{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:29:45Z","timestamp":1783016985035,"version":"3.54.6"},"reference-count":63,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100011263","name":"FP7 Nanosciences, Nanotechnologies, Materials and new Production Technologies","doi-asserted-by":"crossref","award":["263363"],"award-info":[{"award-number":["263363"]}],"id":[{"id":"10.13039\/100011263","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","award":["Centre for Innovative Manufacturing in Medical Dev"],"award-info":[{"award-number":["Centre for Innovative Manufacturing in Medical Dev"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","award":["EP\/K029592\/1"],"award-info":[{"award-number":["EP\/K029592\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>A major challenge in orthopedics is the repair of large non-union bone fractures.<\/p>","DOI":"10.1039\/c9bm01827a","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T06:03:51Z","timestamp":1580105031000},"page":"1683-1694","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Preclinical biological and physicochemical evaluation of two-photon engineered 3D biomimetic copolymer scaffolds for bone healing"],"prefix":"10.1039","volume":"8","author":[{"given":"Carina","family":"Kampleitner","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology"},{"name":"University of Vienna"},{"name":"Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoon","family":"Changi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Allergy"},{"name":"Division of Immunology"},{"name":"Allergy and Infectious Diseases"},{"name":"Medical University of Vienna"},{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda M.","family":"Felfel","sequence":"additional","affiliation":[{"name":"Advanced Materials Research Group"},{"name":"Faculty of Engineering"},{"name":"University of Nottingham"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A.","family":"Scotchford","sequence":"additional","affiliation":[{"name":"Advanced Materials Research Group"},{"name":"Faculty of Engineering"},{"name":"University of Nottingham"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-5738","authenticated-orcid":false,"given":"Virginie","family":"Sottile","sequence":"additional","affiliation":[{"name":"Danube Hospital Vienna"},{"name":"Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Kluger","sequence":"additional","affiliation":[{"name":"Wolfson STEM Centre"},{"name":"School of Medicine"},{"name":"University of Nottingham"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology"},{"name":"University of Vienna"},{"name":"Vienna"},{"name":"Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Grant","sequence":"additional","affiliation":[{"name":"Advanced Materials Research Group"},{"name":"Faculty of Engineering"},{"name":"University of Nottingham"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-0224","authenticated-orcid":false,"given":"Michelle M.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Allergy"},{"name":"Division of Immunology"},{"name":"Allergy and Infectious Diseases"},{"name":"Medical University of Vienna"},{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"C9BM01827A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bone.2015.07.007","volume":"81","author":"Garcia-Gareta","year":"2015","journal-title":"Bone"},{"key":"C9BM01827A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.msec.2015.07.016","volume":"57","author":"Yunus Basha","year":"2015","journal-title":"Mater. Sci. Eng., C"},{"key":"C9BM01827A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00264-015-2728-4","volume":"39","author":"Dumic-Cule","year":"2015","journal-title":"Int. Orthop."},{"key":"C9BM01827A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00264-014-2281-6","volume":"38","author":"Bumbasirevic","year":"2014","journal-title":"Int. Orthop."},{"key":"C9BM01827A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00003086-199706000-00011","author":"Goulet","year":"1997","journal-title":"Clin. Orthop. Relat. Res."},{"key":"C9BM01827A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/154405910808700215","volume":"87","author":"Ai-Aql","year":"2008","journal-title":"J. Dent. Res."},{"key":"C9BM01827A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.injury.2007.02.006","volume":"38","author":"Tsiridis","year":"2007","journal-title":"Injury"},{"key":"C9BM01827A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00003086-199605000-00009","volume":"326","author":"Merritt","year":"1996","journal-title":"Clin. Orthop. Relat. Res."},{"key":"C9BM01827A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jcb.10435","volume":"88","author":"Gerstenfeld","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"C9BM01827A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jcb.20373","volume":"95","author":"Li","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"C9BM01827A-(cit11)\/*[position()=1]","volume-title":"Biomaterials and stem cells in regenerative medicine","author":"Medine","year":"2012","unstructured":"C. N. Medine  ,  F.Khan ,  S.Pernagallo ,  R.Zhang ,  O.Tura ,  M.Bradley  and  D. C.Hay , in  Biomaterials and stem cells in regenerative medicine , ed.  