{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:05:18Z","timestamp":1788476718985,"version":"build-2803163510"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"48","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"am","delay-in-days":696,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21072102"],"award-info":[{"award-number":["21072102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004945","name":"Nankai University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004945","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>\n                    A sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones afforded cyclopentanone-fused spiro-pyrazolones catalyzed by DPPB\n                    <italic>via<\/italic>\n                    dual \u03b1\u2032,\u03b1\u2032-C(sp\n                    <sup>3<\/sup>\n                    )\u2013H bifunctionalization.\n                  <\/p>","DOI":"10.1039\/c8ob02675k","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T23:04:24Z","timestamp":1543359864000},"page":"9461-9471","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones\n                    <i>via<\/i>\n                    dual \u03b1\u2032,\u03b1\u2032-C(sp\n                    <sup>3<\/sup>\n                    )\u2013H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones"],"prefix":"10.1039","volume":"16","author":[{"given":"Jiayong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry"},{"name":"College of Chemistry"},{"name":"Nankai University"},{"name":"Tianjin 300071"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-7501","authenticated-orcid":false,"given":"Zhiwei","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry"},{"name":"College of Chemistry"},{"name":"Nankai University"},{"name":"Tianjin 300071"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8OB02675K-(cit1a)\/*[position()=1]","first-page":"143","volume-title":"Advances in Heterocyclic Chemistry","volume":"98","author":"Varvounis","year":"2009","unstructured":"G. Varvounis  ,  Pyrazol-3-ones. Part IV: Synthesis and Applications , in  Advances in Heterocyclic Chemistry , ed.  A. R. Katritzky ,  Academic Press ,  New York ,  2009 , vol.  98 , p.  143"},{"key":"C8OB02675K-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/cr020033s","volume":"103","author":"Horton","year":"2003","journal-title":"Chem. Rev."},{"key":"C8OB02675K-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1039\/b920767h","volume":"38","author":"Dalpozzo","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0028-1083300","author":"Kotha","year":"2009","journal-title":"Synthesis"},{"key":"C8OB02675K-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1021\/ol802952e","volume":"11","author":"Wang","year":"2009","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit2c)\/*[position()=1]","first-page":"2768","author":"Shaw","year":"2016","journal-title":"Synthesis"},{"key":"C8OB02675K-(cit2d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1002\/chem.201600515","volume":"22","author":"Wang","year":"2016","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8OB02675K-(cit2e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/anie.201510602","volume":"55","author":"Hack","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit3a)\/*[position()=1]","volume-title":"Recent Progress in the Chemical Synthesis of Antibiotics","author":"Marchand-Brynaert","year":"1990","unstructured":"J. Marchand-Brynaert   and  L.Ghosez , in  Recent Progress in the Chemical Synthesis of Antibiotics , ed.  G. Lukacs  and  M. Ohno ,  Springer ,  Berlin ,  1990"},{"key":"C8OB02675K-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12789","DOI":"10.1016\/S0040-4020(97)00476-6","volume":"53","author":"Hanessian","year":"1997","journal-title":"Tetrahedron"},{"key":"C8OB02675K-(cit3c)\/*[position()=1]","first-page":"287","volume":"2","author":"Konaklieva","year":"2003","journal-title":"Curr. Med. Chem.: Anti-Infect. Agents"},{"key":"C8OB02675K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1471-4159.1982.tb04733.x","volume":"39","author":"White","year":"1982","journal-title":"J. Neurochem."},{"key":"C8OB02675K-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1096-9063(199610)48:2<165::AID-PS455>3.0.CO;2-Z","volume":"48","author":"Tada","year":"1996","journal-title":"Pestic. Sci."},{"key":"C8OB02675K-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1002\/anie.201700021","volume":"56","author":"Zheng","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1002\/anie.201311214","volume":"53","author":"Han","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/anie.201510602","volume":"55","author":"Hack","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1002\/chem.201600515","volume":"22","author":"Wang","year":"2016","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8OB02675K-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1039\/B607547A","volume":"36","author":"Campos","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ar800164n","volume":"42","author":"Li","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit7c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/cr100280d","volume":"111","author":"Yeung","year":"2011","journal-title":"Chem. Rev."},{"key":"C8OB02675K-(cit7d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/ar200185g","volume":"45","author":"Engle","year":"2012","journal-title":"Acc.\nChem. Res."},{"key":"C8OB02675K-(cit7e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/ar200318q","volume":"45","author":"Roizen","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit7f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1207661","volume":"335","author":"White","year":"2012","journal-title":"Science"},{"key":"C8OB02675K-(cit7g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11726","DOI":"10.1002\/anie.201301451","volume":"52","author":"Rouquet","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ar800164n","volume":"42","author":"Li","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/chem.200902374","volume":"16","author":"Jazzar","year":"2010","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8OB02675K-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11726","DOI":"10.1002\/anie.201301451","volume":"52","author":"Rouquet","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit8d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c0cs00063a","volume":"40","author":"Zhang","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit8e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1039\/C4QO00207E","volume":"2","author":"Qiu","year":"2015","journal-title":"Org. Chem. Front."