{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:16:53Z","timestamp":1790824613609,"version":"4.1.0"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"34","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":200,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006234","name":"Sandia National Laboratories","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006234","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["P41-GM104601"],"award-info":[{"award-number":["P41-GM104601"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01-GM123455"],"award-info":[{"award-number":["R01-GM123455"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["U54-GM087519"],"award-info":[{"award-number":["U54-GM087519"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<p>Two binding poses of the teixobactin\u2013lipid II complex were captured with MD simulations at the membrane surface.<\/p>","DOI":"10.1039\/c8sc02616e","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T09:35:28Z","timestamp":1532079328000},"page":"6997-7008","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Probing key elements of teixobactin\u2013lipid II interactions in membranes"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-6904","authenticated-orcid":false,"given":"Po-Chao","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Biochemistry"},{"name":"Center for Biophysics and Quantitative Biology"},{"name":"Beckman Institute for Advanced Science and Technology"},{"name":"University of Illinois at Urbana-Champaign"},{"name":"Urbana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Vanegas","sequence":"additional","affiliation":[{"name":"Department of Nanobiology"},{"name":"Center for Biological and Engineering Sciences"},{"name":"Sandia National Laboratories"},{"name":"Albuquerque"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1623-2108","authenticated-orcid":false,"given":"Susan B.","family":"Rempe","sequence":"additional","affiliation":[{"name":"Department of Nanobiology"},{"name":"Center for Biological and Engineering Sciences"},{"name":"Sandia National Laboratories"},{"name":"Albuquerque"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-1010","authenticated-orcid":false,"given":"Emad","family":"Tajkhorshid","sequence":"additional","affiliation":[{"name":"Department of Biochemistry"},{"name":"Center for Biophysics and Quantitative Biology"},{"name":"Beckman Institute for Advanced Science and Technology"},{"name":"University of Illinois at Urbana-Champaign"},{"name":"Urbana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8SC02616E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1254163","volume":"345","author":"Laxminarayan","year":"2014","journal-title":"Science"},{"key":"C8SC02616E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ja.2017.30","volume":"70","author":"Martens","year":"2017","journal-title":"J. Antibiot."},{"key":"C8SC02616E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/EBC20160053","volume":"61","author":"Venter","year":"2017","journal-title":"Essays Biochem."},{"key":"C8SC02616E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1002\/anie.201506818","volume":"55","author":"Chellat","year":"2016","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"C8SC02616E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cmi.2017.06.020","volume":"23","author":"Theuretzbacher","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"C8SC02616E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"C8SC02616E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1128\/AAC.01050-16","volume":"60","author":"Homma","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"C8SC02616E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1021\/acs.orglett.5b03176","volume":"17","author":"Jad","year":"2015","journal-title":"Org. Lett."},{"key":"C8SC02616E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1021\/acschembio.6b00295","volume":"11","author":"Yang","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"C8SC02616E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73827","DOI":"10.1039\/C6RA17720D","volume":"6","author":"Monaim","year":"2016","journal-title":"RSC Adv."},{"key":"C8SC02616E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1021\/acsomega.6b00354","volume":"1","author":"Monaim","year":"2016","journal-title":"ACS Omega"},{"key":"C8SC02616E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1039\/C5CC10249A","volume":"52","author":"Parmar","year":"2016","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1039\/C6CC09490B","volume":"53","author":"Parmar","year":"2017","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1039\/C7CC04021K","volume":"53","author":"Parmar","year":"2017","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1039\/C7CC00783C","volume":"53","author":"Yang","year":"2017","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1016\/j.bmc.2017.04.039","volume":"25","author":"Jin","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"C8SC02616E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1021\/acs.jmedchem.7b00834","volume":"60","author":"Monaim","year":"2017","journal-title":"J. Med. Chem."},{"key":"C8SC02616E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.3390\/molecules22101632","volume":"22","author":"Monaim","year":"2017","journal-title":"Molecules"},{"key":"C8SC02616E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1039\/C7OB02169K","volume":"15","author":"Schumacher","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"C8SC02616E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11357","DOI":"10.1039\/C7CC03415F","volume":"53","author":"Chen","year":"2017","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1016\/j.bmc.2017.09.040","volume":"26","author":"Monaim","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"C8SC02616E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1039\/C7SC03241B","volume":"8","author":"Parmar","year":"2017","journal-title":"Chem. Sci."},{"key":"C8SC02616E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bmc.2018.01.016","volume":"26","author":"Jin","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"C8SC02616E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/acs.jmedchem.7b01634","volume":"61","author":"Parmar","year":"2018","journal-title":"J. Med. Chem."},{"key":"C8SC02616E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1039\/C7CC06093A","volume":"54","author":"Girt","year":"2018","journal-title":"Chem. Commun."