinum complexes","volume":"45","author":"Du","year":"2016","journal-title":"Dalton Trans."},{"key":"2026041420234858400_cit83","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1039\/C7MT00256D","article-title":"Metal binding properties of zinc fingers with a naturally altered metal binding site","volume":"10","author":"Kluska","year":"2018","journal-title":"Metallomics"},{"key":"2026041420234858400_cit84","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1155\/2017\/1527247","article-title":"Co(ii) Coordination in Prokaryotic Zinc Finger Domains as Revealed by UV-Vis Spectroscopy","volume":"2017","author":"Sivo","year":"2017","journal-title":"Bioinorg. Chem. Appl."},{"key":"2026041420234858400_cit85","volume-title":"US Pat.","author":"Gershon","year":"2010"},{"key":"2026041420234858400_cit86","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","article-title":"Metallodrugs in Medicinal Inorganic Chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"2026041420234858400_cit87","doi-asserted-by":"crossref","first-page":"17043","DOI":"10.1002\/chem.201301659","article-title":"Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors by cobalt(iii) Schiff base complexes","volume":"19","author":"Heffern","year":"2013","journal-title":"Chemistry"},{"key":"2026041420234858400_cit88","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/ic302379j","article-title":"Axial Ligand Exchange of N-heterocyclic Cobalt(iii) Schiff Base Complexes: Molecular Structure and NMR Solution Dynamics","volume":"52","author":"Manus","year":"2013","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit89","doi-asserted-by":"crossref","first-page":"13162","DOI":"10.1021\/ja4065393","article-title":"Photoinduced Electron Transfer from PbS Quantum Dots to Cobalt(iii) Schiff Base Complexes: Light Activation of a Protein Inhibitor","volume":"135","author":"Peterson","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"2026041420234858400_cit90","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1021\/acs.inorgchem.5b01415","article-title":"Tuning Cobalt(iii) Schiff Base Complexes as Activated Protein Inhibitors","volume":"54","author":"Heffern","year":"2015","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit91","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1471-2164-11-283","article-title":"Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major","volume":"11","author":"Kramer","year":"2010","journal-title":"BMC Genomics"},{"key":"2026041420234858400_cit92","doi-asserted-by":"crossref","first-page":"e0170068","DOI":"10.1371\/journal.pone.0170068","article-title":"Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture","volume":"12","author":"Nandan","year":"2017","journal-title":"PLoS One"},{"key":"2026041420234858400_cit93","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1021\/acschembio.7b00728","article-title":"Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition","volume":"12","author":"Yu","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"2026041420234858400_cit94","first-page":"259","volume-title":"Adv. Cancer Res.","author":"Bartolini","year":"2017"},{"key":"2026041420234858400_cit95","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jinorgbio.2016.01.013","article-title":"Chalcogen bonding interactions between reducible sulfur and selenium compounds and models of zinc finger proteins","volume":"157","author":"Lutz","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit96","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s11033-014-3417-x","article-title":"Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways","volume":"41","author":"Azad","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"2026041420234858400_cit97","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bcp.2013.08.028","article-title":"The early research and development of ebselen","volume":"86","author":"Parnham","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2026041420234858400_cit98","doi-asserted-by":"crossref","first-page":"74686","DOI":"10.18632\/oncotarget.12531","article-title":"Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells","volume":"7","author":"Misra","year":"2016","journal-title":"Oncotarget"},{"key":"2026041420234858400_cit99","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1039\/C7MT00184C","article-title":"Copper-finger protein of Sp1: the molecular basis of copper sensing","volume":"9","author":"Yuan","year":"2017","journal-title":"Metallomics"},{"key":"2026041420234858400_cit100","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1021\/acs.inorgchem.7b00125","article-title":"Cu(i) Disrupts the Structure and Function of the Nonclassical Zinc Finger Protein Tristetraprolin (TTP)","volume":"56","author":"Shimberg","year":"2017","journal-title":"Inorg. Chem."},{"key":"2026041420234858400_cit101","doi-asserted-by":"crossref","first-page":"23905","DOI":"10.18632\/oncotarget.14733","article-title":"Metabolism, toxicity and anticancer activities of arsenic compounds","volume":"8","author":"Khairul","year":"2017","journal-title":"Oncotarget"},{"key":"2026041420234858400_cit102","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jinorgbio.2016.08.003","article-title":"Kinetics and thermodynamics of zinc(ii) and arsenic(iii) binding to XPA and PARP-1 zinc finger peptides","volume":"163","author":"Huestis","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"2026041420234858400_cit103","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1021\/tx500022j","article-title":"Differential Binding of Monomethylarsonous Acid Compared to Arsenite and Arsenic Trioxide with Zinc Finger Peptides and Proteins","volume":"27","author":"Zhou","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"2026041420234858400_cit104","doi-asserted-by":"crossref","first-page":"e0141014","DOI":"10.1371\/journal.pone.0141014","article-title":"Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"2026041420234858400_cit105","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1021\/acs.chemrestox.7b00146","article-title":"Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome","volume":"30","author":"Tam","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"2026041420234858400_cit106","first-page":"1133","article-title":"Arsenic