{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:53:09Z","timestamp":1782975189827,"version":"3.54.5"},"reference-count":72,"publisher":"Royal Society of Chemistry (RSC)","issue":"28","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"am","delay-in-days":516,"URL":"http:\/\/rsc.li\/journals-terms-of-use#chorus"}],"funder":[{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"crossref","award":["1438255"],"award-info":[{"award-number":["1438255"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011132","name":"Rutgers, The State University of New Jersey","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011132","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Soft Matter"],"abstract":"<p>Locomotion of amoeboid cells is mediated by finger-like protrusions of the cell body, known as pseudopods, which grow, bifurcate, and retract in a dynamic fashion.<\/p>","DOI":"10.1039\/c8sm00457a","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T07:34:25Z","timestamp":1527838465000},"page":"5741-5763","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A computational model of amoeboid cell motility in the presence of obstacles"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-3930","authenticated-orcid":false,"given":"Eric J.","family":"Campbell","sequence":"first","affiliation":[{"name":"Mechanical and Aerospace Engineering Department"},{"name":"Rutgers"},{"name":"The State University of New Jersey"},{"name":"Piscataway"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-7455","authenticated-orcid":false,"given":"Prosenjit","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Mechanical and Aerospace Engineering Department"},{"name":"Rutgers"},{"name":"The State University of New Jersey"},{"name":"Piscataway"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"key":"C8SM00457A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fimmu.2016.00428","volume":"7","author":"Gaylo","year":"2016","journal-title":"Front. Immunol."},{"key":"C8SM00457A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tcb.2015.07.013","volume":"25","author":"Petrie","year":"2015","journal-title":"Trends Cell Biol."},{"key":"C8SM00457A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.compbiomed.2015.04.009","volume":"62","author":"Scianna","year":"2015","journal-title":"Comput. Biol. Med."},{"key":"C8SM00457A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.022418","volume":"136","author":"Raz","year":"2009","journal-title":"Development"},{"key":"C8SM00457A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tips.2013.03.001","volume":"34","author":"Wells","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"C8SM00457A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.4324\/9780203833582","volume-title":"Cell movements: from molecules to motility","author":"Bray","year":"2000","unstructured":"D. Bray , Cell movements: from molecules to motility , New York , 2000"},{"key":"C8SM00457A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1073\/pnas.1006327107","volume":"107","author":"Barry","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8SM00457A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E165","DOI":"10.1073\/pnas.1011900107","volume":"107","author":"Bae","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8SM00457A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e27532","DOI":"10.1371\/journal.pone.0027532","volume":"6","author":"Van Haastert","year":"2011","journal-title":"PLoS One"},{"key":"C8SM00457A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.1106587","volume":"310","author":"Stevens","year":"2005","journal-title":"Science"},{"key":"C8SM00457A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrc.2016.123","volume":"17","author":"Paul","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"C8SM00457A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-61779-207-6_11","volume":"769","author":"Sixt","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"C8SM00457A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ceb.2005.08.002","volume":"17","author":"Yamaguchi","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"C8SM00457A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.semcdb.2009.08.005","volume":"20","author":"Wolf","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"C8SM00457A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1016\/j.bbagen.2016.09.026","volume":"1861","author":"Huber","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"C8SM00457A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2015.01.007","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"C8SM00457A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jlb.61.2.188","volume":"61","author":"Mandeville","year":"1997","journal-title":"J. Leukocyte Biol."},{"key":"C8SM00457A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200209006","volume":"160","author":"Wolf","year":"2003","journal-title":"J. Cell Biol."},{"key":"C8SM00457A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"050701","DOI":"10.1103\/PhysRevE.92.050701","volume":"92","author":"Wu","year":"2015","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C8SM00457A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1080\/10255842.2012.757598","volume":"16","author":"Lim","year":"2013","journal-title":"Comput. Meth. Biomech. Biomed. Eng."