},{"key":"C8OB02675K-(cit8f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1039\/c2cs15323h","volume":"41","author":"Zhang","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit8g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1039\/B607547A","volume":"36","author":"Campos","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit8h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1039\/c1cs15058h","volume":"40","author":"Baudoin","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit8i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1039\/c2cs35096c","volume":"41","author":"Li","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit8j)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/ar200318q","volume":"45","author":"Roizen","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit8k)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1039\/C1CS15104E","volume":"41","author":"Ramirez","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1021\/jacs.5b05735","volume":"137","author":"Qiu","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"C8OB02675K-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/acs.orglett.6b03546","volume":"19","author":"Sun","year":"2017","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1002\/anie.201504603","volume":"54","author":"Hu","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"C8OB02675K-(cit9d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1039\/C4CC01277A","volume":"50","author":"Gao","year":"2014","journal-title":"Chem. Commun."},{"key":"C8OB02675K-(cit9e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/adsc.201601260","volume":"359","author":"Peng","year":"2017","journal-title":"Adv. Synth. Catal."},{"key":"C8OB02675K-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1021\/ar000253x","volume":"34","author":"Lu","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit10b)\/*[position()=1]","first-page":"317","author":"Valentine","year":"2003","journal-title":"Synthesis"},{"key":"C8OB02675K-(cit10c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/adsc.200404087","volume":"346","author":"Methot","year":"2004","journal-title":"Adv. Synth. Catal."},{"key":"C8OB02675K-(cit10d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1351\/pac200577121985","volume":"77","author":"Lu","year":"2005","journal-title":"Pure Appl. Chem."},{"key":"C8OB02675K-(cit10e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1021\/ar0502026","volume":"39","author":"Nair","year":"2006","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit10f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1039\/b717758e","volume":"37","author":"Ye","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"C8OB02675K-(cit10g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1055\/s-0030-1260804","author":"Kinderman","year":"2011","journal-title":"Synlett"},{"key":"C8OB02675K-(cit10h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.3762\/bjoc.10.218","volume":"10","author":"Xiao","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"C8OB02675K-(cit10i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1021\/acs.accounts.6b00163","volume":"49","author":"Wang","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"C8OB02675K-(cit10j)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/ol020198n","volume":"5","author":"Kuroda","year":"2003","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit10k)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1021\/acscatal.8b00397","volume":"8","author":"Mondal","year":"2018","journal-title":"ACS Catal."},{"key":"C8OB02675K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18316","DOI":"10.1002\/chem.201604562","volume":"22","author":"Raghu","year":"2016","journal-title":"Chem. \u2013 Eur. J."},{"key":"C8OB02675K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1021\/acs.orglett.7b01482","volume":"19","author":"Huang","year":"2017","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit13)\/*[position()=1]","first-page":"4720","author":"Yu","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"C8OB02675K-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"91108","DOI":"10.1039\/C5RA17792H","volume":"5","author":"Zheng","year":"2015","journal-title":"RSC Adv."},{"key":"C8OB02675K-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107984","DOI":"10.1039\/C6RA23399F","volume":"6","author":"Zhang","year":"2016","journal-title":"RSC Adv."},{"key":"C8OB02675K-(cit14c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"63246","DOI":"10.1039\/C4RA12997K","volume":"4","author":"Yu","year":"2014","journal-title":"RSC Adv."},{"key":"C8OB02675K-(cit14d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1021\/acs.joc.7b01582","volume":"82","author":"Zhang","year":"2017","journal-title":"J. Org. Chem."},{"key":"C8OB02675K-(cit14e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1002\/adsc.201701013","volume":"359","author":"Li","year":"2017","journal-title":"Adv. Synth. Catal."},{"key":"C8OB02675K-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1039\/C1OB06010D","volume":"10","author":"Hopewell","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"C8OB02675K-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1021\/acs.orglett.7b01309","volume":"19","author":"Sadamitsu","year":"2017","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1021\/ol402364t","volume":"15","author":"Yang","year":"2013","journal-title":"Org. Lett."},{"key":"C8OB02675K-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1021\/ja971238z","volume":"119","author":"Trost","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"C8OB02675K-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1039\/c2ob25801c","volume":"10","author":"Lian","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"C8OB02675K-(cit19a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12928","DOI":"10.1021\/ja073754n","volume":"129","author":"Sriramurthy","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C8OB02675K-(cit19b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1021\/ja110147w","volume":"133","author":"Tan","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C8OB02675K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.mencom.2011.11.019","volume":"21","author":"Khasiyatullina","year":"2011","journal-title":"Mendeleev Commun."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/OB\/C8OB02675K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:59:34Z","timestamp":1782968374000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/16\/48\/9461-9471\/614238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":67,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2018,12,12]]}},"URL":"https:\/\/doi.org\/10.1039\/c8ob02675k","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8OB02675K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=C8OB02675K","name":"related_data"},{"value":"Zhiwei Miao (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3534-7501","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 October 2018; Accepted 27 November 2018;  Accepted Manuscript published 28 November 2018;  Advance Article published 5 December 2018;  Version of Record published 12 December 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}