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Res."},{"key":"C8RA03620A-(cit96)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1002\/chem.201103546","volume":"18","author":"Jensen","year":"2012","journal-title":"Chem.\u2013Eur. J."},{"key":"C8RA03620A-(cit97)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1002\/chem.201600286","volume":"22","author":"Caballero","year":"2016","journal-title":"Chem.\u2013Eur. J."},{"key":"C8RA03620A-(cit98)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1021\/acschemneuro.6b00175","volume":"7","author":"Rajasekhar","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"C8RA03620A-(cit99)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1021\/acs.accounts.5b00119","volume":"48","author":"Robert","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"C8RA03620A-(cit100)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"C8RA03620A-(cit101)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1471-4159.2011.07402.x","volume":"119","author":"Crouch","year":"2011","journal-title":"J. Neurochem."},{"key":"C8RA03620A-(cit102)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1021\/ja210588m","volume":"134","author":"Sharma","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C8RA03620A-(cit103)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1021\/jm400567s","volume":"56","author":"Lu","year":"2013","journal-title":"J. Med. 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Res."},{"key":"C8RA03620A-(cit108)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e34929","DOI":"10.1371\/journal.pone.0034929","volume":"7","author":"Cha","year":"2012","journal-title":"PLoS One"},{"key":"C8RA03620A-(cit109)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrclinonc.2018.36","volume":"15","author":"Ott","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"C8RA03620A-(cit110)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4161\/hv.28183","volume":"10","author":"Fettelschoss","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"C8RA03620A-(cit111)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9810","DOI":"10.1073\/pnas.0703137104","volume":"104","author":"Muhs","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. 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Disord.: Drug Targets"},{"key":"C8RA03620A-(cit133)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1126\/science.1156609","volume":"320","author":"Rajendran","year":"2008","journal-title":"Science"},{"key":"C8RA03620A-(cit134)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1210951","volume":"369","author":"Doody","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"C8RA03620A-(cit135)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1001\/archneurol.2012.2194","volume":"69","author":"Coric","year":"2009","journal-title":"Arch. Neurol."},{"key":"C8RA03620A-(cit136)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"P259","DOI":"10.1016\/j.jalz.2009.04.287","volume":"5","author":"Grossman","journal-title":"Alzheimer's Dementia"},{"key":"C8RA03620A-(cit137)\/*[position()=1]","first-page":"427","volume":"8","author":"Zhang","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"C8RA03620A-(cit138)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3389\/fncel.2013.00189","volume":"7","author":"Tell","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"C8RA03620A-(cit139)\/*[position()=1]","first-page":"595","volume":"13","author":"Dolan","year":"2010","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"C8RA03620A-(cit140)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1074\/jbc.M111.306472","volume":"287","author":"Dom\u00ednguez","year":"2012","journal-title":"J. Biol. Chem."},{"key":"C8RA03620A-(cit141)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1007\/s12035-015-9369-x","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"C8RA03620A-(cit142)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/WAD.0b013e318204b550","volume":"25","author":"Sabbagh","year":"2011","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"C8RA03620A-(cit143)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2217\/14796708.4.2.167","volume":"4","author":"Lue","year":"2009","journal-title":"Future Neurol."},{"key":"C8RA03620A-(cit144)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/nm.1872","volume":"14","author":"Schilling","year":"2008","journal-title":"Nat. Med."},{"key":"C8RA03620A-(cit145)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ajpath.2013.05.005","volume":"183","author":"Frost","year":"2013","journal-title":"Am. J. Pathol."},{"key":"C8RA03620A-(cit146)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/jpet.117.240614","volume":"362","author":"Hoffmann","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"C8RA03620A-(cit147)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1074\/jbc.M114.586602","volume":"290","author":"Hori","year":"2015","journal-title":"J. Biol. Chem."},{"key":"C8RA03620A-(cit148)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2174\/1567205013666160819124206","volume":"13","author":"Budni","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"C8RA03620A-(cit149)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1021\/acschemneuro.5b00002","volume":"6","author":"Roy","year":"2015","journal-title":"ACS Chem. 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