},{"key":"C8SC02616E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1021\/acs.jmedchem.7b01241","volume":"61","author":"Zong","year":"2018","journal-title":"J. Med. Chem."},{"key":"C8SC02616E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9136","DOI":"10.1002\/chem.201801423","volume":"24","author":"Ng","year":"2018","journal-title":"Chem.\u2013Eur. J."},{"key":"C8SC02616E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17197","DOI":"10.1038\/s41598-017-17606-5","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"C8SC02616E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/ct300400x","volume":"8","author":"Best","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"C8SC02616E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1021\/jp101759q","volume":"114","author":"Klauda","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"C8SC02616E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1021\/ct200328p","volume":"7","author":"Guvench","year":"2011","journal-title":"J. Chem. Theory Comput."},{"key":"C8SC02616E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.bpj.2014.09.007","volume":"107","author":"Kern","year":"2014","journal-title":"Biophys. J."},{"key":"C8SC02616E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J. Comput. Chem."},{"key":"C8SC02616E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1074\/jbc.271.12.6801","volume":"271","author":"Morein","year":"1996","journal-title":"J. Biol. Chem."},{"key":"C8SC02616E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1128\/JB.135.3.1043-1052.1978","volume":"135","author":"Rilfors","year":"1978","journal-title":"J. Bacteriol."},{"key":"C8SC02616E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1016\/j.bbamem.2007.05.023","volume":"1768","author":"Epand","year":"2007","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C8SC02616E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nsmb830","volume":"11","author":"Hsu","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C8SC02616E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"244101","DOI":"10.1063\/1.3435332","volume":"132","author":"Zhang","year":"2010","journal-title":"J. Chem. Phys."},{"key":"C8SC02616E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.abb.2011.10.018","volume":"517","author":"Hartley","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"C8SC02616E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/femsre\/fuv008","volume":"40","author":"Sohlenkamp","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"C8SC02616E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1128\/JB.121.1.137-143.1975","volume":"121","author":"Beining","year":"1975","journal-title":"J. Bacteriol."},{"key":"C8SC02616E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/AAC.44.1.24-29.2000","volume":"44","author":"Mota-Meira","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"C8SC02616E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31749","DOI":"10.1038\/srep31749","author":"Barbour","year":"2016","journal-title":"Sci. Rep."},{"key":"C8SC02616E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/mdr.2011.0242","volume":"18","author":"M\u00fcller","year":"2012","journal-title":"Microb. Drug Resist."},{"key":"C8SC02616E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1074\/jbc.M006770200","volume":"276","author":"Wiedemann","year":"2000","journal-title":"J. Biol. Chem."},{"key":"C8SC02616E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11567","DOI":"10.1021\/bi049476b","volume":"43","author":"Hasper","year":"2004","journal-title":"Biochemistry"},{"key":"C8SC02616E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrd2004","volume":"5","author":"Breukink","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C8SC02616E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12606","DOI":"10.1002\/chem.201601315","volume":"22","author":"Ng","year":"2016","journal-title":"Chem.\u2013Eur. J."},{"key":"C8SC02616E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1039\/C7NP00012J","volume":"34","author":"M\u00fcller","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"C8SC02616E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19868","DOI":"10.1016\/j.jmb.2008.10.026","volume":"385","author":"Nitanai","year":"2009","journal-title":"J. Mol. Biol."},{"key":"C8SC02616E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14207","DOI":"10.1073\/pnas.1308268110","volume":"110","author":"Economou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8SC02616E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1002\/anie.201501440","volume":"54","author":"von NussBaum","year":"2015","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"C8SC02616E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.7164\/antibiotics.42.1460","volume":"42","author":"Shoji","year":"1989","journal-title":"J. Antibiot."},{"key":"C8SC02616E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","volume":"32","author":"Sauvage","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"C8SC02616E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.1136611","volume":"315","author":"Lovering","year":"2007","journal-title":"Science"},{"key":"C8SC02616E-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.1203900109","volume":"109","author":"Huang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/SC\/C8SC02616E","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/SC\/C8SC02616E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:30:09Z","timestamp":1782966609000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/9\/34\/6997-7008\/622173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":56,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8sc02616e","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8SC02616E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Po-Chao Wen (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6049-6904","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Po-Chao Wen (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/I-5031-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Susan B. Rempe (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1623-2108","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Emad Tajkhorshid (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8434-1010","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 June 2018; Accepted 19 July 2018; Accepted Manuscript published 20 July 2018; Advance Article published 31 July 2018; Version of Record published 29 August 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}