{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:54:09Z","timestamp":1770072849476,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":879,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1039\/c8pp00019k","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T17:04:14Z","timestamp":1524848654000},"page":"773-780","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lack of phototoxicity potential with delafloxacin in healthy male and female subjects: comparison to lomefloxacin"],"prefix":"10.1007","volume":"17","author":[{"given":"R. S.","family":"Dawe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ibbotson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cammarata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"170609_CR1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1128\/AAC.48.3.799-803.2004","volume":"48","author":"N Hayashi","year":"2004","unstructured":"N. Hayashi, Y. Nakata and A. Yazaki, New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1, Antimicrob. Agents Chemother., 2004, 48 (3), 799\u2013803.","journal-title":"Antimicrob. Agents Chemother."},{"key":"170609_CR2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1021\/tx400377s","volume":"27","author":"S Soldevila","year":"2014","unstructured":"S. Soldevila, Consuelo Cuquerella M, Bosca, F. Understanding of the Photoallergic Properties of Fluroquinolones: Photoreactivity of Lomefloxacin with Amino Acids and Albumin, Chem. Res. Toxicol., 2014, 27 (4), 514\u2013523.","journal-title":"Chem. Res. Toxicol."},{"key":"170609_CR3","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1086\/428055","volume":"41","author":"R C Owens","year":"2005","unstructured":"R. C. Owens and P. G. Ambrose, Antimicrobial safety: focus on fluoroquinolones, Clin. Infect. Dis., 2005, 41 (Suppl. 2), S144\u2013S157.","journal-title":"Clin. Infect. Dis."},{"key":"170609_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/jac\/33.4.685","volume":"33","author":"J M Domagala","year":"1994","unstructured":"J. M. Domagala, Structure-activity and structure-side-effect relationships for the quinolone antibacterials, J. Antimicrob. Chemother., 1994, 33 (4), 685\u2013706.","journal-title":"J. Antimicrob. Chemother."},{"key":"170609_CR5","first-page":"32","volume":"1810","author":"FoodDrug Administration","year":"1993","unstructured":"Food and Drug Administration, FDA Committee urges stronger warnings on Maxaquin, Script, 1993, 1810, 32\u201333.","journal-title":"Script"},{"key":"170609_CR6","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1001\/archderm.1994.01690060142028","volume":"130","author":"J B Cohen","year":"1994","unstructured":"J. B. Cohen and P. R. Bergstresser, Inadvertent phototoxicity from home tanning equipment, Arch. Dermatol., 1994, 130 (6), 804\u2013806.","journal-title":"Arch. Dermatol."},{"key":"170609_CR7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1574886308666140106154754","volume":"9","author":"J Sousa","year":"2014","unstructured":"J. Sousa, G. Alves, A. Fortuna and A. Falcao, Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles, Curr. Drug Saf., 2014, 9 (2), 89\u2013105.","journal-title":"Curr. Drug Saf."},{"key":"170609_CR8","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1086\/515104","volume":"28","author":"B A Lipsky","year":"1999","unstructured":"B. A. Lipsky and C. A. Baker, Fluoroquinolone toxicity profiles: a review focusing on newer agents, Clin. Infect. Dis, 1999, 28 (2), 352\u2013361.","journal-title":"Clin. Infect. Dis"},{"key":"170609_CR9","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/S0025-7125(05)70297-2","volume":"84","author":"R C Owens","year":"2000","unstructured":"R. C. Owens and P. G. Ambrose, Clinical use of the fluoroquinolones, Med. Clin. North. Am., 2000, 84 (6), 1447\u20131469.","journal-title":"Med. Clin. North. Am."},{"key":"170609_CR10","first-page":"415","volume":"21","author":"T File","year":"2003","unstructured":"T. File and P. Iannini, A profile of gemifloxacin, a new respiratory fluoroquinolone, Todays Ther. Trends, 2003, 21 (4), 415\u2013435.","journal-title":"Todays Ther. Trends"},{"key":"170609_CR11","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/S0149-2918(04)90170-1","volume":"26","author":"P Ball","year":"2004","unstructured":"P. Ball, R. Stahlmann, R. Kubin and S. Choudhri, Owens R. Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies, Clin. Ther., 2004, 26 (7), 940\u2013950.","journal-title":"Clin. Ther."