{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:46:48Z","timestamp":1790066808593,"version":"4.0.1"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>We present the concept of aptachain. An aptamer is split into two overlapping strands that form an oligomer when it binds its target. Aptachain formation can be used to detect ligand binding and may be beneficial in other biotechnology applications.<\/jats:p>","DOI":"10.1039\/c8ra07462c","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T03:24:09Z","timestamp":1547436249000},"page":"1690-1695","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A proof of concept application of aptachain: ligand-induced self-assembly of a DNA aptamer"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-486X","authenticated-orcid":false,"given":"Miguel A. D.","family":"Neves","sequence":"first","affiliation":[{"name":"Department of Chemistry & Centre for Research on Biomolecular Interactions, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sladjana","family":"Slavkovic","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Centre for Research on Biomolecular Interactions, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Reinstein","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Centre for Research on Biomolecular Interactions, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5580-1273","authenticated-orcid":false,"given":"Aron A.","family":"Shoara","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Centre for Research on Biomolecular Interactions, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-4891","authenticated-orcid":false,"given":"Philip E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Centre for Research on Biomolecular Interactions, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C8RA07462C\/cit1\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.coche.2015.01.001","volume":"7","author":"Lanier","year":"2015","journal-title":"Curr. Opin. Chem. Eng."},{"key":"C8RA07462C\/cit2\/1","doi-asserted-by":"crossref","first-page":"17068","DOI":"10.1038\/natrevmats.2017.68","volume":"3","author":"Seeman","year":"2017","journal-title":"Nat. Rev. Mater."},{"key":"C8RA07462C\/cit3\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cbpa.2018.04.012","volume":"46","author":"Chidchob","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"C8RA07462C\/cit4\/1","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1039\/C7NR07348H","volume":"10","author":"Harroun","year":"2018","journal-title":"Nanoscale"},{"key":"C8RA07462C\/cit5\/1","doi-asserted-by":"crossref","first-page":"1703658","DOI":"10.1002\/adma.201703658","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"key":"C8RA07462C\/cit6\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-anchem-071015-041446","volume":"9","author":"Schoukroun-Barnes","year":"2016","journal-title":"Annu. Rev. Anal. Chem."},{"key":"C8RA07462C\/cit7\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2018.04.007","volume":"134","author":"R\u00f6thlisberger","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"C8RA07462C\/cit8\/1","doi-asserted-by":"crossref","first-page":"11547","DOI":"10.1021\/ja0022223","volume":"122","author":"Stojanovic","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"C8RA07462C\/cit9\/1","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.1021\/bi100952k","volume":"49","author":"Neves","year":"2010","journal-title":"Biochemistry"},{"key":"C8RA07462C\/cit10\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bpc.2010.09.009","volume":"153","author":"Neves","year":"2010","journal-title":"Biophys. Chem."},{"key":"C8RA07462C\/cit11\/1","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.1021\/ja205518e","volume":"133","author":"Sharma","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C8RA07462C\/cit12\/1","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1039\/c2ra20307c","volume":"2","author":"Zou","year":"2012","journal-title":"RSC Adv."},{"key":"C8RA07462C\/cit13\/1","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1039\/b900001a","author":"Pei","year":"2009","journal-title":"Chem. Commun."},{"key":"C8RA07462C\/cit14\/1","doi-asserted-by":"crossref","first-page":"8652","DOI":"10.1021\/bi4010039","volume":"52","author":"Reinstein","year":"2013","journal-title":"Biochemistry"},{"key":"C8RA07462C\/cit15\/1","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.bmc.2015.02.052","volume":"23","author":"Slavkovic","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"C8RA07462C\/cit16\/1","doi-asserted-by":"crossref","first-page":"13471","DOI":"10.1039\/C6CC05576A","volume":"52","author":"Harkness V","year":"2016","journal-title":"Chem. Commun."},{"key":"C8RA07462C\/cit17\/1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1139\/cjc-2017-0380","volume":"95","author":"Shoara","year":"2017","journal-title":"Can. J. Chem."},{"key":"C8RA07462C\/cit18\/1","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1021\/jacs.7b13044","volume":"140","author":"G\u00fclbakan","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"C8RA07462C\/cit19\/1","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1039\/C8AY00585K","volume":"10","author":"Qiu","year":"2018","journal-title":"Anal. Methods"},{"key":"C8RA07462C\/cit20\/1","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1016\/j.bmc.2018.09.017","volume":"26","author":"Slavkovic","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"C8RA07462C\/cit21\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bios.2017.10.025","volume":"101","author":"Wang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"C8RA07462C\/cit22\/1","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1021\/acs.langmuir.7b02104","volume":"33","author":"Lu","year":"2017","journal-title":"Langmuir"},{"key":"C8RA07462C\/cit23\/1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/nar\/gkx1267","volume":"46","author":"Az\u00e9ma","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"C8RA07462C\/cit24\/1","first-page":"45","volume":"2","author":"Slavkovic","year":"2018","journal-title":"Aptamers"},{"key":"C8RA07462C\/cit25\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mas.20100","volume":"26","author":"Lavagnini","year":"2007","journal-title":"Mass Spectrom. Rev."},{"key":"C8RA07462C\/cit26\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.snb.2015.12.044","volume":"227","author":"Zuber","year":"2016","journal-title":"Sens. Actuators, B"},{"key":"C8RA07462C\/cit27\/1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s11671-009-9415-6","volume":"4","author":"Guo","year":"2009","journal-title":"Nanoscale Res. Lett."},{"key":"C8RA07462C\/cit28\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1743-8977-10-50","volume":"10","author":"Vetten","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"C8RA07462C\/cit29\/1","volume-title":"Statistics and Chemometrics for Analytical Chemistry","author":"Miller","year":"2010","unstructured":"J. N.Miller  and  J. C.Miller ,  Statistics and Chemometrics for Analytical Chemistry ,  Pearson Education Limited ,  Harlow, England , 6th edn,  2010"},{"key":"C8RA07462C\/cit30\/1","first-page":"1041","volume":"45","author":"Neves","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"C8RA07462C\/cit31\/1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/smll.200901012","volume":"6","author":"Zhang","year":"2010","journal-title":"Small"},{"key":"C8RA07462C\/cit32\/1","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.bios.2010.12.012","volume":"26","author":"Zhang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"C8RA07462C\/cit33\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jim.2010.02.007","volume":"356","author":"Thobhani","year":"2010","journal-title":"J. Immunol. Methods"},{"key":"C8RA07462C\/cit34\/1","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1021\/ac800589s","volume":"80","author":"Wu","year":"2008","journal-title":"Anal. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/RA\/C8RA07462C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:40:22Z","timestamp":1782927622000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/9\/3\/1690-1695\/1236008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,1,9]]}},"URL":"https:\/\/doi.org\/10.1039\/c8ra07462c","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}