M. Ramalingam ,  S. Ramakrishna  and  S. Best ,  2012 , pp.  1\u201330"},{"key":"C9BM01827A-(cit12)\/*[position()=1]","first-page":"522","volume":"24","author":"Pape","year":"2010","journal-title":"J. Orthop. Traumatol."},{"key":"C9BM01827A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1189\/jlb.0810446","volume":"89","author":"Bastian","year":"2011","journal-title":"J. Leukocyte Biol."},{"key":"C9BM01827A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2019.00164","volume":"7","author":"Tamay","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"C9BM01827A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","volume":"21","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/290602","volume":"2011","author":"Dhandayuthapani","year":"2011","journal-title":"Int. J. Polym. Sci."},{"key":"C9BM01827A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22203\/eCM.v005a01","volume":"5","author":"Gunatillake","year":"2003","journal-title":"Eur. Cells Mater."},{"key":"C9BM01827A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/polb.22259","volume":"49","author":"Ulery","year":"2011","journal-title":"J. Polym. Sci., Part B: Polym. Phys."},{"key":"C9BM01827A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"180811","DOI":"10.1098\/rsos.180811","volume":"5","author":"Sartoneva","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"C9BM01827A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1557\/jmr.2018.111","volume":"33","author":"Moncal","year":"2018","journal-title":"J. Mater. Res."},{"key":"C9BM01827A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.3390\/ijms10094033","volume":"10","author":"Lyu","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"C9BM01827A-(cit22)\/*[position()=1]","volume-title":"Biomaterial fabrication and processing handbook","author":"Taylor and Francis Group","year":"2008","unstructured":"Taylor and Francis Group  ,  Biomaterial fabrication and processing handbook ,  CRC Press ,  2008"},{"key":"C9BM01827A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800029","DOI":"10.1002\/adem.201800029","volume":"20","author":"Al-Ketan","year":"2018","journal-title":"Adv. Eng. Mater."},{"key":"C9BM01827A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1364\/OE.19.005602","volume":"19","author":"Malinauskas","year":"2011","journal-title":"Opt. Express"},{"key":"C9BM01827A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.msec.2019.03.037","volume":"100","author":"Moreno Madrid","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"C9BM01827A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jbm.a.30418","volume":"75","author":"Holmbom","year":"2005","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"C9BM01827A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1748-6041\/11\/1\/015011","volume":"11","author":"Felfel","year":"2016","journal-title":"Biomed. Mater."},{"key":"C9BM01827A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.matdes.2018.09.035","volume":"160","author":"Felfel","year":"2018","journal-title":"Mater. Des."},{"key":"C9BM01827A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"015011","DOI":"10.1088\/1748-6041\/11\/1\/015011","volume":"11","author":"Felfel","year":"2016","journal-title":"Biomed. Mater."},{"key":"C9BM01827A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1210\/endo-123-5-2600","volume":"123","author":"Takahashi","year":"1988","journal-title":"Endocrinology"},{"key":"C9BM01827A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-61779-415-5_2","volume-title":"Bone Research Protocols","volume":"816","author":"Bakker","year":"2012","unstructured":"A. D. Bakker   and  J.Klein-Nulend , in  Bone Research Protocols , ed.  M. Helfrich  and  S. Ralston ,  Humana Press ,  2012 , vol.  816 , pp.  19\u201329"},{"key":"C9BM01827A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/jor.22019","volume":"30","author":"Meyer","year":"2012","journal-title":"J. Orthop. Res."},{"key":"C9BM01827A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/jbm.a.36290","volume":"106","author":"Changi","year":"2018","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"C9BM01827A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.smim.2007.11.005","volume":"20","author":"Jones","year":"2008","journal-title":"Semin. Immunol."},{"key":"C9BM01827A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2353\/ajpath.2009.080962","volume":"175","author":"Higgins","year":"2009","journal-title":"Am. J. Pathol."},{"key":"C9BM01827A-(cit36)\/*[position()=1]","volume-title":"BS EN ISO 10993-13: Biological evaluation of medical devices. Identification and quantification of degradation products from polymeric medical devices","author":"ISO","year":"2010","unstructured":"ISO  ,  BS EN ISO 10993-13: Biological evaluation of medical devices. Identification and quantification of degradation products from polymeric medical devices ,  2010"},{"key":"C9BM01827A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1748-6041\/4\/5\/055009","volume":"4","author":"Jung","year":"2009","journal-title":"Biomed. Mater."