},{"key":"C8SM00457A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bpj.2012.07.048","volume":"103","author":"Schl\u00fcter","year":"2012","journal-title":"Biophys. J."},{"key":"C8SM00457A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1098\/rsif.2012.0276","volume":"9","author":"Elliott","year":"2012","journal-title":"J. R. Soc., Interface"},{"key":"C8SM00457A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e21955","DOI":"10.1371\/journal.pone.0021955","volume":"6","author":"Hecht","year":"2011","journal-title":"PLoS One"},{"key":"C8SM00457A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cma.2017.03.025","volume":"320","author":"Moure","year":"2017","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"C8SM00457A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1137\/100815335","volume":"9","author":"Vanderlei","year":"2011","journal-title":"Multiscale Model. Simul."},{"key":"C8SM00457A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s002490050163","volume":"27","author":"Bottino","year":"1998","journal-title":"Eur. Biophys. J."},{"key":"C8SM00457A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"228102","DOI":"10.1103\/PhysRevLett.111.228102","volume":"111","author":"Farutin","year":"2013","journal-title":"Phys. Rev. Lett."},{"key":"C8SM00457A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"034702","DOI":"10.1103\/PhysRevE.88.034702","volume":"88","author":"Najem","year":"2013","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C8SM00457A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1017\/jfm.2012.637","volume":"718","author":"Yazdani","year":"2013","journal-title":"J. Fluid Mech."},{"key":"C8SM00457A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"056308","DOI":"10.1103\/PhysRevE.85.056308","volume":"85","author":"Yazdani","year":"2012","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C8SM00457A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"041902","DOI":"10.1063\/1.4871300","volume":"26","author":"Cordasco","year":"2014","journal-title":"Phys. Fluids"},{"key":"C8SM00457A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101902","DOI":"10.1063\/1.4990543","volume":"29","author":"Campbell","year":"2017","journal-title":"Phys. Fluids"},{"key":"C8SM00457A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06887","volume":"453","author":"L\u00e4mmermann","year":"2008","journal-title":"Nature"},{"key":"C8SM00457A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1189\/jlb.70.4.491","volume":"70","author":"Friedl","year":"2001","journal-title":"J. Leukocyte Biol."},{"key":"C8SM00457A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-3495(73)85983-1","volume":"13","author":"Skalak","year":"1973","journal-title":"Biophys. J."},{"key":"C8SM00457A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1103\/PhysRevA.39.5280","volume":"39","author":"Zhong-can","year":"1989","journal-title":"Phys. Rev. A: At., Mol., Opt. Phys."},{"key":"C8SM00457A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1063\/PT.3.1884","volume":"66","author":"Levine","year":"2013","journal-title":"Phys. Today"},{"key":"C8SM00457A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ceb.2009.05.003","volume":"21","author":"L\u00e4mmermann","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"C8SM00457A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCRESAHA.109.200717","volume":"105","author":"Muller","year":"2009","journal-title":"Circ. Res."},{"key":"C8SM00457A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1039\/c0ib00050g","volume":"2","author":"Guck","year":"2010","journal-title":"Integr. Biol."},{"key":"C8SM00457A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gde.2004.12.002","volume":"15","author":"Sahai","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"C8SM00457A-(cit42)\/*[position()=1]","first-page":"2869","volume":"112","author":"Meinhardt","year":"1999","journal-title":"J. Cell Sci."},{"key":"C8SM00457A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1137\/100788938","volume":"33","author":"Neilson","year":"2011","journal-title":"SIAM J. Sci. Comput."},{"key":"C8SM00457A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e5253","DOI":"10.1371\/journal.pone.0005253","volume":"4","author":"Bosgraaf","year":"2009","journal-title":"PLoS One"},{"key":"C8SM00457A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-5193(81)90334-9","volume":"88","author":"Murray","year":"1981","journal-title":"J. Theor. Biol."},{"key":"C8SM00457A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1039\/a702602a","volume":"93","author":"Maini","year":"1997","journal-title":"J. Chem. Soc., Faraday Trans."},{"key":"C8SM00457A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1073\/pnas.0601302103","volume":"103","author":"Levine","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C8SM00457A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1001127","DOI":"10.1371\/journal.pcbi.1001127","volume":"7","author":"Kabaso","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"C8SM00457A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S0962492902000077","volume":"11","author":"Peskin","year":"2002","journal-title":"Acta Numerica"},{"key":"C8SM00457A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1006\/jcph.2001.6726","volume":"169","author":"Tryggvason","year":"2001","journal-title":"J. Comput. Phys."