{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:58:23Z","timestamp":1789588703176,"version":"build-2803163510"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"am","delay-in-days":506,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100009510","name":"University of Hull","doi-asserted-by":"crossref","award":["Advanced Wound Care PhD cluster"],"award-info":[{"award-number":["Advanced Wound Care PhD cluster"]}],"id":[{"id":"10.13039\/100009510","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>We demonstrate that nanogel carriers for tetracycline and lincomycin coated with a biocompatible cationic polyelectrolyte can overcome the antibiotic resistance against a range of wound isolated pathogens.<\/p>","DOI":"10.1039\/c8nr10022e","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T15:01:57Z","timestamp":1558450917000},"page":"10472-10485","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Breathing new life into old antibiotics: overcoming antibacterial resistance by antibiotic-loaded nanogel carriers with cationic surface functionality"],"prefix":"10.1039","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-5659","authenticated-orcid":false,"given":"Paul J.","family":"Weldrick","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of Hull"},{"name":"Hull"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammi","family":"Iveson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences"},{"name":"University of Hull"},{"name":"Hull"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-5074","authenticated-orcid":false,"given":"Matthew J.","family":"Hardman","sequence":"additional","affiliation":[{"name":"Centre for Atherothrombosis and Metabolic Disease"},{"name":"Hull York Medical School"},{"name":"Hull"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-1681","authenticated-orcid":false,"given":"Vesselin N.","family":"Paunov","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of Hull"},{"name":"Hull"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8NR10022E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4065\/mcp.2010.0639","volume":"86","author":"Leekha","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"C8NR10022E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1039\/c3mb70027e","volume":"9","author":"Peach","year":"2013","journal-title":"Mol. BioSyst."},{"key":"C8NR10022E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro2333","volume":"8","author":"Kohanski","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"C8NR10022E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"C8NR10022E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/2042098614554919","volume":"5","author":"Llor","year":"2014","journal-title":"Ther. Adv. Drug Saf."},{"key":"C8NR10022E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1128\/CMR.00030-10","volume":"24","author":"Silver","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"C8NR10022E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4065\/mcp.2011.0358","volume":"86","author":"Doron","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"C8NR10022E-(cit8)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","volume":"4","author":"Munita","year":"2016","journal-title":"Microbiol. Spectrum"},{"key":"C8NR10022E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0966-842X(97)01033-0","volume":"5","author":"Davies","year":"1997","journal-title":"Trends Microbiol."},{"key":"C8NR10022E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13059-017-1252-9","volume":"18","author":"Harkins","year":"2017","journal-title":"Genome Biol."},{"key":"C8NR10022E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1172\/JCI68834","volume":"124","author":"Gardete","year":"2014","journal-title":"J. Clin. Invest."},{"key":"C8NR10022E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2017.03.001","volume":"31","author":"Assis","year":"2017","journal-title":"Drug Resist. Updates"},{"key":"C8NR10022E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1098\/rspb.2011.1933","volume":"279","author":"Perron","year":"2012","journal-title":"Proc. R. Soc. B"},{"key":"C8NR10022E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"C8NR10022E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmicb.2011.00065","volume":"2","author":"Poole","year":"2011","journal-title":"Front. Microbiol."},{"key":"C8NR10022E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3389\/fmicb.2018.01058","volume":"9","author":"Markley","year":"2018","journal-title":"Front. Microbiol."},{"key":"C8NR10022E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/ncomms2470","volume":"4","author":"Li","year":"2013","journal-title":"Nat. Commun."},{"key":"C8NR10022E-(cit18)\/*[position()=1]","first-page":"1056","volume":"91","author":"MacLeod","year":"1964","journal-title":"Can. Med. Assoc. J."},{"key":"C8NR10022E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10284","DOI":"10.1093\/nar\/gkx658","volume":"45","author":"Matzov","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"C8NR10022E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00253-003-1545-7","volume":"64","author":"Spizek","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"C8NR10022E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.apsb.2014.06.012","volume":"4","author":"Hong","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"C8NR10022E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1128\/AAC.46.9.2727-2734.2002","volume":"46","author":"Leclercq","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"C8NR10022E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1002104","DOI":"10.1371\/journal.pbio.1002104","volume":"13","author":"Fuentes-Hernandez","year":"2015","journal-title":"PLoS Biol."