{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:42:18Z","timestamp":1792114938450,"version":"4.4.0"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"am","delay-in-days":409,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001712","name":"Foundation for Fundamental Research on Matter","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001712","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>The ability of adenoviruses to infect a broad range of species has spurred a growing interest in nanomedicine to use adenovirus as a cargo delivery vehicle.<\/p>","DOI":"10.1039\/c8nr10182e","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T10:21:36Z","timestamp":1550139696000},"page":"4015-4024","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Maturation of adenovirus primes the protein nano-shell for successful endosomal escape"],"prefix":"10.1039","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-0465","authenticated-orcid":false,"given":"D.","family":"Denning","sequence":"first","affiliation":[{"name":"Moleculaire Biofysica"},{"name":"Zernike Instituut"},{"name":"Rijksuniversiteit Groningen"},{"name":"The Netherlands"},{"name":"Natuur- en Sterrenkunde and LaserLaB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology"},{"name":"the Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology"},{"name":"the Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moyer","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology"},{"name":"the Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vorselen","sequence":"additional","affiliation":[{"name":"Natuur- en Sterrenkunde and LaserLaB"},{"name":"Vrije Universiteit Amsterdam"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J. L.","family":"Wuite","sequence":"additional","affiliation":[{"name":"Natuur- en Sterrenkunde and LaserLaB"},{"name":"Vrije Universiteit Amsterdam"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nemerow","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology"},{"name":"the Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H.","family":"Roos","sequence":"additional","affiliation":[{"name":"Moleculaire Biofysica"},{"name":"Zernike Instituut"},{"name":"Rijksuniversiteit Groningen"},{"name":"The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8NR10182E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrg3742","volume":"15","author":"Kotterman","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"C8NR10182E-(cit2)\/*[position()=1]","volume-title":"Human Adenoviruses: From Villains to Vectors","author":"Flint","year":"2016","unstructured":"J. Flint and G. R.Nemerow , Human Adenoviruses: From Villains to Vectors , World Scientific , New Jersey , 2016"},{"key":"C8NR10182E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1529\/biophysj.106.093914","volume":"92","author":"Kol","year":"2007","journal-title":"Biophys. J."},{"key":"C8NR10182E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nphys1797","volume":"6","author":"Roos","year":"2010","journal-title":"Nat. Phys."},{"key":"C8NR10182E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10826","DOI":"10.1021\/acsnano.5b03417","volume":"9","author":"Ortega-Esteban","year":"2015","journal-title":"ACS Nano"},{"key":"C8NR10182E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/v4050847","volume":"4","author":"San Mart\u00edn","year":"2012","journal-title":"Viruses"},{"key":"C8NR10182E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.3390\/v6114536","volume":"6","author":"Mangel","year":"2014","journal-title":"Viruses"},{"key":"C8NR10182E-(cit8)\/*[position()=1]","volume-title":"In Adenoviruses: Model and Vectors in Virus-Host Interactions","author":"Ostapchuk","year":"2003","unstructured":"P. Ostapchuk and P.Hearing , In Adenoviruses: Model and Vectors in Virus-Host Interactions , Springer , 2003 , pp. 165\u2013185"},{"key":"C8NR10182E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jcb.20523","volume":"96","author":"Ostapchuk","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"C8NR10182E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/JVI.19.2.533-547.1976","volume":"19","author":"Edvardsson","year":"1976","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3389\/fmicb.2016.01503","volume":"7","author":"Ahi","year":"2016","journal-title":"Front. Microbiol."},{"key":"C8NR10182E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1099\/0022-1317-70-12-3225","volume":"70","author":"Webster","year":"1989","journal-title":"J. Gen. Virol."},{"key":"C8NR10182E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1128\/JVI.66.10.6133-6142.1992","volume":"66","author":"Hasson","year":"1992","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/JVI.17.2.462-471.1976","volume":"17","author":"Weber","year":"1976","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/JVI.02014-15","volume":"90","author":"Moyer","year":"2016","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/JVI.79.4.1992-2000.2005","volume":"79","author":"Wiethoff","year":"2005","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0092-8674(93)90382-Z","volume":"75","author":"Greber","year":"1993","journal-title":"Cell"},{"key":"C8NR10182E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.1408462111","volume":"111","author":"Reddy","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8NR10182E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1602670","DOI":"10.1126\/sciadv.1602670","volume":"3","author":"Yu","year":"2017","journal-title":"Sci. Adv."