},{"key":"C8SM00457A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108104","DOI":"10.1103\/PhysRevLett.105.108104","volume":"105","author":"Shao","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"C8SM00457A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1002044","DOI":"10.1371\/journal.pcbi.1002044","volume":"7","author":"Hecht","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"C8SM00457A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1016\/j.bpj.2009.01.037","volume":"96","author":"Ditlev","year":"2009","journal-title":"Biophys. J."},{"key":"C8SM00457A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jbiomech.2009.09.025","volume":"43","author":"Young","year":"2010","journal-title":"J. Biomech."},{"key":"C8SM00457A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jcp.2017.01.007","volume":"334","author":"Balogh","year":"2017","journal-title":"J. Comput. Phys."},{"key":"C8SM00457A-(cit56)\/*[position()=1]","volume-title":"Mechanics of motor proteins and the cytoskeleton","author":"Howard","year":"2011","unstructured":"J. Howard , Mechanics of motor proteins and the cytoskeleton , Sunderland , 2011"},{"key":"C8SM00457A-(cit57)\/*[position()=1]","volume-title":"Mechanics of the cell","author":"Boal","year":"2002","unstructured":"D. Boal , Mechanics of the cell , Cambridge , 2002"},{"key":"C8SM00457A-(cit58)\/*[position()=1]","first-page":"1025","volume":"11","author":"Wakatsuki","year":"2000","journal-title":"J. Cell Sci."},{"key":"C8SM00457A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e46609","DOI":"10.1371\/journal.pone.0046609","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"C8SM00457A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nnano.2007.388","volume":"2","author":"Cross","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"C8SM00457A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nphys1800","volume":"6","author":"Fritsch","year":"2010","journal-title":"Nat. Phys."},{"key":"C8SM00457A-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ceb.2015.08.001","volume":"36","author":"Sarris","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"C8SM00457A-(cit63)\/*[position()=1]","first-page":"639","volume":"2","author":"Ambravaneswaran","year":"2010","journal-title":"R. Soc. Chem."},{"key":"C8SM00457A-(cit64)\/*[position()=1]","first-page":"362","volume":"3","author":"Friedl","year":"2003","journal-title":"Nature"},{"key":"C8SM00457A-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm3897","volume":"15","author":"Charras","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C8SM00457A-(cit66)\/*[position()=1]","first-page":"2504","volume":"60","author":"Wyckoff","year":"2000","journal-title":"Cancer Res."},{"key":"C8SM00457A-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.devcel.2018.01.026","volume":"44","author":"Franz","year":"2018","journal-title":"Dev. Cell"},{"key":"C8SM00457A-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2015.01.008","volume":"160","author":"Rupercht","year":"2015","journal-title":"Cell"},{"key":"C8SM00457A-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev-cellbio-111315-125341","volume":"32","author":"Paluch","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"C8SM00457A-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-28282-9","volume-title":"Tissue Engineering III: Cell \u2013 Surface Interactions for Tissue Culture","author":"Kasper","year":"2012","unstructured":"C. Kasper , F.Witte and R.P\u00f6rtner , Tissue Engineering III: Cell \u2013 Surface Interactions for Tissue Culture , Berlin , 2012"},{"key":"C8SM00457A-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"061113","DOI":"10.1103\/PhysRevE.81.061113","volume":"81","author":"Ogawa","year":"2010","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C8SM00457A-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1063\/1.1456024","volume":"116","author":"Faraudo","year":"2002","journal-title":"J. Chem. Phys."}],"container-title":["Soft Matter"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/SM\/C8SM00457A","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/SM\/C8SM00457A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:20:30Z","timestamp":1782969630000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sm\/article\/14\/28\/5741-5763\/623548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":72,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8sm00457a","relation":{},"ISSN":["1744-683X","1744-6848"],"issn-type":[{"value":"1744-683X","type":"print"},{"value":"1744-6848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C8SM00457A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Eric J. Campbell (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4559-3930","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Prosenjit Bagchi (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4573-7455","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 March 2018; Accepted 31 May 2018; Accepted Manuscript published 1 June 2018; Advance Article published 6 June 2018; Version of Record published 18 July 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}