{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:31:35Z","timestamp":1782970295995,"version":"3.54.5"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"am","delay-in-days":534,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["NORTE-01-0145-FEDER-000012"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000012"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["POCI-01-0145-FEDER-007274"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007274"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["PT2020 UID\/QUI\/50006\/2013"],"award-info":[{"award-number":["PT2020 UID\/QUI\/50006\/2013"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["POCI\/01\/0145\/FEDER\/007265"],"award-info":[{"award-number":["POCI\/01\/0145\/FEDER\/007265"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"crossref","award":["SFRH\/BD\/96519\/2013"],"award-info":[{"award-number":["SFRH\/BD\/96519\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"crossref","award":["SFRH\/BPD\/92934\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/92934\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>The incorporation of nanoparticles into a thermosensitive enema enhances colorectal distribution and retention.<\/p>","DOI":"10.1039\/c9bm00759h","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T05:34:24Z","timestamp":1560836064000},"page":"3801-3811","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Colorectal distribution and retention of polymeric nanoparticles following incorporation into a thermosensitive enema"],"prefix":"10.1039","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-0019","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Melo","sequence":"first","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"},{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-4404","authenticated-orcid":false,"given":"Rute","family":"Nunes","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"},{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-7553","authenticated-orcid":false,"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"},{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-2759","authenticated-orcid":false,"given":"Jos\u00e9","family":"das Neves","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"},{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9BM00759H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4155\/tde-2017-0056","volume":"8","author":"Ham","year":"2017","journal-title":"Ther. Delivery"},{"key":"C9BM00759H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/10837450.2018.1484766","volume":"23","author":"Purohit","year":"2018","journal-title":"Pharm. Dev. Technol."},{"key":"C9BM00759H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1517\/14656566.2013.836181","volume":"14","author":"Altomare","year":"2013","journal-title":"Expert Opin. Pharmacother."},{"key":"C9BM00759H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","volume":"313","author":"Chey","year":"2015","journal-title":"J. Am. Med. Assoc."},{"key":"C9BM00759H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.addr.2014.05.012","volume":"73","author":"Jannin","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9BM00759H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jconrel.2014.09.013","volume":"194","author":"Nunes","year":"2014","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mtchem.2018.09.001","volume":"10","author":"Melo","year":"2018","journal-title":"Mater. Today Chem."},{"key":"C9BM00759H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/gut.2009.184556","volume":"59","author":"Zuo","year":"2010","journal-title":"Gut"},{"key":"C9BM00759H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jconrel.2014.05.046","volume":"188","author":"Moulari","year":"2014","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34942","DOI":"10.1021\/acsami.8b12214","volume":"10","author":"Nunes","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C9BM00759H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"79ra33","DOI":"10.1126\/scitranslmed.3001963","volume":"3","author":"Thakor","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"C9BM00759H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2014.10.026","volume":"197","author":"Maisel","year":"2015","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejpb.2018.06.029","volume":"130","author":"Nunes","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C9BM00759H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jconrel.2012.10.019","volume":"165","author":"Schmidt","year":"2013","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"0078","DOI":"10.1038\/s41551-017-0078","volume":"1","author":"Luginbuhl","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"C9BM00759H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"eaau8581","DOI":"10.1126\/scitranslmed.aau8581","volume":"11","author":"Babaee","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"C9BM00759H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.biomaterials.2015.10.021","volume":"75","author":"Monette","year":"2016","journal-title":"Biomaterials"},{"key":"C9BM00759H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1500758","DOI":"10.1126\/sciadv.1500758","volume":"1","author":"Hinton","year":"2015","journal-title":"Sci. Adv."},{"key":"C9BM00759H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ejpb.2015.05.017","volume":"97","author":"Klouda","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C9BM00759H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/jfb9010011","volume":"9","author":"Bodratti","year":"2018","journal-title":"J. Funct. Biomater."},{"key":"C9BM00759H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2012.03.054","volume":"430","author":"Yuan","year":"2012","journal-title":"Int. J. Pharm."},{"key":"C9BM00759H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1208\/s12249-017-0839-5","volume":"19","author":"Liu","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"C9BM00759H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejpb.2007.09.017","volume":"69","author":"Koffi","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C9BM00759H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/03639045.2018.1534858","volume":"45","author":"Akl","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"C9BM00759H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejpb.2015.04.019","volume":"94","author":"Din","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C9BM00759H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/10717544.2016.1272651","volume":"24","author":"Din","year":"2017","journal-title":"Drug Delivery"},{"key":"C9BM00759H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/10717544.2016.1245369","volume":"24","author":"Moawad","year":"2017","journal-title":"Drug Delivery"},{"key":"C9BM00759H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/pharmaceutics6030530","volume":"6","author":"Cunha","year":"2014","journal-title":"Pharmaceutics"},{"key":"C9BM00759H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1021\/mp4002365","volume":"10","author":"das Neves","year":"2013","journal-title":"Mol. Pharm."