},{"key":"C8NR10022E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2001644","DOI":"10.1371\/journal.pbio.2001644","volume":"15","author":"Wambaugh","year":"2017","journal-title":"PLoS Biol."},{"key":"C8NR10022E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1002552","DOI":"10.1371\/journal.pbio.1002552","volume":"14","author":"Ayhan","year":"2016","journal-title":"PLoS Biol."},{"key":"C8NR10022E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.2147\/IJN.S146315","volume":"12","author":"Din","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"C8NR10022E-(cit27)\/*[position()=1]","first-page":"1087250","author":"Yu","year":"2016","journal-title":"Nanomater."},{"key":"C8NR10022E-(cit28)\/*[position()=1]","first-page":"265","volume":"13","author":"Kumari","year":"2014","journal-title":"EXCLI J."},{"key":"C8NR10022E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.2147\/IJN.S127683","volume":"12","author":"Jahangirian","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"C8NR10022E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jconrel.2015.11.009","volume":"240","author":"Soni","year":"2016","journal-title":"J. Controlled Release"},{"key":"C8NR10022E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1039\/C7TB02262J","volume":"5","author":"Al-Awady","year":"2017","journal-title":"Mater. Chem. B"},{"key":"C8NR10022E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1039\/C8QM00343B","volume":"2","author":"Al-Awady","year":"2018","journal-title":"Mater. Chem. Front."},{"key":"C8NR10022E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1039\/C8NA00121A","volume":"1","author":"Al-Obaidy","year":"2019","journal-title":"Nanoscale Adv."},{"key":"C8NR10022E-(cit34)\/*[position()=1]","unstructured":"EUCAST Breakpoint Tables v 8.0 & v 8.1, 2018, http:\/\/www.eucast.org\/clinical_breakpoints\/"},{"key":"C8NR10022E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800103","DOI":"10.1002\/adhm.201800103","volume":"7","author":"Mi","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"C8NR10022E-(cit36)\/*[position()=1]","first-page":"2767","volume":"7","author":"Seil","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"C8NR10022E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jor.23656","volume":"36","author":"Li","year":"2018","journal-title":"J. Orthop. Res."},{"key":"C8NR10022E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1039\/C4NR05823B","volume":"7","author":"Geilich","year":"2015","journal-title":"Nanoscale"},{"key":"C8NR10022E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"a000414","DOI":"10.1101\/cshperspect.a000414","volume":"2","author":"Silhavy","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"C8NR10022E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1039\/C7CS00748E","volume":"48","author":"Gupta","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"C8NR10022E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/pi.1839","volume":"54","author":"Bajpai","year":"2005","journal-title":"Polym. Int."},{"key":"C8NR10022E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12232","DOI":"10.1021\/acsami.8b21862","volume":"11","author":"Halbus","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C8NR10022E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cis.2017.05.012","volume":"249","author":"Halbus","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"C8NR10022E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1039\/C8TB03102A","volume":"7","author":"Al-Obaidy","year":"2019","journal-title":"J. Mater. Chem. B"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/NR\/C8NR10022E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:51:46Z","timestamp":1782885106000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/11\/21\/10472-10485\/612911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":44,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2019,5,30]]}},"URL":"https:\/\/doi.org\/10.1039\/c8nr10022e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8NR10022E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Paul J. Weldrick (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1791-5659","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Paul J. Weldrick (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/N-8030-2018","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Matthew J. Hardman (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6423-5074","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Vesselin N. Paunov (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6878-1681","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Vesselin N. Paunov (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/K-4330-2017","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 11 December 2018; Accepted 24 April 2019; Advance Article published 21 May 2019; Version of Record published 30 May 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}