},{"key":"C9BM01827A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevLett.89.266601","volume":"89","author":"Torquato","year":"2002","journal-title":"Phys. Rev. Lett."},{"key":"C9BM01827A-(cit39)\/*[position()=1]","first-page":"1","volume":"72","author":"Jung","year":"2005","journal-title":"Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys."},{"key":"C9BM01827A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.22203\/eCM.v020a10","volume":"20","author":"Zong","year":"2010","journal-title":"Eur. Cells Mater."},{"key":"C9BM01827A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jbm.a.30324","volume":"74","author":"Ren","year":"2005","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"C9BM01827A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1016\/j.biomaterials.2013.09.011","volume":"34","author":"Cipitria","year":"2013","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1089\/ten.tea.2016.0347","volume":"23","author":"Barbieri","year":"2017","journal-title":"Tissue Eng., Part A"},{"key":"C9BM01827A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1016\/j.biomaterials.2011.02.047","volume":"32","author":"Roberts","year":"2011","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit45)\/*[position()=1]","first-page":"1","volume":"12","author":"Walsh","year":"2017","journal-title":"PLoS One"},{"key":"C9BM01827A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/j.biomaterials.2010.03.024","volume":"31","author":"Chatterjee","year":"2010","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1016\/j.biomaterials.2009.07.028","volume":"30","author":"Jones","year":"2009","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biomaterials.2016.05.004","volume":"98","author":"Mao","year":"2016","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jbmr.278","volume":"26","author":"Shih","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"C9BM01827A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22203\/eCM.v018a01","volume":"18","author":"Evans","year":"2009","journal-title":"Eur. Cells Mater."},{"key":"C9BM01827A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"312","DOI":"10.22203\/eCM.v031a20","volume":"31","author":"Hulsart-Billstrom","year":"2016","journal-title":"Eur. Cells Mater."},{"key":"C9BM01827A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/foc.2001.10.4.2","volume":"10","author":"Kalfas","year":"2001","journal-title":"Neurosurg Focus"},{"key":"C9BM01827A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00441-011-1205-7","volume":"347","author":"Schmidt-Bleek","year":"2012","journal-title":"Cell Tissue Res."},{"key":"C9BM01827A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11420-005-0111-5","volume":"1","author":"Bostrom","year":"2005","journal-title":"HSS J."},{"key":"C9BM01827A-(cit55)\/*[position()=1]","first-page":"20","volume":"41","author":"Van Hoff","year":"2012","journal-title":"Am. J. Orthop."},{"key":"C9BM01827A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4248\/BR201303002","volume":"1","author":"Henkel","year":"2013","journal-title":"Bone Res."},{"key":"C9BM01827A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1016\/j.biomaterials.2008.05.024","volume":"29","author":"Guarino","year":"2008","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.biomaterials.2004.04.036","volume":"26","author":"Jeong","year":"2005","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1021\/bm049921i","volume":"5","author":"Jeong","year":"2004","journal-title":"Biomacromolecules"},{"key":"C9BM01827A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.otsm.2004.07.015","volume":"12","author":"Maurus","year":"2004","journal-title":"Oper. Tech. Sports Med."},{"key":"C9BM01827A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/S0142-9612(00)00101-0","volume":"21","author":"Middleton","year":"2000","journal-title":"Biomaterials"},{"key":"C9BM01827A-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.progpolymsci.2010.04.002","volume":"35","author":"Woodruff","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"C9BM01827A-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jbm.a.31300","volume":"83","author":"Bramfeldt","year":"2007","journal-title":"J. Biomed. Mater. Res., Part A"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/BM\/C9BM01827A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:29:09Z","timestamp":1783013349000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/8\/6\/1683-1694\/633438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3,17]]}},"URL":"https:\/\/doi.org\/10.1039\/c9bm01827a","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Virginie Sottile (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6064-5738","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Michelle M. Epstein (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4755-0224","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 November 2019; Accepted 17 January 2020;  Advance Article published 27 January 2020;  Version of Record published 17 March 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}