},{"key":"C9BM00759H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpba.2010.01.007","volume":"52","author":"das Neves","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"C9BM00759H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijpharm.2004.05.002","volume":"280","author":"Fawaz","year":"2004","journal-title":"Int. J. Pharm."},{"key":"C9BM00759H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-6405-8-12","volume":"8","author":"Wang","year":"2011","journal-title":"AIDS Res. Ther."},{"key":"C9BM00759H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5173(99)00227-6","volume":"189","author":"Yun","year":"1999","journal-title":"Int. J. Pharm."},{"key":"C9BM00759H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejps.2005.11.001","volume":"27","author":"Koffi","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"C9BM00759H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1208\/s12248-015-9723-y","volume":"17","author":"Stevens","year":"2015","journal-title":"AAPS J."},{"key":"C9BM00759H-(cit36)\/*[position()=1]","first-page":"64","volume":"20","author":"Moore","year":"1996","journal-title":"Pharm. Technol."},{"key":"C9BM00759H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1701035","DOI":"10.1002\/adhm.201701035","volume":"7","author":"Martins","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"C9BM00759H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijpharm.2017.08.064","volume":"532","author":"Mart\u00ednez Rivas","year":"2017","journal-title":"Int. J. Pharm."},{"key":"C9BM00759H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"C9BM00759H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20530","DOI":"10.1021\/acsami.5b06043","volume":"7","author":"Shen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C9BM00759H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e48328","DOI":"10.1371\/journal.pone.0048328","volume":"7","author":"Dezzutti","year":"2012","journal-title":"PLoS One"},{"key":"C9BM00759H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/156720109787048294","volume":"6","author":"das Neves","year":"2009","journal-title":"Curr. Drug Delivery"},{"key":"C9BM00759H-(cit44)\/*[position()=1]","volume-title":"Use and Procurement of Additional Lubricants for Male and Female Condoms: WHO\/UNFPA\/FHI360","author":"World Health Organization","year":"2012","unstructured":"World Health Organization  ,  Use and Procurement of Additional Lubricants for Male and Female Condoms: WHO\/UNFPA\/FHI360 , Advisory Note.  WHO ,  Geneva, Switzerland ,  2012"},{"key":"C9BM00759H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/aid.2010.0252","volume":"27","author":"Begay","year":"2011","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"C9BM00759H-(cit46)\/*[position()=1]","volume-title":"ISO 10993-5:2009 Biological Evaluation of Medical Devices : Part 5: Tests for In Vitro Cytotoxicity","author":"International Organization for Standardization","year":"2009","unstructured":"International Organization for Standardization  ,  ISO 10993-5:2009 Biological Evaluation of Medical Devices  \u2013  Part 5: Tests for In Vitro Cytotoxicity ,  Geneva, Switzerland ,  2009"},{"key":"C9BM00759H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e60147","DOI":"10.1371\/journal.pone.0060147","volume":"8","author":"McGowan","year":"2013","journal-title":"PLoS One"},{"key":"C9BM00759H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e23243","DOI":"10.1371\/journal.pone.0023243","volume":"6","author":"Anton","year":"2011","journal-title":"PLoS One"},{"key":"C9BM00759H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.addr.2015.12.015","volume":"103","author":"das Neves","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9BM00759H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actbio.2015.02.007","volume":"18","author":"das Neves","year":"2015","journal-title":"Acta Biomater."},{"key":"C9BM00759H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/pharmaceutics11040184","volume":"11","author":"Yang","year":"2019","journal-title":"Pharmaceutics"},{"key":"C9BM00759H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"0010","DOI":"10.1038\/s41551-016-0010","volume":"1","author":"Hong","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"C9BM00759H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2191-219X-3-60","volume":"3","author":"Padmanabhan","year":"2013","journal-title":"EJNMMI Res."},{"key":"C9BM00759H-(cit54)\/*[position()=1]","first-page":"G341","volume":"305","author":"Ermund","year":"2013","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"C9BM00759H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2015.04.040","volume":"209","author":"Maisel","year":"2015","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jconrel.2011.06.036","volume":"156","author":"Cu","year":"2011","journal-title":"J. Controlled Release"},{"key":"C9BM00759H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1007\/s11095-013-1287-x","volume":"31","author":"das Neves","year":"2014","journal-title":"Pharm. Res."},{"key":"C9BM00759H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"054005","DOI":"10.1117\/1.3213606","volume":"14","author":"Texier","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"C9BM00759H-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/anie.201006849","volume":"50","author":"Yang","year":"2011","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/BM\/C9BM00759H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:17:09Z","timestamp":1782965829000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/7\/9\/3801-3811\/633186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8,20]]}},"URL":"https:\/\/doi.org\/10.1039\/c9bm00759h","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9BM00759H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"M\u00e9lanie Melo (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5817-0019","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Rute Nunes (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8633-4404","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Bruno Sarmento (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5763-7553","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Jos\u00e9 das Neves (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2317-2759","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 May 2019; Accepted 17 June 2019;  Accepted Manuscript published 18 June 2019;  Advance Article published 25 June 2019;  Version of Record published 20 August 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}