},{"issue":"34","key":"C8NR10182E-(cit20)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00850-17","volume":"91","author":"Dai","year":"2017","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1073\/pnas.0308198101","volume":"101","author":"Ivanovska","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8NR10182E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nchem.1627","volume":"5","author":"Snijder","year":"2013","journal-title":"Nat. Chem."},{"key":"C8NR10182E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-007-6552-8","volume-title":"In Structure and Physics of Viruses","author":"Mateu","year":"2013","unstructured":"M. G. Mateu , In Structure and Physics of Viruses , Springer , 2013 , pp. 3\u201351"},{"key":"C8NR10182E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.coviro.2016.05.002","volume":"18","author":"Marchetti","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"C8NR10182E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1128\/JVI.02516-12","volume":"87","author":"Snijder","year":"2013","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10571","DOI":"10.1021\/acsnano.5b03020","volume":"9","author":"Ortega-Esteban","year":"2015","journal-title":"ACS Nano"},{"key":"C8NR10182E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10867-017-9479-y","volume":"44","author":"van Rosmalen","year":"2018","journal-title":"J. Biol. Phys."},{"key":"C8NR10182E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1128\/JVI.01453-15","volume":"89","author":"Condezo","year":"2015","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit29)\/*[position()=1]","volume-title":"Single Molecule Analysis: Methods and Protocols","author":"Roos","year":"2011","unstructured":"W. H. Roos , How to perform a nanoindentation experiment on a virus , in Single Molecule Analysis: Methods and Protocols , 2011 , pp. 251\u2013264"},{"key":"C8NR10182E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"031901","DOI":"10.1103\/PhysRevE.75.031901","volume":"75","author":"Gibbons","year":"2007","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C8NR10182E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.0901514106","volume":"106","author":"Roos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8NR10182E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168104","DOI":"10.1103\/PhysRevLett.109.168104","volume":"109","author":"Klug","year":"2012","journal-title":"Phys. Rev. Lett."},{"key":"C8NR10182E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31582","DOI":"10.1074\/jbc.M112.389957","volume":"287","author":"P\u00e9rez-Bern\u00e1","year":"2012","journal-title":"J. Biol. Chem."},{"key":"C8NR10182E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/JVI.02884-13","volume":"88","author":"P\u00e9rez-Bern\u00e1","year":"2014","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/srep01434","volume":"3","author":"Ortega-Esteban","year":"2013","journal-title":"Sci. Rep."},{"key":"C8NR10182E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.chom.2011.08.010","volume":"10","author":"Strunze","year":"2011","journal-title":"Cell Host Microbe"},{"key":"C8NR10182E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1016\/j.jmb.2018.08.011","volume":"430","author":"Natchiar","year":"2018","journal-title":"J. Mol. Biol."},{"key":"C8NR10182E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chom.2011.07.006","volume":"10","author":"Burckhardt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"C8NR10182E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1126\/science.1187292","volume":"329","author":"Reddy","year":"2010","journal-title":"Science"},{"key":"C8NR10182E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/JVI.01926-06","volume":"81","author":"Iacobelli-Martinez","year":"2007","journal-title":"J. Virol."},{"key":"C8NR10182E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.virol.2010.03.028","volume":"402","author":"Reddy","year":"2010","journal-title":"Virology"},{"key":"C8NR10182E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1063\/1.1150021","volume":"70","author":"Sader","year":"1999","journal-title":"Rev. Sci. Instrum."},{"key":"C8NR10182E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"36972","DOI":"10.1038\/srep36972","volume":"6","author":"Vorselen","year":"2016","journal-title":"Sci. Rep."},{"key":"C8NR10182E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ultramic.2012.01.007","volume":"114","author":"Ortega-Esteban","year":"2012","journal-title":"Ultramicroscopy"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/NR\/C8NR10182E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:46:06Z","timestamp":1782884766000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/11\/9\/4015-4024\/612946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,2,28]]}},"URL":"https:\/\/doi.org\/10.1039\/c8nr10182e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8NR10182E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"D. Denning (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2158-0465","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 17 December 2018; Accepted 11 February 2019; Accepted Manuscript published 14 February 2019; Advance Article published 15 February 2019; Version of Record published 28 February 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}