{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:06:31Z","timestamp":1782936391877,"version":"3.54.5"},"reference-count":16,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"am","delay-in-days":393,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072555"],"award-info":[{"award-number":["81072555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81425022"],"award-info":[{"award-number":["81425022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["41306140"],"award-info":[{"award-number":["41306140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","award":["2012AA092104"],"award-info":[{"award-number":["2012AA092104"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"crossref","award":["201806010109"],"award-info":[{"award-number":["201806010109"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"crossref","award":["201707010454"],"award-info":[{"award-number":["201707010454"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>MtdV is a chorismate lyase involved in converting chorismate to 4HB, a vital precursor of A201A; precursor-directed biosynthesis enabled production of new A201A analogs.<\/p>","DOI":"10.1039\/c8ob02852d","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:34:21Z","timestamp":1548722061000},"page":"3760-3764","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs"],"prefix":"10.1039","volume":"17","author":[{"given":"Qinghua","family":"Zhu","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology"},{"name":"Guangdong Key Laboratory of Marine Materia Medica"},{"name":"RNAM Center for Marine Microbiology"},{"name":"South China Sea Institute of Oceanology"},{"name":"Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Song","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology"},{"name":"Guangdong Key Laboratory of Marine Materia Medica"},{"name":"RNAM Center for Marine Microbiology"},{"name":"South China Sea Institute of Oceanology"},{"name":"Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Huang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology"},{"name":"Guangdong Key Laboratory of Marine Materia Medica"},{"name":"RNAM Center for Marine Microbiology"},{"name":"South China Sea Institute of Oceanology"},{"name":"Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglian","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology"},{"name":"Guangdong Key Laboratory of Marine Materia Medica"},{"name":"RNAM Center for Marine Microbiology"},{"name":"South China Sea Institute of Oceanology"},{"name":"Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-8027","authenticated-orcid":false,"given":"Jianhua","family":"Ju","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology"},{"name":"Guangdong Key Laboratory of Marine Materia Medica"},{"name":"RNAM Center for Marine Microbiology"},{"name":"South China Sea Institute of Oceanology"},{"name":"Chinese Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8OB02852D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"C8OB02852D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/jac\/dkp255","volume":"64","author":"Livermore","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"C8OB02852D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","volume":"6","author":"Payne","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C8OB02852D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/acsinfecdis.5b00100","volume":"1","author":"Bush","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"C8OB02852D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrd.2016.155","volume":"15","author":"Outterson","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C8OB02852D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.7164\/antibiotics.38.575","volume":"38","author":"Kirst","year":"1985","journal-title":"J. Antibiot."},{"key":"C8OB02852D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1021\/np200399t","volume":"74","author":"Huang","year":"2011","journal-title":"J. Nat. Prod."},{"key":"C8OB02852D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.molcel.2015.04.014","volume":"58","author":"Polikanov","year":"2015","journal-title":"Mol. Cell"},{"key":"C8OB02852D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/AAC.05278-11","volume":"56","author":"Zhu","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"C8OB02852D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1073\/pnas.1620191114","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8OB02852D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1128\/AAC.47.7.2065-2071.2003","volume":"47","author":"Habib","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"C8OB02852D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.chembiol.2006.05.013","volume":"13","author":"Palaniappan","year":"2006","journal-title":"Chem. Biol."},{"key":"C8OB02852D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ja.2016.123","volume":"70","author":"Saugar","year":"2017","journal-title":"J. Antibiot."},{"key":"C8OB02852D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1128\/jb.174.16.5309-5316.1992","volume":"174","author":"Nichols","year":"1992","journal-title":"J. Bacteriol."},{"key":"C8OB02852D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1099\/00221287-140-4-897","volume":"140","author":"Siebert","year":"1994","journal-title":"Microbiol."},{"key":"C8OB02852D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1128\/JCM.38.9.3341-3348.2000","volume":"38","author":"Kiehlbauch","year":"2000","journal-title":"J. Clin. Microbiol."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/OB\/C8OB02852D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:20:22Z","timestamp":1782930022000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/17\/15\/3760-3764\/614321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":16,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,4,10]]}},"URL":"https:\/\/doi.org\/10.1039\/c8ob02852d","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8OB02852D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Jianhua Ju (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7712-8027","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 November 2018; Accepted 23 January 2019; Accepted Manuscript published 29 January 2019; Advance Article published 31 January 2019; Version of Record published 10 April 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}