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Many spider venom components show potential activity against a wide range of human diseases. However, the development of novel venom-derived therapeutics requires an understanding of their mechanisms of action. This review will highlight the structures, activities and the possible mechanisms of action of spider venoms and their components against cancer, microbial infections, and pain.<\/jats:p>","DOI":"10.1039\/c8tx00022k","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T09:43:57Z","timestamp":1520502237000},"page":"381-395","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anticancer, antimicrobial, and analgesic activities of spider venoms"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-6096","authenticated-orcid":false,"given":"Hassan M.","family":"Akef","sequence":"first","affiliation":[{"name":"National Organization for Research and Control of Biologicals (NORCB), Giza, Egypt. 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