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Chem."],"abstract":"<p>\n                    The screening of a small chemical library showed 2-thioxodihydropyrido[2,3-\n                    <italic>d<\/italic>\n                    ]pyrimidine\n                    <bold>10a<\/bold>\n                    had broad spectrum antibacterial activity (MIC 0.49\u20133.9 \u03bcg mL\n                    <sup>\u22121<\/sup>\n                    ), and reasonable antifungal activity (MIC 31.25 \u03bcg mL\n                    <sup>\u22121<\/sup>\n                    ).\n                  <\/p>","DOI":"10.1039\/c8ob00627j","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T16:03:42Z","timestamp":1523289822000},"page":"3389-3395","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["An improved synthesis of pyrido[2,3-\n                    <i>d<\/i>\n                    ]pyrimidin-4(1\n                    <i>H<\/i>\n                    )-ones and their antimicrobial activity"],"prefix":"10.1039","volume":"16","author":[{"given":"Mohamed","family":"Fares","sequence":"first","affiliation":[{"name":"School of Chemistry"},{"name":"University of Wollongong"},{"name":"Wollongong 2522"},{"name":"Australia"},{"name":"Department of Pharmaceutical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha R.","family":"Abd El Hadi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Egyptian Russian University"},{"name":"Cairo"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwa A.","family":"Eladwy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology"},{"name":"Faculty of Pharmacy"},{"name":"Egyptian Russian University"},{"name":"Cairo 11829"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly A.","family":"Shoun","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology"},{"name":"Faculty of Pharmacy"},{"name":"Badr University in Cairo"},{"name":"Cairo"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Abdel-Aziz","sequence":"additional","affiliation":[{"name":"The Regional Center for Mycology and Biotechnology"},{"name":"Al-Azhar University"},{"name":"Cairo 11759"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Kafrelsheikh University"},{"name":"Kafrelsheikh"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem A.","family":"Abdel-Aziz","sequence":"additional","affiliation":[{"name":"Department of Applied Organic Chemistry"},{"name":"National Research Center"},{"name":"Cairo 12622"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-845X","authenticated-orcid":false,"given":"Paul A.","family":"Keller","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"University of Wollongong"},{"name":"Wollongong 2522"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8OB00627J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"C8OB00627J-(cit2)\/*[position()=1]","first-page":"25","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. 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