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Selenium is an essential micronutrient, required for normal development and functioning of many organisms. While selenium is known to counteract mercury's toxicity under some conditions, to date information about the mercury-selenium relationship is fragmented and often controversial. As part of a systematic study of mercury and selenium interactions, zebrafish (Danio rerio) larvae (a model verterbrate) were exposed to methylmercury chloride or mercuric chloride. The influence of pre- and post-treatment of selenomethionine on the level and distribution of mercury and selenium in the brain and eye sections, as well as on toxicity, were examined. Selenomethionine treatment decreased the amount of maternally transfered mercury in the larval brain. Selenomethionine treatment prior to exposure to mercuric chloride increased both mercury and selenium levels in the brain but decreased their toxic effects. Conversely, methylmercury levels were not changed as a result of selenium pre-treatment, while toxicity was increased. Strikingly, both forms of mercury severely disrupted selenium metabolism, not only by depleting selenium levels due to formation of Hg\u2013Se complexes, but also by blocking selenium transport into and out of tissues, suggesting that restoring normal selenium levels by treating the organism with selenium after mercury exposure may not be possible. Disruption of selenium metabolism by mercury may lead to disruption in function of selenoproteins. Indeed, the production of thyroid hormones by selenoprotein deiodinases was found to be severely impaired as a result of mercury exposure, with selenomethionine not always being a suitable source of selenium to restore thyroid hormone levels.<\/jats:p>","DOI":"10.1039\/c8mt00315g","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T15:05:58Z","timestamp":1547478358000},"page":"621-631","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-6634","authenticated-orcid":false,"given":"Natalia V","family":"Dolgova","sequence":"first","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-3701","authenticated-orcid":false,"given":"Susan","family":"Nehzati","sequence":"additional","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy C","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-5052","authenticated-orcid":false,"given":"Kelly L","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-7955","authenticated-orcid":false,"given":"Andrew M","family":"Crawford","sequence":"additional","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H","family":"Krone","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-7493","authenticated-orcid":false,"given":"Graham N","family":"George","sequence":"additional","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"},{"name":"Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0936-2994","authenticated-orcid":false,"given":"Ingrid J","family":"Pickering","sequence":"additional","affiliation":[{"name":"Molecular and Environment Sciences Group, Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada"},{"name":"Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"2021121516073486200_cit1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12940-015-0050-7","article-title":"Urgent need to reealuate the latest World Health Organization guidelines for toxic inorganic substances in drinking water","volume":"14","author":"Frisbie","year":"2015","journal-title":"Environ. 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Biochem."},{"key":"2021121516073486200_cit24","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.jinorgbio.2007.06.008","article-title":"Strong poison revisited","volume":"101","author":"Prince","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"2021121516073486200_cit25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2013.08.043","article-title":"Analytical and bioanalytical approaches to unravel the selenium-mercury antagonism: a review","volume":"801","author":"Luque-Garcia","year":"2013","journal-title":"Anal. Chim. 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Neurosci."},{"key":"2021121516073486200_cit32","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/tx000050h","article-title":"Structural basis of the antagonism between inorganic mercury and selenium in mammals","volume":"13","author":"Gailer","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"2021121516073486200_cit33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/bbrc.1996.6036","article-title":"Equimolar Hg-Se complex binds to Selenoprotein P","volume":"231","author":"Yoneda","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021121516073486200_cit34","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00018-014-1816-8","article-title":"Metabolic insights from zebrafish genetics, physiology, and chemical biology","volume":"72","author":"Schlegel","year":"2015","journal-title":"Cell. Mol. 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Biol."},{"key":"2021121516073486200_cit40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquatox.2012.01.008","article-title":"Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae","volume":"110-111","author":"Chen","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"2021121516073486200_cit41","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/etc.3282","article-title":"Embryotoxicity of maternally transferred methylmercury to fathead minnows (Pimephales promelas)","volume":"35","author":"Bridges","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"2021121516073486200_cit42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12011-013-9743-3","article-title":"Mercury transfer during pregnancy and breastfeeding: hair mercury concentrations as biomarker","volume":"154","author":"Marques","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"2021121516073486200_cit43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.envpol.2013.03.046","article-title":"Maternally transferred mercury in wild largemouth bass, Micropterus salmoides","volume":"178","author":"Sackett","year":"2013","journal-title":"Environ. Pollut."},{"key":"2021121516073486200_cit44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/jrf.0.0250157","article-title":"Effect of mercuric compounds on the maternal transmission of selenium in the pregnant and lactating rat","volume":"25","author":"Parizek","year":"1971","journal-title":"J. Reprod. Fertil."},{"key":"2021121516073486200_cit45","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00775-010-0674-6","article-title":"Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae","volume":"15","author":"Korbas","year":"2010","journal-title":"J. Biol. Inorg. 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Total Environ."},{"key":"2021121516073486200_cit58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/ijerph14020169","article-title":"A review of mercury bioavailability in humans and fish","volume":"14","author":"Bradley","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2021121516073486200_cit59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.beem.2013.05.014","article-title":"Inherited defects in thyroid hormone cell-membrane transport and metabolism","volume":"28","author":"Fu","year":"2014","journal-title":"Best Pract. Res., Clin. Endocrinol. Metab."},{"key":"2021121516073486200_cit60","first-page":"R761","article-title":"Methylmercury transport across the blood-brain barrier by an amino acid carrier","volume":"262","author":"Kepler","year":"1992","journal-title":"Am. J. Physiol."},{"key":"2021121516073486200_cit61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/bj20020841","article-title":"Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type lare neutral amino acid transporter (LAT) 1 and LAT2","volume":"367","author":"Simmons-Willis","year":"2002","journal-title":"Biochem. J."},{"issue":"4","key":"2021121516073486200_cit62","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2008.05683.x","article-title":"The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter, LAT1","volume":"107","author":"Yin","year":"2008","journal-title":"J. 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