trioxide inhibits cancer stem-like cells via down-regulation of Gli1 in lung cancer","volume":"8","author":"Chang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"2026041420234858400_cit107","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1021\/acs.est.5b03386","article-title":"Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine","volume":"49","author":"Liu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"2026041420234858400_cit108","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/bgx038","article-title":"Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells","volume":"38","author":"Scanlon","year":"2017","journal-title":"Carcinogenesis"},{"key":"2026041420234858400_cit109","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1039\/C8MT00098K","article-title":"Nickel(ii)-promoted specific hydrolysis of zinc finger proteins","volume":"10","author":"Belczyk-Ciesielska","year":"2018","journal-title":"Metallomics"},{"key":"2026041420234858400_cit110","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1039\/c1mt00081k","article-title":"The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity","volume":"3","author":"Kurowska","year":"2011","journal-title":"Metallomics"},{"key":"2026041420234858400_cit111","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00894-016-3017-x","article-title":"Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair","volume":"22","author":"Hu","year":"2016","journal-title":"J. Mol. Model."},{"key":"2026041420234858400_cit112","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/tx500320f","article-title":"Unusual Zn(ii) Affinities of Zinc Fingers of Poly(ADP-ribose) Polymerase 1 (PARP-1) Nuclear Protein","volume":"28","author":"Bossak","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"2026041420234858400_cit113","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/mc.22802","article-title":"Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1","volume":"57","author":"Jose Cynthia","year":"2018","journal-title":"Mol. Carcinog."},{"key":"2026041420234858400_cit114","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/carcin\/bgy070","article-title":"A molecular mechanism of nickel(ii): reduction of nucleotide excision repair activity by structural and functional disruption of p53","volume":"39","author":"Kim","year":"2018","journal-title":"Carcinogenesis"},{"key":"2026041420234858400_cit115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1039\/C7MT00346C","article-title":"Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells","volume":"10","author":"Yin","year":"2018","journal-title":"Metallomics"},{"key":"2026041420234858400_cit116","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1021\/acschembio.7b00261","article-title":"Nickel(ii) Inhibits Tet-Mediated 5-Methylcytosine Oxidation by High Affinity Displacement of the Cofactor Iron(ii)","volume":"12","author":"Yin","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"2026041420234858400_cit117","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.bbapap.2016.09.008","article-title":"Nickel impact on human health: An intrinsic disorder perspective","volume":"1864","author":"Zambelli","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2026041420234858400_cit118","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/9783110434330-010","volume-title":"Lead: Its Effects on Environment and Health","author":"Cangelosi","year":"2017"},{"key":"2026041420234858400_cit119","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1039\/C5MT00300H","article-title":"Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health","volume":"8","author":"Ordemann","year":"2016","journal-title":"Metallomics"},{"key":"2026041420234858400_cit120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10142-011-0246-z","article-title":"Emerging roles of epigenetic mechanisms in Parkinson's disease","volume":"11","author":"Habibi","year":"2011","journal-title":"Funct. Integr. Genomics"},{"key":"2026041420234858400_cit121","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2174\/156720512800617991","article-title":"Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics","volume":"9","author":"Bakulski","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"2026041420234858400_cit122","first-page":"108","article-title":"Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature","volume":"3","author":"Saxena","year":"2017","journal-title":"Mol. Neuropsychiatry"},{"key":"2026041420234858400_cit123","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1001\/jamapsychiatry.2014.1079","article-title":"Expression of znf804a in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: A novel transcript fetally regulated by the psychosis risk variant rs1344706","volume":"71","author":"Tao","year":"2014","journal-title":"JAMA Psychiatry"}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/11\/1\/15\/34529548\/c8mt00262b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/11\/1\/15\/34529548\/c8mt00262b.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:46:49Z","timestamp":1776214009000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/11\/1\/15\/5962218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":123,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,23]]}},"URL":"https:\/\/doi.org\/10.1039\/c8mt00262b","relation":{},"ISSN":["1756-5901","1756-591X"],"issn-type":[{"value":"1756-5901","type":"print"},{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,9,25]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"C. Abbehausen (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8410-2252","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"C. Abbehausen (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-4575-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 September 2018; Accepted 25 September 2018; Accepted Manuscript published 25 September 2018; Advance Article published 10 October 2018; Version of Record published 23 January 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}