},{"key":"170609_CR12","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1086\/378809","volume":"37","author":"L D Saravolatz","year":"2003","unstructured":"L. D. Saravolatz and J. Leggett, Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones, Clin. Infect. Dis, 2003, 37 (9), 1210\u20131215.","journal-title":"Clin. Infect. Dis"},{"key":"170609_CR13","doi-asserted-by":"publisher","first-page":"S113","DOI":"10.1086\/428051","volume":"41","author":"V T Andriole","year":"2005","unstructured":"V. T. Andriole, The quinolones: past, present, and future, Clin. Infect. Dis, 2005, 41 (Suppl. 2), S113\u2013S119.","journal-title":"Clin. Infect. Dis"},{"key":"170609_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/jac\/43.suppl_2.77","volume":"43","author":"I Man","year":"1999","unstructured":"I. Man, J. Murphy and J. Ferguson, Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers, J. Antimicrob. Chemother., 1999, 43 (Suppl. 2), 77\u201382.","journal-title":"J. Antimicrob. Chemother."},{"key":"170609_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2165\/00003495-199958002-00138","volume":"58","author":"J Ferguson","year":"1999","unstructured":"J. Ferguson, J. McEwen, K. Gohler, A. Mignot and D. Watson, Phototoxic potential of gatifloxacin, a new fluoroquinolone antimicrobial, Drugs, 1999, 58 (2), 397\u2013399.","journal-title":"Drugs"},{"key":"170609_CR16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.clinthera.2015.10.016","volume":"38","author":"R Hoover","year":"2016","unstructured":"R. Hoover, T. Hunt, M. Benedict, {etet al.} Single and Multiple Ascending-dose Studies of Oral Delafloxacin: Effects of Food, Sex, and Age, Clin. Ther., 2016, 38 (1), 39\u201352.","journal-title":"Clin. Ther."},{"key":"170609_CR17","volume-title":"Photosafety Evaluation of Pharmaceuticals: Guidance for Industry","author":"US Department of HealthHuman Services FoodDrug Administration","year":"2014","unstructured":"US Department of Health and Human Services Food and Drug Administration, Photosafety Evaluation of Pharmaceuticals: Guidance for Industry, 2014."},{"key":"170609_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1001\/archderm.1988.01670060015008","volume":"124","author":"T B Fitzpatrick","year":"1988","unstructured":"T. B. Fitzpatrick, The validity and practicality of sun-reactive skin types I through VI, Arch. Dermatol., 1988, 124 (6), 869\u2013871.","journal-title":"Arch. Dermatol."},{"key":"170609_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2133.1973.tb02972.x","volume":"89","author":"L Mackenzie","year":"1973","unstructured":"L. Mackenzie and W. Frain-Bell, The construction and development of a grating monochromator and its application to the study of the reaction of the skin to light, Br.J. Dermatol., 1973, 89 (3), 251\u2013264.","journal-title":"Br.J. Dermatol."},{"key":"170609_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1600-0781.2009.00487.x","volume":"26","author":"H Moseley","year":"2010","unstructured":"H. Moseley and J. Ferguson, Which light source should be used for the investigation of clinical phototoxicity: monochromator or solar simulator?, Photodermatol., Photoimmunol. Photomed., 2010, 26 (1), 3\u20136.","journal-title":"Photodermatol., Photoimmunol. Photomed."},{"key":"170609_CR21","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1600-0781.1999.tb00050.x","volume":"15","author":"I Man","year":"1999","unstructured":"I. Man, N. Traynor and J. Ferguson, Recent developments in fluoroquinolone phototoxicity, Photodermatol., Photoimmunol. Photomed., 1999, 15 (1), 32\u201333.","journal-title":"Photodermatol., Photoimmunol. Photomed."},{"key":"170609_CR22","unstructured":"FDA, Clinical Reivew - Baxdela\u2122 (delafloxacin) application numbers NDA 208,610 and NDA 208,611, 2017. Retrieved from https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2017\/208610Orig1s000,208611Orig1s000MedR.pdf."}],"container-title":["Photochemical & Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c8pp00019k.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1039\/c8pp00019k\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/PP\/C8PP00019K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c8pp00019k.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T15:25:45Z","timestamp":1667402745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1039\/c8pp00019k"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["170609"],"URL":"https:\/\/doi.org\/10.1039\/c8pp00019k","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"17 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}