{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:23:25Z","timestamp":1790508205131,"version":"4.1.0"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"49","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"am","delay-in-days":498,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"crossref","award":["Zukunftskolleg Incoming Fellowship (ZIF)"],"award-info":[{"award-number":["Zukunftskolleg Incoming Fellowship (ZIF)"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Emmy Noether Program"],"award-info":[{"award-number":["Emmy Noether Program"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DP2AI138239"],"award-info":[{"award-number":["DP2AI138239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>\n                    We describe a tandem reaction leading to tricyclic pyrrolo[1,2-\n                    <italic>a<\/italic>\n                    ]quinolin-5-ones with unique selectivity against the liver stage of the malaria parasite.\n                  <\/p>","DOI":"10.1039\/c9cc01689a","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T04:39:36Z","timestamp":1557722376000},"page":"7009-7012","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-\n                    <i>a<\/i>\n                    ]quinolin-5-ones with potent anti-protozoal activity"],"prefix":"10.1039","volume":"55","author":[{"given":"D\u00e1vid","family":"Szamosv\u00e1ri","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Konstanz Research School Chemical Biology"},{"name":"Zukunftskolleg"},{"name":"University of Konstanz"},{"name":"78457 Konstanz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Sylvester","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology"},{"name":"School of Medicine"},{"name":"Duke University"},{"name":"Durham"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-7876","authenticated-orcid":false,"given":"Philipp","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Konstanz Research School Chemical Biology"},{"name":"Zukunftskolleg"},{"name":"University of Konstanz"},{"name":"78457 Konstanz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology"},{"name":"School of Medicine"},{"name":"Duke University"},{"name":"Durham"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-8844","authenticated-orcid":false,"given":"Emily R.","family":"Derbyshire","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology"},{"name":"School of Medicine"},{"name":"Duke University"},{"name":"Durham"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-4825","authenticated-orcid":false,"given":"Thomas","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Konstanz Research School Chemical Biology"},{"name":"Zukunftskolleg"},{"name":"University of Konstanz"},{"name":"78457 Konstanz"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9CC01689A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1574-6976.2010.00247.x","volume":"35","author":"Heeb","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"C9CC01689A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1021\/acs.jmedchem.5b01485","volume":"59","author":"Fernandez-Alvaro","year":"2016","journal-title":"J. Med. Chem."},{"key":"C9CC01689A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejmech.2018.10.035","volume":"161","author":"Chu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"C9CC01689A-(cit4)\/*[position()=1]","first-page":"542","author":"Szamosv\u00e1ri","year":"2018","journal-title":"Synlett"},{"key":"C9CC01689A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0924-8579(00)00192-8","volume":"16","author":"Appelbaum","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"C9CC01689A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/j.ejmech.2010.04.011","volume":"45","author":"Kaur","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"C9CC01689A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.01.039","volume":"146","author":"Fan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"C9CC01689A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.1002\/anie.201702944","volume":"56","author":"Szamosv\u00e1ri","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9CC01689A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1128\/AAC.00895-06","volume":"51","author":"Saleh","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9CC01689A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3987\/COM-10-S(E)9","volume":"82","author":"Tietze","year":"2010","journal-title":"Heterocycles"},{"key":"C9CC01689A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.bbabio.2008.08.006","volume":"1777","author":"Lin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"C9CC01689A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1073\/pnas.1205651109","volume":"109","author":"Biagini","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9CC01689A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4155\/fmc.13.121","volume":"5","author":"Nixon","year":"2013","journal-title":"Future Med. Chem."},{"key":"C9CC01689A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/acs.jmedchem.6b01718","volume":"60","author":"Hong","year":"2017","journal-title":"J. Med. Chem."},{"key":"C9CC01689A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1021\/np8004612","volume":"71","author":"H\u00f6fle","year":"2008","journal-title":"J. Nat. Prod."},{"key":"C9CC01689A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/AAC.38.5.1169","volume":"38","author":"Basco","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9CC01689A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1124\/mol.108.045120","volume":"73","author":"Biagini","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"C9CC01689A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/cr950010w","volume":"96","author":"Harvey","year":"1996","journal-title":"Chem. Rev."},{"key":"C9CC01689A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/jo802196r","volume":"74","author":"Mehta","year":"2009","journal-title":"J. Org. Chem."},{"key":"C9CC01689A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8217","DOI":"10.3390\/molecules17078217","volume":"17","author":"Wube","year":"2012","journal-title":"Molecules"},{"key":"C9CC01689A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jhet.5570220256","volume":"22","author":"Coppola","year":"1985","journal-title":"J. Heterocycl. Chem."},{"key":"C9CC01689A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/cmdc.201800456","volume":"13","author":"Pedron","year":"2018","journal-title":"ChemMedChem"},{"key":"C9CC01689A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1021\/ol053048w","volume":"8","author":"Aillaud","year":"2006","journal-title":"Org. Lett."},{"key":"C9CC01689A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ptr.2894","volume":"24","author":"Wansi","year":"2010","journal-title":"Phytother. Res."},{"key":"C9CC01689A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1016\/S0040-4039(97)82976-0","volume":"37","author":"Michael","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"C9CC01689A-(cit26)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"6369","DOI":"10.1002\/ejoc.201701060","author":"Huang","year":"2017","journal-title":"Eur. J. Org. Chem."},{"key":"C9CC01689A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1021\/jo200680j","volume":"76","author":"Audisio","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9CC01689A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1021\/ol800837z","volume":"10","author":"Huang","year":"2008","journal-title":"Org. Lett."},{"key":"C9CC01689A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1073\/pnas.1118370109","volume":"109","author":"Derbyshire","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9CC01689A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1128\/AAC.02110-15","volume":"60","author":"Raphemot","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9CC01689A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/cb200105d","volume":"6","author":"Nam","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"C9CC01689A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncomms1081","volume":"1","author":"Galloway","year":"2010","journal-title":"Nat. Commun."},{"key":"C9CC01689A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/CC\/C9CC01689A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:18:49Z","timestamp":1782879529000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/55\/49\/7009-7012\/634068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":33,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2019,6,13]]}},"URL":"https:\/\/doi.org\/10.1039\/c9cc01689a","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9CC01689A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Philipp Schmid (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8286-7876","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Emily R. Derbyshire (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6664-8844","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Thomas B\u00f6ttcher (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0235-4825","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Authors can choose between single-blind and double-blind peer review","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 28 February 2019; Accepted 10 May 2019; Accepted Manuscript published 13 May 2019; Advance Article published 23 May 2019; Version of Record published 13 June 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}